Development Level

Tbio 93 | 10,625
Tchem 50 | 1,890
Tdark 23 | 7,003
Tclin 3 | 602

Collection

Eligible Kinase Proteins 1 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal bone structure 3 | 131
male infertility 3 | 62
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal heart left ventricle ... 2 | 20
abnormal sleep behavior 2 | 63
decreased NK T cell number 2 | 28
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased lumbar vertebrae num... 2 | 62
decreased neutrophil cell numb... 2 | 37
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased fasted circulating g... 2 | 68
limb grasping 2 | 35
abnormal anxiety-related respo... 1 | 1
abnormal coat/hair pigmentatio... 1 | 54
abnormal ear morphology 1 | 5
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal social/conspecific in... 1 | 3
abnormal testis morphology 1 | 30
absent startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 35
decreased CD8-positive, alpha-... 1 | 26
decreased alpha-beta T cell nu... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 5
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating choleste... 1 | 85
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating thyroxin... 1 | 5
decreased circulating total pr... 1 | 41
decreased dendritic cell numbe... 1 | 3
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased kidney weight 1 | 7
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased thoracic vertebrae n... 1 | 7
decreased total body fat amoun... 1 | 186
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
hydrops fetalis 1 | 22
hypoactivity 1 | 89
improved glucose tolerance 1 | 56
increased KLRG1-positive gamma... 1 | 2
increased bone mineral content 1 | 92
increased circulating alanine ... 1 | 11
increased circulating calcium ... 1 | 32
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased effector memory T-he... 1 | 5
increased exploration in new e... 1 | 56
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased heart left ventricle... 1 | 1
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased myeloid cell number 1 | 2
increased prepulse inhibition 1 | 21
increased sacral vertebrae num... 1 | 62
increased thoracic vertebrae n... 1 | 8
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
small testis 1 | 37
thick ventricular wall 1 | 7
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 92 | 8,484
osteosarcoma 87 | 7,933
medulloblastoma, large-cell 78 | 6,234
glioblastoma 71 | 5,572
psoriasis 70 | 6,685
lung cancer 60 | 4,466
atypical teratoid / rhabdoid tumor 59 | 4,369
Carcinoma 52 | 2,147
Breast cancer 48 | 3,094
lung carcinoma 48 | 2,844
lung adenocarcinoma 45 | 2,713
pilocytic astrocytoma 45 | 3,086
invasive ductal carcinoma 43 | 2,950
malignant mesothelioma 42 | 3,162
oligodendroglioma 41 | 2,849
primitive neuroectodermal tumor 40 | 3,031
non-small cell lung cancer 39 | 2,798
ulcerative colitis 39 | 2,087
Cancer 38 | 2,346
interstitial cystitis 38 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
pediatric high grade glioma 36 | 2,712
group 4 medulloblastoma 34 | 1,875
group 3 medulloblastoma 32 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,956
subependymal giant cell astrocytoma 30 | 2,287
Pick disease 29 | 1,893
astrocytic glioma 29 | 2,241
breast carcinoma 29 | 1,614
adult high grade glioma 28 | 2,148
colon cancer 28 | 1,475
ependymoma 28 | 2,514
ductal carcinoma in situ 27 | 1,745
pituitary cancer 27 | 1,972
posterior fossa group A ependymoma 27 | 1,511
pancreatic cancer 23 | 2,300
Rheumatoid Arthritis 21 | 1,160
adrenocortical carcinoma 21 | 1,427
tuberculosis 21 | 1,557
cutaneous lupus erythematosus 20 | 1,056
sonic hedgehog group medulloblastoma 18 | 1,482
astrocytoma 17 | 1,493
cystic fibrosis 17 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
Atopic dermatitis 15 | 944
Multiple myeloma 15 | 1,327
gastric carcinoma 15 | 832
posterior fossa group B ependymoma 15 | 1,530
atypical teratoid/rhabdoid tumor 14 | 1,095
medulloblastoma 14 | 1,524
primary Sjogren syndrome 14 | 789
Asthma 13 | 349
Multiple Sclerosis 13 | 498
diabetes mellitus 13 | 1,663
juvenile dermatomyositis 13 | 1,189
primary pancreatic ductal adenocarcinoma 13 | 1,271
spina bifida 13 | 1,064
Obesity 12 | 616
active Crohn's disease 11 | 918
esophageal adenocarcinoma 11 | 737
hepatocellular carcinoma 11 | 532
Down syndrome 10 | 548
Duchenne muscular dystrophy 10 | 602
Hypersensitivity reaction type II disease 10 | 235
Waldenstrons macroglobulinemia 10 | 765
dermatomyositis 10 | 933
Alzheimer's disease 9 | 644
Autistic Disorder 9 | 320
acute quadriplegic myopathy 9 | 1,157
aldosterone-producing adenoma 9 | 664
fibroadenoma 9 | 557
non-small cell lung carcinoma 9 | 413
Celiac disease 8 | 112
IGA Glomerulonephritis 8 | 454
Inflammatory bowel disease 8 | 142
interstitial lung disease 8 | 291
nasopharyngeal carcinoma 8 | 1,056
progressive supranuclear palsy 8 | 674
Human immunodeficiency virus infectious disease 7 | 92
Intellectual disability 7 | 573
Peripheral Neuropathy 7 | 303
Pneumonia 7 | 133
Schizophrenia 7 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
gastric cancer 7 | 430
glioblastoma multiforme 7 | 347
head and neck cancer and chronic obstructive pulmonary disease 7 | 237
pancreatic carcinoma 7 | 567
Crohn's disease 6 | 304
Hypersensitivity 6 | 63
Kidney disease 6 | 396
Melanoma 6 | 261
hereditary spastic paraplegia 6 | 313
non primary Sjogren syndrome sicca 6 | 840
sarcoidosis 6 | 358
urothelial carcinoma 6 | 318
Vascular disease 5 | 281
mucosa-associated lymphoid tissue lymphoma 5 | 480
nephrosclerosis 5 | 329

Tissue

Blood and immune system 167 | 17,995
Digestive Tract 166 | 18,473
Female tissues 166 | 18,647
Male tissues 166 | 17,969
Skin and soft tissues 166 | 18,115
Endocrine System 165 | 18,512
Liver and Pancreas 165 | 18,136
Nervous System 165 | 18,561
Respiratory system 165 | 17,484
Urinary Tract 165 | 18,444
Cardiovascular System 164 | 17,958

Target Family

Enzyme 83 | 4,146
Non-IDG 57 | 11,971
GPCR 23 | 406
Kinase 5 | 634
Ion Channel 1 | 341

PANTHER Protein Class (2)

protein phosphatase 169 | 169
protein kinase 370 | 370
KRAB box transcription factor 333 | 333
serine protease 285 | 285
homeobox transcription factor 221 | 221
ribosomal protein 216 | 216
guanyl-nucleotide exchange fac... 168 | 168
chromatin/chromatin-binding pr... 164 | 164
non-motor actin binding protei... 161 | 161
small GTPase 130 | 130
mRNA processing factor 129 | 129
serine protease inhibitor 119 | 119
calmodulin 105 | 105
ligand-gated ion channel 104 | 104
translation factor 96 | 96
metalloprotease 75 | 75
kinase activator 72 | 72
microtubule binding motor prot... 69 | 69
potassium channel 68 | 68
RNA helicase 67 | 67
cysteine protease 62 | 62
histone 62 | 62
actin binding motor protein 60 | 60
non-motor microtubule binding ... 60 | 60
chemokine 48 | 48
ribonucleoprotein 48 | 48
kinase inhibitor 47 | 47
nucleotide kinase 46 | 46
DNA-directed RNA polymerase 43 | 43
type I cytokine receptor 43 | 43
DNA helicase 42 | 42
centromere DNA-binding protein 42 | 42
phospholipase 42 | 42
endoribonuclease 41 | 41
calcium channel 37 | 37
heterotrimeric G-protein 35 | 35
interleukin superfamily 35 | 35
nucleotide phosphatase 35 | 35
ATP synthase 34 | 34
phosphatase inhibitor 33 | 33
actin and actin related protei... 30 | 30
neuropeptide 30 | 30
exoribonuclease 27 | 27
aspartic protease 24 | 24
tumor necrosis factor receptor 23 | 23
DNA-directed DNA polymerase 22 | 22
anion channel 21 | 21
carbohydrate kinase 21 | 21
tubulin 21 | 21
guanylate cyclase 20 | 20
cysteine protease inhibitor 17 | 17
interferon superfamily 17 | 17
endodeoxyribonuclease 16 | 16
DNA methyltransferase 15 | 15
RNA methyltransferase 13 | 13
carbohydrate phosphatase 13 | 13
CREB transcription factor 12 | 12
type II cytokine receptor 12 | 12
damaged DNA-binding protein 11 | 11
intermediate filament binding ... 11 | 11
tumor necrosis factor family m... 11 | 11
neurotrophic factor 9 | 9
sodium channel 9 | 9
replication origin binding pro... 8 | 8
DNA strand-pairing protein 7 | 7
DNA topoisomerase 4 | 4
amino acid kinase 4 | 4
exodeoxyribonuclease 4 | 4
TGF-beta receptor 3 | 3
metalloprotease inhibitor 3 | 3
DNA glycosylase 2 | 2
DNA photolyase 2 | 2
DNA polymerase processivity fa... 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1
voltage-gated ion channel 1 | 1

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