Development Level

Tbio 75 | 11,651
Tchem 52 | 1,388
Tdark 38 | 6,593
Tclin 10 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 6 | 499
abnormal behavior 5 | 298
abnormal embryo size 4 | 220
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased lean body mass 4 | 135
embryonic lethality prior to t... 4 | 278
hyperactivity 4 | 148
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased circulating triglyce... 3 | 79
embryonic growth retardation 3 | 106
hypoactivity 3 | 132
increased blood urea nitrogen ... 3 | 48
increased mean corpuscular hem... 3 | 96
increased startle reflex 3 | 112
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal limb bud morphology 2 | 17
abnormal seminal vesicle morph... 2 | 114
decreased body length 2 | 101
decreased circulating glucose ... 2 | 126
decreased fasted circulating g... 2 | 65
decreased leukocyte cell numbe... 2 | 73
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased leukocyte cell numbe... 2 | 47
increased total body fat amoun... 2 | 134
male infertility 2 | 123
thrombocytopenia 2 | 56
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal liver size 1 | 5
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
convulsive seizures 1 | 13
decreased CD8-positive, alpha-... 1 | 8
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased cardiac muscle contr... 1 | 11
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating phosphat... 1 | 27
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
dilated heart left ventricle 1 | 11
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased T cell number 1 | 6
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased heart rate variabili... 1 | 7
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small testis 1 | 58

Disease

Carcinoma 111 | 11,493
psoriasis 78 | 6,694
ovarian cancer 68 | 8,520
osteosarcoma 58 | 7,950
lung cancer 48 | 4,740
Cancer 46 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 46 | 3,291
glioblastoma 45 | 5,792
medulloblastoma, large-cell 45 | 6,241
pancreatic cancer 45 | 2,398
Breast cancer 40 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
lung adenocarcinoma 38 | 2,716
atypical teratoid / rhabdoid tumor 36 | 5,112
lung carcinoma 36 | 2,843
invasive ductal carcinoma 33 | 2,951
ependymoma 32 | 4,679
diabetes mellitus 31 | 1,728
adult high grade glioma 30 | 3,801
cystic fibrosis 29 | 1,696
interstitial cystitis 29 | 2,312
Astrocytoma, Pilocytic 27 | 3,081
group 3 medulloblastoma 26 | 4,104
Autosomal recessive predisposition 25 | 1,442
malignant mesothelioma 25 | 3,232
non-small cell lung cancer 25 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
ulcerative colitis 25 | 1,819
oligodendroglioma 23 | 2,850
tuberculosis 23 | 2,010
cutaneous lupus erythematosus 22 | 1,057
Atopic dermatitis 21 | 952
subependymal giant cell astrocytoma 21 | 2,287
colon cancer 20 | 1,478
Hypertension 18 | 396
Kidney cancer 18 | 2,613
esophageal adenocarcinoma 18 | 737
pituitary cancer 18 | 1,972
primary pancreatic ductal adenocarcinoma 17 | 1,109
primitive neuroectodermal tumor 17 | 3,035
breast carcinoma 16 | 1,638
group 4 medulloblastoma 16 | 1,855
Pancreatitis 15 | 123
ductal carcinoma in situ 15 | 1,745
Liver Cirrhosis, Experimental 14 | 769
adrenocortical carcinoma 14 | 1,428
nasopharyngeal carcinoma 14 | 1,058
Cerebrovascular disease 13 | 238
Prostatic Neoplasms 13 | 495
astrocytic glioma 13 | 2,597
gastric carcinoma 13 | 807
active ulcerative colitis 12 | 764
fibroadenoma 12 | 559
Atherosclerosis 11 | 291
Kidney disease 11 | 430
Rheumatoid arthritis 11 | 1,191
Schizophrenia 11 | 1,160
active Crohn's disease 11 | 922
astrocytoma 11 | 1,146
spina bifida 11 | 1,074
Alzheimer's disease 10 | 658
Pick disease 10 | 1,894
dermatomyositis 10 | 966
juvenile dermatomyositis 10 | 1,187
Hypertensive disease 9 | 292
Melanoma 9 | 711
Multiple myeloma 9 | 1,332
Obesity 9 | 678
Thrombophilia 9 | 38
mucosa-associated lymphoid tissue lymphoma 9 | 484
Angioedema 8 | 38
Coronary artery disease 8 | 268
Diarrhea 8 | 253
Duchenne muscular dystrophy 8 | 601
Liver disease 8 | 237
Myocardial Infarction 8 | 151
Pulmonary embolism 8 | 55
Thrombosis 8 | 46
head and neck cancer and chronic obstructive pulmonary disease 8 | 239
non primary Sjogren syndrome sicca 8 | 891
pediatric high grade glioma 8 | 1,064
primary Sjogren syndrome 8 | 735
Crohn's disease 7 | 321
Exocrine pancreatic insufficiency 7 | 32
Heart disease 7 | 306
Netherton syndrome 7 | 15
Neurodegenerative disease 7 | 414
Thromboembolism 7 | 15
Vascular disease 7 | 319
Venous Thrombosis 7 | 47
acute quadriplegic myopathy 7 | 1,158
non-small cell lung carcinoma 7 | 317
posterior fossa group A ependymoma 7 | 468
Arthritis 6 | 290
Bipolar Disorder 6 | 666
Down syndrome 6 | 499
limb girdle muscular dystrophy 2A 6 | 213
pancreatic carcinoma 6 | 562
urothelial carcinoma 6 | 318

Tissue

Endocrine System 166 | 18,159
Skin and soft tissues 164 | 17,230
Female tissues 163 | 17,400
Digestive Tract 162 | 17,369
Liver and Pancreas 154 | 16,750
Blood and immune system 153 | 16,909
Male tissues 152 | 17,142
Urinary Tract 151 | 16,678
Respiratory system 145 | 16,393
Nervous System 144 | 16,725
Cardiovascular System 120 | 15,192

Target Family

Enzyme 148 | 4,145
Non-IDG 25 | 12,091
Kinase 2 | 634

PANTHER Protein Class (2)

serine protease 175 | 175
protein kinase 257 | 257
ribosomal protein 152 | 152
cysteine protease 142 | 142
metalloprotease 135 | 135
mRNA processing factor 122 | 122
calmodulin 113 | 113
chromatin/chromatin-binding pr... 106 | 106
serine protease inhibitor 94 | 94
non-motor actin binding protei... 90 | 90
homeodomain transcription fact... 88 | 88
small GTPase 81 | 81
guanyl-nucleotide exchange fac... 77 | 77
translation factor 76 | 76
ligand-gated ion channel 69 | 69
microtubule binding motor prot... 62 | 62
histone 61 | 61
non-motor microtubule binding ... 57 | 57
kinase activator 55 | 55
chemokine 48 | 48
DNA-directed RNA polymerase 46 | 46
ribonucleoprotein 44 | 44
heterotrimeric G-protein 43 | 43
protein phosphatase 41 | 41
nucleotide kinase 37 | 37
RNA helicase 35 | 35
phosphatase inhibitor 34 | 34
nucleotide phosphatase 33 | 33
actin and actin related protei... 31 | 31
kinase inhibitor 31 | 31
phospholipase 30 | 30
ATP synthase 28 | 28
DNA helicase 28 | 28
actin binding motor protein 27 | 27
C2H2 zinc finger transcription... 25 | 25
calcium channel 23 | 23
DNA-directed DNA polymerase 22 | 22
endoribonuclease 22 | 22
tubulin 22 | 22
aspartic protease 21 | 21
exoribonuclease 21 | 21
type I cytokine receptor 20 | 20
anion channel 19 | 19
carbohydrate kinase 17 | 17
endodeoxyribonuclease 15 | 15
intermediate filament binding ... 15 | 15
neuropeptide 15 | 15
potassium channel 15 | 15
DNA methyltransferase 12 | 12
type II cytokine receptor 12 | 12
RNA methyltransferase 11 | 11
damaged DNA-binding protein 11 | 11
tumor necrosis factor family m... 11 | 11
sodium channel 9 | 9
neurotrophic factor 8 | 8
replication origin binding pro... 8 | 8
winged helix/forkhead transcri... 8 | 8
carbohydrate phosphatase 6 | 6
amino acid kinase 5 | 5
guanylate cyclase 5 | 5
DNA topoisomerase 4 | 4
interleukin superfamily 4 | 4
CREB-related transcription fac... 3 | 3
C4 zinc finger nuclear recepto... 2 | 2
DNA photolyase 2 | 2
Lambda repressor-like transcri... 2 | 2
cysteine protease inhibitor 2 | 2
tumor necrosis factor receptor 2 | 2
DNA glycosylase 1 | 1
DNA polymerase processivity fa... 1 | 1
centromere DNA-binding protein 1 | 1
exodeoxyribonuclease 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kallikrein-9 KLK9 Tbio Enzyme -0.89030 8.64 143
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Serine protease 55 PRSS55 Tdark Enzyme -0.51631 3.86 70
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Inactive serine protease PAMR1 PAMR1 Tdark Enzyme -0.86262 5.98 22
Tripeptidyl-peptidase 2 TPP2 Tbio Enzyme -1.97332 108.2 72
Neurotrypsin PRSS12 Tbio Non-IDG -1.46986 30.6 77
Probable inactive serine protease 37 PRSS37 Tdark Enzyme -0.32034 2.85 18
Chymotrypsin-like protease CTRL-1 CTRL Tchem Enzyme -3.14577 1283.5 150
Kallikrein-13 KLK13 Tbio Enzyme -1.25859 19.3 201