Development Level

Tbio 126 | 10,625
Tdark 50 | 7,003
Tchem 10 | 1,890

IMPC Term

decreased lean body mass 8 | 195
decreased bone mineral content 7 | 157
abnormal behavior 6 | 226
decreased body weight 6 | 174
decreased grip strength 6 | 123
decreased heart weight 6 | 44
preweaning lethality, incomple... 6 | 260
abnormal bone structure 5 | 131
decreased bone mineral density 5 | 126
preweaning lethality, complete... 5 | 633
abnormal retina morphology 4 | 100
decreased total body fat amoun... 4 | 186
decreased body length 3 | 108
decreased circulating HDL chol... 3 | 77
decreased prepulse inhibition 3 | 52
hyperactivity 3 | 108
increased fasted circulating g... 3 | 68
increased or absent threshold ... 3 | 128
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal eye morphology 2 | 38
abnormal heart left ventricle ... 2 | 20
abnormal spleen morphology 2 | 36
abnormal tail movements 2 | 12
abnormal vocalization 2 | 21
decreased B cell number 2 | 30
decreased blood urea nitrogen ... 2 | 31
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 34
decreased rib number 2 | 59
decreased startle reflex 2 | 48
embryonic lethality prior to t... 2 | 187
enlarged heart 2 | 111
hypoactivity 2 | 89
increased circulating calcium ... 2 | 32
increased circulating total pr... 2 | 20
increased heart weight 2 | 37
narrow eye opening 2 | 15
short tibia 2 | 82
small spleen 2 | 11
thrombocytopenia 2 | 46
tremors 2 | 34
trunk curl 2 | 15
abnormal coping response 1 | 12
abnormal defecation 1 | 1
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eyelid morphology 1 | 6
abnormal gait 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased CD5-positive Ly6C-po... 1 | 4
decreased CD8-positive, alpha-... 1 | 26
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 11
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased eosinophil cell numb... 1 | 41
decreased heart rate 1 | 10
decreased hematocrit 1 | 25
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
dilated heart left ventricle 1 | 10
female infertility 1 | 34
hydrops fetalis 1 | 22
increased B cell number 1 | 23
increased KLRG1+ CD4 alpha bet... 1 | 5
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating serum al... 1 | 25
increased effector memory CD4-... 1 | 15
increased gamma-delta T cell n... 1 | 16
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
prolonged RR interval 1 | 2
shortened ST segment 1 | 9
small testis 1 | 37
small thymus 1 | 11
straub tail 1 | 26

Disease

ovarian cancer 104 | 8,484
osteosarcoma 98 | 7,933
medulloblastoma, large-cell 74 | 6,234
glioblastoma 64 | 5,572
psoriasis 58 | 6,685
atypical teratoid / rhabdoid tumor 55 | 4,369
lung cancer 48 | 4,466
primitive neuroectodermal tumor 38 | 3,031
oligodendroglioma 37 | 2,849
pilocytic astrocytoma 35 | 3,086
ependymoma 33 | 2,514
Breast cancer 32 | 3,094
subependymal giant cell astrocytoma 32 | 2,287
adult high grade glioma 31 | 2,148
group 4 medulloblastoma 30 | 1,875
juvenile dermatomyositis 29 | 1,189
malignant mesothelioma 29 | 3,162
group 3 medulloblastoma 26 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,289
Pick disease 23 | 1,893
astrocytic glioma 23 | 2,241
pediatric high grade glioma 23 | 2,712
Carcinoma 22 | 2,147
Cancer 21 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
Multiple myeloma 20 | 1,327
medulloblastoma 20 | 1,524
non-small cell lung cancer 20 | 2,798
invasive ductal carcinoma 19 | 2,950
lung adenocarcinoma 18 | 2,713
lung carcinoma 18 | 2,844
ulcerative colitis 18 | 2,087
Rheumatoid Arthritis 17 | 1,160
spina bifida 17 | 1,064
astrocytoma 16 | 1,493
atypical teratoid/rhabdoid tumor 16 | 1,095
sonic hedgehog group medulloblastoma 16 | 1,482
tuberculosis and treatment for 6 months 15 | 686
cystic fibrosis 14 | 1,665
primary Sjogren syndrome 14 | 789
dermatomyositis 13 | 933
tuberculosis 13 | 1,557
Intellectual disability 12 | 573
adrenocortical carcinoma 12 | 1,427
interstitial cystitis 12 | 2,299
progressive supranuclear palsy 12 | 674
acute quadriplegic myopathy 11 | 1,157
breast carcinoma 11 | 1,614
ductal carcinoma in situ 11 | 1,745
hepatocellular carcinoma 11 | 532
pancreatic cancer 11 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
pituitary cancer 10 | 1,972
posterior fossa group B ependymoma 10 | 1,530
active Crohn's disease 9 | 918
acute myeloid leukemia 9 | 780
posterior fossa group A ependymoma 9 | 1,511
primary pancreatic ductal adenocarcinoma 9 | 1,271
diabetes mellitus 8 | 1,663
cutaneous lupus erythematosus 7 | 1,056
Amyotrophic Lateral Sclerosis 6 | 431
Multiple Sclerosis 6 | 498
colon cancer 6 | 1,475
gastric cancer 6 | 430
sarcoidosis 6 | 358
Atopic dermatitis 5 | 944
Endometriosis 5 | 535
IGA Glomerulonephritis 5 | 454
Mammary Neoplasms 5 | 410
Parkinson's disease 5 | 364
aldosterone-producing adenoma 5 | 664
esophageal adenocarcinoma 5 | 737
glioblastoma multiforme 5 | 347
hereditary spastic paraplegia 5 | 313
non primary Sjogren syndrome sicca 5 | 840
Acquired metabolic disease 4 | 267
Angelman syndrome 4 | 38
Autistic Disorder 4 | 320
Duchenne muscular dystrophy 4 | 602
Hypertension 4 | 287
Neurodegenerative disease 4 | 383
Stevens-Johnson syndrome 4 | 78
Waldenstrons macroglobulinemia 4 | 765
gastric carcinoma 4 | 832
interstitial lung disease 4 | 291
nasopharyngeal carcinoma 4 | 1,056
pancreatic carcinoma 4 | 567
Adenoid Cystic Carcinoma 3 | 99
Gaucher disease type 1 3 | 171
Lice infestation 3 | 16
Malaria 3 | 140
Malignant neoplasm of breast 3 | 63
Prostate cancer 3 | 172
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
head and neck cancer and chronic obstructive pulmonary disease 3 | 237
mucosa-associated lymphoid tissue lymphoma 3 | 480
non-small cell lung carcinoma 3 | 413
systemic lupus erythematosus 3 | 156
urothelial carcinoma 3 | 318

Tissue

Nervous System 184 | 18,561
Blood and immune system 183 | 17,995
Digestive Tract 183 | 18,473
Female tissues 183 | 18,647
Cardiovascular System 182 | 17,958
Liver and Pancreas 182 | 18,136
Male tissues 182 | 17,969
Endocrine System 181 | 18,512
Skin and soft tissues 181 | 18,115
Urinary Tract 181 | 18,444
Respiratory system 179 | 17,484

Target Family

Enzyme 101 | 4,146
Non-IDG 71 | 11,971
Epigenetic 12 | 242
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

PANTHER Protein Class (1)

ubiquitin-protein ligase 186 | 186
DNA binding protein 527 | 527
kinase 502 | 502
RNA binding protein 490 | 490
zinc finger transcription fact... 403 | 403
protease 375 | 375
actin family cytoskeletal prot... 342 | 342
G-protein modulator 330 | 330
G-protein coupled receptor 325 | 325
ion channel 304 | 304
dehydrogenase 239 | 239
phosphatase 230 | 230
helix-turn-helix transcription... 221 | 221
microtubule family cytoskeleta... 211 | 211
G-protein 193 | 193
glycosyltransferase 191 | 191
cytokine 175 | 175
protease inhibitor 167 | 167
immunoglobulin receptor superf... 162 | 162
peptide hormone 162 | 162
nuclease 152 | 152
kinase modulator 149 | 149
cation transporter 139 | 139
transcription cofactor 139 | 139
membrane-bound signaling molec... 125 | 125
helicase 124 | 124
growth factor 109 | 109
cadherin 107 | 107
membrane trafficking regulator... 106 | 106
acetyltransferase 91 | 91
extracellular matrix glycoprot... 85 | 85
intermediate filament 83 | 83
extracellular matrix structura... 75 | 75
antibacterial response protein 74 | 74
basic helix-loop-helix transcr... 74 | 74
oxygenase 73 | 73
acyltransferase 63 | 63
cytokine receptor 60 | 60
intracellular calcium-sensing ... 60 | 60
methyltransferase 60 | 60
mitochondrial carrier protein 58 | 58
lipase 55 | 55
esterase 54 | 54
phosphatase modulator 53 | 53
carbohydrate transporter 46 | 46
nuclear hormone receptor 46 | 46
major histocompatibility compl... 45 | 45
reductase 44 | 44
dehydratase 42 | 42
ATP-binding cassette (ABC) tra... 41 | 41
SNARE protein 40 | 40
vesicle coat protein 40 | 40
oxidase 39 | 39
amino acid transporter 37 | 37
tight junction 36 | 36
nucleotidyltransferase 33 | 33
aminoacyl-tRNA synthetase 28 | 28
phosphodiesterase 28 | 28
deaminase 27 | 27
extracellular matrix linker pr... 26 | 26
glycosidase 24 | 24
peroxidase 24 | 24
transaminase 24 | 24
HMG box transcription factor 22 | 22
cyclase 22 | 22
decarboxylase 21 | 21
gap junction 21 | 21
chaperonin 19 | 19
epimerase/racemase 19 | 19
Hsp70 family chaperone 18 | 18
apolipoprotein 16 | 16
annexin 14 | 14
immunoglobulin superfamily cel... 14 | 14
basic leucine zipper transcrip... 12 | 12
deacetylase 12 | 12
glucosidase 12 | 12
mutase 12 | 12
Hsp90 family chaperone 11 | 11
phosphorylase 11 | 11
hydroxylase 8 | 8
viral coat protein 8 | 8
amylase 6 | 6
galactosidase 6 | 6
immunoglobulin 5 | 5
pyrophosphatase 5 | 5
myelin protein 4 | 4
calsequestrin 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
E3 ubiquitin-protein ligase ZSWIM2 ZSWIM2 Tbio Enzyme -2.21919 171.7 87
Ubiquitin-conjugating enzyme E2 variant 3 UEVLD Tdark Non-IDG 0.18 0.85 86
Cullin-5 CUL5 Tbio Non-IDG -1.93258 89.1 172
E3 ubiquitin-protein ligase TRIM62 TRIM62 Tbio Enzyme -0.57145 6.96 129
Tripartite motif-containing protein 67 TRIM67 Tdark Non-IDG -1.92838 86.9 22
NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 Tbio Enzyme -1.57709 42.8 121
RING finger protein 113A RNF113A Tbio Non-IDG -0.57403 5.70 73
Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 Tbio Enzyme -0.18436 2.95 181
RNA-binding protein MEX3A MEX3A Tdark Non-IDG -0.02462 1.61 35