Development Level

Tbio 8 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal lens morphology 1 | 81
abnormal vitreous body morphol... 1 | 10
increased startle reflex 1 | 112
preweaning lethality, complete... 1 | 979

Disease

Porphyria 8 | 10
osteosarcoma 8 | 7,950
Hereditary coproporphyria 7 | 8
Acute intermittent porphyria 6 | 15
Carcinoma 6 | 11,493
Erythropoietic protoporphyria 6 | 15
Photosensitivity of skin 6 | 51
Variegate Porphyria 6 | 10
ovarian cancer 6 | 8,520
Porphyria cutanea tarda 5 | 12
Abdominal Pain 4 | 98
Anemia 4 | 365
Anemia, Hemolytic 4 | 55
Constipation 4 | 181
Cutaneous porphyria 4 | 6
Dyschezia 4 | 135
Vomiting 4 | 116
lung cancer 4 | 4,740
malignant mesothelioma 4 | 3,232
psoriasis 4 | 6,694
Abnormal blistering of the skin 3 | 54
Autosomal recessive predisposition 3 | 1,442
Blister of skin 3 | 54
Diarrhea 3 | 253
Elevated heart rate 3 | 25
Hypertensive disease 3 | 292
Peripheral Neuropathy 3 | 134
Respiratory Paralysis 3 | 7
Skin bulla 3 | 54
Tachycardia 3 | 43
Thin skin 3 | 47
astrocytic glioma 3 | 2,597
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
medulloblastoma, large-cell 3 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
tuberculosis 3 | 2,010
Abnormality of the heme biosynthetic pathway 2 | 3
Acute episodes of neuropathic symptoms 2 | 2
Alopecia 2 | 115
Anxiety 2 | 136
Anxiety disease 2 | 113
Childhood onset 2 | 38
Cholelithiasis 2 | 33
Depressive disorder 2 | 409
Elevated urinary delta-aminolevulinic acid 2 | 3
Hepatoerythropoietic porphyria 2 | 5
Hypertrichosis 2 | 46
Increase in blood pressure 2 | 119
Increased hepatocellular carcinoma risk 2 | 27
Increased incidence of hepatocellular carcinoma 2 | 27
Liver Cirrhosis 2 | 181
Liver carcinoma 2 | 240
Muscle Weakness 2 | 170
Myalgia 2 | 54
Nausea and vomiting 2 | 97
Neuropathy 2 | 261
Paresthesia 2 | 32
Psychotic Disorders 2 | 151
Scleroderma 2 | 7
Scleroderma-like secondary cutaneous sclerosis 2 | 7
Seizures 2 | 596
Sideroblastic anemia 2 | 20
Sleeplessness 2 | 16
Splenomegaly 2 | 190
Urine color abnormal 2 | 6
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,428
cutaneous lupus erythematosus 2 | 1,057
dermatomyositis 2 | 966
glioblastoma 2 | 5,792
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
subependymal giant cell astrocytoma 2 | 2,287
Anorexia 1 | 43
Cicatrization 1 | 3
Collapse of vertebra 1 | 14
Compression fracture of vertebral column 1 | 14
Confusion 1 | 21
Conjunctivitis 1 | 53
Conjunctivitis, recurrent 1 | 37
Edema 1 | 81
Erythema 1 | 58
Flushing 1 | 60
Fragile skin 1 | 18
Head and Neck Neoplasms 1 | 26
Hyperpigmented macules 1 | 42
Hypertriglyceridemia result 1 | 37
Inverted follicular keratosis 1 | 3
Irritation - emotion 1 | 68
Liver Neoplasms, Experimental 1 | 59
Meningioma 1 | 41
Microcytic hypochromic anemia (disorder) 1 | 10
Nausea 1 | 20
Respiratory Distress Syndrome, Adult 1 | 40
Tyrosinemia 1 | 10
X- linked recessive 1 | 110
X-linked sideroblastic anemia 1 | 4
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 9 | 16,909
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678
Cardiovascular System 8 | 15,192
Nervous System 8 | 16,725

Target Family

Enzyme 9 | 4,145

PathwayCommons: humancyc Pathway

http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 68 | 68
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 37 | 37
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 27 | 27
http://pathwaycommons.org/pc2/... 25 | 25
http://pathwaycommons.org/pc2/... 23 | 23
http://pathwaycommons.org/pc2/... 22 | 22
http://pathwaycommons.org/pc2/... 22 | 22
http://pathwaycommons.org/pc2/... 21 | 21
http://pathwaycommons.org/pc2/... 20 | 20
http://pathwaycommons.org/pc2/... 20 | 20
http://pathwaycommons.org/pc2/... 19 | 19
http://pathwaycommons.org/pc2/... 19 | 19
http://pathwaycommons.org/pc2/... 18 | 18
http://pathwaycommons.org/pc2/... 16 | 16
http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 14 | 14
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http://pathwaycommons.org/pc2/... 13 | 13
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http://pathwaycommons.org/pc2/... 13 | 13
http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 12 | 12
http://pathwaycommons.org/pc2/... 11 | 11
http://pathwaycommons.org/pc2/... 11 | 11
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 10 | 10
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 9 | 9
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 8 | 8
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
http://pathwaycommons.org/pc2/... 7 | 7
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http://pathwaycommons.org/pc2/... 6 | 6
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http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 6 | 6
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
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http://pathwaycommons.org/pc2/... 5 | 5
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http://pathwaycommons.org/pc2/... 5 | 5
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http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5
http://pathwaycommons.org/pc2/... 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.80580 61.7 153
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial CPOX Tbio Enzyme -2.05504 112.4 87
Protoporphyrinogen oxidase PPOX Tchem Enzyme -2.47389 296.8 173
Porphobilinogen deaminase HMBS Tbio Enzyme -2.78202 588.5 255
5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 Tbio Enzyme -2.18341 149.7 219
Delta-aminolevulinic acid dehydratase ALAD Tbio Enzyme -3.02024 1068.6 166
Uroporphyrinogen-III synthase UROS Tbio Enzyme -2.48982 310.9 67
Ferrochelatase, mitochondrial FECH Tbio Enzyme -2.73759 528.2 136
Uroporphyrinogen decarboxylase UROD Tbio Enzyme -2.94694 872.4 188