Development Level

Tbio 17 | 11,651
Tdark 3 | 6,593
Tchem 1 | 1,388

IMPC Phenotype

abnormal embryo size 1 | 220
abnormal skin morphology 1 | 50
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hydrometra 1 | 53
increased grip strength 1 | 41
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
small superior vagus ganglion 1 | 74

Disease

lung carcinoma 13 | 2,843
diabetes mellitus 11 | 1,728
ovarian cancer 11 | 8,520
Rheumatoid arthritis 10 | 1,191
glioblastoma 10 | 5,792
lung cancer 10 | 4,740
breast carcinoma 9 | 1,638
active Crohn's disease 8 | 922
adult high grade glioma 8 | 3,801
invasive ductal carcinoma 8 | 2,951
non-small cell lung cancer 8 | 2,890
osteosarcoma 8 | 7,950
subependymal giant cell astrocytoma 8 | 2,287
Astrocytoma, Pilocytic 7 | 3,081
Multiple Sclerosis 7 | 540
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Carcinoma 6 | 11,493
Duchenne muscular dystrophy 6 | 601
Hypersensitivity reaction type II disease 6 | 253
Narcolepsy 5 | 72
Type 1 diabetes mellitus 5 | 109
active ulcerative colitis 5 | 764
adrenocortical carcinoma 5 | 1,428
ependymoma 5 | 4,679
esophageal adenocarcinoma 5 | 737
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
juvenile dermatomyositis 5 | 1,187
medulloblastoma, large-cell 5 | 6,241
primary Sjogren syndrome 5 | 735
psoriasis 5 | 6,694
Celiac disease 4 | 116
Down syndrome 4 | 499
Hypersensitivity 4 | 63
Juvenile rheumatoid arthritis 4 | 111
Schizophrenia 4 | 1,160
Waldenstrons macroglobulinemia 4 | 765
astrocytoma 4 | 1,146
head and neck cancer and chronic obstructive pulmonary disease 4 | 239
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Alopecia universalis 3 | 16
Asthma 3 | 385
Autoimmune Diseases 3 | 67
Becker muscular dystrophy 3 | 191
Berylliosis 3 | 28
Breast cancer 3 | 3,578
Collagen disease 3 | 27
Hepatitis B 3 | 108
Proteinuria 3 | 144
Weight decreased 3 | 103
astrocytic glioma 3 | 2,597
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
limb girdle muscular dystrophy 2A 3 | 213
lung adenocarcinoma 3 | 2,716
nephrosclerosis 3 | 333
non primary Sjogren syndrome sicca 3 | 891
pancreatic cancer 3 | 2,398
primary pancreatic ductal adenocarcinoma 3 | 1,109
Addison's disease 2 | 31
Angioedema 2 | 38
Arthritis, Rheumatoid 2 | 174
Autoimmune thyroiditis 2 | 27
Cancer 2 | 2,499
Dermatitis, Irritant 2 | 9
Diabetes Mellitus, Insulin-Dependent 2 | 48
Diabetes Mellitus, Type 1 2 | 43
Drug Eruptions 2 | 18
Endometriosis 2 | 540
Esophageal Achalasia 2 | 9
Exanthema 2 | 43
Graves' disease 2 | 24
Hematuria 2 | 36
Hepatitis B, Chronic 2 | 7
Kleine-Levin syndrome 2 | 6
Liver disease 2 | 237
Membranous glomerulonephritis 2 | 13
Multiple Sclerosis, Susceptibility to 2 | 15
Myasthenia gravis 2 | 23
Narcolepsy-cataplexy 2 | 21
Oropharyngeal Neoplasms 2 | 4
Oropharynx cancer 2 | 9
Parkinson Disease 2 | 64
Pick disease 2 | 1,894
Systemic lupus erythematosus 2 | 194
Systemic scleroderma 2 | 60
Urticaria 2 | 67
Vasculitis 2 | 80
colon cancer 2 | 1,478
dermatomyositis 2 | 966
group 3 medulloblastoma 2 | 4,104
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
sarcoidosis 2 | 370
tuberculosis and treatment for 3 months 2 | 179
type I diabetes mellitus 2 | 22

Tissue

Blood and immune system 17 | 16,909
Liver and Pancreas 17 | 16,750
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Male tissues 16 | 17,142
Urinary Tract 16 | 16,678
Cardiovascular System 15 | 15,192
Nervous System 13 | 16,725

Target Family

Non-IDG 21 | 12,091

PANTHER Protein Class (1)

major histocompatibility compl... 21 | 21
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

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