Development Level

Tchem 252 | 1,890
Tbio 177 | 10,625
Tdark 46 | 7,003
Tclin 27 | 602

Collection

Eligible Kinase Proteins 94 | 134

IMPC Term

preweaning lethality, complete... 20 | 633
embryonic lethality prior to t... 8 | 187
preweaning lethality, incomple... 8 | 260
abnormal behavior 7 | 226
abnormal embryo size 7 | 112
embryonic lethality prior to o... 7 | 148
decreased body weight 5 | 174
decreased total body fat amoun... 5 | 186
increased circulating alkaline... 5 | 119
small testis 5 | 37
abnormal lens morphology 4 | 73
decreased body length 4 | 108
decreased circulating glucose ... 4 | 121
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
increased or absent threshold ... 4 | 128
abnormal bone mineralization 3 | 55
abnormal testis morphology 3 | 30
decreased bone mineral content 3 | 157
decreased lean body mass 3 | 195
decreased lumbar vertebrae num... 3 | 62
increased bone mineral content 3 | 92
increased circulating LDL chol... 3 | 15
increased circulating choleste... 3 | 53
increased circulating iron lev... 3 | 25
increased hemoglobin content 3 | 45
increased lean body mass 3 | 107
microphthalmia 3 | 15
short tibia 3 | 82
abnormal behavioral response t... 2 | 52
abnormal bone structure 2 | 131
abnormal eye morphology 2 | 38
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal kidney morphology 2 | 30
abnormal lumbar vertebrae morp... 2 | 6
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal response to tactile s... 2 | 16
abnormal retina morphology 2 | 100
abnormal spleen morphology 2 | 36
decreased NK T cell number 2 | 28
decreased blood urea nitrogen ... 2 | 31
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased leukocyte cell numbe... 2 | 54
enlarged lymph nodes 2 | 27
hydrops fetalis 2 | 22
improved glucose tolerance 2 | 56
increased circulating HDL chol... 2 | 63
increased circulating chloride... 2 | 43
increased circulating serum al... 2 | 25
increased erythrocyte cell num... 2 | 26
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased mature B cell number 2 | 12
increased neutrophil cell numb... 2 | 15
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
male infertility 2 | 62
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating iron lev... 1 | 25
decreased gamma-delta T cell n... 1 | 18
decreased neutrophil cell numb... 1 | 37
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
female infertility 1 | 34
increased NK T cell number 1 | 11
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased eosinophil cell numb... 1 | 9
long tibia 1 | 13
thrombocytosis 1 | 23
tremors 1 | 34

Disease

osteosarcoma 280 | 7,933
ovarian cancer 257 | 8,484
medulloblastoma, large-cell 217 | 6,234
psoriasis 196 | 6,685
glioblastoma 193 | 5,572
atypical teratoid / rhabdoid tumor 153 | 4,369
lung cancer 142 | 4,466
Cancer 113 | 2,346
pilocytic astrocytoma 112 | 3,086
malignant mesothelioma 110 | 3,162
primitive neuroectodermal tumor 103 | 3,031
ependymoma 100 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 97 | 3,289
oligodendroglioma 96 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 94 | 2,988
Breast cancer 91 | 3,094
invasive ductal carcinoma 91 | 2,950
lung carcinoma 91 | 2,844
pediatric high grade glioma 90 | 2,712
Carcinoma 85 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 84 | 2,956
non-small cell lung cancer 83 | 2,798
adult high grade glioma 81 | 2,148
subependymal giant cell astrocytoma 78 | 2,287
ulcerative colitis 78 | 2,087
lung adenocarcinoma 77 | 2,713
interstitial cystitis 75 | 2,299
Pick disease 74 | 1,893
astrocytic glioma 73 | 2,241
medulloblastoma 69 | 1,524
group 3 medulloblastoma 68 | 2,254
astrocytoma 63 | 1,493
group 4 medulloblastoma 63 | 1,875
posterior fossa group B ependymoma 61 | 1,530
pancreatic cancer 58 | 2,300
adrenocortical carcinoma 49 | 1,427
cystic fibrosis 49 | 1,665
pituitary cancer 49 | 1,972
ductal carcinoma in situ 47 | 1,745
Rheumatoid Arthritis 46 | 1,160
tuberculosis 45 | 1,557
breast carcinoma 44 | 1,614
diabetes mellitus 44 | 1,663
colon cancer 41 | 1,475
atypical teratoid/rhabdoid tumor 40 | 1,095
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,795
posterior fossa group A ependymoma 39 | 1,511
sonic hedgehog group medulloblastoma 39 | 1,482
juvenile dermatomyositis 38 | 1,189
nasopharyngeal carcinoma 36 | 1,056
primary pancreatic ductal adenocarcinoma 35 | 1,271
Multiple myeloma 34 | 1,327
acute quadriplegic myopathy 34 | 1,157
cutaneous lupus erythematosus 34 | 1,056
primary Sjogren syndrome 34 | 789
Renal Cell Carcinoma 33 | 199
dermatomyositis 32 | 933
Waldenstrons macroglobulinemia 27 | 765
acute myeloid leukemia 27 | 780
spina bifida 27 | 1,064
Alzheimer's disease 26 | 644
Chronic Myelocytic Leukemia Accelerated Phase 26 | 59
progressive supranuclear palsy 26 | 674
tuberculosis and treatment for 6 months 26 | 686
Atopic dermatitis 25 | 944
Blastic phase chronic myeloid leukemia 25 | 58
esophageal adenocarcinoma 25 | 737
gastric carcinoma 25 | 832
Philadelphia chromosome-positive acute lymphoblastic leukemia 24 | 47
Schizophrenia 24 | 501
Chronic phase chronic myeloid leukemia 23 | 45
Gastrointestinal stromal tumor 23 | 61
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 23 | 45
aldosterone-producing adenoma 22 | 664
IGA Glomerulonephritis 21 | 454
Pancreatic Neuroendocrine Tumor 20 | 45
active Crohn's disease 20 | 918
Down syndrome 19 | 548
Obesity 19 | 616
Endometriosis 18 | 535
Intellectual disability 18 | 573
Neurodegenerative disease 18 | 383
Parkinson's disease 17 | 364
Chronic Lymphocytic Leukemia 16 | 242
Prostatic Neoplasms 16 | 471
Vascular disease 16 | 281
sarcoidosis 16 | 358
Amyotrophic Lateral Sclerosis 15 | 431
Hamman-Rich syndrome 15 | 35
non primary Sjogren syndrome sicca 15 | 840
pancreatic carcinoma 15 | 567
Epilepsy 13 | 346
Kidney disease 13 | 396
Mammary Neoplasms 13 | 410
Melanoma 13 | 261
active ulcerative colitis 13 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 499
Heart disease 12 | 279
Peripheral Neuropathy 12 | 303
mucosa-associated lymphoid tissue lymphoma 12 | 480

Tissue

Blood and immune system 493 | 17,995
Female tissues 493 | 18,647
Nervous System 493 | 18,561
Endocrine System 492 | 18,512
Liver and Pancreas 492 | 18,136
Urinary Tract 492 | 18,444
Cardiovascular System 491 | 17,958
Digestive Tract 491 | 18,473
Male tissues 491 | 17,969
Respiratory system 484 | 17,484
Skin and soft tissues 484 | 18,115

Target Family

Kinase 416 | 634
Non-IDG 55 | 11,971
Enzyme 30 | 4,146
Epigenetic 1 | 242

PANTHER Protein Class (1)

kinase 502 | 502
DNA binding protein 527 | 527
RNA binding protein 490 | 490
zinc finger transcription fact... 403 | 403
protease 375 | 375
actin family cytoskeletal prot... 342 | 342
G-protein modulator 330 | 330
G-protein coupled receptor 325 | 325
ion channel 304 | 304
dehydrogenase 239 | 239
phosphatase 230 | 230
helix-turn-helix transcription... 221 | 221
microtubule family cytoskeleta... 211 | 211
G-protein 193 | 193
glycosyltransferase 191 | 191
ubiquitin-protein ligase 186 | 186
cytokine 175 | 175
protease inhibitor 167 | 167
immunoglobulin receptor superf... 162 | 162
peptide hormone 162 | 162
nuclease 152 | 152
kinase modulator 149 | 149
cation transporter 139 | 139
transcription cofactor 139 | 139
membrane-bound signaling molec... 125 | 125
helicase 124 | 124
growth factor 109 | 109
cadherin 107 | 107
membrane trafficking regulator... 106 | 106
acetyltransferase 91 | 91
extracellular matrix glycoprot... 85 | 85
intermediate filament 83 | 83
extracellular matrix structura... 75 | 75
antibacterial response protein 74 | 74
basic helix-loop-helix transcr... 74 | 74
oxygenase 73 | 73
acyltransferase 63 | 63
cytokine receptor 60 | 60
intracellular calcium-sensing ... 60 | 60
methyltransferase 60 | 60
mitochondrial carrier protein 58 | 58
lipase 55 | 55
esterase 54 | 54
phosphatase modulator 53 | 53
carbohydrate transporter 46 | 46
nuclear hormone receptor 46 | 46
major histocompatibility compl... 45 | 45
reductase 44 | 44
dehydratase 42 | 42
ATP-binding cassette (ABC) tra... 41 | 41
SNARE protein 40 | 40
vesicle coat protein 40 | 40
oxidase 39 | 39
amino acid transporter 37 | 37
tight junction 36 | 36
nucleotidyltransferase 33 | 33
aminoacyl-tRNA synthetase 28 | 28
phosphodiesterase 28 | 28
deaminase 27 | 27
extracellular matrix linker pr... 26 | 26
glycosidase 24 | 24
peroxidase 24 | 24
transaminase 24 | 24
HMG box transcription factor 22 | 22
cyclase 22 | 22
decarboxylase 21 | 21
gap junction 21 | 21
chaperonin 19 | 19
epimerase/racemase 19 | 19
Hsp70 family chaperone 18 | 18
apolipoprotein 16 | 16
annexin 14 | 14
immunoglobulin superfamily cel... 14 | 14
basic leucine zipper transcrip... 12 | 12
deacetylase 12 | 12
glucosidase 12 | 12
mutase 12 | 12
Hsp90 family chaperone 11 | 11
phosphorylase 11 | 11
hydroxylase 8 | 8
viral coat protein 8 | 8
amylase 6 | 6
galactosidase 6 | 6
immunoglobulin 5 | 5
pyrophosphatase 5 | 5
myelin protein 4 | 4
calsequestrin 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Natural killer cell receptor 2B4 CD244 Tbio Non-IDG -2.27438 190.1 418
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Inositol-trisphosphate 3-kinase B ITPKB Tbio Kinase -1.40405 29.1 141
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Calcium/calmodulin-dependent protein kinase type 1D CAMK1D Tchem Kinase -1.06137 12.5 282
Calcium/calmodulin-dependent protein kinase type 1B PNCK Tbio Kinase -1.08940 47.1 143
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104
Cyclin-dependent kinase 18 CDK18 Tchem Kinase -1.04154 10.8 122
Homeodomain-interacting protein kinase 1 HIPK1 Tbio Kinase -0.62325 4.93 166