Development Level

Tbio 98 | 10,625
Tdark 35 | 7,003
Tchem 31 | 1,890

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal embryo size 6 | 112
decreased body weight 6 | 174
decreased rib number 6 | 59
decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
preweaning lethality, incomple... 5 | 260
decreased body length 4 | 108
decreased circulating HDL chol... 4 | 77
decreased circulating LDL chol... 4 | 37
decreased circulating choleste... 4 | 85
decreased lumbar vertebrae num... 4 | 62
increased bone mineral content 4 | 92
increased sacral vertebrae num... 4 | 62
abnormal behavior 3 | 226
abnormal bone structure 3 | 131
decreased bone mineral content 3 | 157
decreased caudal vertebrae num... 3 | 49
decreased circulating total pr... 3 | 41
decreased leukocyte cell numbe... 3 | 54
hypoactivity 3 | 89
increased grip strength 3 | 83
increased lean body mass 3 | 107
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal gait 2 | 51
abnormal neural tube closure 2 | 37
abnormal rib morphology 2 | 28
abnormal tail morphology 2 | 17
abnormal thoracic vertebrae mo... 2 | 16
abnormal vertebral arch morpho... 2 | 9
craniofacial phenotype 2 | 9
decreased circulating calcium ... 2 | 33
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
hydrops fetalis 2 | 22
increased bone mineral density 2 | 52
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating fructosa... 2 | 11
increased mean corpuscular hem... 2 | 25
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased respiratory quotient 2 | 12
male infertility 2 | 62
narrow eye opening 2 | 15
prenatal lethality prior to he... 2 | 64
vertebral fusion 2 | 23
vertebral transformation 2 | 12
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal head morphology 1 | 10
abnormal iris morphology 1 | 12
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal neural tube morpholog... 1 | 8
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal skin appearance 1 | 8
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
cardiovascular system phenotyp... 1 | 35
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating bilirubi... 1 | 14
decreased effector memory CD8-... 1 | 24
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
female infertility 1 | 34
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased circulating creatini... 1 | 29
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased mean platelet volume 1 | 19
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
tremors 1 | 34

Disease

ovarian cancer 88 | 8,484
osteosarcoma 87 | 7,933
medulloblastoma, large-cell 57 | 6,234
glioblastoma 51 | 5,572
psoriasis 50 | 6,685
lung cancer 42 | 4,466
primitive neuroectodermal tumor 39 | 3,031
atypical teratoid / rhabdoid tumor 36 | 4,369
Breast cancer 33 | 3,094
malignant mesothelioma 33 | 3,162
group 3 medulloblastoma 31 | 2,254
oligodendroglioma 31 | 2,849
Cancer 29 | 2,346
pediatric high grade glioma 28 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
Rheumatoid Arthritis 25 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
medulloblastoma 25 | 1,524
Carcinoma 24 | 2,147
diabetes mellitus 22 | 1,663
ependymoma 21 | 2,514
lung adenocarcinoma 21 | 2,713
astrocytoma 20 | 1,493
pituitary cancer 20 | 1,972
astrocytic glioma 19 | 2,241
pilocytic astrocytoma 18 | 3,086
sonic hedgehog group medulloblastoma 18 | 1,482
subependymal giant cell astrocytoma 18 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
invasive ductal carcinoma 17 | 2,950
juvenile dermatomyositis 17 | 1,189
non-small cell lung cancer 17 | 2,798
Pick disease 16 | 1,893
tuberculosis 15 | 1,557
Multiple myeloma 14 | 1,327
acute myeloid leukemia 14 | 780
ulcerative colitis 14 | 2,087
adrenocortical carcinoma 13 | 1,427
group 4 medulloblastoma 13 | 1,875
progressive supranuclear palsy 13 | 674
acute quadriplegic myopathy 12 | 1,157
adult high grade glioma 12 | 2,148
posterior fossa group A ependymoma 12 | 1,511
Waldenstrons macroglobulinemia 11 | 765
atypical teratoid/rhabdoid tumor 11 | 1,095
colon cancer 11 | 1,475
dermatomyositis 11 | 933
ductal carcinoma in situ 11 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
tuberculosis and treatment for 6 months 11 | 686
lung carcinoma 10 | 2,844
pancreatic cancer 10 | 2,300
spina bifida 10 | 1,064
Alzheimer's disease 9 | 644
Intellectual disability 9 | 573
Obesity 9 | 616
aldosterone-producing adenoma 9 | 664
interstitial cystitis 9 | 2,299
nasopharyngeal carcinoma 9 | 1,056
primary pancreatic ductal adenocarcinoma 9 | 1,271
primary Sjogren syndrome 8 | 789
Adenoid Cystic Carcinoma 7 | 99
active Crohn's disease 7 | 918
breast carcinoma 7 | 1,614
cutaneous lupus erythematosus 7 | 1,056
cystic fibrosis 7 | 1,665
gastric carcinoma 7 | 832
posterior fossa group B ependymoma 7 | 1,530
Bladder Neoplasm 6 | 109
Down syndrome 6 | 548
Metabolic syndrome X 6 | 155
Prostatic Neoplasms 6 | 471
Cornelia de Lange syndrome 5 | 21
Male infertility 5 | 170
Mammary Neoplasms 5 | 410
Microcephaly 5 | 149
gastric cancer 5 | 430
hepatocellular carcinoma 5 | 532
non primary Sjogren syndrome sicca 5 | 840
Acquired metabolic disease 4 | 267
Arthritis 4 | 248
Chronic Lymphocytic Leukemia 4 | 242
Heart disease 4 | 279
Parkinson's disease 4 | 364
Vascular disease 4 | 281
esophageal adenocarcinoma 4 | 737
pancreatic carcinoma 4 | 567
periodontitis 4 | 269
Amyotrophic Lateral Sclerosis 3 | 431
Crohn's disease 3 | 304
Huntington's disease 3 | 72
IGA Glomerulonephritis 3 | 454
Leukemia 3 | 88
Myeloid Leukemia 3 | 19
Peripheral Neuropathy 3 | 303
Polycystic Ovary Syndrome 3 | 332
Prostate cancer 3 | 172
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
glioblastoma multiforme 3 | 347
inflammatory breast cancer 3 | 404

Tissue

Female tissues 156 | 18,647
Nervous System 156 | 18,561
Blood and immune system 155 | 17,995
Endocrine System 155 | 18,512
Digestive Tract 154 | 18,473
Urinary Tract 154 | 18,444
Cardiovascular System 153 | 17,958
Liver and Pancreas 153 | 18,136
Male tissues 153 | 17,969
Skin and soft tissues 153 | 18,115
Respiratory system 149 | 17,484

Target Family

Non-IDG 76 | 11,971
Epigenetic 51 | 242
Transcription Factor 21 | 1,400
TF/Epigenetic 11 | 38
Enzyme 5 | 4,146

PANTHER Protein Class (2)

chromatin/chromatin-binding pr... 164 | 164
protein kinase 370 | 370
KRAB box transcription factor 333 | 333
serine protease 285 | 285
homeobox transcription factor 221 | 221
ribosomal protein 216 | 216
protein phosphatase 169 | 169
guanyl-nucleotide exchange fac... 168 | 168
non-motor actin binding protei... 161 | 161
small GTPase 130 | 130
mRNA processing factor 129 | 129
serine protease inhibitor 119 | 119
calmodulin 105 | 105
ligand-gated ion channel 104 | 104
translation factor 96 | 96
metalloprotease 75 | 75
kinase activator 72 | 72
microtubule binding motor prot... 69 | 69
potassium channel 68 | 68
RNA helicase 67 | 67
cysteine protease 62 | 62
histone 62 | 62
actin binding motor protein 60 | 60
non-motor microtubule binding ... 60 | 60
chemokine 48 | 48
ribonucleoprotein 48 | 48
kinase inhibitor 47 | 47
nucleotide kinase 46 | 46
DNA-directed RNA polymerase 43 | 43
type I cytokine receptor 43 | 43
DNA helicase 42 | 42
centromere DNA-binding protein 42 | 42
phospholipase 42 | 42
endoribonuclease 41 | 41
calcium channel 37 | 37
heterotrimeric G-protein 35 | 35
interleukin superfamily 35 | 35
nucleotide phosphatase 35 | 35
ATP synthase 34 | 34
phosphatase inhibitor 33 | 33
actin and actin related protei... 30 | 30
neuropeptide 30 | 30
exoribonuclease 27 | 27
aspartic protease 24 | 24
tumor necrosis factor receptor 23 | 23
DNA-directed DNA polymerase 22 | 22
anion channel 21 | 21
carbohydrate kinase 21 | 21
tubulin 21 | 21
guanylate cyclase 20 | 20
cysteine protease inhibitor 17 | 17
interferon superfamily 17 | 17
endodeoxyribonuclease 16 | 16
DNA methyltransferase 15 | 15
RNA methyltransferase 13 | 13
carbohydrate phosphatase 13 | 13
CREB transcription factor 12 | 12
type II cytokine receptor 12 | 12
damaged DNA-binding protein 11 | 11
intermediate filament binding ... 11 | 11
tumor necrosis factor family m... 11 | 11
neurotrophic factor 9 | 9
sodium channel 9 | 9
replication origin binding pro... 8 | 8
DNA strand-pairing protein 7 | 7
DNA topoisomerase 4 | 4
amino acid kinase 4 | 4
exodeoxyribonuclease 4 | 4
TGF-beta receptor 3 | 3
metalloprotease inhibitor 3 | 3
DNA glycosylase 2 | 2
DNA photolyase 2 | 2
DNA polymerase processivity fa... 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1
voltage-gated ion channel 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sex comb on midleg-like protein 2 SCML2 Tbio Epigenetic -1.13986 13.7 93
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Polyhomeotic-like protein 3 PHC3 Tbio Non-IDG -2.68637 475.4 59
Bromodomain-containing protein 2 BRD2 Tchem Epigenetic -2.42927 0.00000 306
Putative high mobility group protein B1-like 1 HMGB1P1 Tdark Non-IDG -3.17050 1948.8 0
Transcriptional repressor p66-alpha GATAD2A Tbio Non-IDG -0.79314 7.11 142
Structural maintenance of chromosomes protein 1B SMC1B Tbio Non-IDG -1.26509 19.6 93
Cytoskeleton-associated protein 4 CKAP4 Tbio Non-IDG -1.40375 25.5 174
Calcium-responsive transactivator SS18L1 Tbio Non-IDG -0.76611 6.13 75
Protein lin-9 homolog LIN9 Tbio Non-IDG -1.88736 79.3 89