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  3. nucleic acid binding
  4. RNA binding protein
  5. translation factor
Target Filters...

Development Level

Tbio 61 | 11,445
Tdark 9 | 6,588
Tchem 6 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal bone structure 3 | 187
increased circulating alkaline... 3 | 122
preweaning lethality, incomple... 3 | 499
decreased bone mineral content 2 | 151
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased circulating total pr... 2 | 28
increased lean body mass 2 | 172
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased vertical activity 1 | 24
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
thrombocytosis 1 | 27
vertebral transformation 1 | 12

Disease

ovarian cancer 48 | 8,520
Carcinoma 42 | 11,493
osteosarcoma 32 | 7,950
medulloblastoma, large-cell 29 | 6,241
psoriasis 27 | 6,694
lung cancer 23 | 4,740
glioblastoma 20 | 5,792
Multiple myeloma 18 | 1,332
ependymoma 16 | 4,679
oligodendroglioma 15 | 2,850
Breast cancer 14 | 3,578
Cancer 14 | 2,499
group 3 medulloblastoma 14 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
astrocytic glioma 13 | 2,597
atypical teratoid / rhabdoid tumor 13 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
acute quadriplegic myopathy 11 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
non-small cell lung cancer 11 | 2,890
dermatomyositis 10 | 966
lung adenocarcinoma 10 | 2,716
pancreatic cancer 10 | 2,398
group 4 medulloblastoma 9 | 1,855
Kidney cancer 8 | 2,613
adult high grade glioma 8 | 3,801
diabetes mellitus 8 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primary pancreatic ductal adenocarcinoma 8 | 1,109
primitive neuroectodermal tumor 8 | 3,035
tuberculosis 8 | 2,010
Astrocytoma, Pilocytic 7 | 3,081
Pick disease 7 | 1,894
Waldenstrons macroglobulinemia 7 | 765
hereditary spastic paraplegia 7 | 318
invasive ductal carcinoma 7 | 2,951
juvenile dermatomyositis 6 | 1,187
malignant mesothelioma 6 | 3,232
pediatric high grade glioma 6 | 1,064
sonic hedgehog group medulloblastoma 6 | 467
Amyotrophic lateral sclerosis 5 | 451
Leigh disease 5 | 100
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
non primary Sjogren syndrome sicca 5 | 891
Breast Neoplasms 4 | 445
Intellectual disability 4 | 1,016
Mammary Neoplasms 4 | 425
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819
HIV Infections 3 | 102
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Neurodegenerative disease 3 | 414
Ophthalmoplegia 3 | 106
Optic Atrophy 3 | 242
Renal Cell Carcinoma 3 | 214
Rheumatoid arthritis 3 | 1,191
Small head 3 | 374
aldosterone-producing adenoma 3 | 665
gastric carcinoma 3 | 807
lung carcinoma 3 | 2,843
progressive supranuclear palsy 3 | 676
tuberculosis and treatment for 6 months 3 | 409
Adenocarcinoma of lung 2 | 142
Animal Mammary Neoplasms 2 | 136
Autosomal recessive predisposition 2 | 1,442
Cataract 4 multiple types 2 | 14
Cognitive delay 2 | 608
Congenital Epicanthus 2 | 177
Disease Models, Animal 2 | 155
Disease Progression 2 | 136
Downward slant of palpebral fissure 2 | 158
Dull intelligence 2 | 645
Epilepsy 2 | 792
Liver cancer 2 | 604
Lung Neoplasms 2 | 232
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Microcephaly 2 | 166
Poor school performance 2 | 645
Retinitis pigmentosa 49 2 | 14
Schizophrenia 2 | 1,160
Shwachman-Diamond syndrome 2 | 17
Stomach Neoplasms 2 | 300
X-linked cerebral adrenoleukodystrophy 2 | 116
hepatocellular carcinoma 2 | 547
interstitial cystitis 2 | 2,312
mucosa-associated lymphoid tissue lymphoma 2 | 484
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562
posterior fossa group A ependymoma 2 | 468
tuberculosis and treatment for 3 months 2 | 179

Tissue

Endocrine System 74 | 18,159
Male tissues 74 | 17,142
Nervous System 74 | 16,725
Blood and immune system 73 | 16,909
Cardiovascular System 73 | 15,192
Digestive Tract 73 | 17,369
Female tissues 73 | 17,400
Liver and Pancreas 73 | 16,750
Respiratory system 73 | 16,393
Skin and soft tissues 73 | 17,230
Urinary Tract 73 | 16,678

Target Family

Non-IDG 67 | 12,091
Enzyme 6 | 4,145
Transporter 3 | 473

PANTHER Protein Class (2)

translation factor 76 | 76
protein kinase 257 | 257
serine protease 175 | 175
ribosomal protein 152 | 152
cysteine protease 142 | 142
metalloprotease 135 | 135
mRNA processing factor 122 | 122
calmodulin 113 | 113
chromatin/chromatin-binding pr... 106 | 106
serine protease inhibitor 94 | 94
non-motor actin binding protei... 90 | 90
homeodomain transcription fact... 88 | 88
small GTPase 81 | 81
guanyl-nucleotide exchange fac... 77 | 77
ligand-gated ion channel 69 | 69
microtubule binding motor prot... 62 | 62
histone 61 | 61
non-motor microtubule binding ... 57 | 57
kinase activator 55 | 55
chemokine 48 | 48
DNA-directed RNA polymerase 46 | 46
ribonucleoprotein 44 | 44
heterotrimeric G-protein 43 | 43
protein phosphatase 41 | 41
nucleotide kinase 37 | 37
RNA helicase 35 | 35
phosphatase inhibitor 34 | 34
nucleotide phosphatase 33 | 33
actin and actin related protei... 31 | 31
kinase inhibitor 31 | 31
phospholipase 30 | 30
ATP synthase 28 | 28
DNA helicase 28 | 28
actin binding motor protein 27 | 27
C2H2 zinc finger transcription... 25 | 25
calcium channel 23 | 23
DNA-directed DNA polymerase 22 | 22
endoribonuclease 22 | 22
tubulin 22 | 22
aspartic protease 21 | 21
exoribonuclease 21 | 21
type I cytokine receptor 20 | 20
anion channel 19 | 19
carbohydrate kinase 17 | 17
endodeoxyribonuclease 15 | 15
intermediate filament binding ... 15 | 15
neuropeptide 15 | 15
potassium channel 15 | 15
DNA methyltransferase 12 | 12
type II cytokine receptor 12 | 12
RNA methyltransferase 11 | 11
damaged DNA-binding protein 11 | 11
tumor necrosis factor family m... 11 | 11
sodium channel 9 | 9
neurotrophic factor 8 | 8
replication origin binding pro... 8 | 8
winged helix/forkhead transcri... 8 | 8
carbohydrate phosphatase 6 | 6
amino acid kinase 5 | 5
guanylate cyclase 5 | 5
DNA topoisomerase 4 | 4
interleukin superfamily 4 | 4
CREB-related transcription fac... 3 | 3
C4 zinc finger nuclear recepto... 2 | 2
DNA photolyase 2 | 2
Lambda repressor-like transcri... 2 | 2
cysteine protease inhibitor 2 | 2
tumor necrosis factor receptor 2 | 2
DNA glycosylase 1 | 1
DNA polymerase processivity fa... 1 | 1
centromere DNA-binding protein 1 | 1
exodeoxyribonuclease 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein pelota homolog PELO Tbio Non-IDG -1.33842 18.2 100
Elongation factor G, mitochondrial GFM1 Tbio Non-IDG -2.39993 250.5 121
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A GSPT1 Tbio Enzyme -1.35573 22.8 99
Eukaryotic translation initiation factor 3 subunit C EIF3C Tbio Non-IDG -1.20680 14.1 159
Eukaryotic translation initiation factor 3 subunit B EIF3B Tbio Non-IDG -1.83618 70.5 84
Eukaryotic translation initiation factor 4E-binding protein 2 EIF4EBP2 Tbio Non-IDG -1.55776 33.4 189
ATP-binding cassette sub-family F member 3 ABCF3 Tdark Transporter -0.30626 2.60 137
Eukaryotic translation initiation factor 2A EIF2A Tbio Non-IDG -0.62095 4.12 272
Eukaryotic translation initiation factor 5A-1 EIF5A Tbio Non-IDG -2.10288 142.0 231
GTP-binding protein 2 GTPBP2 Tbio Non-IDG -0.72990 5.05 143