Development Level

Tbio 15 | 10,625
Tchem 2 | 1,890

IMPC Term

preweaning lethality, complete... 5 | 633
embryonic lethality prior to o... 2 | 148
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal kidney morphology 1 | 30
decreased IgM level 1 | 1
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased lean body mass 1 | 107

Disease

ovarian cancer 13 | 8,484
psoriasis 11 | 6,685
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Multiple myeloma 7 | 1,327
glioblastoma 7 | 5,572
astrocytic glioma 6 | 2,241
medulloblastoma, large-cell 6 | 6,234
Neoplastic Syndromes, Hereditary 5 | 48
atypical teratoid / rhabdoid tumor 5 | 4,369
medulloblastoma 5 | 1,524
osteosarcoma 5 | 7,933
Breast cancer 4 | 3,094
Gastrointestinal stromal tumor 4 | 61
Persistent generalized lymphadenopathy 4 | 15
Phaeochromocytoma 4 | 20
Pick disease 4 | 1,893
adult high grade glioma 4 | 2,148
ependymoma 4 | 2,514
Carney Triad 3 | 3
Gastrointestinal Stromal Tumors 3 | 8
Hamartoma Syndrome, Multiple 3 | 9
Hemangioma 3 | 35
Leigh disease 3 | 81
Methylmalonic acidemia 3 | 39
Mitochondrial complex II deficiency 3 | 5
Neurofibromatosis 3 | 37
Obesity 3 | 616
PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA 3 | 3
Paraganglioma 3 | 12
Sideroblastic anemia with spinocerebellar ataxia 3 | 6
Waldenstrons macroglobulinemia 3 | 765
extra-adrenal pheochromocytoma 3 | 7
lung cancer 3 | 4,466
malignant mesothelioma 3 | 3,162
non primary Sjogren syndrome sicca 3 | 840
oligodendroglioma 3 | 2,849
pilocytic astrocytoma 3 | 3,086
primitive neuroectodermal tumor 3 | 3,031
ulcerative colitis 3 | 2,087
COWDEN-LIKE SYNDROME (disorder) 2 | 2
Cancer 2 | 2,346
Chondroma 2 | 12
Cowden disease 2 | 16
Degenerative polyarthritis 2 | 93
Disease Progression 2 | 125
Hereditary Paraganglioma-Pheochromocytoma Syndrome 2 | 3
Lactic acidosis 2 | 42
Mitochondrial myopathy 2 | 23
Pheochromocytoma 2 | 22
Stomach Neoplasms 2 | 282
Thyroid cancer 2 | 25
aldosterone-producing adenoma 2 | 664
colon cancer 2 | 1,475
group 4 medulloblastoma 2 | 1,875
hereditary spastic paraplegia 2 | 313
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
pituitary cancer 2 | 1,972
Animal Mammary Neoplasms 1 | 136
Anoxia 1 | 33
Cardiomyopathies 1 | 90
Cardiomyopathy 1 | 110
Cardiomyopathy, Dilated 1 | 47
Carnitine palmitoyltransferase II deficiency 1 | 16
Cellulitis 1 | 13
Cholera 1 | 33
Deafness dystonia syndrome 1 | 20
Drug-Induced Liver Injury 1 | 118
Dystonia 1 | 77
Echinococcosis 1 | 28
Heart conduction disease 1 | 65
Heart failure 1 | 80
Hypertensive disease 1 | 193
INFANTILE CEREBELLAR-RETINAL DEGENERATION 1 | 3
Inflammatory dermatosis 1 | 38
Inguinal hernia 1 | 13
Leiomyoma 1 | 25
Leprosy 1 | 77
Liver carcinoma 1 | 217
MITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE) 1 | 5
MITOCHONDRIAL DNA DEPLETION SYNDROME 9 (ENCEPHALOMYOPATHIC TYPE WITH METHYLMALONIC ACIDURIA) 1 | 1
Mammary Neoplasms, Experimental 1 | 150
Melanoma 1 | 261
Neurodegenerative disease 1 | 383
Orotic aciduria 1 | 16
Parkinson's disease 1 | 364
Pearson syndrome 1 | 17
Pharyngitis 1 | 17
Renal Cell Carcinoma 1 | 199
Respiratory failure 1 | 30
Retinitis pigmentosa 1 | 153
Reye syndrome 1 | 11
Sideroblastic anemia 1 | 18
Spotted fever 1 | 7
Uterine fibroid 1 | 29
Vasomotor rhinitis 1 | 15
Von Hippel-Lindau disease 1 | 11
Zellweger Syndrome 1 | 38
atypical teratoid/rhabdoid tumor 1 | 1,095
glioblastoma multiforme 1 | 347
tuberculosis 1 | 1,557

Tissue

Blood and immune system 17 | 17,995
Cardiovascular System 17 | 17,958
Digestive Tract 17 | 18,473
Endocrine System 17 | 18,512
Female tissues 17 | 18,647
Liver and Pancreas 17 | 18,136
Male tissues 17 | 17,969
Nervous System 17 | 18,561
Respiratory system 17 | 17,484
Skin and soft tissues 17 | 18,115
Urinary Tract 17 | 18,444

Target Family

Enzyme 17 | 4,146

PathwayCommons: humancyc Pathway

TCA cycle 17 | 17
superpathway of inositol phosp... 68 | 68
superpathway of conversion of ... 46 | 46
purine nucleotides de novo bio... 43 | 43
superpathway of purine nucleot... 43 | 43
tRNA charging 38 | 38
phospholipases 37 | 37
mucin core 1 and core 2 O-glyc... 28 | 28
3-phosphoinositide biosynthesi... 27 | 27
triacylglycerol biosynthesis 27 | 27
D-myo-inositol (1,4,5)-trispho... 25 | 25
superpathway of cholesterol bi... 25 | 25
gluconeogenesis 24 | 24
glycolysis 24 | 24
adenosine ribonucleotides de n... 23 | 23
CDP-diacylglycerol biosynthesi... 22 | 22
glutathione-mediated detoxific... 22 | 22
superpathway of pyrimidine deo... 21 | 21
3-phosphoinositide degradation 20 | 20
superpathway of D-myo-inositol... 20 | 20
D-myo-inositol-5-phosphate met... 19 | 19
retinol biosynthesis 18 | 18
superpathway of methionine deg... 17 | 17
fatty acid β-oxidation 16 | 16
superpathway of pyrimidine deo... 16 | 16
the visual cycle I (vertebrate... 16 | 16
1D-myo-inositol hexakisphospha... 15 | 15
D-myo-inositol (1,3,4)-trispho... 15 | 15
fatty acid β-oxidation (p... 15 | 15
guanosine nucleotides de novo ... 15 | 15
pyrimidine deoxyribonucleotide... 15 | 15
pyrimidine deoxyribonucleotide... 15 | 15
γ-linolenate biosynthesi... 14 | 14
bile acid biosynthesis, neutra... 14 | 14
superpathway of pyrimidine rib... 14 | 14
triacylglycerol degradation 14 | 14
D-myo-inositol (1,4,5)-trispho... 13 | 13
L-kynurenine degradation 13 | 13
cholesterol biosynthesis I 13 | 13
cholesterol biosynthesis II (v... 13 | 13
cholesterol biosynthesis III (... 13 | 13
icosapentaenoate biosynthesis ... 13 | 13
stearate biosynthesis 13 | 13
valine degradation 13 | 13
NAD de novo biosynthesis 12 | 12
UTP and CTP de novo biosynthes... 12 | 12
guanosine ribonucleotides de n... 12 | 12
isoleucine degradation 12 | 12
leucine degradation 12 | 12
purine deoxyribonucleosides sa... 12 | 12
superpathway of geranylgeranyl... 12 | 12
adenosine deoxyribonucleotides... 11 | 11
guanosine deoxyribonucleotides... 11 | 11
pyrimidine deoxyribonucleotide... 11 | 11
reactive oxygen species degrad... 11 | 11
CMP phosphorylation 10 | 10
mevalonate pathway 10 | 10
noradrenaline and adrenaline d... 10 | 10
purine nucleotides degradation 10 | 10
putrescine degradation III 10 | 10
terminal O-glycans residues mo... 10 | 10
C20 prostanoid biosynthesis 9 | 9
UDP-N-acetyl-D-galactosamine b... 9 | 9
dolichyl-diphosphooligosacchar... 9 | 9
glycogenolysis 9 | 9
heme biosynthesis 9 | 9
methionine salvage cycle III 9 | 9
serotonin degradation 9 | 9
sphingosine and sphingosine-1-... 9 | 9
tryptophan degradation 9 | 9
2-oxobutanoate degradation 8 | 8
chondroitin sulfate biosynthes... 8 | 8
fatty acid activation 8 | 8
retinoate biosynthesis I 8 | 8
sphingomyelin metabolism/ceram... 8 | 8
sucrose degradation 8 | 8
γ-glutamyl cycle 7 | 7
GABA shunt 7 | 7
adenosine nucleotides degradat... 7 | 7
androgen biosynthesis 7 | 7
ceramide de novo biosynthesis 7 | 7
chondroitin sulfate degradatio... 7 | 7
inositol pyrophosphates biosyn... 7 | 7
leukotriene biosynthesis 7 | 7
oxidative ethanol degradation ... 7 | 7
pentose phosphate pathway 7 | 7
serine and glycine biosynthesi... 7 | 7
superpathway of choline degrad... 7 | 7
thyroid hormone metabolism II ... 7 | 7
tryptophan degradation to 2-am... 7 | 7
ubiquinol-10 biosynthesis 7 | 7
2'-deoxy-α-D-ribose 1-ph... 6 | 6
GDP-mannose biosynthesis 6 | 6
cysteine biosynthesis 6 | 6
lysine degradation II (pipecol... 6 | 6
oleate biosynthesis 6 | 6
phosphatidylcholine biosynthes... 6 | 6
phosphatidylethanolamine biosy... 6 | 6
selenocysteine biosynthesis 6 | 6
zymosterol biosynthesis 6 | 6

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