Development Level

Tchem 117 | 1,598
Tbio 31 | 11,445
Tdark 8 | 6,588
Tclin 6 | 613

Collection

Kinase: IDG Consortium (Target... 43 | 125
Kinase: IDG Consortium (Comple... 12 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
increased mean corpuscular vol... 5 | 92
abnormal behavior 3 | 298
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
decreased prepulse inhibition 3 | 82
decreased total body fat amoun... 3 | 207
increased circulating LDL chol... 3 | 13
increased circulating alkaline... 3 | 122
increased monocyte cell number 3 | 63
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
abnormal behavioral response t... 2 | 66
abnormal embryo size 2 | 220
abnormal spleen morphology 2 | 55
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
enlarged heart 2 | 210
enlarged spleen 2 | 41
improved glucose tolerance 2 | 79
increased circulating iron lev... 2 | 30
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
thrombocytosis 2 | 27
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal clavicle morphology 1 | 6
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
abnormal testis morphology 1 | 43
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
decreased circulating creatini... 1 | 39
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating total pr... 1 | 49
decreased circulating unsatura... 1 | 2
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased startle reflex 1 | 112
increased vertical activity 1 | 24
male infertility 1 | 123
megacolon 1 | 2
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 137 | 11,493
osteosarcoma 88 | 7,950
ovarian cancer 81 | 8,520
medulloblastoma, large-cell 74 | 6,241
glioblastoma 73 | 5,792
psoriasis 73 | 6,694
ependymoma 67 | 4,679
atypical teratoid / rhabdoid tumor 66 | 5,112
adult high grade glioma 56 | 3,801
group 3 medulloblastoma 55 | 4,104
lung cancer 50 | 4,740
Astrocytoma, Pilocytic 42 | 3,081
Cancer 42 | 2,499
Breast cancer 41 | 3,578
primitive neuroectodermal tumor 41 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
Kidney cancer 38 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
malignant mesothelioma 37 | 3,232
oligodendroglioma 37 | 2,850
invasive ductal carcinoma 31 | 2,951
astrocytic glioma 30 | 2,597
subependymal giant cell astrocytoma 29 | 2,287
Pick disease 28 | 1,894
non-small cell lung cancer 28 | 2,890
lung adenocarcinoma 27 | 2,716
Schizophrenia 23 | 1,160
group 4 medulloblastoma 23 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
lung carcinoma 23 | 2,843
interstitial cystitis 22 | 2,312
adrenocortical carcinoma 20 | 1,428
astrocytoma 20 | 1,146
tuberculosis 20 | 2,010
ductal carcinoma in situ 19 | 1,745
breast carcinoma 18 | 1,638
diabetes mellitus 18 | 1,728
Renal Cell Carcinoma 17 | 214
cystic fibrosis 17 | 1,696
pancreatic cancer 17 | 2,398
Rheumatoid arthritis 16 | 1,191
nasopharyngeal carcinoma 15 | 1,058
progressive supranuclear palsy 15 | 676
Autosomal recessive predisposition 14 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
spina bifida 14 | 1,074
Multiple myeloma 13 | 1,332
colon cancer 13 | 1,478
ulcerative colitis 13 | 1,819
Alzheimer's disease 12 | 658
Hypertension 12 | 396
juvenile dermatomyositis 12 | 1,187
pituitary cancer 12 | 1,972
Bipolar Disorder 11 | 666
Epilepsy 11 | 792
Intellectual disability 11 | 1,016
Parkinson's disease 11 | 392
acute quadriplegic myopathy 11 | 1,158
Gastrointestinal stromal tumor 10 | 62
Pancreatic Neuroendocrine Tumor 10 | 45
Vascular disease 10 | 319
acute myeloid leukemia 10 | 783
esophageal adenocarcinoma 10 | 737
Depressive disorder 9 | 409
Dull intelligence 9 | 645
Liver cancer 9 | 604
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Neurodegenerative disease 9 | 414
Obesity 9 | 678
Poor school performance 9 | 645
Prostatic Neoplasms 9 | 495
Stomach Neoplasms 9 | 300
cutaneous lupus erythematosus 9 | 1,057
non primary Sjogren syndrome sicca 9 | 891
Arthritis 8 | 290
Atopic dermatitis 8 | 952
Cardiomyopathies 8 | 110
Endometriosis 8 | 540
Glaucoma 8 | 239
Hyperalgesia 8 | 83
aldosterone-producing adenoma 8 | 665
pediatric high grade glioma 8 | 1,064
Amyotrophic lateral sclerosis 7 | 451
Cardiomegaly 7 | 116
Endometrial cancer 7 | 311
Hyperglycemia 7 | 137
Kidney disease 7 | 430
Major Depressive Disorder 7 | 301
Seizures 7 | 596
Waldenstrons macroglobulinemia 7 | 765
dermatomyositis 7 | 966
medulloblastoma 7 | 720
primary Sjogren syndrome 7 | 735
tuberculosis and treatment for 6 months 7 | 409
Asthma 6 | 385
Chronic Lymphocytic Leukemia 6 | 262
Mental Depression 6 | 333
primary pancreatic ductal adenocarcinoma 6 | 1,109

Tissue

Endocrine System 160 | 18,159
Skin and soft tissues 158 | 17,230
Blood and immune system 157 | 16,909
Digestive Tract 157 | 17,369
Nervous System 156 | 16,725
Female tissues 154 | 17,400
Liver and Pancreas 154 | 16,750
Male tissues 154 | 17,142
Urinary Tract 153 | 16,678
Respiratory system 152 | 16,393
Cardiovascular System 146 | 15,192

Target Family

Kinase 159 | 634
Non-IDG 2 | 12,091
Enzyme 1 | 4,145

PANTHER Protein Class (3)

non-receptor serine/threonine ... 162 | 162
mRNA splicing factor 107 | 107
translation initiation factor 58 | 58
acetylcholine receptor 47 | 47
non-receptor tyrosine protein ... 37 | 37
voltage-gated calcium channel 23 | 23
mRNA polyadenylation factor 17 | 17
serine/threonine protein kinas... 15 | 15
voltage-gated potassium channe... 15 | 15
voltage-gated sodium channel 9 | 9
translation elongation factor 8 | 8
translation release factor 6 | 6
ionotropic glutamate receptor 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Serine/threonine-protein kinase tousled-like 1 TLK1 Tchem Kinase -1.25235 19.2 305
Serine/threonine-protein kinase MRCK beta CDC42BPB Tbio Kinase -0.59618 3.72 111
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.61615 60.9 195
Serine/threonine-protein kinase VRK2 VRK2 Tbio Kinase -1.28897 20.5 123
PAS domain-containing serine/threonine-protein kinase PASK Tbio Kinase -1.01354 12.3 95
Testis-specific serine/threonine-protein kinase 3 TSSK3 Tbio Kinase -0.52985 3.86 47
Serine/threonine-protein kinase 32B STK32B Tchem Kinase -0.54101 2.56 98
Testis-specific serine/threonine-protein kinase 2 TSSK2 Tchem Kinase -1.03725 12.0 54
Serine/threonine-protein kinase WNK2 WNK2 Tchem Kinase -0.94627 9.07 108