Development Level

Tbio 78 | 11,651
Tchem 33 | 1,388
Tdark 31 | 6,593

IMPC Phenotype

preweaning lethality, complete... 12 | 979
decreased lean body mass 5 | 135
abnormal behavior 4 | 298
increased circulating glucose ... 4 | 24
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
preweaning lethality, incomple... 3 | 499
short tibia 3 | 97
abnormal coat-hair pigmentatio... 2 | 64
decreased body length 2 | 101
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased leukocyte cell numbe... 2 | 73
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
hyperactivity 2 | 148
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
long tibia 2 | 25
male infertility 2 | 123
thrombocytopenia 2 | 56
abnormal bone structure 1 | 187
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal spine curvature 1 | 9
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
cataract 1 | 92
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
female infertility 1 | 60
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 94 | 11,493
ovarian cancer 71 | 8,520
osteosarcoma 59 | 7,950
glioblastoma 46 | 5,792
medulloblastoma, large-cell 43 | 6,241
psoriasis 39 | 6,694
atypical teratoid / rhabdoid tumor 35 | 5,112
lung cancer 34 | 4,740
Cancer 29 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
malignant mesothelioma 29 | 3,232
lung carcinoma 26 | 2,843
adult high grade glioma 24 | 3,801
subependymal giant cell astrocytoma 23 | 2,287
diabetes mellitus 22 | 1,728
group 3 medulloblastoma 22 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
ependymoma 21 | 4,679
Breast cancer 20 | 3,578
non-small cell lung cancer 19 | 2,890
juvenile dermatomyositis 18 | 1,187
lung adenocarcinoma 18 | 2,716
Astrocytoma, Pilocytic 17 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
invasive ductal carcinoma 16 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
primitive neuroectodermal tumor 15 | 3,035
ulcerative colitis 15 | 1,819
Kidney cancer 14 | 2,613
tuberculosis 14 | 2,010
Multiple myeloma 13 | 1,332
astrocytic glioma 13 | 2,597
oligodendroglioma 13 | 2,850
pancreatic cancer 13 | 2,398
adrenocortical carcinoma 12 | 1,428
cystic fibrosis 12 | 1,696
interstitial cystitis 12 | 2,312
Atopic dermatitis 11 | 952
Pick disease 11 | 1,894
cutaneous lupus erythematosus 11 | 1,057
group 4 medulloblastoma 11 | 1,855
Liver Cirrhosis, Experimental 10 | 769
acute myeloid leukemia 10 | 783
Alzheimer's disease 9 | 658
Autosomal recessive predisposition 9 | 1,442
Parkinson's disease 9 | 392
colon cancer 9 | 1,478
dermatomyositis 9 | 966
pituitary cancer 9 | 1,972
spina bifida 9 | 1,074
progressive supranuclear palsy 8 | 676
Neurodegenerative disease 7 | 414
Stomach Neoplasms 7 | 300
acute quadriplegic myopathy 7 | 1,158
gastric carcinoma 7 | 807
Arthritis 6 | 290
Bipolar Disorder 6 | 666
Melanoma 6 | 711
Myocardial Reperfusion Injury 6 | 37
Vascular disease 6 | 319
Waldenstrons macroglobulinemia 6 | 765
active Crohn's disease 6 | 922
astrocytoma 6 | 1,146
breast carcinoma 6 | 1,638
hereditary spastic paraplegia 6 | 318
pediatric high grade glioma 6 | 1,064
primary Sjogren syndrome 6 | 735
primary pancreatic ductal adenocarcinoma 6 | 1,109
Carcinoma, Hepatocellular 5 | 228
Chronic hepatitis C 5 | 12
Duchenne muscular dystrophy 5 | 601
Liver carcinoma 5 | 240
Obesity 5 | 678
Osteoporosis 5 | 363
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
Toxic encephalopathy 5 | 141
active ulcerative colitis 5 | 764
aldosterone-producing adenoma 5 | 665
esophageal adenocarcinoma 5 | 737
inflammatory breast cancer 5 | 286
nasopharyngeal carcinoma 5 | 1,058
nephrosclerosis 5 | 333
non-small cell lung carcinoma 5 | 317
posterior fossa group A ependymoma 5 | 468
Amyotrophic lateral sclerosis 4 | 451
Carcinoma, Non-Small-Cell Lung 4 | 107
Dementia 4 | 175
Endometriosis 4 | 540
Infertility 4 | 188
Intellectual disability 4 | 1,016
Kidney disease 4 | 430
Leukemia, Myelocytic, Acute 4 | 120
Leukemia, Myeloid, Acute 4 | 105
Lung Neoplasms 4 | 232
Short stature 4 | 531
hepatocellular carcinoma 4 | 547
mucosa-associated lymphoid tissue lymphoma 4 | 484
pancreatic carcinoma 4 | 562
tuberculosis and treatment for 6 months 4 | 409

Tissue

Endocrine System 121 | 18,159
Blood and immune system 118 | 16,909
Digestive Tract 118 | 17,369
Skin and soft tissues 118 | 17,230
Female tissues 117 | 17,400
Male tissues 116 | 17,142
Liver and Pancreas 115 | 16,750
Respiratory system 115 | 16,393
Urinary Tract 115 | 16,678
Nervous System 114 | 16,725
Cardiovascular System 110 | 15,192

Target Family

Enzyme 114 | 4,145
Non-IDG 28 | 12,091

PANTHER Protein Class (2)

cysteine protease 142 | 142
protein kinase 257 | 257
serine protease 175 | 175
ribosomal protein 152 | 152
metalloprotease 135 | 135
mRNA processing factor 122 | 122
calmodulin 113 | 113
chromatin/chromatin-binding pr... 106 | 106
serine protease inhibitor 94 | 94
non-motor actin binding protei... 90 | 90
homeodomain transcription fact... 88 | 88
small GTPase 81 | 81
guanyl-nucleotide exchange fac... 77 | 77
translation factor 76 | 76
ligand-gated ion channel 69 | 69
microtubule binding motor prot... 62 | 62
histone 61 | 61
non-motor microtubule binding ... 57 | 57
kinase activator 55 | 55
chemokine 48 | 48
DNA-directed RNA polymerase 46 | 46
ribonucleoprotein 44 | 44
heterotrimeric G-protein 43 | 43
protein phosphatase 41 | 41
nucleotide kinase 37 | 37
RNA helicase 35 | 35
phosphatase inhibitor 34 | 34
nucleotide phosphatase 33 | 33
actin and actin related protei... 31 | 31
kinase inhibitor 31 | 31
phospholipase 30 | 30
ATP synthase 28 | 28
DNA helicase 28 | 28
actin binding motor protein 27 | 27
C2H2 zinc finger transcription... 25 | 25
calcium channel 23 | 23
DNA-directed DNA polymerase 22 | 22
endoribonuclease 22 | 22
tubulin 22 | 22
aspartic protease 21 | 21
exoribonuclease 21 | 21
type I cytokine receptor 20 | 20
anion channel 19 | 19
carbohydrate kinase 17 | 17
endodeoxyribonuclease 15 | 15
intermediate filament binding ... 15 | 15
neuropeptide 15 | 15
potassium channel 15 | 15
DNA methyltransferase 12 | 12
type II cytokine receptor 12 | 12
RNA methyltransferase 11 | 11
damaged DNA-binding protein 11 | 11
tumor necrosis factor family m... 11 | 11
sodium channel 9 | 9
neurotrophic factor 8 | 8
replication origin binding pro... 8 | 8
winged helix/forkhead transcri... 8 | 8
carbohydrate phosphatase 6 | 6
amino acid kinase 5 | 5
guanylate cyclase 5 | 5
DNA topoisomerase 4 | 4
interleukin superfamily 4 | 4
CREB-related transcription fac... 3 | 3
C4 zinc finger nuclear recepto... 2 | 2
DNA photolyase 2 | 2
Lambda repressor-like transcri... 2 | 2
cysteine protease inhibitor 2 | 2
tumor necrosis factor receptor 2 | 2
DNA glycosylase 1 | 1
DNA polymerase processivity fa... 1 | 1
centromere DNA-binding protein 1 | 1
exodeoxyribonuclease 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive caspase-12 CASP12 Tbio Enzyme -2.64252 415.1 429
Pyroglutamyl-peptidase 1 PGPEP1 Tbio Enzyme -2.39412 250.8 91
Ubiquitin carboxyl-terminal hydrolase 3 USP3 Tbio Enzyme -1.16770 14.5 246
Desumoylating isopeptidase 2 DESI2 Tbio Enzyme -2.81944 648.8 75
Calpain-6 CAPN6 Tbio Non-IDG -1.20335 17.9 140
Ubiquitin carboxyl-terminal hydrolase 16 USP16 Tbio Enzyme -0.67094 5.97 248
Ubiquitin carboxyl-terminal hydrolase isozyme L5 UCHL5 Tbio Enzyme -1.71687 51.9 225
Ubiquitin carboxyl-terminal hydrolase 1 USP1 Tchem Enzyme -1.88853 73.3 271
Tubulointerstitial nephritis antigen TINAG Tbio Non-IDG -1.39157 27.8 58
Calpain-2 catalytic subunit CAPN2 Tchem Non-IDG -1.69585 48.5 220