Development Level

Tclin 129 | 602
Tbio 84 | 10,625
Tchem 71 | 1,890
Tdark 20 | 7,003

Collection

Eligible Ion Channel Proteins 83 | 117

IMPC Term

preweaning lethality, complete... 9 | 633
abnormal behavior 7 | 226
abnormal gait 4 | 51
decreased body weight 4 | 174
decreased lean body mass 4 | 195
hyperactivity 4 | 108
abnormal epididymis morphology 3 | 31
decreased eosinophil cell numb... 3 | 41
decreased grip strength 3 | 123
embryonic lethality prior to t... 3 | 187
enlarged heart 3 | 111
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
absent vibrissae 2 | 14
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 24
decreased circulating glycerol... 2 | 19
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased rib number 2 | 59
enlarged epididymis 2 | 27
increased bone mineral content 2 | 92
increased caudal vertebrae num... 2 | 8
increased circulating chloride... 2 | 43
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
limb grasping 2 | 35
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
straub tail 2 | 26
abnormal bone mineralization 1 | 55
abnormal facial morphology 1 | 9
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal locomotor activation 1 | 26
abnormal lung morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pancreas morphology 1 | 6
abnormal pelvic girdle bone mo... 1 | 11
abnormal placenta vasculature 1 | 2
abnormal response to new envir... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal sensory capabilities/... 1 | 3
abnormal skin morphology 1 | 23
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
corneal vascularization 1 | 5
cyanosis 1 | 6
decreased NK T cell number 1 | 28
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased mature B cell number 1 | 25
decreased prepulse inhibition 1 | 52
edema 1 | 11
hemorrhage 1 | 12
hydrometra 1 | 13
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating choleste... 1 | 53
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased vertical activity 1 | 18
male infertility 1 | 62
prenatal lethality 1 | 16
respiratory system phenotype 1 | 2
small heart 1 | 8
small liver 1 | 8
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

medulloblastoma, large-cell 127 | 6,234
psoriasis 119 | 6,685
glioblastoma 115 | 5,572
Carcinoma 110 | 2,147
osteosarcoma 102 | 7,933
atypical teratoid / rhabdoid tumor 92 | 4,369
pilocytic astrocytoma 84 | 3,086
primitive neuroectodermal tumor 82 | 3,031
ovarian cancer 80 | 8,484
oligodendroglioma 79 | 2,849
Epilepsy 76 | 346
lung carcinoma 74 | 2,844
lung cancer 65 | 4,466
pediatric high grade glioma 65 | 2,712
ependymoma 57 | 2,514
subependymal giant cell astrocytoma 57 | 2,287
astrocytic glioma 55 | 2,241
adult high grade glioma 48 | 2,148
medulloblastoma 48 | 1,524
intraductal papillary-mucinous neoplasm (IPMN) 46 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,956
Pick disease 44 | 1,893
pituitary cancer 44 | 1,972
Multiple Sclerosis 43 | 498
malignant mesothelioma 43 | 3,162
lung adenocarcinoma 41 | 2,713
Eaton-Lambert syndrome 40 | 40
General anesthesia 39 | 53
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
Breast cancer 38 | 3,094
interstitial cystitis 38 | 2,299
Tonic-clonic epilepsy 35 | 47
posterior fossa group A ependymoma 34 | 1,511
Schizophrenia 33 | 501
cystic fibrosis 33 | 1,665
Local anesthesia 30 | 40
colon cancer 30 | 1,475
atypical teratoid/rhabdoid tumor 29 | 1,095
astrocytoma 28 | 1,493
group 4 medulloblastoma 28 | 1,875
non-small cell lung cancer 28 | 2,798
sonic hedgehog group medulloblastoma 28 | 1,482
invasive ductal carcinoma 27 | 2,950
Atrial Fibrillation 26 | 110
Autistic Disorder 26 | 320
Intellectual disability 25 | 573
Lennox-Gastaut syndrome 25 | 34
group 3 medulloblastoma 25 | 2,254
ulcerative colitis 25 | 2,087
Bipolar Disorder 24 | 266
posterior fossa group B ependymoma 24 | 1,530
Epilepsy characterized by intractable complex partial seizures 22 | 28
Parkinson's disease 22 | 364
Simple partial seizure 22 | 26
Long QT syndrome 21 | 52
pancreatic cancer 21 | 2,300
Status Epilepticus 19 | 85
adrenocortical carcinoma 19 | 1,427
ductal carcinoma in situ 19 | 1,745
Alcohol dependence 18 | 107
Neurodegenerative disease 18 | 383
Nicotine dependence 17 | 53
Anxiety 16 | 24
Cancer 16 | 2,346
Hypertension 16 | 287
Insomnia 16 | 20
Irritable bowel syndrome 16 | 59
Spasticity 16 | 26
cutaneous lupus erythematosus 16 | 1,056
non primary Sjogren syndrome sicca 16 | 840
active Crohn's disease 15 | 918
Hypertensive disease 14 | 193
Hypertensive disorder 14 | 58
Migraine Prevention 14 | 22
Partial seizure 14 | 15
breast carcinoma 14 | 1,614
nasopharyngeal carcinoma 14 | 1,056
tuberculosis 14 | 1,557
Brugada syndrome 13 | 26
Dysuria 13 | 24
Localization-related epilepsy 13 | 13
Migraine 13 | 79
Neuropathy 13 | 210
Partial Epilepsy Treatment Adjunct 13 | 16
Sedation as Adjunct to Anesthesia 13 | 15
Urinary Tract Irritation 13 | 24
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
progressive supranuclear palsy 13 | 674
Alzheimer's disease 12 | 644
Episodic ataxia 12 | 17
Panic disorder 12 | 55
Parkinsonism 12 | 19
diabetes mellitus 12 | 1,663
gastric carcinoma 12 | 832
Heart disease 11 | 279
Itching of skin 11 | 19
Minor Skin Wound Pain 11 | 12
Pain agnosia 11 | 99
Skin irritation 11 | 12
Suppression of the Gag Reflex 11 | 12

Tissue

Nervous System 302 | 18,561
Endocrine System 301 | 18,512
Female tissues 301 | 18,647
Digestive Tract 300 | 18,473
Urinary Tract 300 | 18,444
Liver and Pancreas 297 | 18,136
Skin and soft tissues 295 | 18,115
Cardiovascular System 294 | 17,958
Blood and immune system 289 | 17,995
Male tissues 289 | 17,969
Respiratory system 285 | 17,484

Target Family

Ion Channel 258 | 341
Transporter 20 | 473
Non-IDG 14 | 11,971
Enzyme 6 | 4,146
GPCR 5 | 406
Kinase 1 | 634

PANTHER Protein Class (1)

ion channel 304 | 304
DNA binding protein 527 | 527
kinase 502 | 502
RNA binding protein 490 | 490
zinc finger transcription fact... 403 | 403
protease 375 | 375
actin family cytoskeletal prot... 342 | 342
G-protein modulator 330 | 330
G-protein coupled receptor 325 | 325
dehydrogenase 239 | 239
phosphatase 230 | 230
helix-turn-helix transcription... 221 | 221
microtubule family cytoskeleta... 211 | 211
G-protein 193 | 193
glycosyltransferase 191 | 191
ubiquitin-protein ligase 186 | 186
cytokine 175 | 175
protease inhibitor 167 | 167
immunoglobulin receptor superf... 162 | 162
peptide hormone 162 | 162
nuclease 152 | 152
kinase modulator 149 | 149
cation transporter 139 | 139
transcription cofactor 139 | 139
membrane-bound signaling molec... 125 | 125
helicase 124 | 124
growth factor 109 | 109
cadherin 107 | 107
membrane trafficking regulator... 106 | 106
acetyltransferase 91 | 91
extracellular matrix glycoprot... 85 | 85
intermediate filament 83 | 83
extracellular matrix structura... 75 | 75
antibacterial response protein 74 | 74
basic helix-loop-helix transcr... 74 | 74
oxygenase 73 | 73
acyltransferase 63 | 63
cytokine receptor 60 | 60
intracellular calcium-sensing ... 60 | 60
methyltransferase 60 | 60
mitochondrial carrier protein 58 | 58
lipase 55 | 55
esterase 54 | 54
phosphatase modulator 53 | 53
carbohydrate transporter 46 | 46
nuclear hormone receptor 46 | 46
major histocompatibility compl... 45 | 45
reductase 44 | 44
dehydratase 42 | 42
ATP-binding cassette (ABC) tra... 41 | 41
SNARE protein 40 | 40
vesicle coat protein 40 | 40
oxidase 39 | 39
amino acid transporter 37 | 37
tight junction 36 | 36
nucleotidyltransferase 33 | 33
aminoacyl-tRNA synthetase 28 | 28
phosphodiesterase 28 | 28
deaminase 27 | 27
extracellular matrix linker pr... 26 | 26
glycosidase 24 | 24
peroxidase 24 | 24
transaminase 24 | 24
HMG box transcription factor 22 | 22
cyclase 22 | 22
decarboxylase 21 | 21
gap junction 21 | 21
chaperonin 19 | 19
epimerase/racemase 19 | 19
Hsp70 family chaperone 18 | 18
apolipoprotein 16 | 16
annexin 14 | 14
immunoglobulin superfamily cel... 14 | 14
basic leucine zipper transcrip... 12 | 12
deacetylase 12 | 12
glucosidase 12 | 12
mutase 12 | 12
Hsp90 family chaperone 11 | 11
phosphorylase 11 | 11
hydroxylase 8 | 8
viral coat protein 8 | 8
amylase 6 | 6
galactosidase 6 | 6
immunoglobulin 5 | 5
pyrophosphatase 5 | 5
myelin protein 4 | 4
calsequestrin 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Taste receptor type 1 member 3 TAS1R3 Tbio GPCR -2.19758 165.4 232
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Transmembrane channel-like protein 8 TMC8 Tbio Ion Channel -1.45295 32.2 147
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
Cation channel sperm-associated protein 4 CATSPER4 Tchem Ion Channel 0.06 0.89 32
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.23749 17.4 128
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Amiloride-sensitive sodium channel subunit beta SCNN1B Tclin Ion Channel -1.69464 46.7 245