Development Level

Tbio 123 | 10,625
Tdark 34 | 7,003
Tchem 10 | 1,890
Tclin 1 | 602

IMPC Term

abnormal retina morphology 6 | 100
abnormal behavior 5 | 226
decreased bone mineral density 5 | 126
preweaning lethality, complete... 5 | 633
abnormal retinal pigmentation 4 | 61
decreased bone mineral content 4 | 157
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
decreased lean body mass 4 | 195
abnormal bone structure 3 | 131
decreased circulating HDL chol... 3 | 77
decreased circulating triglyce... 3 | 83
decreased hemoglobin content 3 | 53
decreased lumbar vertebrae num... 3 | 62
decreased total body fat amoun... 3 | 186
hypoactivity 3 | 89
increased circulating alkaline... 3 | 119
decreased T cell number 2 | 31
decreased body length 2 | 108
decreased body weight 2 | 174
decreased caudal vertebrae num... 2 | 49
decreased circulating free fat... 2 | 39
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased mature B cell number 2 | 25
decreased mean corpuscular vol... 2 | 50
decreased vertical activity 2 | 22
increased fasted circulating g... 2 | 68
increased sacral vertebrae num... 2 | 62
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal eye anterior chamber ... 1 | 3
abnormal maxilla morphology 1 | 16
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 11
abnormal response to tactile s... 1 | 16
abnormal spleen morphology 1 | 36
abnormal vertebrae morphology 1 | 14
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased IgE level 1 | 3
decreased IgG1 level 1 | 4
decreased NK T cell number 1 | 28
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased circulating phosphat... 1 | 15
decreased dendritic cell numbe... 1 | 3
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 19
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
improved glucose tolerance 1 | 56
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased KLRG1-positive NK ce... 1 | 9
increased Ly6C high monocyte n... 1 | 12
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating calcium ... 1 | 32
increased circulating free fat... 1 | 17
increased circulating fructosa... 1 | 11
increased circulating phosphat... 1 | 24
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased heart rate 1 | 17
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 12
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased prepulse inhibition 1 | 21
increased red blood cell distr... 1 | 21
increased rib number 1 | 41
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 57
male infertility 1 | 62
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened ST segment 1 | 9
vertebral fusion 1 | 23

Disease

osteosarcoma 97 | 7,933
medulloblastoma, large-cell 89 | 6,234
glioblastoma 85 | 5,572
ovarian cancer 79 | 8,484
psoriasis 71 | 6,685
atypical teratoid / rhabdoid tumor 68 | 4,369
pilocytic astrocytoma 56 | 3,086
Carcinoma 51 | 2,147
primitive neuroectodermal tumor 50 | 3,031
ependymoma 46 | 2,514
invasive ductal carcinoma 46 | 2,950
lung cancer 46 | 4,466
oligodendroglioma 45 | 2,849
non-small cell lung cancer 44 | 2,798
lung carcinoma 43 | 2,844
malignant mesothelioma 43 | 3,162
pediatric high grade glioma 42 | 2,712
subependymal giant cell astrocytoma 41 | 2,287
Breast cancer 40 | 3,094
interstitial cystitis 36 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,988
adult high grade glioma 35 | 2,148
astrocytic glioma 34 | 2,241
lung adenocarcinoma 34 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,956
group 3 medulloblastoma 31 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,289
ductal carcinoma in situ 27 | 1,745
ulcerative colitis 27 | 2,087
cystic fibrosis 26 | 1,665
group 4 medulloblastoma 25 | 1,875
pituitary cancer 25 | 1,972
spina bifida 25 | 1,064
Pick disease 24 | 1,893
medulloblastoma 23 | 1,524
astrocytoma 21 | 1,493
Cancer 20 | 2,346
pancreatic cancer 20 | 2,300
posterior fossa group B ependymoma 19 | 1,530
primary Sjogren syndrome 17 | 789
aldosterone-producing adenoma 15 | 664
atypical teratoid/rhabdoid tumor 15 | 1,095
cutaneous lupus erythematosus 15 | 1,056
tuberculosis 15 | 1,557
breast carcinoma 14 | 1,614
posterior fossa group A ependymoma 14 | 1,511
active Crohn's disease 13 | 918
adrenocortical carcinoma 13 | 1,427
colon cancer 13 | 1,475
sonic hedgehog group medulloblastoma 13 | 1,482
dermatomyositis 12 | 933
juvenile dermatomyositis 12 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Intellectual disability 11 | 573
esophageal adenocarcinoma 11 | 737
gastric carcinoma 11 | 832
primary pancreatic ductal adenocarcinoma 11 | 1,271
tuberculosis and treatment for 6 months 10 | 686
Chronic Lymphocytic Leukemia 9 | 242
Rheumatoid Arthritis 9 | 1,160
Atopic dermatitis 8 | 944
fibroadenoma 8 | 557
mucosa-associated lymphoid tissue lymphoma 8 | 480
Waldenstrons macroglobulinemia 7 | 765
acute quadriplegic myopathy 7 | 1,157
progressive supranuclear palsy 7 | 674
Aarskog-Scott syndrome 6 | 11
Down syndrome 6 | 548
acute myeloid leukemia 6 | 780
diabetes mellitus 6 | 1,663
interstitial lung disease 6 | 291
nasopharyngeal carcinoma 6 | 1,056
urothelial carcinoma 6 | 318
COPD 5 | 113
IGA Glomerulonephritis 5 | 454
Schizophrenia 5 | 501
active ulcerative colitis 5 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
hereditary spastic paraplegia 5 | 313
inflammatory breast cancer 5 | 404
non primary Sjogren syndrome sicca 5 | 840
non-small cell lung carcinoma 5 | 413
Amyotrophic Lateral Sclerosis 4 | 431
Cardiovascular system disease 4 | 194
Duchenne muscular dystrophy 4 | 602
Leukemia, Myelocytic, Acute 4 | 113
Multiple Sclerosis 4 | 498
Multiple myeloma 4 | 1,327
Neuropathy 4 | 210
Wiskott-Aldrich syndrome 4 | 27
chronic rhinosinusitis 4 | 512
nephrosclerosis 4 | 329
sarcoidosis 4 | 358
substance-related disorder 4 | 105
tuberculosis and treatment for 3 months 4 | 327
Crohn's disease 3 | 304
Endometriosis 3 | 535
Vascular disease 3 | 281
pancreatic carcinoma 3 | 567
periodontitis 3 | 269

Tissue

Cardiovascular System 167 | 17,958
Digestive Tract 167 | 18,473
Endocrine System 167 | 18,512
Female tissues 167 | 18,647
Liver and Pancreas 167 | 18,136
Male tissues 167 | 17,969
Nervous System 167 | 18,561
Skin and soft tissues 167 | 18,115
Urinary Tract 167 | 18,444
Blood and immune system 166 | 17,995
Respiratory system 165 | 17,484

Target Family

Non-IDG 144 | 11,971
Enzyme 22 | 4,146
Kinase 2 | 634

PANTHER Protein Class (2)

guanyl-nucleotide exchange fac... 168 | 168
protein kinase 370 | 370
KRAB box transcription factor 333 | 333
serine protease 285 | 285
homeobox transcription factor 221 | 221
ribosomal protein 216 | 216
protein phosphatase 169 | 169
chromatin/chromatin-binding pr... 164 | 164
non-motor actin binding protei... 161 | 161
small GTPase 130 | 130
mRNA processing factor 129 | 129
serine protease inhibitor 119 | 119
calmodulin 105 | 105
ligand-gated ion channel 104 | 104
translation factor 96 | 96
metalloprotease 75 | 75
kinase activator 72 | 72
microtubule binding motor prot... 69 | 69
potassium channel 68 | 68
RNA helicase 67 | 67
cysteine protease 62 | 62
histone 62 | 62
actin binding motor protein 60 | 60
non-motor microtubule binding ... 60 | 60
chemokine 48 | 48
ribonucleoprotein 48 | 48
kinase inhibitor 47 | 47
nucleotide kinase 46 | 46
DNA-directed RNA polymerase 43 | 43
type I cytokine receptor 43 | 43
DNA helicase 42 | 42
centromere DNA-binding protein 42 | 42
phospholipase 42 | 42
endoribonuclease 41 | 41
calcium channel 37 | 37
heterotrimeric G-protein 35 | 35
interleukin superfamily 35 | 35
nucleotide phosphatase 35 | 35
ATP synthase 34 | 34
phosphatase inhibitor 33 | 33
actin and actin related protei... 30 | 30
neuropeptide 30 | 30
exoribonuclease 27 | 27
aspartic protease 24 | 24
tumor necrosis factor receptor 23 | 23
DNA-directed DNA polymerase 22 | 22
anion channel 21 | 21
carbohydrate kinase 21 | 21
tubulin 21 | 21
guanylate cyclase 20 | 20
cysteine protease inhibitor 17 | 17
interferon superfamily 17 | 17
endodeoxyribonuclease 16 | 16
DNA methyltransferase 15 | 15
RNA methyltransferase 13 | 13
carbohydrate phosphatase 13 | 13
CREB transcription factor 12 | 12
type II cytokine receptor 12 | 12
damaged DNA-binding protein 11 | 11
intermediate filament binding ... 11 | 11
tumor necrosis factor family m... 11 | 11
neurotrophic factor 9 | 9
sodium channel 9 | 9
replication origin binding pro... 8 | 8
DNA strand-pairing protein 7 | 7
DNA topoisomerase 4 | 4
amino acid kinase 4 | 4
exodeoxyribonuclease 4 | 4
TGF-beta receptor 3 | 3
metalloprotease inhibitor 3 | 3
DNA glycosylase 2 | 2
DNA photolyase 2 | 2
DNA polymerase processivity fa... 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1
voltage-gated ion channel 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive phospholipase C-like protein 2 PLCL2 Tbio Enzyme -0.27372 2.11 81
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.54485 39.7 163
Brefeldin A-inhibited guanine nucleotide-exchange protein 3 ARFGEF3 Tdark Non-IDG 0.27 0.56 5
PH and SEC7 domain-containing protein 3 PSD3 Tbio Non-IDG -1.18771 15.6 120
Ras and Rab interactor 2 RIN2 Tbio Non-IDG -1.36829 24.1 51
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.16125 137.5 96
GTPase-activating protein and VPS9 domain-containing protein 1 GAPVD1 Tbio Enzyme -0.50735 3.46 71
Probable guanine nucleotide exchange factor MCF2L2 MCF2L2 Tbio Non-IDG -1.61296 41.6 11
G-protein-signaling modulator 1 GPSM1 Tbio Non-IDG -1.32467 28.6 99
Amphiphysin AMPH Tbio Non-IDG -2.64544 426.2 341