Development Level

Tchem 155 | 1,388
Tbio 76 | 11,651
Tdark 16 | 6,593
Tclin 10 | 612

Collection

Kinase: IDG Consortium (Target... 69 | 125
RFA-RM-18-021 69 | 328
Kinase: IDG Consortium (Comple... 22 | 37

IMPC Phenotype

preweaning lethality, incomple... 18 | 499
preweaning lethality, complete... 16 | 979
abnormal embryo size 8 | 220
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 8 | 278
abnormal behavior 5 | 298
abnormal bone structure 5 | 187
increased mean corpuscular vol... 5 | 92
increased or absent threshold ... 5 | 101
decreased circulating glucose ... 4 | 126
decreased total body fat amoun... 4 | 207
increased circulating alkaline... 4 | 122
abnormal heart morphology 3 | 162
abnormal spleen morphology 3 | 55
decreased blood urea nitrogen ... 3 | 51
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
decreased vertical activity 3 | 208
enlarged heart 3 | 210
hyperactivity 3 | 148
increased circulating LDL chol... 3 | 13
increased monocyte cell number 3 | 63
increased total body fat amoun... 3 | 134
male infertility 3 | 123
microphthalmia 3 | 26
small superior vagus ganglion 3 | 74
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal embryo turning 2 | 31
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal neural tube closure 2 | 46
abnormal skin morphology 2 | 50
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating magnesiu... 2 | 13
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased large unstained cell... 2 | 11
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
edema 2 | 59
enlarged epididymis 2 | 31
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating iron lev... 2 | 30
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
thrombocytosis 2 | 27
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased hematocrit 1 | 46
increased prepulse inhibition 1 | 32
short tibia 1 | 97
shortened RR interval 1 | 17
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 207 | 11,493
osteosarcoma 148 | 7,950
ovarian cancer 133 | 8,520
medulloblastoma, large-cell 122 | 6,241
glioblastoma 117 | 5,792
psoriasis 115 | 6,694
atypical teratoid / rhabdoid tumor 104 | 5,112
ependymoma 93 | 4,679
adult high grade glioma 84 | 3,801
group 3 medulloblastoma 83 | 4,104
lung cancer 81 | 4,740
Cancer 66 | 2,499
Astrocytoma, Pilocytic 62 | 3,081
primitive neuroectodermal tumor 62 | 3,035
Breast cancer 60 | 3,578
malignant mesothelioma 60 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 58 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 58 | 3,291
invasive ductal carcinoma 58 | 2,951
oligodendroglioma 56 | 2,850
Kidney cancer 50 | 2,613
non-small cell lung cancer 48 | 2,890
lung adenocarcinoma 46 | 2,716
astrocytic glioma 45 | 2,597
Pick disease 41 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 41 | 2,955
lung carcinoma 41 | 2,843
subependymal giant cell astrocytoma 41 | 2,287
interstitial cystitis 39 | 2,312
adrenocortical carcinoma 34 | 1,428
group 4 medulloblastoma 34 | 1,855
breast carcinoma 33 | 1,638
ductal carcinoma in situ 32 | 1,745
pancreatic cancer 31 | 2,398
ulcerative colitis 31 | 1,819
Rheumatoid arthritis 30 | 1,191
Schizophrenia 30 | 1,160
cystic fibrosis 29 | 1,696
astrocytoma 28 | 1,146
tuberculosis 28 | 2,010
colon cancer 26 | 1,478
pituitary cancer 26 | 1,972
diabetes mellitus 25 | 1,728
nasopharyngeal carcinoma 25 | 1,058
juvenile dermatomyositis 21 | 1,187
Intellectual disability 20 | 1,016
Renal Cell Carcinoma 20 | 214
acute quadriplegic myopathy 20 | 1,158
Autosomal recessive predisposition 19 | 1,442
acute myeloid leukemia 19 | 783
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Epilepsy 18 | 792
pediatric high grade glioma 18 | 1,064
Alzheimer's disease 17 | 658
Atopic dermatitis 17 | 952
cutaneous lupus erythematosus 17 | 1,057
primary pancreatic ductal adenocarcinoma 17 | 1,109
progressive supranuclear palsy 17 | 676
spina bifida 17 | 1,074
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Multiple myeloma 16 | 1,332
Poor school performance 16 | 645
esophageal adenocarcinoma 16 | 737
primary Sjogren syndrome 16 | 735
dermatomyositis 15 | 966
Hypertension 14 | 396
Parkinson's disease 14 | 392
Endometriosis 13 | 540
Seizures 13 | 596
Down syndrome 12 | 499
Liver cancer 12 | 604
Neurodegenerative disease 12 | 414
Obesity 12 | 678
Small head 12 | 374
Waldenstrons macroglobulinemia 12 | 765
aldosterone-producing adenoma 12 | 665
tuberculosis and treatment for 6 months 12 | 409
Bipolar Disorder 11 | 666
Cognitive delay 11 | 608
Gastrointestinal stromal tumor 11 | 62
Global developmental delay 11 | 608
Hypertensive disease 11 | 292
Mental and motor retardation 11 | 608
Pancreatic Neuroendocrine Tumor 11 | 45
Prostatic Neoplasms 11 | 495
Vascular disease 11 | 319
medulloblastoma 11 | 720
sarcoidosis 11 | 370
Amyotrophic lateral sclerosis 10 | 451
Depressive disorder 10 | 409
Melanoma 10 | 711
Stomach Neoplasms 10 | 300
active Crohn's disease 10 | 922
active ulcerative colitis 10 | 764
non primary Sjogren syndrome sicca 10 | 891
Chronic Lymphocytic Leukemia 9 | 262
Short stature 9 | 531

Tissue

Endocrine System 254 | 18,159
Skin and soft tissues 251 | 17,230
Digestive Tract 250 | 17,369
Blood and immune system 248 | 16,909
Female tissues 247 | 17,400
Liver and Pancreas 247 | 16,750
Male tissues 246 | 17,142
Nervous System 246 | 16,725
Urinary Tract 244 | 16,678
Respiratory system 242 | 16,393
Cardiovascular System 234 | 15,192

Target Family

Kinase 234 | 634
Non-IDG 21 | 12,091
Enzyme 1 | 4,145
Epigenetic 1 | 242

PANTHER Protein Class (2)

protein kinase 257 | 257
serine protease 175 | 175
ribosomal protein 152 | 152
cysteine protease 142 | 142
metalloprotease 135 | 135
mRNA processing factor 122 | 122
calmodulin 113 | 113
chromatin/chromatin-binding pr... 106 | 106
serine protease inhibitor 94 | 94
non-motor actin binding protei... 90 | 90
homeodomain transcription fact... 88 | 88
small GTPase 81 | 81
guanyl-nucleotide exchange fac... 77 | 77
translation factor 76 | 76
ligand-gated ion channel 69 | 69
microtubule binding motor prot... 62 | 62
histone 61 | 61
non-motor microtubule binding ... 57 | 57
kinase activator 55 | 55
chemokine 48 | 48
DNA-directed RNA polymerase 46 | 46
ribonucleoprotein 44 | 44
heterotrimeric G-protein 43 | 43
protein phosphatase 41 | 41
nucleotide kinase 37 | 37
RNA helicase 35 | 35
phosphatase inhibitor 34 | 34
nucleotide phosphatase 33 | 33
actin and actin related protei... 31 | 31
kinase inhibitor 31 | 31
phospholipase 30 | 30
ATP synthase 28 | 28
DNA helicase 28 | 28
actin binding motor protein 27 | 27
C2H2 zinc finger transcription... 25 | 25
calcium channel 23 | 23
DNA-directed DNA polymerase 22 | 22
endoribonuclease 22 | 22
tubulin 22 | 22
aspartic protease 21 | 21
exoribonuclease 21 | 21
type I cytokine receptor 20 | 20
anion channel 19 | 19
carbohydrate kinase 17 | 17
endodeoxyribonuclease 15 | 15
intermediate filament binding ... 15 | 15
neuropeptide 15 | 15
potassium channel 15 | 15
DNA methyltransferase 12 | 12
type II cytokine receptor 12 | 12
RNA methyltransferase 11 | 11
damaged DNA-binding protein 11 | 11
tumor necrosis factor family m... 11 | 11
sodium channel 9 | 9
neurotrophic factor 8 | 8
replication origin binding pro... 8 | 8
winged helix/forkhead transcri... 8 | 8
carbohydrate phosphatase 6 | 6
amino acid kinase 5 | 5
guanylate cyclase 5 | 5
DNA topoisomerase 4 | 4
interleukin superfamily 4 | 4
CREB-related transcription fac... 3 | 3
C4 zinc finger nuclear recepto... 2 | 2
DNA photolyase 2 | 2
Lambda repressor-like transcri... 2 | 2
cysteine protease inhibitor 2 | 2
tumor necrosis factor receptor 2 | 2
DNA glycosylase 1 | 1
DNA polymerase processivity fa... 1 | 1
centromere DNA-binding protein 1 | 1
exodeoxyribonuclease 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Serine/threonine-protein kinase VRK1 VRK1 Tbio Kinase -2.05267 119.8 168
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303
Collagen type IV alpha-3-binding protein COL4A3BP Tbio Non-IDG -1.84397 60.0 282
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603
Serine/threonine-protein kinase 17B STK17B Tchem Kinase -1.26923 26.6 344
Carcinoembryonic antigen-related cell adhesion molecule 21 CEACAM21 Tdark Non-IDG 0.29 0.45 106
SRSF protein kinase 1 SRPK1 Tchem Kinase -1.86831 75.3 351