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  3. oxidoreductase
  4. oxidase
Target Filters...

Development Level

Tbio 29 | 11,651
Tchem 6 | 1,388
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
pallor 2 | 34
abnormal behavior 1 | 298
abnormal embryonic autopod pla... 1 | 2
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 5
abnormal sleep behavior 1 | 70
decreased caudal vertebrae num... 1 | 53
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
hypoactivity 1 | 132
increased circulating glucose ... 1 | 24
increased fasted circulating g... 1 | 76
increased spleen weight 1 | 10
pale liver 1 | 6
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 20 | 11,493
ovarian cancer 17 | 8,520
osteosarcoma 14 | 7,950
psoriasis 14 | 6,694
Autosomal recessive predisposition 11 | 1,442
lung cancer 11 | 4,740
glioblastoma 10 | 5,792
interstitial cystitis 10 | 2,312
atypical teratoid / rhabdoid tumor 9 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung adenocarcinoma 9 | 2,716
medulloblastoma, large-cell 9 | 6,241
adult high grade glioma 8 | 3,801
diabetes mellitus 8 | 1,728
non-small cell lung cancer 8 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
lung carcinoma 7 | 2,843
Breast cancer 6 | 3,578
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hypertension 6 | 396
Increased serum lactate 6 | 60
Mental and motor retardation 6 | 608
adrenocortical carcinoma 6 | 1,428
cytochrome-c oxidase deficiency disease 6 | 19
ependymoma 6 | 4,679
pancreatic cancer 6 | 2,398
Acidosis, Lactic 5 | 97
Astrocytoma, Pilocytic 5 | 3,081
Atherosclerosis 5 | 291
Blepharoptosis 5 | 231
Cerebellar Ataxia 5 | 304
Cytochrome-c Oxidase Deficiency 5 | 17
Heart failure 5 | 162
Hepatomegaly 5 | 285
Kidney disease 5 | 430
Lactic acidemia 5 | 95
Leigh disease 5 | 100
Multiple myeloma 5 | 1,332
Muscle hypotonia 5 | 571
Sensorineural Hearing Loss (disorder) 5 | 284
astrocytoma 5 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
malignant mesothelioma 5 | 3,232
primitive neuroectodermal tumor 5 | 3,035
Anemia 4 | 365
Atopic dermatitis 4 | 952
Chronic granulomatous disease 4 | 13
Depressive disorder 4 | 409
Epilepsy 4 | 792
Failure to gain weight 4 | 365
Hypertensive disease 4 | 292
Intellectual disability 4 | 1,016
Nausea and vomiting 4 | 97
Neurodegenerative disease 4 | 414
Optic Atrophy 4 | 242
Pediatric failure to thrive 4 | 365
Schizophrenia 4 | 1,160
Seizures 4 | 596
Short stature 4 | 531
primary Sjogren syndrome 4 | 735
Abdominal Pain 3 | 98
Cancer 3 | 2,499
Cerebrovascular disease 3 | 238
Colonic Neoplasms 3 | 142
Congenital Bilateral Cataracts 3 | 50
Congenital cataract 3 | 50
Dementia 3 | 175
Dull intelligence 3 | 645
Encephalopathies 3 | 43
Endometriosis 3 | 540
Fatigue 3 | 182
Heart disease 3 | 306
Hemoglobin low 3 | 124
Increase in blood pressure 3 | 119
Liver Cirrhosis, Experimental 3 | 769
Low intelligence 3 | 645
Mental deficiency 3 | 645
Myopathy 3 | 185
Neuropathy 3 | 261
Ophthalmoplegia 3 | 106
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
Splenomegaly 3 | 190
active Crohn's disease 3 | 922
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
gastric carcinoma 3 | 807
group 3 medulloblastoma 3 | 4,104
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
nephrosclerosis 3 | 333
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819

Tissue

Endocrine System 38 | 18,159
Blood and immune system 37 | 16,909
Digestive Tract 37 | 17,369
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Nervous System 36 | 16,725
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Male tissues 35 | 17,142
Cardiovascular System 33 | 15,192
Respiratory system 32 | 16,393

Target Family

Enzyme 28 | 4,145
Non-IDG 10 | 12,091
Ion Channel 1 | 344

PANTHER Protein Class (1)

oxidase 39 | 39
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual oxidase 2 DUOX2 Tbio Enzyme -2.45061 251.8 126
Dual oxidase 1 DUOX1 Tbio Enzyme -2.50131 279.5 85
Hydroxyproline dehydrogenase PRODH2 Tbio Enzyme -0.72861 5.94 76
NADPH oxidase 1 NOX1 Tchem Enzyme -2.59188 397.6 233
NADPH oxidase 5 NOX5 Tbio Enzyme -1.82693 76.8 174
Cytochrome b5 CYB5A Tbio Non-IDG -3.24845 1711.7 270
Cytochrome c oxidase subunit 7A2, mitochondrial COX7A2 Tdark Enzyme -0.95678 16.5 0
Cytochrome b5 type B CYB5B Tbio Non-IDG -0.95003 7.55 47
NADPH oxidase 3 NOX3 Tbio Enzyme -1.52922 32.9 139
NADPH oxidase activator 1 NOXA1 Tbio Enzyme -1.24428 16.9 95