Development Level

Tbio 8 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal rib morphology 1 | 10
decreased caudal vertebrae num... 1 | 53
embryonic lethality prior to o... 1 | 239
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased lean body mass 1 | 172
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
vertebral fusion 1 | 23

Disease

Carcinoma 6 | 11,493
group 3 medulloblastoma 6 | 4,104
lung cancer 6 | 4,740
psoriasis 6 | 6,694
Meier-Gorlin syndrome 5 | 10
non-small cell lung cancer 5 | 2,890
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
EAR, PATELLA, SHORT STATURE SYNDROME 4 | 7
adrenocortical carcinoma 4 | 1,428
malignant mesothelioma 4 | 3,232
medulloblastoma, large-cell 4 | 6,241
Autosomal recessive predisposition 3 | 1,442
Birth length less than 3rd percentile 3 | 6
Breast cancer 3 | 3,578
Congenital hypoplasia of breast 3 | 25
Congenital small ears 3 | 48
Delayed bone age 3 | 136
Failure to gain weight 3 | 365
Fetal Growth Retardation 3 | 189
Hypertrophy of clitoris 3 | 40
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Isolated growth hormone deficiency 3 | 30
Microcephaly 3 | 166
Microstomia 3 | 78
Pediatric failure to thrive 3 | 365
Seckel syndrome 3 | 34
Slender, gracile long tubular bones 3 | 21
Small head 3 | 374
atypical teratoid / rhabdoid tumor 3 | 5,112
glioblastoma 3 | 5,792
primitive neuroectodermal tumor 3 | 3,035
Absent bone maturation in sternum 2 | 4
Absent sternal ossification 2 | 4
Cryptorchidism 2 | 296
Decreased projection of maxilla 2 | 66
Deficiency of upper jaw bones 2 | 66
DiGeorge syndrome 2 | 47
Feeding difficulties 2 | 127
Full lower lip 2 | 64
Gastroesophageal reflux disease 2 | 110
Genu varum 2 | 29
Heartburn 2 | 78
Hypoplasia of the maxilla 2 | 66
Hypoplastic mandible condyle 2 | 275
Hypotrophic maxilla 2 | 66
Mandibular hypoplasia 2 | 275
Maxillary retrognathia 2 | 66
Micrognathism 2 | 275
Patella aplasia-hypoplasia 2 | 12
Prominent lower lip 2 | 64
Pulmonary emphysema 2 | 48
Retrusion of upper jaw bones 2 | 66
Short ribs 2 | 30
Small labia majora 2 | 16
colon cancer 2 | 1,478
ductal carcinoma in situ 2 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
Abnormality of pelvic girdle bone morphology 1 | 37
Absent auditory canals 1 | 23
Absent external auditory canals 1 | 23
Atresia of the external auditory canal 1 | 23
Atretic auditory canal 1 | 23
Blepharophimosis 1 | 70
Congenital Camptodactyly 1 | 40
Congenital clubfoot 1 | 109
Congenital deafness 1 | 185
Contracture of joint of hand 1 | 30
Deafness 1 | 198
Dwarfism 1 | 37
Dyspnea 1 | 76
Frontal bossing 1 | 157
Gout 1 | 106
Hearing Loss, Partial 1 | 185
Knee joint valgus deformity 1 | 56
Long eyelashes 1 | 37
Long narrow head 1 | 75
Low Birth Weights 1 | 69
Microretrognathia 1 | 13
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Narrow thorax 1 | 53
Overcurvature of nail 1 | 6
Range of joint movement increased 1 | 32
Respiratory distress 1 | 43
Short palpebral fissure 1 | 38
Small for gestational age (disorder) 1 | 69
Thin rib 1 | 21
Thin skin 1 | 47
Tracheomalacia 1 | 22
Triangular face 1 | 58
Turridolichocephaly 1 | 75
hearing impairment 1 | 199
substance-related disorder 1 | 162
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Non-IDG 8 | 12,091

PANTHER Protein Class (2)

replication origin binding pro... 8 | 8
protein kinase 257 | 257
serine protease 175 | 175
ribosomal protein 152 | 152
cysteine protease 142 | 142
metalloprotease 135 | 135
mRNA processing factor 122 | 122
calmodulin 113 | 113
chromatin/chromatin-binding pr... 106 | 106
serine protease inhibitor 94 | 94
non-motor actin binding protei... 90 | 90
homeodomain transcription fact... 88 | 88
small GTPase 81 | 81
guanyl-nucleotide exchange fac... 77 | 77
translation factor 76 | 76
ligand-gated ion channel 69 | 69
microtubule binding motor prot... 62 | 62
histone 61 | 61
non-motor microtubule binding ... 57 | 57
kinase activator 55 | 55
chemokine 48 | 48
DNA-directed RNA polymerase 46 | 46
ribonucleoprotein 44 | 44
heterotrimeric G-protein 43 | 43
protein phosphatase 41 | 41
nucleotide kinase 37 | 37
RNA helicase 35 | 35
phosphatase inhibitor 34 | 34
nucleotide phosphatase 33 | 33
actin and actin related protei... 31 | 31
kinase inhibitor 31 | 31
phospholipase 30 | 30
ATP synthase 28 | 28
DNA helicase 28 | 28
actin binding motor protein 27 | 27
C2H2 zinc finger transcription... 25 | 25
calcium channel 23 | 23
DNA-directed DNA polymerase 22 | 22
endoribonuclease 22 | 22
tubulin 22 | 22
aspartic protease 21 | 21
exoribonuclease 21 | 21
type I cytokine receptor 20 | 20
anion channel 19 | 19
carbohydrate kinase 17 | 17
endodeoxyribonuclease 15 | 15
intermediate filament binding ... 15 | 15
neuropeptide 15 | 15
potassium channel 15 | 15
DNA methyltransferase 12 | 12
type II cytokine receptor 12 | 12
RNA methyltransferase 11 | 11
damaged DNA-binding protein 11 | 11
tumor necrosis factor family m... 11 | 11
sodium channel 9 | 9
neurotrophic factor 8 | 8
winged helix/forkhead transcri... 8 | 8
carbohydrate phosphatase 6 | 6
amino acid kinase 5 | 5
guanylate cyclase 5 | 5
DNA topoisomerase 4 | 4
interleukin superfamily 4 | 4
CREB-related transcription fac... 3 | 3
C4 zinc finger nuclear recepto... 2 | 2
DNA photolyase 2 | 2
Lambda repressor-like transcri... 2 | 2
cysteine protease inhibitor 2 | 2
tumor necrosis factor receptor 2 | 2
DNA glycosylase 1 | 1
DNA polymerase processivity fa... 1 | 1
centromere DNA-binding protein 1 | 1
exodeoxyribonuclease 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
Origin recognition complex subunit 2 ORC2 Tbio Non-IDG -0.68275 4.92 168
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50983 31.3 71
Cell division control protein 45 homolog CDC45 Tbio Non-IDG -2.10913 117.6 265
Origin recognition complex subunit 3 ORC3 Tbio Non-IDG -1.25409 17.4 192
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.52127 33.7 155
Sister chromatid cohesion protein DCC1 DSCC1 Tbio Non-IDG -1.10259 11.9 144