Development Level

Tbio 7 | 10,625
Tchem 2 | 1,890

Disease

Porphyria 8 | 9
osteosarcoma 8 | 7,933
Hereditary coproporphyria 7 | 9
Acute intermittent porphyria 6 | 14
Erythropoietic protoporphyria 6 | 15
Variegate Porphyria 6 | 9
ovarian cancer 6 | 8,484
Porphyria cutanea tarda 5 | 12
Anemia 4 | 252
Cutaneous porphyria 4 | 6
lung cancer 4 | 4,466
malignant mesothelioma 4 | 3,162
psoriasis 4 | 6,685
group 3 medulloblastoma 3 | 2,254
medulloblastoma, large-cell 3 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
tuberculosis 3 | 1,557
Hepatoerythropoietic porphyria 2 | 5
Hypertrichosis 2 | 23
Sideroblastic anemia 2 | 18
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,427
astrocytic glioma 2 | 2,241
cutaneous lupus erythematosus 2 | 1,056
dermatomyositis 2 | 933
ependymoma 2 | 2,514
glioblastoma 2 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
lung adenocarcinoma 2 | 2,713
subependymal giant cell astrocytoma 2 | 2,287
Angelman syndrome 1 | 38
Cancer 1 | 2,346
Clubfoot 1 | 35
Coproporphyria 1 | 1
Dermatitis 1 | 107
Disorders of Porphyrin Metabolism 1 | 1
Endogenous depression 1 | 4
Fibrosis 1 | 40
Friedreich ataxia 1 | 23
Harderoporphyria 1 | 1
Head and Neck Neoplasms 1 | 23
Hematological Disease 1 | 8
Hemochromatosis 1 | 55
Histidinemia 1 | 9
Hypertensive disease 1 | 193
Hypospadias 1 | 65
Inverted follicular keratosis 1 | 3
Kidney Diseases 1 | 86
Lead Poisoning 1 | 6
Lead Poisoning, Nervous System 1 | 1
Liver Neoplasms, Experimental 1 | 48
Liver disease 1 | 219
Liver diseases 1 | 66
Meningioma 1 | 26
Microcephaly 1 | 149
Neonatal diabetes mellitus 1 | 6
Ohdo syndrome 1 | 6
Omphalocele 1 | 22
Patau syndrome 1 | 15
Pearson syndrome 1 | 17
Pick disease 1 | 1,893
Polyhydramnios 1 | 29
Porphobilinogen synthase deficiency 1 | 1
Porphyria, Erythropoietic 1 | 2
Porphyria, South African type 1 | 2
Porphyrias, Hepatic 1 | 1
Prader-Willi syndrome 1 | 45
Prostatic Neoplasms 1 | 471
Renal Cell Carcinoma 1 | 199
Scleritis 1 | 5
Seizures 1 | 95
Siderosis 1 | 9
Silver-Russell syndrome 1 | 37
Spinal cord disease 1 | 22
Toxic encephalopathy 1 | 131
Tyrosinemia 1 | 12
X-linked sideroblastic anemia 1 | 4
acute quadriplegic myopathy 1 | 1,157
adult high grade glioma 1 | 2,148
aldosterone-producing adenoma 1 | 664
astrocytoma 1 | 1,493
atypical teratoid/rhabdoid tumor 1 | 1,095
breast carcinoma 1 | 1,614
cystic fibrosis 1 | 1,665
gastric carcinoma 1 | 832
hepatocellular carcinoma 1 | 532
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,988
medulloblastoma 1 | 1,524
mucosa-associated lymphoid tissue lymphoma 1 | 480
nasopharyngeal carcinoma 1 | 1,056
non-small cell lung cancer 1 | 2,798
non-syndromic X-linked intellectual disability 1 | 10
oligodendroglioma 1 | 2,849
pancreatic cancer 1 | 2,300
pancreatic carcinoma 1 | 567
pituitary cancer 1 | 1,972
sarcoidosis 1 | 358
sonic hedgehog group medulloblastoma 1 | 1,482
tuberculosis and treatment for 6 months 1 | 686

Tissue

Blood and immune system 9 | 17,995
Cardiovascular System 9 | 17,958
Digestive Tract 9 | 18,473
Endocrine System 9 | 18,512
Female tissues 9 | 18,647
Liver and Pancreas 9 | 18,136
Male tissues 9 | 17,969
Nervous System 9 | 18,561
Respiratory system 9 | 17,484
Skin and soft tissues 9 | 18,115
Urinary Tract 9 | 18,444

Target Family

Enzyme 9 | 4,146

PathwayCommons: humancyc Pathway

heme biosynthesis 9 | 9
superpathway of inositol phosp... 68 | 68
superpathway of conversion of ... 46 | 46
purine nucleotides de novo bio... 43 | 43
superpathway of purine nucleot... 43 | 43
tRNA charging 38 | 38
phospholipases 37 | 37
mucin core 1 and core 2 O-glyc... 28 | 28
3-phosphoinositide biosynthesi... 27 | 27
triacylglycerol biosynthesis 27 | 27
D-myo-inositol (1,4,5)-trispho... 25 | 25
superpathway of cholesterol bi... 25 | 25
gluconeogenesis 24 | 24
glycolysis 24 | 24
adenosine ribonucleotides de n... 23 | 23
CDP-diacylglycerol biosynthesi... 22 | 22
glutathione-mediated detoxific... 22 | 22
superpathway of pyrimidine deo... 21 | 21
3-phosphoinositide degradation 20 | 20
superpathway of D-myo-inositol... 20 | 20
D-myo-inositol-5-phosphate met... 19 | 19
retinol biosynthesis 18 | 18
TCA cycle 17 | 17
superpathway of methionine deg... 17 | 17
fatty acid β-oxidation 16 | 16
superpathway of pyrimidine deo... 16 | 16
the visual cycle I (vertebrate... 16 | 16
1D-myo-inositol hexakisphospha... 15 | 15
D-myo-inositol (1,3,4)-trispho... 15 | 15
fatty acid β-oxidation (p... 15 | 15
guanosine nucleotides de novo ... 15 | 15
pyrimidine deoxyribonucleotide... 15 | 15
pyrimidine deoxyribonucleotide... 15 | 15
γ-linolenate biosynthesi... 14 | 14
bile acid biosynthesis, neutra... 14 | 14
superpathway of pyrimidine rib... 14 | 14
triacylglycerol degradation 14 | 14
D-myo-inositol (1,4,5)-trispho... 13 | 13
L-kynurenine degradation 13 | 13
cholesterol biosynthesis I 13 | 13
cholesterol biosynthesis II (v... 13 | 13
cholesterol biosynthesis III (... 13 | 13
icosapentaenoate biosynthesis ... 13 | 13
stearate biosynthesis 13 | 13
valine degradation 13 | 13
NAD de novo biosynthesis 12 | 12
UTP and CTP de novo biosynthes... 12 | 12
guanosine ribonucleotides de n... 12 | 12
isoleucine degradation 12 | 12
leucine degradation 12 | 12
purine deoxyribonucleosides sa... 12 | 12
superpathway of geranylgeranyl... 12 | 12
adenosine deoxyribonucleotides... 11 | 11
guanosine deoxyribonucleotides... 11 | 11
pyrimidine deoxyribonucleotide... 11 | 11
reactive oxygen species degrad... 11 | 11
CMP phosphorylation 10 | 10
mevalonate pathway 10 | 10
noradrenaline and adrenaline d... 10 | 10
purine nucleotides degradation 10 | 10
putrescine degradation III 10 | 10
terminal O-glycans residues mo... 10 | 10
C20 prostanoid biosynthesis 9 | 9
UDP-N-acetyl-D-galactosamine b... 9 | 9
dolichyl-diphosphooligosacchar... 9 | 9
glycogenolysis 9 | 9
methionine salvage cycle III 9 | 9
serotonin degradation 9 | 9
sphingosine and sphingosine-1-... 9 | 9
tryptophan degradation 9 | 9
2-oxobutanoate degradation 8 | 8
chondroitin sulfate biosynthes... 8 | 8
fatty acid activation 8 | 8
retinoate biosynthesis I 8 | 8
sphingomyelin metabolism/ceram... 8 | 8
sucrose degradation 8 | 8
γ-glutamyl cycle 7 | 7
GABA shunt 7 | 7
adenosine nucleotides degradat... 7 | 7
androgen biosynthesis 7 | 7
ceramide de novo biosynthesis 7 | 7
chondroitin sulfate degradatio... 7 | 7
inositol pyrophosphates biosyn... 7 | 7
leukotriene biosynthesis 7 | 7
oxidative ethanol degradation ... 7 | 7
pentose phosphate pathway 7 | 7
serine and glycine biosynthesi... 7 | 7
superpathway of choline degrad... 7 | 7
thyroid hormone metabolism II ... 7 | 7
tryptophan degradation to 2-am... 7 | 7
ubiquinol-10 biosynthesis 7 | 7
2'-deoxy-α-D-ribose 1-ph... 6 | 6
GDP-mannose biosynthesis 6 | 6
cysteine biosynthesis 6 | 6
lysine degradation II (pipecol... 6 | 6
oleate biosynthesis 6 | 6
phosphatidylcholine biosynthes... 6 | 6
phosphatidylethanolamine biosy... 6 | 6
selenocysteine biosynthesis 6 | 6
zymosterol biosynthesis 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial CPOX Tbio Enzyme -2.02257 108.1 75
Protoporphyrinogen oxidase PPOX Tchem Enzyme -2.45770 291.0 158
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.74695 57.8 136
Delta-aminolevulinic acid dehydratase ALAD Tbio Enzyme -2.97616 979.9 141
5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 Tbio Enzyme -2.15025 144.4 189
Porphobilinogen deaminase HMBS Tbio Enzyme -2.72357 543.7 180
Uroporphyrinogen-III synthase UROS Tchem Enzyme -2.47605 304.4 58
Ferrochelatase, mitochondrial FECH Tbio Enzyme -2.69516 505.0 124
Uroporphyrinogen decarboxylase UROD Tbio Enzyme -2.91885 838.2 164