Development Level

Tchem 194 | 1,598
Tbio 129 | 11,445
Tdark 26 | 6,588
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Target... 75 | 125
RFA-RM-18-021 75 | 328
Kinase: IDG Consortium (Comple... 23 | 37

IMPC Phenotype

preweaning lethality, complete... 26 | 979
preweaning lethality, incomple... 20 | 499
abnormal embryo size 13 | 220
embryonic lethality prior to o... 12 | 239
embryonic lethality prior to t... 12 | 278
abnormal behavior 7 | 298
abnormal bone structure 5 | 187
decreased total body fat amoun... 5 | 207
embryonic growth retardation 5 | 106
increased circulating alkaline... 5 | 122
increased mean corpuscular vol... 5 | 92
increased or absent threshold ... 5 | 101
abnormal heart morphology 4 | 162
abnormal neural tube closure 4 | 46
abnormal spleen morphology 4 | 55
decreased circulating glucose ... 4 | 126
decreased vertical activity 4 | 208
enlarged heart 4 | 210
increased lean body mass 4 | 172
increased total body fat amoun... 4 | 134
microphthalmia 4 | 26
small testis 4 | 58
abnormal midbrain development 3 | 20
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
edema 3 | 59
enlarged lymph nodes 3 | 37
hyperactivity 3 | 148
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased circulating LDL chol... 3 | 13
increased heart weight 3 | 62
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
male infertility 3 | 123
small superior vagus ganglion 3 | 74
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal embryo turning 2 | 31
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal skin morphology 2 | 50
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
decreased body length 2 | 101
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating magnesiu... 2 | 13
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased large unstained cell... 2 | 11
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
enlarged epididymis 2 | 31
enlarged spleen 2 | 41
hydrometra 2 | 53
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased circulating choleste... 2 | 66
increased circulating iron lev... 2 | 30
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
short tibia 2 | 97
thrombocytosis 2 | 27
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal vocalization 1 | 21
decreased circulating bilirubi... 1 | 19
decreased circulating iron lev... 1 | 32
decreased eosinophil cell numb... 1 | 24
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased circulating aspartat... 1 | 15
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 276 | 11,493
osteosarcoma 199 | 7,950
ovarian cancer 183 | 8,520
medulloblastoma, large-cell 165 | 6,241
psoriasis 153 | 6,694
glioblastoma 148 | 5,792
atypical teratoid / rhabdoid tumor 135 | 5,112
ependymoma 124 | 4,679
lung cancer 114 | 4,740
adult high grade glioma 105 | 3,801
group 3 medulloblastoma 104 | 4,104
malignant mesothelioma 83 | 3,232
primitive neuroectodermal tumor 81 | 3,035
Astrocytoma, Pilocytic 78 | 3,081
Cancer 77 | 2,499
Breast cancer 75 | 3,578
invasive ductal carcinoma 75 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 71 | 2,989
oligodendroglioma 70 | 2,850
astrocytic glioma 65 | 2,597
non-small cell lung cancer 64 | 2,890
Kidney cancer 60 | 2,613
lung adenocarcinoma 60 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 58 | 2,955
lung carcinoma 56 | 2,843
subependymal giant cell astrocytoma 56 | 2,287
Pick disease 53 | 1,894
interstitial cystitis 49 | 2,312
group 4 medulloblastoma 48 | 1,855
ulcerative colitis 48 | 1,819
pancreatic cancer 46 | 2,398
breast carcinoma 44 | 1,638
adrenocortical carcinoma 43 | 1,428
tuberculosis 43 | 2,010
Schizophrenia 42 | 1,160
ductal carcinoma in situ 38 | 1,745
cystic fibrosis 37 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,962
astrocytoma 36 | 1,146
colon cancer 36 | 1,478
pituitary cancer 36 | 1,972
Rheumatoid arthritis 35 | 1,191
Autosomal recessive predisposition 34 | 1,442
nasopharyngeal carcinoma 34 | 1,058
Epilepsy 30 | 792
Intellectual disability 30 | 1,016
diabetes mellitus 29 | 1,728
acute quadriplegic myopathy 27 | 1,158
Multiple myeloma 26 | 1,332
Dull intelligence 25 | 645
Low intelligence 25 | 645
Mental Retardation 25 | 645
Mental deficiency 25 | 645
Poor school performance 25 | 645
Seizures 25 | 596
acute myeloid leukemia 25 | 783
juvenile dermatomyositis 25 | 1,187
primary Sjogren syndrome 24 | 735
primary pancreatic ductal adenocarcinoma 24 | 1,109
pediatric high grade glioma 23 | 1,064
Renal Cell Carcinoma 22 | 214
cutaneous lupus erythematosus 22 | 1,057
spina bifida 22 | 1,074
medulloblastoma 21 | 720
progressive supranuclear palsy 21 | 676
Alzheimer's disease 20 | 658
Waldenstrons macroglobulinemia 20 | 765
esophageal adenocarcinoma 20 | 737
Atopic dermatitis 18 | 952
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
dermatomyositis 18 | 966
Bipolar Disorder 17 | 666
Endometriosis 17 | 540
Neurodegenerative disease 17 | 414
aldosterone-producing adenoma 17 | 665
Small head 16 | 374
Prostatic Neoplasms 15 | 495
Down syndrome 14 | 499
Hypertension 14 | 396
Obesity 14 | 678
Short stature 14 | 531
active Crohn's disease 14 | 922
tuberculosis and treatment for 6 months 14 | 409
Cerebellar Ataxia 13 | 304
Liver cancer 13 | 604
Muscle hypotonia 13 | 571
Parkinson's disease 13 | 392
Vascular disease 13 | 319
active ulcerative colitis 13 | 764
posterior fossa group B ependymoma 13 | 416
sarcoidosis 13 | 370
Cataract 12 | 297
Depressive disorder 12 | 409
Nystagmus 12 | 317
fibroadenoma 12 | 559
gastric carcinoma 12 | 807
non primary Sjogren syndrome sicca 12 | 891

Tissue

Endocrine System 356 | 18,159
Skin and soft tissues 350 | 17,230
Digestive Tract 349 | 17,369
Female tissues 347 | 17,400
Blood and immune system 346 | 16,909
Male tissues 346 | 17,142
Liver and Pancreas 345 | 16,750
Nervous System 345 | 16,725
Urinary Tract 341 | 16,678
Respiratory system 338 | 16,393
Cardiovascular System 330 | 15,192

Target Family

Kinase 308 | 634
Non-IDG 31 | 12,091
Enzyme 23 | 4,145

PANTHER Protein Class (1)

kinase 362 | 362
protease 516 | 516
RNA binding protein 483 | 483
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase pim-3 PIM3 Tchem Kinase -1.87886 77.4 105
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Uridine-cytidine kinase-like 1 UCKL1 Tdark Kinase -0.15970 2.21 110
Nicotinamide riboside kinase 1 NMRK1 Tbio Kinase -0.84939 6.66 143
Adenylate kinase isoenzyme 5 AK5 Tbio Kinase -1.83209 76.0 225
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
PAS domain-containing serine/threonine-protein kinase PASK Tbio Kinase -1.01354 12.3 95
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.61615 60.9 195