Development Level

Tbio 98 | 10,625
Tdark 20 | 7,003
Tchem 12 | 1,890

IMPC Term

decreased body weight 5 | 174
preweaning lethality, incomple... 5 | 260
abnormal behavior 4 | 226
decreased bone mineral content 4 | 157
decreased lean body mass 4 | 195
enlarged heart 4 | 111
abnormal heart morphology 3 | 51
decreased body length 3 | 108
embryonic lethality prior to t... 3 | 187
preweaning lethality, complete... 3 | 633
abnormal locomotor activation 2 | 26
decreased circulating iron lev... 2 | 25
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
increased blood urea nitrogen ... 2 | 44
increased mean corpuscular vol... 2 | 91
abnormal QRS complex 1 | 25
abnormal brain morphology 1 | 6
abnormal coat/ hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal joint morphology 1 | 14
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 18
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 35
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased thoracic vertebrae n... 1 | 7
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
hydroencephaly 1 | 6
hyperactivity 1 | 108
immune system phenotype 1 | 17
improved glucose tolerance 1 | 56
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased heart rate 1 | 17
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
long tibia 1 | 13
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
short tibia 1 | 82
shortened RR interval 1 | 19
shortened ST segment 1 | 9
small spleen 1 | 11
thrombocytopenia 1 | 46

Disease

ovarian cancer 73 | 8,484
glioblastoma 64 | 5,572
medulloblastoma, large-cell 61 | 6,234
osteosarcoma 59 | 7,933
psoriasis 53 | 6,685
atypical teratoid / rhabdoid tumor 40 | 4,369
primitive neuroectodermal tumor 36 | 3,031
Breast cancer 35 | 3,094
lung cancer 35 | 4,466
pilocytic astrocytoma 32 | 3,086
pediatric high grade glioma 31 | 2,712
malignant mesothelioma 30 | 3,162
oligodendroglioma 30 | 2,849
Cancer 29 | 2,346
invasive ductal carcinoma 28 | 2,950
lung carcinoma 28 | 2,844
subependymal giant cell astrocytoma 28 | 2,287
astrocytic glioma 27 | 2,241
ependymoma 24 | 2,514
adult high grade glioma 23 | 2,148
group 4 medulloblastoma 23 | 1,875
pancreatic cancer 23 | 2,300
Multiple myeloma 22 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
lung adenocarcinoma 22 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,956
Pick disease 19 | 1,893
medulloblastoma 18 | 1,524
primary pancreatic ductal adenocarcinoma 18 | 1,271
juvenile dermatomyositis 17 | 1,189
non-small cell lung cancer 17 | 2,798
astrocytoma 16 | 1,493
cystic fibrosis 16 | 1,665
ductal carcinoma in situ 16 | 1,745
acute quadriplegic myopathy 15 | 1,157
breast carcinoma 15 | 1,614
group 3 medulloblastoma 15 | 2,254
interstitial cystitis 15 | 2,299
atypical teratoid/rhabdoid tumor 14 | 1,095
cutaneous lupus erythematosus 14 | 1,056
ulcerative colitis 14 | 2,087
dermatomyositis 13 | 933
posterior fossa group B ependymoma 13 | 1,530
sonic hedgehog group medulloblastoma 13 | 1,482
diabetes mellitus 12 | 1,663
pituitary cancer 12 | 1,972
posterior fossa group A ependymoma 12 | 1,511
Rheumatoid Arthritis 10 | 1,160
colon cancer 10 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
Waldenstrons macroglobulinemia 9 | 765
progressive supranuclear palsy 9 | 674
spina bifida 9 | 1,064
esophageal adenocarcinoma 8 | 737
gastric cancer 8 | 430
tuberculosis 8 | 1,557
tuberculosis and treatment for 6 months 8 | 686
Melanoma 7 | 261
hereditary spastic paraplegia 7 | 313
nasopharyngeal carcinoma 7 | 1,056
primary Sjogren syndrome 7 | 789
Alzheimer's disease 6 | 644
Carcinoma 6 | 2,147
Down syndrome 6 | 548
Duchenne muscular dystrophy 6 | 602
Parkinson's disease 6 | 364
active Crohn's disease 6 | 918
acute myeloid leukemia 6 | 780
adrenocortical carcinoma 6 | 1,427
pancreatic carcinoma 6 | 567
Amyotrophic Lateral Sclerosis 5 | 431
Atopic dermatitis 5 | 944
Chronic Lymphocytic Leukemia 5 | 242
Juvenile Myelomonocytic Leukemia 5 | 21
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
fibroadenoma 5 | 557
gastric carcinoma 5 | 832
interstitial lung disease 5 | 291
non-small cell lung carcinoma 5 | 413
Amyotrophic neuralgia 4 | 13
Cardiomyopathy 4 | 110
Chylomicron retention disease 4 | 11
Endometriosis 4 | 535
Heart disease 4 | 279
Impotence 4 | 45
Intellectual disability 4 | 573
Joubert syndrome 4 | 61
Lymphoma 4 | 56
Noonan Syndrome 4 | 33
Stomach Neoplasms 4 | 282
glioblastoma multiforme 4 | 347
hepatocellular carcinoma 4 | 532
non primary Sjogren syndrome sicca 4 | 840
IGA Glomerulonephritis 3 | 454
Myocardial Ischemia 3 | 169
Polycystic Ovary Syndrome 3 | 332
aldosterone-producing adenoma 3 | 664
inflammatory breast cancer 3 | 404
mucosa-associated lymphoid tissue lymphoma 3 | 480

Tissue

Blood and immune system 128 | 17,995
Digestive Tract 128 | 18,473
Male tissues 128 | 17,969
Cardiovascular System 127 | 17,958
Endocrine System 127 | 18,512
Female tissues 127 | 18,647
Liver and Pancreas 127 | 18,136
Nervous System 127 | 18,561
Respiratory system 127 | 17,484
Skin and soft tissues 127 | 18,115
Urinary Tract 127 | 18,444

Target Family

Enzyme 90 | 4,146
Non-IDG 40 | 11,971

PANTHER Protein Class (2)

small GTPase 130 | 130
protein kinase 370 | 370
KRAB box transcription factor 333 | 333
serine protease 285 | 285
homeobox transcription factor 221 | 221
ribosomal protein 216 | 216
protein phosphatase 169 | 169
guanyl-nucleotide exchange fac... 168 | 168
chromatin/chromatin-binding pr... 164 | 164
non-motor actin binding protei... 161 | 161
mRNA processing factor 129 | 129
serine protease inhibitor 119 | 119
calmodulin 105 | 105
ligand-gated ion channel 104 | 104
translation factor 96 | 96
metalloprotease 75 | 75
kinase activator 72 | 72
microtubule binding motor prot... 69 | 69
potassium channel 68 | 68
RNA helicase 67 | 67
cysteine protease 62 | 62
histone 62 | 62
actin binding motor protein 60 | 60
non-motor microtubule binding ... 60 | 60
chemokine 48 | 48
ribonucleoprotein 48 | 48
kinase inhibitor 47 | 47
nucleotide kinase 46 | 46
DNA-directed RNA polymerase 43 | 43
type I cytokine receptor 43 | 43
DNA helicase 42 | 42
centromere DNA-binding protein 42 | 42
phospholipase 42 | 42
endoribonuclease 41 | 41
calcium channel 37 | 37
heterotrimeric G-protein 35 | 35
interleukin superfamily 35 | 35
nucleotide phosphatase 35 | 35
ATP synthase 34 | 34
phosphatase inhibitor 33 | 33
actin and actin related protei... 30 | 30
neuropeptide 30 | 30
exoribonuclease 27 | 27
aspartic protease 24 | 24
tumor necrosis factor receptor 23 | 23
DNA-directed DNA polymerase 22 | 22
anion channel 21 | 21
carbohydrate kinase 21 | 21
tubulin 21 | 21
guanylate cyclase 20 | 20
cysteine protease inhibitor 17 | 17
interferon superfamily 17 | 17
endodeoxyribonuclease 16 | 16
DNA methyltransferase 15 | 15
RNA methyltransferase 13 | 13
carbohydrate phosphatase 13 | 13
CREB transcription factor 12 | 12
type II cytokine receptor 12 | 12
damaged DNA-binding protein 11 | 11
intermediate filament binding ... 11 | 11
tumor necrosis factor family m... 11 | 11
neurotrophic factor 9 | 9
sodium channel 9 | 9
replication origin binding pro... 8 | 8
DNA strand-pairing protein 7 | 7
DNA topoisomerase 4 | 4
amino acid kinase 4 | 4
exodeoxyribonuclease 4 | 4
TGF-beta receptor 3 | 3
metalloprotease inhibitor 3 | 3
DNA glycosylase 2 | 2
DNA photolyase 2 | 2
DNA polymerase processivity fa... 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1
voltage-gated ion channel 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
ADP-ribosylation factor-like protein 16 ARL16 Tdark Enzyme -0.13389 1.44 17
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.21425 1443.3 95
Septin-1 SEPT1 Tdark Non-IDG -1.92957 87.4 0
Ras-like protein family member 12 RASL12 Tbio Enzyme -2.73221 568.7 87
Ras-related protein Ral-B RALB Tbio Enzyme -1.69182 49.7 204
Ras-related protein Ral-A RALA Tbio Enzyme -2.17133 159.2 185
GTP-binding protein REM 2 REM2 Tbio Enzyme -1.45477 32.4 17
Septin-12 SEPT12 Tbio Non-IDG -1.27742 20.7 89
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467