Development Level

Tbio 106 | 11,651
Tdark 30 | 6,593
Tchem 26 | 1,388
Tclin 1 | 612

IMPC Phenotype

abnormal bone structure 7 | 187
preweaning lethality, complete... 6 | 979
decreased bone mineral density 4 | 126
decreased lean body mass 4 | 135
decreased neutrophil cell numb... 4 | 42
increased lymphocyte cell numb... 4 | 32
preweaning lethality, incomple... 4 | 499
decreased body length 3 | 101
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased mean corpuscular vol... 3 | 79
increased lean body mass 3 | 172
persistence of hyaloid vascula... 3 | 33
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
decreased erythrocyte cell num... 2 | 62
decreased mean corpuscular hem... 2 | 50
edema 2 | 59
hypoactivity 2 | 132
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased startle reflex 2 | 112
male infertility 2 | 123
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
thin ventricular wall 2 | 24
thrombocytopenia 2 | 56
tremors 2 | 39
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal locomotor behavior 1 | 24
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
anophthalmia 1 | 33
aorta dilation 1 | 3
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased cornea thickness 1 | 2
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
enlarged testis 1 | 6
female infertility 1 | 60
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased T cell number 1 | 6
increased body temperature 1 | 9
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased vertical activity 1 | 24
limb grasping 1 | 41
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
shortened QT interval 1 | 4
small adrenal glands 1 | 16
thick ventricular wall 1 | 7

Disease

Carcinoma 99 | 11,493
ovarian cancer 90 | 8,520
osteosarcoma 79 | 7,950
medulloblastoma, large-cell 73 | 6,241
glioblastoma 66 | 5,792
psoriasis 59 | 6,694
atypical teratoid / rhabdoid tumor 58 | 5,112
ependymoma 52 | 4,679
lung cancer 50 | 4,740
adult high grade glioma 47 | 3,801
group 3 medulloblastoma 43 | 4,104
Breast cancer 38 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
invasive ductal carcinoma 33 | 2,951
Astrocytoma, Pilocytic 31 | 3,081
malignant mesothelioma 30 | 3,232
oligodendroglioma 30 | 2,850
subependymal giant cell astrocytoma 30 | 2,287
Pick disease 29 | 1,894
astrocytic glioma 29 | 2,597
group 4 medulloblastoma 29 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
primitive neuroectodermal tumor 28 | 3,035
colon cancer 26 | 1,478
non-small cell lung cancer 26 | 2,890
Kidney cancer 25 | 2,613
interstitial cystitis 25 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,962
pancreatic cancer 23 | 2,398
ductal carcinoma in situ 21 | 1,745
lung adenocarcinoma 21 | 2,716
ulcerative colitis 21 | 1,819
lung carcinoma 20 | 2,843
tuberculosis 20 | 2,010
Autosomal recessive predisposition 19 | 1,442
pituitary cancer 19 | 1,972
Cancer 15 | 2,499
cystic fibrosis 15 | 1,696
juvenile dermatomyositis 15 | 1,187
spina bifida 15 | 1,074
acute quadriplegic myopathy 14 | 1,158
breast carcinoma 14 | 1,638
gastric carcinoma 14 | 807
Bipolar Disorder 13 | 666
Epilepsy 13 | 792
Intellectual disability 13 | 1,016
Seizures 13 | 596
active Crohn's disease 13 | 922
adrenocortical carcinoma 12 | 1,428
dermatomyositis 12 | 966
Multiple myeloma 11 | 1,332
Schizophrenia 11 | 1,160
aldosterone-producing adenoma 11 | 665
astrocytoma 11 | 1,146
diabetes mellitus 11 | 1,728
pediatric high grade glioma 11 | 1,064
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Rheumatoid arthritis 10 | 1,191
Waldenstrons macroglobulinemia 10 | 765
esophageal adenocarcinoma 10 | 737
non primary Sjogren syndrome sicca 10 | 891
primary pancreatic ductal adenocarcinoma 10 | 1,109
Endometriosis 9 | 540
Neurodegenerative disease 9 | 414
cutaneous lupus erythematosus 9 | 1,057
medulloblastoma 9 | 720
Atopic dermatitis 8 | 952
Centronuclear myopathy 8 | 27
Cognitive delay 8 | 608
Down syndrome 8 | 499
Global developmental delay 8 | 608
Melanoma 8 | 711
Mental and motor retardation 8 | 608
Muscle hypotonia 8 | 571
Skin cancer 8 | 469
active ulcerative colitis 8 | 764
Acquired scoliosis 7 | 281
Curvature of spine 7 | 282
Neuropathy 7 | 261
acute myeloid leukemia 7 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
fibroadenoma 7 | 559
hereditary spastic paraplegia 7 | 318
progressive supranuclear palsy 7 | 676
Acquired metabolic disease 6 | 336
Charcot-Marie-Tooth disease 6 | 62
Obesity 6 | 678
Oculocerebrorenal syndrome 6 | 29
Short stature 6 | 531
nasopharyngeal carcinoma 6 | 1,058
nephrosclerosis 6 | 333
posterior fossa group B ependymoma 6 | 416
Attention deficit hyperactivity disorder 5 | 278
Duchenne muscular dystrophy 5 | 601
pancreatic carcinoma 5 | 562

Tissue

Digestive Tract 160 | 17,369
Endocrine System 160 | 18,159
Female tissues 160 | 17,400
Blood and immune system 157 | 16,909
Liver and Pancreas 155 | 16,750
Nervous System 155 | 16,725
Respiratory system 155 | 16,393
Male tissues 154 | 17,142
Skin and soft tissues 153 | 17,230
Urinary Tract 153 | 16,678
Cardiovascular System 146 | 15,192

Target Family

Enzyme 141 | 4,145
Non-IDG 18 | 12,091
Kinase 4 | 634

PANTHER Protein Class (1)

phosphatase 163 | 163
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alkaline phosphatase, placental type ALPP Tbio Enzyme -2.71952 511.2 929
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A INPP5J Tbio Enzyme -1.87182 73.3 126
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Myotubularin-related protein 2 MTMR2 Tbio Enzyme -1.64906 46.5 124
Diphosphoinositol polyphosphate phosphohydrolase 1 NUDT3 Tbio Enzyme -2.01736 105.3 40
Protein phosphatase 1E PPM1E Tbio Enzyme -0.97004 9.49 44
Inositol monophosphatase 3 IMPAD1 Tdark Enzyme -0.78606 4.97 79
Myotubularin-related protein 10 MTMR10 Tdark Non-IDG 0.10 0.58 25
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta PPP2R3B Tbio Enzyme -1.28190 19.5 142
Myotubularin-related protein 9 MTMR9 Tbio Non-IDG -0.73836 6.81 80