Development Level

Tbio 70 | 11,651
Tdark 26 | 6,593
Tchem 3 | 1,388

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
abnormal behavior 4 | 298
abnormal bone structure 4 | 187
decreased prepulse inhibition 4 | 82
decreased body weight 3 | 161
decreased bone mineral density 3 | 126
decreased circulating chloride... 3 | 30
decreased circulating total pr... 3 | 49
decreased startle reflex 3 | 75
enlarged heart 3 | 210
hypoactivity 3 | 132
increased circulating calcium ... 3 | 34
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal vocalization 2 | 21
cataract 2 | 92
corneal opacity 2 | 32
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
increased circulating phosphat... 2 | 26
increased circulating total pr... 2 | 28
increased eosinophil cell numb... 2 | 11
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
narrow eye opening 2 | 12
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal defecation 1 | 1
abnormal embryo size 1 | 220
abnormal esophagus morphology 1 | 5
abnormal forebrain development 1 | 20
abnormal hair growth 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal locomotor activation 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
anophthalmia 1 | 33
cystolithiasis 1 | 3
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased total retina thickne... 1 | 17
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased circulating alanine ... 1 | 13
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality 1 | 28
prolonged RR interval 1 | 8
thick skin 1 | 4
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 65 | 11,493
ovarian cancer 63 | 8,520
osteosarcoma 49 | 7,950
medulloblastoma, large-cell 40 | 6,241
atypical teratoid / rhabdoid tumor 36 | 5,112
glioblastoma 36 | 5,792
group 3 medulloblastoma 29 | 4,104
ependymoma 28 | 4,679
lung cancer 28 | 4,740
psoriasis 28 | 6,694
adult high grade glioma 23 | 3,801
primitive neuroectodermal tumor 23 | 3,035
oligodendroglioma 21 | 2,850
subependymal giant cell astrocytoma 21 | 2,287
Breast cancer 20 | 3,578
Astrocytoma, Pilocytic 18 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
astrocytic glioma 17 | 2,597
non-small cell lung cancer 16 | 2,890
Kidney cancer 15 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
malignant mesothelioma 14 | 3,232
spina bifida 14 | 1,074
Cancer 13 | 2,499
Pick disease 13 | 1,894
lung adenocarcinoma 13 | 2,716
tuberculosis 13 | 2,010
Multiple myeloma 12 | 1,332
Rheumatoid arthritis 12 | 1,191
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
invasive ductal carcinoma 12 | 2,951
juvenile dermatomyositis 12 | 1,187
group 4 medulloblastoma 11 | 1,855
pancreatic cancer 11 | 2,398
adrenocortical carcinoma 10 | 1,428
breast carcinoma 10 | 1,638
lung carcinoma 10 | 2,843
cystic fibrosis 8 | 1,696
hepatocellular carcinoma 8 | 547
interstitial cystitis 8 | 2,312
medulloblastoma 8 | 720
pituitary cancer 8 | 1,972
acute myeloid leukemia 7 | 783
primary pancreatic ductal adenocarcinoma 7 | 1,109
tuberculosis and treatment for 6 months 7 | 409
ulcerative colitis 7 | 1,819
acute quadriplegic myopathy 6 | 1,158
atypical teratoid/rhabdoid tumor 6 | 357
ductal carcinoma in situ 6 | 1,745
pediatric high grade glioma 6 | 1,064
progressive supranuclear palsy 6 | 676
Intellectual disability 5 | 1,016
Liver cancer 5 | 604
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Atopic dermatitis 4 | 952
Autosomal recessive predisposition 4 | 1,442
Breast Neoplasms 4 | 445
Duchenne muscular dystrophy 4 | 601
Dull intelligence 4 | 645
Hypertension 4 | 396
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple Sclerosis 4 | 540
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Short stature 4 | 531
Stevens-Johnson syndrome 4 | 92
active Crohn's disease 4 | 922
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
gastric cancer 4 | 459
non primary Sjogren syndrome sicca 4 | 891
sonic hedgehog group medulloblastoma 4 | 467
Acquired metabolic disease 3 | 336
Acquired scoliosis 3 | 281
Adenoid Cystic Carcinoma 3 | 99
Amyotrophic lateral sclerosis 3 | 451
Carcinoma, Adenoid Cystic 3 | 99
Congenital hypoplasia of penis 3 | 176
Curvature of spine 3 | 282
Endometriosis 3 | 540
Liddle syndrome 3 | 14
Mammary Neoplasms 3 | 425
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Waldenstrons macroglobulinemia 3 | 765
chronic rhinosinusitis 3 | 512
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 807
interstitial lung disease 3 | 298
nasopharyngeal carcinoma 3 | 1,058
pancreatic carcinoma 3 | 562
sarcoidosis 3 | 370
urothelial carcinoma 3 | 318
Chronic obstructive pulmonary disease 2 | 184
Endometrial cancer 2 | 311
Prostate cancer 2 | 175
Seizures 2 | 596
colon cancer 2 | 1,478

Tissue

Endocrine System 98 | 18,159
Female tissues 97 | 17,400
Nervous System 97 | 16,725
Blood and immune system 96 | 16,909
Respiratory system 96 | 16,393
Urinary Tract 96 | 16,678
Digestive Tract 95 | 17,369
Liver and Pancreas 95 | 16,750
Male tissues 95 | 17,142
Skin and soft tissues 95 | 17,230
Cardiovascular System 91 | 15,192

Target Family

Enzyme 58 | 4,145
Non-IDG 37 | 12,091
Epigenetic 4 | 242

PANTHER Protein Class (1)

ubiquitin-protein ligase 99 | 99
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81
E3 ubiquitin-protein ligase DTX1 DTX1 Tbio Enzyme -2.07595 115.2 134
E3 ubiquitin-protein ligase RNF5 RNF5 Tbio Enzyme -1.20054 15.1 166
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.52486 353.9 144
E3 ubiquitin-protein ligase MARCH5 MARCH5 Tbio Epigenetic -1.47833 33.3 156
RING finger and CHY zinc finger domain-containing protein 1 RCHY1 Tbio Non-IDG -2.47052 287.7 126
E3 ubiquitin-protein ligase SMURF1 SMURF1 Tbio Enzyme -1.95365 89.3 331
E3 ubiquitin-protein ligase UHRF1 UHRF1 Tbio Epigenetic 0.00000 279
E3 ubiquitin-protein ligase ZSWIM2 ZSWIM2 Tbio Enzyme -2.28388 186.1 92
E3 ubiquitin-protein ligase RNF19B RNF19B Tbio Enzyme -0.77784 6.71 95