Development Level

Tbio 32 | 10,625
Tchem 22 | 1,890
Tclin 10 | 602
Tdark 9 | 7,003

IMPC Phenotype

decreased bone mineral density 3 | 126
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal neural tube closure 2 | 37
decreased bone mineral content 2 | 157
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased leukocyte cell numbe... 2 | 54
decreased mean platelet volume 2 | 12
decreased total body fat amoun... 2 | 186
hyperactivity 2 | 108
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased circulating alkaline... 2 | 119
preweaning lethality, complete... 2 | 633
small kidney 2 | 10
abnormal behavioral response t... 1 | 52
abnormal clavicle morphology 1 | 5
abnormal coat appearance 1 | 25
abnormal coat- hair morphology 1 | 18
abnormal coat-hair pigmentatio... 1 | 54
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal forebrain morphology 1 | 4
abnormal gait 1 | 51
abnormal hindbrain morphology 1 | 2
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal midbrain morphology 1 | 2
abnormal pelvic girdle bone mo... 1 | 11
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal scapula morphology 1 | 3
abnormal tail bud morphology 1 | 6
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vitreous body morphol... 1 | 7
absent mammary gland 1 | 1
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating triglyce... 1 | 83
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased skeletal muscle mass 1 | 1
decreased vertical activity 1 | 22
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
impaired glucose tolerance 1 | 52
impaired pupillary reflex 1 | 14
increased circulating HDL chol... 1 | 63
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased leukocyte cell numbe... 1 | 37
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
mydriasis 1 | 9
persistence of hyaloid vascula... 1 | 22
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
shortened QRS complex duration 1 | 1
small heart 1 | 8
small ovary 1 | 1
small spleen 1 | 11
small uterus 1 | 1
thin skin 1 | 1

Disease

psoriasis 41 | 6,685
ovarian cancer 31 | 8,491
osteosarcoma 29 | 7,933
non-small cell lung cancer 25 | 2,798
interstitial cystitis 24 | 2,299
lung cancer 23 | 4,473
lung carcinoma 23 | 2,844
lung adenocarcinoma 22 | 2,714
glioblastoma 20 | 5,572
Breast cancer 19 | 3,098
medulloblastoma, large-cell 19 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
Cancer 16 | 2,346
cystic fibrosis 15 | 1,670
malignant mesothelioma 15 | 3,163
posterior fossa group A ependymoma 15 | 1,511
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
atypical teratoid / rhabdoid tumor 13 | 4,369
cutaneous lupus erythematosus 13 | 1,056
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
pilocytic astrocytoma 12 | 3,086
Prostatic Neoplasms 11 | 471
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
invasive ductal carcinoma 11 | 2,950
pancreatic cancer 11 | 2,300
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 11 | 1,563
ulcerative colitis 11 | 2,087
adrenocortical carcinoma 10 | 1,427
esophageal adenocarcinoma 10 | 737
oligodendroglioma 10 | 2,849
primitive neuroectodermal tumor 10 | 3,031
Peripheral Neuropathy 9 | 303
adult high grade glioma 9 | 2,148
ductal carcinoma in situ 9 | 1,745
Hypertension 8 | 293
Mammary Neoplasms 8 | 410
Pick disease 8 | 1,893
active Crohn's disease 8 | 918
diabetes mellitus 8 | 1,663
nephrosclerosis 8 | 329
pituitary cancer 8 | 1,972
Endometriosis 7 | 535
astrocytic glioma 7 | 2,241
astrocytoma 7 | 1,493
breast carcinoma 7 | 1,614
medulloblastoma 7 | 1,524
pediatric high grade glioma 7 | 2,712
posterior fossa group B ependymoma 7 | 1,530
Asthma 6 | 349
Lung Neoplasms 6 | 171
Rheumatoid Arthritis 6 | 1,170
adrenocortical adenoma 6 | 134
group 4 medulloblastoma 6 | 1,875
Alzheimer's disease 5 | 644
Atherosclerosis 5 | 275
Cholestasis 5 | 93
Drug-Induced Liver Injury 5 | 118
Liver Cirrhosis, Experimental 5 | 108
Liver disease 5 | 219
Obesity 5 | 616
chronic rhinosinusitis 5 | 512
ependymoma 5 | 2,514
group 3 medulloblastoma 5 | 2,254
head and neck cancer and chronic obstructive pulmonary disease 5 | 237
mucosa-associated lymphoid tissue lymphoma 5 | 480
pancreatic carcinoma 5 | 567
primary pancreatic ductal adenocarcinoma 5 | 1,271
sonic hedgehog group medulloblastoma 5 | 1,482
Actinic keratosis 4 | 22
Adenocarcinoma 4 | 115
Adenoma 4 | 165
Arthritis 4 | 248
Barrett's esophagus 4 | 185
Carcinoma 4 | 2,147
Cerebrovascular disease 4 | 231
Congenital ichthyosiform erythroderma 4 | 27
Coronary artery disease 4 | 240
Esophageal Neoplasms 4 | 67
Human immunodeficiency virus infection 4 | 6
Hyperalgesia 4 | 71
Hypertensive disease 4 | 193
Kidney disease 4 | 397
Melanoma 4 | 261
Osteoarthritis 4 | 96
Reperfusion Injury 4 | 84
Schizophrenia 4 | 503
active ulcerative colitis 4 | 477
aldosterone-producing adenoma 4 | 664
gastric carcinoma 4 | 832
non diabetic and post-ischemic heart failure 4 | 200
periodontitis 4 | 269
primary Sjogren syndrome 4 | 788
Contact Dermatitis 3 | 80
Male infertility 3 | 170
Prostate cancer 3 | 172
colon cancer 3 | 1,475
fibroadenoma 3 | 557
inflammatory breast cancer 3 | 404
nasopharyngeal carcinoma 3 | 1,056

Tissue

Blood and immune system 71 | 17,994
Cardiovascular System 71 | 17,957
Digestive Tract 71 | 18,472
Endocrine System 71 | 18,511
Female tissues 71 | 18,646
Liver and Pancreas 71 | 18,135
Male tissues 71 | 17,968
Nervous System 71 | 18,560
Skin and soft tissues 71 | 18,114
Urinary Tract 71 | 18,443
Respiratory system 70 | 17,483

Target Family

Enzyme 59 | 4,146
Non-IDG 14 | 11,969

PANTHER Protein Class (1)

oxygenase 73 | 73
DNA binding protein 527 | 527
kinase 502 | 502
RNA binding protein 490 | 490
zinc finger transcription fact... 403 | 403
protease 375 | 375
actin family cytoskeletal prot... 342 | 342
G-protein modulator 330 | 330
G-protein coupled receptor 325 | 325
ion channel 304 | 304
dehydrogenase 239 | 239
phosphatase 230 | 230
helix-turn-helix transcription... 221 | 221
microtubule family cytoskeleta... 211 | 211
G-protein 193 | 193
glycosyltransferase 191 | 191
ubiquitin-protein ligase 186 | 186
cytokine 175 | 175
protease inhibitor 167 | 167
immunoglobulin receptor superf... 162 | 162
peptide hormone 162 | 162
nuclease 152 | 152
kinase modulator 149 | 149
cation transporter 139 | 139
transcription cofactor 139 | 139
membrane-bound signaling molec... 125 | 125
helicase 124 | 124
growth factor 109 | 109
cadherin 107 | 107
membrane trafficking regulator... 106 | 106
acetyltransferase 91 | 91
extracellular matrix glycoprot... 85 | 85
intermediate filament 83 | 83
extracellular matrix structura... 75 | 75
antibacterial response protein 74 | 74
basic helix-loop-helix transcr... 74 | 74
acyltransferase 63 | 63
cytokine receptor 60 | 60
intracellular calcium-sensing ... 60 | 60
methyltransferase 60 | 60
mitochondrial carrier protein 58 | 58
lipase 55 | 55
esterase 54 | 54
phosphatase modulator 53 | 53
carbohydrate transporter 46 | 46
nuclear hormone receptor 46 | 46
major histocompatibility compl... 45 | 45
reductase 44 | 44
dehydratase 42 | 42
ATP-binding cassette (ABC) tra... 41 | 41
SNARE protein 40 | 40
vesicle coat protein 40 | 40
oxidase 39 | 39
amino acid transporter 37 | 37
tight junction 36 | 36
nucleotidyltransferase 33 | 33
aminoacyl-tRNA synthetase 28 | 28
phosphodiesterase 28 | 28
deaminase 27 | 27
extracellular matrix linker pr... 26 | 26
glycosidase 24 | 24
peroxidase 24 | 24
transaminase 24 | 24
HMG box transcription factor 22 | 22
cyclase 22 | 22
decarboxylase 21 | 21
gap junction 21 | 21
chaperonin 19 | 19
epimerase/racemase 19 | 19
Hsp70 family chaperone 18 | 18
apolipoprotein 16 | 16
annexin 14 | 14
immunoglobulin superfamily cel... 14 | 14
basic leucine zipper transcrip... 12 | 12
deacetylase 12 | 12
glucosidase 12 | 12
mutase 12 | 12
Hsp90 family chaperone 11 | 11
phosphorylase 11 | 11
hydroxylase 8 | 8
viral coat protein 8 | 8
amylase 6 | 6
galactosidase 6 | 6
immunoglobulin 5 | 5
pyrophosphatase 5 | 5
myelin protein 4 | 4
calsequestrin 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta,beta-carotene 9',10'-oxygenase BCO2 Tbio Enzyme -1.61283 41.5 82
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.62014 38.3 100
Cytochrome P450 1A1 CYP1A1 Tchem Non-IDG -3.53853 3553.5 340
24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Tbio Enzyme -0.96016 6.43 97
Cytochrome P450 4A22 CYP4A22 Tbio Non-IDG -0.91578 6.79 68
Putative dimethylaniline monooxygenase [N-oxide-forming] 6 FMO6P Tdark Enzyme -0.74036 5.40 0
4-hydroxyphenylpyruvate dioxygenase HPD Tclin Enzyme -2.64865 454.3 211
Cytochrome P450 1A2 CYP1A2 Tchem Non-IDG -3.31421 2022.5 420
Cytochrome P450 3A5 CYP3A5 Tclin Enzyme -2.80197 609.8 100
Sterol 26-hydroxylase, mitochondrial CYP27A1 Tchem Enzyme -2.97838 955.5 136