Development Level

Tchem 31 | 1,598
Tbio 3 | 11,445
Tclin 2 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 16 | 125
Kinase: IDG Consortium (Comple... 9 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
increased or absent threshold ... 2 | 101
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
decreased blood urea nitrogen ... 1 | 51
decreased circulating magnesiu... 1 | 13
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
increased circulating alkaline... 1 | 122
increased heart rate 1 | 23
increased kidney weight 1 | 6
increased startle reflex 1 | 112
microphthalmia 1 | 26
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74

Disease

Carcinoma 25 | 11,493
medulloblastoma, large-cell 21 | 6,241
ovarian cancer 20 | 8,520
osteosarcoma 19 | 7,950
glioblastoma 17 | 5,792
atypical teratoid / rhabdoid tumor 15 | 5,112
psoriasis 15 | 6,694
ependymoma 13 | 4,679
lung cancer 13 | 4,740
malignant mesothelioma 12 | 3,232
Cancer 11 | 2,499
oligodendroglioma 11 | 2,850
primitive neuroectodermal tumor 11 | 3,035
adult high grade glioma 10 | 3,801
group 3 medulloblastoma 10 | 4,104
Pick disease 9 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
Astrocytoma, Pilocytic 7 | 3,081
Down syndrome 7 | 499
Rheumatoid arthritis 7 | 1,191
astrocytic glioma 7 | 2,597
colon cancer 7 | 1,478
group 4 medulloblastoma 7 | 1,855
lung adenocarcinoma 7 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
Breast cancer 5 | 3,578
Kidney cancer 5 | 2,613
adrenocortical carcinoma 5 | 1,428
dermatomyositis 5 | 966
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
non-small cell lung cancer 5 | 2,890
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Intellectual disability 4 | 1,016
Small head 4 | 374
acute myeloid leukemia 4 | 783
cystic fibrosis 4 | 1,696
juvenile dermatomyositis 4 | 1,187
pancreatic cancer 4 | 2,398
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
Alzheimer's disease 3 | 658
Amyotrophic lateral sclerosis 3 | 451
Cognitive delay 3 | 608
Dull intelligence 3 | 645
Gastrointestinal Stromal Tumors 3 | 48
Global developmental delay 3 | 608
Low intelligence 3 | 645
Mammary Neoplasms, Experimental 3 | 154
Meckel syndrome 3 | 46
Melanoma 3 | 711
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Microcephaly 3 | 166
Poor school performance 3 | 645
acute quadriplegic myopathy 3 | 1,158
hereditary spastic paraplegia 3 | 318
interstitial cystitis 3 | 2,312
lung carcinoma 3 | 2,843
medulloblastoma 3 | 720
ulcerative colitis 3 | 1,819
Acquired immunodeficiency syndrome 2 | 197
Acquired metabolic disease 2 | 336
Agenesis of corpus callosum 2 | 83
Atopic dermatitis 2 | 952
Autistic Disorder 2 | 364
Autosomal recessive predisposition 2 | 1,442
Brain Stem Neoplasms 2 | 4
Carcinoma, Hepatocellular 2 | 228
Cerebral atrophy 2 | 178
Chronic myeloid leukemia 2 | 12
Congenital hereditary endothelial dystrophy of cornea 2 | 8
Dilated ventricles (finding) 2 | 121
Enophthalmos 2 | 75
Familial hemophagocytic lymphohistiocytosis 3 2 | 5
Gaucher disease type 1 2 | 180
Gaucher disease type 3 2 | 67
Hamman-Rich syndrome 2 | 34
Hormone receptor positive malignant neoplasm of breast 2 | 10
Human epidermal growth factor 2 negative carcinoma of breast 2 | 3
Liver carcinoma 2 | 240
Neurodevelopmental Disorders 2 | 70
Philadelphia chromosome-positive acute lymphoblastic leukemia 2 | 47
Renal Cell Carcinoma 2 | 214
Schizophrenia 2 | 1,160
Sunken eyes 2 | 63
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,146
diabetes mellitus 2 | 1,728
nasopharyngeal carcinoma 2 | 1,058
posterior fossa group B ependymoma 2 | 416
sarcoidosis 2 | 370
tuberculosis and treatment for 6 months 2 | 409
Abnormality of the lymphatic system 1 | 14
Hair shaft abnormalities 1 | 30
Hereditary Melanoma 1 | 12
MELANOMA, CUTANEOUS MALIGNANT, 1 1 | 13

Tissue

Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Blood and immune system 35 | 16,909
Cardiovascular System 35 | 15,192
Respiratory system 35 | 16,393

Target Family

Kinase 37 | 634

PANTHER Protein Class (3)

non-receptor tyrosine protein ... 37 | 37
non-receptor serine/threonine ... 162 | 162
mRNA splicing factor 107 | 107
translation initiation factor 58 | 58
acetylcholine receptor 47 | 47
voltage-gated calcium channel 23 | 23
mRNA polyadenylation factor 17 | 17
serine/threonine protein kinas... 15 | 15
voltage-gated potassium channe... 15 | 15
voltage-gated sodium channel 9 | 9
translation elongation factor 8 | 8
translation release factor 6 | 6
ionotropic glutamate receptor 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Serine/threonine-protein kinase PRP4 homolog PRPF4B Tchem Kinase -1.17233 14.7 144
Dual specificity tyrosine-phosphorylation-regulated kinase 1B DYRK1B Tchem Kinase -1.63295 52.7 289
Cyclin-dependent kinase 12 CDK12 Tchem Kinase -1.38476 29.4 157
Homeodomain-interacting protein kinase 4 HIPK4 Tchem Kinase -0.41775 3.17 232
Dual specificity tyrosine-phosphorylation-regulated kinase 3 DYRK3 Tchem Kinase -1.46121 29.1 191
Cyclin-dependent kinase 20 CDK20 Tbio Kinase -1.82269 67.7 248
Homeodomain-interacting protein kinase 3 HIPK3 Tchem Kinase -1.82864 58.2 149
Cyclin-dependent kinase 11B CDK11B Tchem Kinase -1.15493 16.6 0
Inactive tyrosine-protein kinase 7 PTK7 Tbio Kinase -2.41253 253.3 438