Development Level

Tbio 74 | 10,625
Tdark 12 | 7,003
Tchem 10 | 1,890

Collection

Eligible Ion Channel Proteins 4 | 117

IMPC Term

preweaning lethality, complete... 3 | 633
abnormal bone structure 2 | 131
decreased lean body mass 2 | 195
decreased monocyte cell number 2 | 28
decreased total body fat amoun... 2 | 186
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased or absent threshold ... 2 | 128
increased rib number 2 | 41
preweaning lethality, incomple... 2 | 260
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal gait 1 | 51
abnormal lumbar vertebrae morp... 1 | 6
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
absent vibrissae 1 | 14
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased Ly6C high monocyte n... 1 | 18
decreased T-helper cell number 1 | 4
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lactate dehydrogenas... 1 | 14
decreased lumbar vertebrae num... 1 | 62
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
improved glucose tolerance 1 | 56
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased KLRG1+ CD4 alpha bet... 1 | 5
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased body length 1 | 20
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased exploration in new e... 1 | 56
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
short snout 1 | 4
shortened RR interval 1 | 19
vertebral transformation 1 | 12

Disease

ovarian cancer 58 | 8,484
osteosarcoma 39 | 7,933
medulloblastoma, large-cell 34 | 6,234
lung cancer 32 | 4,466
psoriasis 30 | 6,685
glioblastoma 25 | 5,572
Multiple myeloma 23 | 1,327
oligodendroglioma 19 | 2,849
Breast cancer 17 | 3,094
astrocytic glioma 17 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
Cancer 15 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
atypical teratoid / rhabdoid tumor 14 | 4,369
ependymoma 14 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
sonic hedgehog group medulloblastoma 14 | 1,482
acute quadriplegic myopathy 13 | 1,157
non-small cell lung cancer 13 | 2,798
pilocytic astrocytoma 13 | 3,086
lung adenocarcinoma 12 | 2,713
pancreatic cancer 12 | 2,300
pediatric high grade glioma 12 | 2,712
invasive ductal carcinoma 11 | 2,950
primitive neuroectodermal tumor 11 | 3,031
dermatomyositis 10 | 933
malignant mesothelioma 10 | 3,162
Pick disease 9 | 1,893
astrocytoma 9 | 1,493
cystic fibrosis 9 | 1,665
group 3 medulloblastoma 9 | 2,254
group 4 medulloblastoma 9 | 1,875
hereditary spastic paraplegia 9 | 313
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
primary pancreatic ductal adenocarcinoma 9 | 1,271
Waldenstrons macroglobulinemia 8 | 765
juvenile dermatomyositis 8 | 1,189
lung carcinoma 8 | 2,844
posterior fossa group A ependymoma 8 | 1,511
adult high grade glioma 7 | 2,148
diabetes mellitus 7 | 1,663
tuberculosis and treatment for 6 months 7 | 686
Amyotrophic Lateral Sclerosis 6 | 431
Carcinoma 6 | 2,147
atypical teratoid/rhabdoid tumor 6 | 1,095
breast carcinoma 6 | 1,614
colon cancer 6 | 1,475
ductal carcinoma in situ 6 | 1,745
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 1,557
Mammary Neoplasms 5 | 410
Optic atrophy 5 | 43
acute myeloid leukemia 5 | 780
adrenocortical carcinoma 5 | 1,427
interstitial cystitis 5 | 2,299
medulloblastoma 5 | 1,524
nasopharyngeal carcinoma 5 | 1,056
ulcerative colitis 5 | 2,087
HIV Infections 4 | 100
Intellectual disability 4 | 573
Neoplasm Metastasis 4 | 138
Neurodegenerative disease 4 | 383
Prostatic Neoplasms 4 | 471
Renal Cell Carcinoma 4 | 199
aldosterone-producing adenoma 4 | 664
gastric carcinoma 4 | 832
hepatocellular carcinoma 4 | 532
non primary Sjogren syndrome sicca 4 | 840
progressive supranuclear palsy 4 | 674
tuberculosis and treatment for 3 months 4 | 327
Alzheimer's disease 3 | 644
Charcot-Marie-Tooth disease 3 | 74
Childhood Ataxia with Central Nervous System Hypomyelinization 3 | 5
Degenerative polyarthritis 3 | 93
Duchenne muscular dystrophy 3 | 602
Leigh disease 3 | 81
Leukodystrophy 3 | 30
OVARIOLEUKODYSTROPHY 3 | 5
Ophthalmoplegia 3 | 18
Rheumatoid Arthritis 3 | 1,160
Schizophrenia 3 | 501
Squamous cell carcinoma of esophagus 3 | 82
pancreatic carcinoma 3 | 567
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
primary Sjogren syndrome 3 | 789
spina bifida 3 | 1,064
Becker muscular dystrophy 2 | 187
Disease Progression 2 | 125
Down syndrome 2 | 548
Epilepsy 2 | 346
Hypertensive disease 2 | 193
Stomach Neoplasms 2 | 282
active Crohn's disease 2 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
esophageal adenocarcinoma 2 | 737
glioblastoma multiforme 2 | 347
inflammatory breast cancer 2 | 404
mucosa-associated lymphoid tissue lymphoma 2 | 480
non-small cell lung carcinoma 2 | 413

Tissue

Blood and immune system 93 | 17,995
Cardiovascular System 93 | 17,958
Digestive Tract 93 | 18,473
Endocrine System 93 | 18,512
Female tissues 93 | 18,647
Liver and Pancreas 93 | 18,136
Male tissues 93 | 17,969
Nervous System 93 | 18,561
Urinary Tract 93 | 18,444
Respiratory system 92 | 17,484
Skin and soft tissues 92 | 18,115

Target Family

Non-IDG 72 | 11,971
Enzyme 15 | 4,146
Ion Channel 6 | 341
Transporter 3 | 473

PANTHER Protein Class (2)

translation factor 96 | 96
protein kinase 370 | 370
KRAB box transcription factor 333 | 333
serine protease 285 | 285
homeobox transcription factor 221 | 221
ribosomal protein 216 | 216
protein phosphatase 169 | 169
guanyl-nucleotide exchange fac... 168 | 168
chromatin/chromatin-binding pr... 164 | 164
non-motor actin binding protei... 161 | 161
small GTPase 130 | 130
mRNA processing factor 129 | 129
serine protease inhibitor 119 | 119
calmodulin 105 | 105
ligand-gated ion channel 104 | 104
metalloprotease 75 | 75
kinase activator 72 | 72
microtubule binding motor prot... 69 | 69
potassium channel 68 | 68
RNA helicase 67 | 67
cysteine protease 62 | 62
histone 62 | 62
actin binding motor protein 60 | 60
non-motor microtubule binding ... 60 | 60
chemokine 48 | 48
ribonucleoprotein 48 | 48
kinase inhibitor 47 | 47
nucleotide kinase 46 | 46
DNA-directed RNA polymerase 43 | 43
type I cytokine receptor 43 | 43
DNA helicase 42 | 42
centromere DNA-binding protein 42 | 42
phospholipase 42 | 42
endoribonuclease 41 | 41
calcium channel 37 | 37
heterotrimeric G-protein 35 | 35
interleukin superfamily 35 | 35
nucleotide phosphatase 35 | 35
ATP synthase 34 | 34
phosphatase inhibitor 33 | 33
actin and actin related protei... 30 | 30
neuropeptide 30 | 30
exoribonuclease 27 | 27
aspartic protease 24 | 24
tumor necrosis factor receptor 23 | 23
DNA-directed DNA polymerase 22 | 22
anion channel 21 | 21
carbohydrate kinase 21 | 21
tubulin 21 | 21
guanylate cyclase 20 | 20
cysteine protease inhibitor 17 | 17
interferon superfamily 17 | 17
endodeoxyribonuclease 16 | 16
DNA methyltransferase 15 | 15
RNA methyltransferase 13 | 13
carbohydrate phosphatase 13 | 13
CREB transcription factor 12 | 12
type II cytokine receptor 12 | 12
damaged DNA-binding protein 11 | 11
intermediate filament binding ... 11 | 11
tumor necrosis factor family m... 11 | 11
neurotrophic factor 9 | 9
sodium channel 9 | 9
replication origin binding pro... 8 | 8
DNA strand-pairing protein 7 | 7
DNA topoisomerase 4 | 4
amino acid kinase 4 | 4
exodeoxyribonuclease 4 | 4
TGF-beta receptor 3 | 3
metalloprotease inhibitor 3 | 3
DNA glycosylase 2 | 2
DNA photolyase 2 | 2
DNA polymerase processivity fa... 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1
voltage-gated ion channel 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Eukaryotic peptide chain release factor subunit 1 ETF1 Tbio Enzyme -1.69308 48.0 90
ATP-binding cassette sub-family F member 1 ABCF1 Tbio Transporter -1.10503 13.7 196
Elongation factor Tu, mitochondrial TUFM Tbio Non-IDG -1.18045 17.6 186
Elongation factor 1-beta EEF1B2 Tbio Non-IDG -1.77658 56.5 100
Clustered mitochondria protein homolog CLUH Tbio Non-IDG -0.53887 4.52 36
Eukaryotic translation initiation factor 3 subunit E EIF3E Tbio Non-IDG -1.39943 28.0 202
Elongation factor 2 EEF2 Tchem Non-IDG -2.93803 911.5 347
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B GSPT2 Tbio Enzyme -0.85966 6.76 95
Chloride intracellular channel protein 2 CLIC2 Tbio Ion Channel -1.42344 26.3 95