Development Level

Tbio 24 | 11,445
Tchem 15 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

abnormal bone structure 2 | 187
male infertility 2 | 123
preweaning lethality, complete... 2 | 979
prolonged ST segment 2 | 36
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal embryo size 1 | 220
abnormal sleep behavior 1 | 70
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
hypoactivity 1 | 132
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
increased vertical activity 1 | 24
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
thrombocytopenia 1 | 56

Disease

Carcinoma 32 | 11,493
ovarian cancer 24 | 8,520
medulloblastoma, large-cell 21 | 6,241
osteosarcoma 21 | 7,950
glioblastoma 18 | 5,792
psoriasis 18 | 6,694
atypical teratoid / rhabdoid tumor 16 | 5,112
Kidney cancer 15 | 2,613
group 3 medulloblastoma 14 | 4,104
Breast cancer 13 | 3,578
ependymoma 13 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
lung cancer 13 | 4,740
adult high grade glioma 12 | 3,801
interstitial cystitis 12 | 2,312
malignant mesothelioma 12 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
non-small cell lung cancer 11 | 2,890
Cancer 9 | 2,499
colon cancer 9 | 1,478
Astrocytoma, Pilocytic 8 | 3,081
group 4 medulloblastoma 8 | 1,855
lung adenocarcinoma 8 | 2,716
oligodendroglioma 8 | 2,850
primitive neuroectodermal tumor 8 | 3,035
Pick disease 7 | 1,894
Skin cancer 7 | 469
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pituitary cancer 7 | 1,972
Melanoma 6 | 711
adrenocortical carcinoma 6 | 1,428
astrocytic glioma 6 | 2,597
invasive ductal carcinoma 6 | 2,951
lung carcinoma 6 | 2,843
subependymal giant cell astrocytoma 6 | 2,287
Autosomal recessive predisposition 5 | 1,442
Endometrial cancer 5 | 311
Schizophrenia 5 | 1,160
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
gastric carcinoma 5 | 807
juvenile dermatomyositis 5 | 1,187
pancreatic cancer 5 | 2,398
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Cognitive delay 4 | 608
Dull intelligence 4 | 645
Epilepsy 4 | 792
Global developmental delay 4 | 608
Intellectual disability 4 | 1,016
Liver cancer 4 | 604
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Poor school performance 4 | 645
Waldenstrons macroglobulinemia 4 | 765
acute quadriplegic myopathy 4 | 1,158
cutaneous lupus erythematosus 4 | 1,057
diabetes mellitus 4 | 1,728
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
pediatric high grade glioma 4 | 1,064
spina bifida 4 | 1,074
Action Tremor 3 | 22
Atopic dermatitis 3 | 952
Cerebellar Ataxia 3 | 304
Disease Progression 3 | 136
Downward slant of palpebral fissure 3 | 158
Endometriosis 3 | 540
Hydrocephalus 3 | 152
Hypoglycemia 3 | 152
Multiple myeloma 3 | 1,332
Orbital separation excessive 3 | 244
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Stomach Neoplasms 3 | 300
Strabismus 3 | 270
Type 2 diabetes mellitus 3 | 272
aldosterone-producing adenoma 3 | 665
dermatomyositis 3 | 966
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Bipolar Disorder 2 | 666
Chronic obstructive pulmonary disease 2 | 184
Heart disease 2 | 306
Kidney disease 2 | 430
Multiple Sclerosis 2 | 540
Neurodevelopmental Disorders 2 | 70
Pectus excavatum 2 | 100
Prostatic Neoplasms 2 | 495
Vascular disease 2 | 319
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
acute myeloid leukemia 2 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
cystic fibrosis 2 | 1,696
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676

Tissue

Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Blood and immune system 39 | 16,909
Digestive Tract 39 | 17,369
Male tissues 39 | 17,142
Nervous System 39 | 16,725
Cardiovascular System 38 | 15,192
Liver and Pancreas 38 | 16,750
Respiratory system 38 | 16,393
Skin and soft tissues 38 | 17,230
Urinary Tract 38 | 16,678

Target Family

Enzyme 41 | 4,145

PANTHER Protein Class (2)

protein phosphatase 41 | 41
protein kinase 257 | 257
serine protease 175 | 175
ribosomal protein 152 | 152
cysteine protease 142 | 142
metalloprotease 135 | 135
mRNA processing factor 122 | 122
calmodulin 113 | 113
chromatin/chromatin-binding pr... 106 | 106
serine protease inhibitor 94 | 94
non-motor actin binding protei... 90 | 90
homeodomain transcription fact... 88 | 88
small GTPase 81 | 81
guanyl-nucleotide exchange fac... 77 | 77
translation factor 76 | 76
ligand-gated ion channel 69 | 69
microtubule binding motor prot... 62 | 62
histone 61 | 61
non-motor microtubule binding ... 57 | 57
kinase activator 55 | 55
chemokine 48 | 48
DNA-directed RNA polymerase 46 | 46
ribonucleoprotein 44 | 44
heterotrimeric G-protein 43 | 43
nucleotide kinase 37 | 37
RNA helicase 35 | 35
phosphatase inhibitor 34 | 34
nucleotide phosphatase 33 | 33
actin and actin related protei... 31 | 31
kinase inhibitor 31 | 31
phospholipase 30 | 30
ATP synthase 28 | 28
DNA helicase 28 | 28
actin binding motor protein 27 | 27
C2H2 zinc finger transcription... 25 | 25
calcium channel 23 | 23
DNA-directed DNA polymerase 22 | 22
endoribonuclease 22 | 22
tubulin 22 | 22
aspartic protease 21 | 21
exoribonuclease 21 | 21
type I cytokine receptor 20 | 20
anion channel 19 | 19
carbohydrate kinase 17 | 17
endodeoxyribonuclease 15 | 15
intermediate filament binding ... 15 | 15
neuropeptide 15 | 15
potassium channel 15 | 15
DNA methyltransferase 12 | 12
type II cytokine receptor 12 | 12
RNA methyltransferase 11 | 11
damaged DNA-binding protein 11 | 11
tumor necrosis factor family m... 11 | 11
sodium channel 9 | 9
neurotrophic factor 8 | 8
replication origin binding pro... 8 | 8
winged helix/forkhead transcri... 8 | 8
carbohydrate phosphatase 6 | 6
amino acid kinase 5 | 5
guanylate cyclase 5 | 5
DNA topoisomerase 4 | 4
interleukin superfamily 4 | 4
CREB-related transcription fac... 3 | 3
C4 zinc finger nuclear recepto... 2 | 2
DNA photolyase 2 | 2
Lambda repressor-like transcri... 2 | 2
cysteine protease inhibitor 2 | 2
tumor necrosis factor receptor 2 | 2
DNA glycosylase 1 | 1
DNA polymerase processivity fa... 1 | 1
centromere DNA-binding protein 1 | 1
exodeoxyribonuclease 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1

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