Development Level

Tchem 225 | 1,890
Tbio 91 | 10,625
Tdark 29 | 7,003
Tclin 25 | 602

Collection

Kinase: IDG Consortium (Targets) 83 | 125
Kinase: IDG Consortium (Complete/Control) 28 | 37

IMPC Phenotype

preweaning lethality, complete... 15 | 633
preweaning lethality, incomple... 8 | 260
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
abnormal lens morphology 4 | 73
decreased body length 4 | 108
decreased body weight 4 | 174
decreased circulating glucose ... 4 | 121
decreased circulating triglyce... 4 | 83
decreased total body fat amoun... 4 | 186
embryonic lethality prior to o... 4 | 148
increased circulating alkaline... 4 | 119
increased mean corpuscular vol... 4 | 91
increased or absent threshold ... 4 | 128
small testis 4 | 37
abnormal behavior 3 | 226
abnormal testis morphology 3 | 30
decreased circulating serum al... 3 | 79
decreased lean body mass 3 | 195
increased bone mineral content 3 | 92
increased circulating LDL chol... 3 | 15
increased circulating iron lev... 3 | 25
increased mean corpuscular hem... 3 | 93
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal eye morphology 2 | 38
abnormal lumbar vertebrae morp... 2 | 6
abnormal retina morphology 2 | 100
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral content 2 | 157
decreased circulating LDL chol... 2 | 37
decreased circulating choleste... 2 | 85
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased neutrophil cell numb... 2 | 37
hydrops fetalis 2 | 22
improved glucose tolerance 2 | 56
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased mature B cell number 2 | 12
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
male infertility 2 | 62
microphthalmia 2 | 15
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal response to new envir... 1 | 8
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal tooth morphology 1 | 24
absent vibrissae 1 | 14
craniofacial phenotype 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
female infertility 1 | 34
impaired glucose tolerance 1 | 52
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased eosinophil cell numb... 1 | 9
increased grip strength 1 | 83
increased heart weight 1 | 37
increased lean body mass 1 | 107
long tibia 1 | 13
short tibia 1 | 82
thrombocytosis 1 | 23
tremors 1 | 34

Disease

osteosarcoma 218 | 7,933
ovarian cancer 198 | 8,491
medulloblastoma, large-cell 165 | 6,234
glioblastoma 153 | 5,572
psoriasis 152 | 6,685
atypical teratoid / rhabdoid tumor 121 | 4,369
lung cancer 103 | 4,473
Cancer 99 | 2,346
pilocytic astrocytoma 91 | 3,086
malignant mesothelioma 84 | 3,163
primitive neuroectodermal tumor 83 | 3,031
oligodendroglioma 80 | 2,849
ependymoma 77 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 77 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 76 | 2,988
Breast cancer 73 | 3,098
Carcinoma 73 | 2,147
invasive ductal carcinoma 73 | 2,950
lung carcinoma 71 | 2,844
pediatric high grade glioma 70 | 2,712
non-small cell lung cancer 66 | 2,798
interstitial cystitis 64 | 2,299
adult high grade glioma 63 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 63 | 2,956
lung adenocarcinoma 61 | 2,714
subependymal giant cell astrocytoma 60 | 2,287
Pick disease 58 | 1,893
group 3 medulloblastoma 55 | 2,254
ulcerative colitis 55 | 2,087
astrocytic glioma 54 | 2,241
astrocytoma 52 | 1,493
medulloblastoma 51 | 1,524
group 4 medulloblastoma 48 | 1,875
cystic fibrosis 42 | 1,670
pancreatic cancer 42 | 2,300
diabetes mellitus 41 | 1,663
posterior fossa group B ependymoma 41 | 1,530
ductal carcinoma in situ 39 | 1,745
Rheumatoid Arthritis 38 | 1,170
adrenocortical carcinoma 38 | 1,427
pituitary cancer 36 | 1,972
tuberculosis 35 | 1,563
breast carcinoma 34 | 1,614
posterior fossa group A ependymoma 32 | 1,511
Renal Cell Carcinoma 31 | 199
juvenile dermatomyositis 31 | 1,189
colon cancer 30 | 1,475
sonic hedgehog group medulloblastoma 29 | 1,482
atypical teratoid/rhabdoid tumor 28 | 1,095
cutaneous lupus erythematosus 27 | 1,056
primary Sjogren syndrome 27 | 788
Chronic Myelocytic Leukemia Accelerated Phase 26 | 59
Blastic phase chronic myeloid leukemia 25 | 58
acute quadriplegic myopathy 25 | 1,157
dermatomyositis 25 | 966
Philadelphia chromosome-positive acute lymphoblastic leukemia 24 | 47
nasopharyngeal carcinoma 24 | 1,056
primary pancreatic ductal adenocarcinoma 24 | 1,271
Chronic phase chronic myeloid leukemia 23 | 45
Gastrointestinal stromal tumor 23 | 61
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 23 | 45
Alzheimer's disease 22 | 644
Atopic dermatitis 22 | 944
Multiple myeloma 22 | 1,327
spina bifida 22 | 1,064
acute myeloid leukemia 21 | 785
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
progressive supranuclear palsy 21 | 674
Pancreatic Neuroendocrine Tumor 20 | 45
esophageal adenocarcinoma 20 | 737
Obesity 19 | 616
tuberculosis and treatment for 6 months 18 | 686
Down syndrome 17 | 548
IGA Glomerulonephritis 17 | 454
Parkinson's disease 17 | 364
Waldenstrons macroglobulinemia 17 | 764
aldosterone-producing adenoma 17 | 664
Endometriosis 15 | 535
Schizophrenia 15 | 503
Vascular disease 15 | 281
Hamman-Rich syndrome 14 | 35
active Crohn's disease 14 | 918
chronic lymphocytic leukemia 14 | 244
gastric carcinoma 14 | 832
sarcoidosis 14 | 368
Amyotrophic Lateral Sclerosis 13 | 432
Intellectual disability 13 | 573
Kidney disease 12 | 397
Mammary Neoplasms 12 | 410
Melanoma 12 | 261
Neurodegenerative disease 12 | 383
Prostatic Neoplasms 12 | 471
non primary Sjogren syndrome sicca 12 | 840
pancreatic carcinoma 12 | 567
Arthritis 11 | 248
Asthma 11 | 349
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
fibroadenoma 11 | 557
hepatocellular carcinoma 11 | 550
mucosa-associated lymphoid tissue lymphoma 11 | 480

Tissue

Endocrine System 367 | 18,511
Female tissues 367 | 18,646
Nervous System 367 | 18,560
Urinary Tract 367 | 18,443
Blood and immune system 366 | 17,994
Digestive Tract 366 | 18,472
Liver and Pancreas 366 | 18,135
Cardiovascular System 365 | 17,957
Male tissues 365 | 17,968
Skin and soft tissues 361 | 18,114
Respiratory system 360 | 17,483

Target Family

Kinase 334 | 634
Non-IDG 34 | 11,969
Enzyme 1 | 4,146
Epigenetic 1 | 242

PANTHER Protein Class (2)

protein kinase 370 | 370
KRAB box transcription factor 333 | 333
serine protease 285 | 285
homeobox transcription factor 221 | 221
ribosomal protein 216 | 216
protein phosphatase 169 | 169
guanyl-nucleotide exchange fac... 168 | 168
chromatin/chromatin-binding pr... 164 | 164
non-motor actin binding protei... 161 | 161
small GTPase 130 | 130
mRNA processing factor 129 | 129
serine protease inhibitor 119 | 119
calmodulin 105 | 105
ligand-gated ion channel 104 | 104
translation factor 96 | 96
metalloprotease 75 | 75
kinase activator 72 | 72
microtubule binding motor prot... 69 | 69
potassium channel 68 | 68
RNA helicase 67 | 67
cysteine protease 62 | 62
histone 62 | 62
actin binding motor protein 60 | 60
non-motor microtubule binding ... 60 | 60
chemokine 48 | 48
ribonucleoprotein 48 | 48
kinase inhibitor 47 | 47
nucleotide kinase 46 | 46
DNA-directed RNA polymerase 43 | 43
type I cytokine receptor 43 | 43
DNA helicase 42 | 42
centromere DNA-binding protein 42 | 42
phospholipase 42 | 42
endoribonuclease 41 | 41
calcium channel 37 | 37
heterotrimeric G-protein 35 | 35
interleukin superfamily 35 | 35
nucleotide phosphatase 35 | 35
ATP synthase 34 | 34
phosphatase inhibitor 33 | 33
actin and actin related protei... 30 | 30
neuropeptide 30 | 30
exoribonuclease 27 | 27
aspartic protease 24 | 24
tumor necrosis factor receptor 23 | 23
DNA-directed DNA polymerase 22 | 22
anion channel 21 | 21
carbohydrate kinase 21 | 21
tubulin 21 | 21
guanylate cyclase 20 | 20
cysteine protease inhibitor 17 | 17
interferon superfamily 17 | 17
endodeoxyribonuclease 16 | 16
DNA methyltransferase 15 | 15
RNA methyltransferase 13 | 13
carbohydrate phosphatase 13 | 13
CREB transcription factor 12 | 12
type II cytokine receptor 12 | 12
damaged DNA-binding protein 11 | 11
intermediate filament binding ... 11 | 11
tumor necrosis factor family m... 11 | 11
neurotrophic factor 9 | 9
sodium channel 9 | 9
replication origin binding pro... 8 | 8
DNA strand-pairing protein 7 | 7
DNA topoisomerase 4 | 4
amino acid kinase 4 | 4
exodeoxyribonuclease 4 | 4
TGF-beta receptor 3 | 3
metalloprotease inhibitor 3 | 3
DNA glycosylase 2 | 2
DNA photolyase 2 | 2
DNA polymerase processivity fa... 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1
voltage-gated ion channel 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Fer FER Tchem Kinase -1.84299 53.1 358
Receptor-interacting serine/threonine-protein kinase 3 RIPK3 Tchem Kinase -2.11581 129.5 456
Ankyrin repeat domain-containing protein 46 ANKRD46 Tdark Non-IDG -1.26881 17.5 45
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.58792 56.8 175
Extracellular tyrosine-protein kinase PKDCC PKDCC Tbio Kinase -1.14420 14.3 48
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.24881 21.2 139
Testis-specific serine/threonine-protein kinase 3 TSSK3 Tbio Kinase -0.53305 3.86 46
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Testis-specific serine/threonine-protein kinase 6 TSSK6 Tchem Kinase -1.32403 18.5 110
Testis-specific serine/threonine-protein kinase 1 TSSK1B Tchem Kinase -1.41882 23.1 26