Development Level

Tbio 69 | 11,651
Tchem 45 | 1,388
Tdark 18 | 6,593
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
hypoactivity 3 | 132
abnormal behavior 2 | 298
abnormal cranium morphology 2 | 36
abnormal heart morphology 2 | 162
abnormal locomotor behavior 2 | 24
abnormal skin coloration 2 | 25
abnormal tail morphology 2 | 25
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating aspartat... 2 | 34
decreased circulating chloride... 2 | 30
decreased circulating phosphat... 2 | 27
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
prolonged ST segment 2 | 36
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal esophagus morphology 1 | 5
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 4
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal maxilla morphology 1 | 17
abnormal pancreas morphology 1 | 13
abnormal radius morphology 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal thyroid gland morphol... 1 | 3
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal trachea morphology 1 | 3
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
absent lymph nodes 1 | 3
anophthalmia 1 | 33
aorta stenosis 1 | 2
athymia 1 | 2
cataract 1 | 92
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating sodium l... 1 | 22
decreased food intake 1 | 13
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged liver 1 | 2
enlarged spleen 1 | 41
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased CD4-positive, CD25-p... 1 | 1
increased KLRG1-positive NK ce... 1 | 1
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased anxiety-related resp... 1 | 2
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased effector memory CD4-... 1 | 1
increased fasted circulating g... 1 | 76
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
long tail 1 | 1
mammalian phenotype 1 | 17
prolonged QT interval 1 | 38
short tibia 1 | 97
thick tail 1 | 1

Disease

Carcinoma 113 | 11,493
osteosarcoma 67 | 7,950
ovarian cancer 64 | 8,520
psoriasis 49 | 6,694
atypical teratoid / rhabdoid tumor 38 | 5,112
glioblastoma 38 | 5,792
lung cancer 36 | 4,740
medulloblastoma, large-cell 36 | 6,241
non-small cell lung cancer 35 | 2,890
invasive ductal carcinoma 34 | 2,951
ependymoma 32 | 4,679
Breast cancer 31 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
lung adenocarcinoma 28 | 2,716
lung carcinoma 28 | 2,843
malignant mesothelioma 28 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
Cancer 26 | 2,499
Kidney cancer 26 | 2,613
adult high grade glioma 26 | 3,801
ductal carcinoma in situ 25 | 1,745
interstitial cystitis 25 | 2,312
cystic fibrosis 24 | 1,696
ulcerative colitis 23 | 1,819
Astrocytoma, Pilocytic 22 | 3,081
group 3 medulloblastoma 20 | 4,104
pancreatic cancer 20 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
breast carcinoma 17 | 1,638
oligodendroglioma 17 | 2,850
primitive neuroectodermal tumor 17 | 3,035
Autosomal recessive predisposition 16 | 1,442
astrocytic glioma 16 | 2,597
colon cancer 16 | 1,478
cutaneous lupus erythematosus 16 | 1,057
Atopic dermatitis 14 | 952
diabetes mellitus 14 | 1,728
group 4 medulloblastoma 14 | 1,855
tuberculosis 14 | 2,010
active Crohn's disease 13 | 922
primary pancreatic ductal adenocarcinoma 13 | 1,109
Liver Cirrhosis, Experimental 12 | 769
pituitary cancer 12 | 1,972
Melanoma 11 | 711
Pick disease 11 | 1,894
adrenocortical carcinoma 11 | 1,428
Asthma 10 | 385
Hypertension 10 | 396
Rheumatoid arthritis 10 | 1,191
active ulcerative colitis 10 | 764
subependymal giant cell astrocytoma 10 | 2,287
Alzheimer's disease 9 | 658
Multiple myeloma 9 | 1,332
Schizophrenia 9 | 1,160
Skin cancer 9 | 469
esophageal adenocarcinoma 9 | 737
head and neck cancer and chronic obstructive pulmonary disease 9 | 239
nasopharyngeal carcinoma 9 | 1,058
periodontitis 9 | 293
Abortion, Spontaneous 8 | 109
Kidney disease 8 | 430
Spontaneous abortion 8 | 113
Vascular disease 8 | 319
astrocytoma 8 | 1,146
Anemia 7 | 365
Arthritis 7 | 290
Atherosclerosis 7 | 291
Bipolar Disorder 7 | 666
Breast Neoplasms 7 | 445
Hypertensive disease 7 | 292
Mammary Neoplasms 7 | 425
Obesity 7 | 678
Osteoporosis 7 | 363
Short stature 7 | 531
Waldenstrons macroglobulinemia 7 | 765
gastric carcinoma 7 | 807
interstitial lung disease 7 | 298
juvenile dermatomyositis 7 | 1,187
non primary Sjogren syndrome sicca 7 | 891
pediatric high grade glioma 7 | 1,064
progressive supranuclear palsy 7 | 676
Coronary artery disease 6 | 268
Dental caries 6 | 164
Endometriosis 6 | 540
Lung Neoplasms 6 | 232
Neoplasm Metastasis 6 | 168
Neurodegenerative disease 6 | 414
Prostatic Neoplasms 6 | 495
acute myeloid leukemia 6 | 783
primary Sjogren syndrome 6 | 735
sarcoidosis 6 | 370
Cerebrovascular disease 5 | 238
Heart disease 5 | 306
Lung disease 5 | 142
Neoplasm Invasiveness 5 | 161
aldosterone-producing adenoma 5 | 665
medulloblastoma 5 | 720
mucosa-associated lymphoid tissue lymphoma 5 | 484
urothelial carcinoma 5 | 318

Tissue

Endocrine System 128 | 18,159
Female tissues 127 | 17,400
Blood and immune system 123 | 16,909
Urinary Tract 123 | 16,678
Digestive Tract 122 | 17,369
Male tissues 122 | 17,142
Liver and Pancreas 120 | 16,750
Skin and soft tissues 119 | 17,230
Respiratory system 115 | 16,393
Nervous System 114 | 16,725
Cardiovascular System 104 | 15,192

Target Family

Enzyme 121 | 4,145
Non-IDG 14 | 12,091

PANTHER Protein Class (2)

metalloprotease 135 | 135
protein kinase 257 | 257
serine protease 175 | 175
ribosomal protein 152 | 152
cysteine protease 142 | 142
mRNA processing factor 122 | 122
calmodulin 113 | 113
chromatin/chromatin-binding pr... 106 | 106
serine protease inhibitor 94 | 94
non-motor actin binding protei... 90 | 90
homeodomain transcription fact... 88 | 88
small GTPase 81 | 81
guanyl-nucleotide exchange fac... 77 | 77
translation factor 76 | 76
ligand-gated ion channel 69 | 69
microtubule binding motor prot... 62 | 62
histone 61 | 61
non-motor microtubule binding ... 57 | 57
kinase activator 55 | 55
chemokine 48 | 48
DNA-directed RNA polymerase 46 | 46
ribonucleoprotein 44 | 44
heterotrimeric G-protein 43 | 43
protein phosphatase 41 | 41
nucleotide kinase 37 | 37
RNA helicase 35 | 35
phosphatase inhibitor 34 | 34
nucleotide phosphatase 33 | 33
actin and actin related protei... 31 | 31
kinase inhibitor 31 | 31
phospholipase 30 | 30
ATP synthase 28 | 28
DNA helicase 28 | 28
actin binding motor protein 27 | 27
C2H2 zinc finger transcription... 25 | 25
calcium channel 23 | 23
DNA-directed DNA polymerase 22 | 22
endoribonuclease 22 | 22
tubulin 22 | 22
aspartic protease 21 | 21
exoribonuclease 21 | 21
type I cytokine receptor 20 | 20
anion channel 19 | 19
carbohydrate kinase 17 | 17
endodeoxyribonuclease 15 | 15
intermediate filament binding ... 15 | 15
neuropeptide 15 | 15
potassium channel 15 | 15
DNA methyltransferase 12 | 12
type II cytokine receptor 12 | 12
RNA methyltransferase 11 | 11
damaged DNA-binding protein 11 | 11
tumor necrosis factor family m... 11 | 11
sodium channel 9 | 9
neurotrophic factor 8 | 8
replication origin binding pro... 8 | 8
winged helix/forkhead transcri... 8 | 8
carbohydrate phosphatase 6 | 6
amino acid kinase 5 | 5
guanylate cyclase 5 | 5
DNA topoisomerase 4 | 4
interleukin superfamily 4 | 4
CREB-related transcription fac... 3 | 3
C4 zinc finger nuclear recepto... 2 | 2
DNA photolyase 2 | 2
Lambda repressor-like transcri... 2 | 2
cysteine protease inhibitor 2 | 2
tumor necrosis factor receptor 2 | 2
DNA glycosylase 1 | 1
DNA polymerase processivity fa... 1 | 1
centromere DNA-binding protein 1 | 1
exodeoxyribonuclease 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Mitochondrial inner membrane protease ATP23 homolog ATP23 Tdark Enzyme -0.86878 7.67 43
Aspartyl aminopeptidase DNPEP Tchem Enzyme -1.52163 32.9 138
Disintegrin and metalloproteinase domain-containing protein 21 ADAM21 Tdark Enzyme -0.76419 6.37 28
Carboxypeptidase A5 CPA5 Tbio Enzyme -0.97002 10.1 64
Tolloid-like protein 2 TLL2 Tbio Non-IDG -1.00652 6.10 35
Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE Tbio Enzyme -1.62910 39.1 51
Disintegrin and metalloproteinase domain-containing protein 2 ADAM2 Tbio Enzyme -2.16398 146.1 148
Disintegrin and metalloproteinase domain-containing protein 30 ADAM30 Tdark Enzyme -0.39305 2.44 64
Leucyl-cystinyl aminopeptidase LNPEP Tchem Enzyme -2.57244 394.0 103