Development Level

Tbio 269 | 11,651
Tchem 120 | 1,388
Tdark 107 | 6,593
Tclin 20 | 612

Collection

RFA-RM-18-021 17 | 328
GPCR: IDG Consortium (Targets) 12 | 126
GPCR: IDG Consortium (Complete... 4 | 25
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 26 | 979
preweaning lethality, incomple... 14 | 499
abnormal behavior 13 | 298
decreased lean body mass 10 | 135
decreased body weight 9 | 161
hyperactivity 8 | 148
hypoactivity 8 | 132
decreased bone mineral content 7 | 151
increased mean corpuscular hem... 7 | 96
decreased body length 6 | 101
increased total body fat amoun... 6 | 134
abnormal embryo size 5 | 220
decreased bone mineral density 5 | 126
decreased circulating triglyce... 5 | 79
decreased leukocyte cell numbe... 5 | 73
decreased vertical activity 5 | 208
embryonic lethality prior to t... 5 | 278
increased circulating alkaline... 5 | 122
increased circulating choleste... 5 | 66
increased startle reflex 5 | 112
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
abnormal tail morphology 4 | 25
decreased circulating choleste... 4 | 93
decreased grip strength 4 | 116
decreased total body fat amoun... 4 | 207
embryonic growth retardation 4 | 106
enlarged heart 4 | 210
increased blood urea nitrogen ... 4 | 48
increased circulating HDL chol... 4 | 80
male infertility 4 | 123
thrombocytopenia 4 | 56
abnormal bone mineralization 3 | 38
abnormal gait 3 | 69
abnormal lens morphology 3 | 81
abnormal seminal vesicle morph... 3 | 114
decreased blood urea nitrogen ... 3 | 51
decreased circulating HDL chol... 3 | 68
decreased circulating creatini... 3 | 39
decreased circulating phosphat... 3 | 27
decreased erythrocyte cell num... 3 | 62
decreased fasted circulating g... 3 | 65
decreased mean platelet volume 3 | 25
decreased neutrophil cell numb... 3 | 42
decreased prepulse inhibition 3 | 82
female infertility 3 | 60
increased circulating chloride... 3 | 41
increased circulating creatini... 3 | 38
increased circulating glucose ... 3 | 24
increased circulating serum al... 3 | 22
increased lean body mass 3 | 172
prolonged ST segment 3 | 36
short tibia 3 | 97
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal eye morphology 2 | 68
abnormal joint morphology 2 | 23
abnormal limb bud morphology 2 | 17
abnormal limb morphology 2 | 13
abnormal locomotor behavior 2 | 24
abnormal maxilla morphology 2 | 17
abnormal skin coloration 2 | 25
abnormal snout morphology 2 | 23
abnormal tibia morphology 2 | 14
cataract 2 | 92
decreased T cell number 2 | 15
decreased basophil cell number 2 | 16
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to o... 2 | 239
hemorrhage 2 | 23
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased NK cell number 2 | 3
increased anti-nuclear antigen... 2 | 19
increased bone mineral content 2 | 108
increased circulating LDL chol... 2 | 13
increased circulating amylase ... 2 | 25
increased circulating bilirubi... 2 | 16
increased circulating iron lev... 2 | 30
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 28
increased heart weight 2 | 62
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
increased prepulse inhibition 2 | 32
long tibia 2 | 25
mammalian phenotype 2 | 17
prenatal lethality prior to he... 2 | 87
tremors 2 | 39
enlarged spleen 1 | 41

Disease

Carcinoma 353 | 11,493
ovarian cancer 223 | 8,520
osteosarcoma 202 | 7,950
psoriasis 186 | 6,694
glioblastoma 148 | 5,792
medulloblastoma, large-cell 140 | 6,241
lung cancer 132 | 4,740
atypical teratoid / rhabdoid tumor 129 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 109 | 3,291
Breast cancer 105 | 3,578
ependymoma 104 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 101 | 2,955
Cancer 100 | 2,499
lung carcinoma 97 | 2,843
lung adenocarcinoma 94 | 2,716
adult high grade glioma 92 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,989
malignant mesothelioma 90 | 3,232
non-small cell lung cancer 90 | 2,890
invasive ductal carcinoma 89 | 2,951
pancreatic cancer 84 | 2,398
Kidney cancer 79 | 2,613
interstitial cystitis 78 | 2,312
group 3 medulloblastoma 76 | 4,104
diabetes mellitus 71 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 70 | 1,962
Astrocytoma, Pilocytic 69 | 3,081
cystic fibrosis 64 | 1,696
oligodendroglioma 61 | 2,850
ulcerative colitis 59 | 1,819
subependymal giant cell astrocytoma 58 | 2,287
primitive neuroectodermal tumor 56 | 3,035
tuberculosis 52 | 2,010
Autosomal recessive predisposition 51 | 1,442
astrocytic glioma 49 | 2,597
ductal carcinoma in situ 48 | 1,745
pituitary cancer 48 | 1,972
Atopic dermatitis 46 | 952
colon cancer 46 | 1,478
group 4 medulloblastoma 46 | 1,855
breast carcinoma 43 | 1,638
cutaneous lupus erythematosus 43 | 1,057
Multiple myeloma 41 | 1,332
Pick disease 38 | 1,894
active Crohn's disease 38 | 922
juvenile dermatomyositis 38 | 1,187
Liver Cirrhosis, Experimental 36 | 769
esophageal adenocarcinoma 36 | 737
primary pancreatic ductal adenocarcinoma 36 | 1,109
adrenocortical carcinoma 35 | 1,428
Hypertension 33 | 396
Melanoma 30 | 711
active ulcerative colitis 30 | 764
Alzheimer's disease 29 | 658
nasopharyngeal carcinoma 29 | 1,058
Rheumatoid arthritis 27 | 1,191
Schizophrenia 27 | 1,160
astrocytoma 27 | 1,146
pediatric high grade glioma 27 | 1,064
gastric carcinoma 26 | 807
Waldenstrons macroglobulinemia 25 | 765
dermatomyositis 25 | 966
spina bifida 25 | 1,074
Atherosclerosis 24 | 291
Kidney disease 24 | 430
acute myeloid leukemia 24 | 783
non primary Sjogren syndrome sicca 24 | 891
Obesity 23 | 678
Prostatic Neoplasms 22 | 495
Skin cancer 22 | 469
mucosa-associated lymphoid tissue lymphoma 22 | 484
Cerebrovascular disease 21 | 238
Neurodegenerative disease 21 | 414
Pancreatitis 21 | 123
Coronary artery disease 19 | 268
fibroadenoma 19 | 559
head and neck cancer and chronic obstructive pulmonary disease 19 | 239
primary Sjogren syndrome 19 | 735
Hypertensive disease 18 | 292
acute quadriplegic myopathy 18 | 1,158
progressive supranuclear palsy 18 | 676
Asthma 17 | 385
Bipolar Disorder 17 | 666
Liver cancer 17 | 604
Vascular disease 17 | 319
non-small cell lung carcinoma 17 | 317
periodontitis 17 | 293
posterior fossa group A ependymoma 17 | 468
Duchenne muscular dystrophy 16 | 601
Intellectual disability 16 | 1,016
medulloblastoma 16 | 720
Epilepsy 15 | 792
Liver disease 15 | 237
Myocardial Infarction 15 | 151
aldosterone-producing adenoma 15 | 665
urothelial carcinoma 15 | 318
Anemia 14 | 365
Arthritis 14 | 290
Endometriosis 14 | 540
Short stature 14 | 531

Tissue

Endocrine System 476 | 18,159
Female tissues 466 | 17,400
Digestive Tract 459 | 17,369
Skin and soft tissues 455 | 17,230
Blood and immune system 449 | 16,909
Male tissues 448 | 17,142
Urinary Tract 444 | 16,678
Liver and Pancreas 442 | 16,750
Respiratory system 434 | 16,393
Nervous System 425 | 16,725
Cardiovascular System 375 | 15,192

Target Family

Enzyme 411 | 4,145
Non-IDG 73 | 12,091
GPCR 24 | 408
Ion Channel 6 | 344
Kinase 2 | 634

PANTHER Protein Class (1)

protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kallikrein-9 KLK9 Tbio Enzyme -0.89030 8.64 143
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Serine protease 55 PRSS55 Tdark Enzyme -0.51631 3.86 70
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Inactive serine protease PAMR1 PAMR1 Tdark Enzyme -0.86262 5.98 22
Tripeptidyl-peptidase 2 TPP2 Tbio Enzyme -1.97332 108.2 72
Neurotrypsin PRSS12 Tbio Non-IDG -1.46986 30.6 77
Cathepsin E CTSE Tchem Enzyme -2.33724 227.7 192