Development Level

Tbio 100 | 10,625
Tdark 28 | 7,003
Tchem 27 | 1,890
Tclin 7 | 602

Collection

GPCR: IDG Consortium (Targets) 1 | 127
Kinase: IDG Consortium (Complete/Control) 1 | 37
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 633
decreased NK T cell number 2 | 28
decreased circulating glucose ... 2 | 121
preweaning lethality, incomple... 2 | 260
abnormal anxiety-related respo... 1 | 1
abnormal behavior 1 | 226
abnormal eye anterior chamber ... 1 | 3
abnormal gait 1 | 51
abnormal pelvic girdle bone mo... 1 | 11
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal social-conspecific in... 1 | 3
abnormal vibrissa morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 11
decreased CD8-positive, alpha-... 1 | 26
decreased alpha-beta T cell nu... 1 | 12
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 5
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating thyroxin... 1 | 5
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased dendritic cell numbe... 1 | 3
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased kidney weight 1 | 7
decreased lumbar vertebrae num... 1 | 62
decreased neutrophil cell numb... 1 | 37
decreased pulmonary respirator... 1 | 4
decreased total body fat amoun... 1 | 186
dilated heart left ventricle 1 | 10
enlarged adrenal glands 1 | 3
improved glucose tolerance 1 | 56
increased KLRG1-positive gamma... 1 | 2
increased circulating alanine ... 1 | 11
increased circulating calcium ... 1 | 32
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased effector memory CD8-... 1 | 14
increased effector memory T-he... 1 | 5
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart left ventricle... 1 | 1
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased monocyte cell number 1 | 27
increased myeloid cell number 1 | 2
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased thoracic vertebrae n... 1 | 8
increased tidal volume 1 | 1
prenatal lethality prior to he... 1 | 64
thick ventricular wall 1 | 7
tremors 1 | 34

Disease

osteosarcoma 81 | 7,933
psoriasis 69 | 6,685
ovarian cancer 58 | 8,491
lung carcinoma 52 | 2,844
medulloblastoma, large-cell 46 | 6,234
lung cancer 45 | 4,473
interstitial cystitis 40 | 2,299
invasive ductal carcinoma 40 | 2,950
glioblastoma 39 | 5,572
Carcinoma 35 | 2,147
Cancer 34 | 2,346
lung adenocarcinoma 31 | 2,714
cutaneous lupus erythematosus 30 | 1,056
pilocytic astrocytoma 30 | 3,086
ulcerative colitis 30 | 2,087
Breast cancer 29 | 3,098
non-small cell lung cancer 29 | 2,798
tuberculosis 29 | 1,563
atypical teratoid / rhabdoid tumor 28 | 4,369
oligodendroglioma 25 | 2,849
subependymal giant cell astrocytoma 24 | 2,287
group 3 medulloblastoma 22 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
ductal carcinoma in situ 21 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
pancreatic cancer 21 | 2,300
pediatric high grade glioma 21 | 2,712
posterior fossa group A ependymoma 21 | 1,511
breast carcinoma 18 | 1,614
pituitary cancer 18 | 1,972
primitive neuroectodermal tumor 18 | 3,031
Rheumatoid Arthritis 17 | 1,170
colon cancer 17 | 1,475
group 4 medulloblastoma 17 | 1,875
primary Sjogren syndrome 17 | 788
Multiple Sclerosis 16 | 498
mucosa-associated lymphoid tissue lymphoma 16 | 480
adult high grade glioma 15 | 2,148
malignant mesothelioma 15 | 3,163
Atopic dermatitis 14 | 944
astrocytoma 14 | 1,493
cystic fibrosis 14 | 1,670
sonic hedgehog group medulloblastoma 14 | 1,482
Asthma 13 | 349
Human immunodeficiency virus infectious disease 12 | 129
head and neck cancer and chronic obstructive pulmonary disease 12 | 237
adrenocortical carcinoma 11 | 1,427
astrocytic glioma 11 | 2,241
gastric carcinoma 11 | 832
pancreatic carcinoma 11 | 567
posterior fossa group B ependymoma 11 | 1,530
IGA Glomerulonephritis 10 | 454
Obesity 10 | 616
diabetes mellitus 10 | 1,663
ependymoma 10 | 2,514
non-small cell lung carcinoma 10 | 413
Hypersensitivity reaction type II disease 9 | 235
Pick disease 9 | 1,893
atypical teratoid/rhabdoid tumor 9 | 1,095
hepatocellular carcinoma 9 | 550
primary pancreatic ductal adenocarcinoma 9 | 1,271
sarcoidosis 9 | 368
tuberculosis and treatment for 6 months 9 | 686
Autistic Disorder 8 | 320
Hypersensitivity 8 | 63
Inflammatory bowel disease 8 | 142
Pneumonia 8 | 133
active Crohn's disease 8 | 918
juvenile dermatomyositis 8 | 1,189
nasopharyngeal carcinoma 8 | 1,056
Alzheimer's disease 7 | 644
Down syndrome 7 | 548
interstitial lung disease 7 | 292
Acquired immunodeficiency syndrome 6 | 164
Ankylosing spondylitis 6 | 138
Celiac disease 6 | 112
Duchenne muscular dystrophy 6 | 602
Encephalitis 6 | 54
HIV Infections 6 | 99
Lung disease 6 | 136
dermatomyositis 6 | 966
esophageal adenocarcinoma 6 | 737
fibroadenoma 6 | 557
gastric cancer 6 | 436
head and neck cancer 6 | 270
Allergic hypersensitivity disease 5 | 123
Anemia 5 | 252
Atherosclerosis 5 | 275
Intellectual disability 5 | 573
Kidney disease 5 | 397
Peripheral Neuropathy 5 | 303
Status Epilepticus 5 | 85
Waldenstrons macroglobulinemia 5 | 764
chronic lymphocytic leukemia 5 | 244
chronic lymphosyte leukemia 5 | 232
non diabetic and post-ischemic heart failure 5 | 200
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
tuberculosis and treatment for 3 months 5 | 327
urothelial carcinoma 5 | 318

Tissue

Blood and immune system 159 | 17,994
Digestive Tract 153 | 18,472
Nervous System 152 | 18,560
Female tissues 151 | 18,646
Liver and Pancreas 151 | 18,135
Respiratory system 150 | 17,483
Urinary Tract 150 | 18,443
Endocrine System 149 | 18,511
Skin and soft tissues 149 | 18,114
Cardiovascular System 147 | 17,957
Male tissues 146 | 17,968

Target Family

Non-IDG 133 | 11,969
GPCR 23 | 408
Kinase 5 | 634
Enzyme 1 | 4,146

PANTHER Protein Class (1)

immunoglobulin receptor superf... 162 | 162
DNA binding protein 527 | 527
kinase 502 | 502
RNA binding protein 490 | 490
zinc finger transcription fact... 403 | 403
protease 375 | 375
actin family cytoskeletal prot... 342 | 342
G-protein modulator 330 | 330
G-protein coupled receptor 325 | 325
ion channel 304 | 304
dehydrogenase 239 | 239
phosphatase 230 | 230
helix-turn-helix transcription... 221 | 221
microtubule family cytoskeleta... 211 | 211
G-protein 193 | 193
glycosyltransferase 191 | 191
ubiquitin-protein ligase 186 | 186
cytokine 175 | 175
protease inhibitor 167 | 167
peptide hormone 162 | 162
nuclease 152 | 152
kinase modulator 149 | 149
cation transporter 139 | 139
transcription cofactor 139 | 139
membrane-bound signaling molec... 125 | 125
helicase 124 | 124
growth factor 109 | 109
cadherin 107 | 107
membrane trafficking regulator... 106 | 106
acetyltransferase 91 | 91
extracellular matrix glycoprot... 85 | 85
intermediate filament 83 | 83
extracellular matrix structura... 75 | 75
antibacterial response protein 74 | 74
basic helix-loop-helix transcr... 74 | 74
oxygenase 73 | 73
acyltransferase 63 | 63
cytokine receptor 60 | 60
intracellular calcium-sensing ... 60 | 60
methyltransferase 60 | 60
mitochondrial carrier protein 58 | 58
lipase 55 | 55
esterase 54 | 54
phosphatase modulator 53 | 53
carbohydrate transporter 46 | 46
nuclear hormone receptor 46 | 46
major histocompatibility compl... 45 | 45
reductase 44 | 44
dehydratase 42 | 42
ATP-binding cassette (ABC) tra... 41 | 41
SNARE protein 40 | 40
vesicle coat protein 40 | 40
oxidase 39 | 39
amino acid transporter 37 | 37
tight junction 36 | 36
nucleotidyltransferase 33 | 33
aminoacyl-tRNA synthetase 28 | 28
phosphodiesterase 28 | 28
deaminase 27 | 27
extracellular matrix linker pr... 26 | 26
glycosidase 24 | 24
peroxidase 24 | 24
transaminase 24 | 24
HMG box transcription factor 22 | 22
cyclase 22 | 22
decarboxylase 21 | 21
gap junction 21 | 21
chaperonin 19 | 19
epimerase/racemase 19 | 19
Hsp70 family chaperone 18 | 18
apolipoprotein 16 | 16
annexin 14 | 14
immunoglobulin superfamily cel... 14 | 14
basic leucine zipper transcrip... 12 | 12
deacetylase 12 | 12
glucosidase 12 | 12
mutase 12 | 12
Hsp90 family chaperone 11 | 11
phosphorylase 11 | 11
hydroxylase 8 | 8
viral coat protein 8 | 8
amylase 6 | 6
galactosidase 6 | 6
immunoglobulin 5 | 5
pyrophosphatase 5 | 5
myelin protein 4 | 4
calsequestrin 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sialic acid-binding Ig-like lectin 12 SIGLEC12 Tbio Non-IDG -2.35522 224.6 122
Coiled-coil domain-containing protein 141 CCDC141 Tdark Non-IDG -0.61681 3.82 82
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.45436 257.8 324
Triggering receptor expressed on myeloid cells 2 TREM2 Tbio Non-IDG -2.32637 219.6 297
Phosphatidylinositol phosphatase PTPRQ PTPRQ Tbio Enzyme -1.02216 10.5 0
Atypical chemokine receptor 3 ACKR3 Tchem GPCR -1.80879 81.4 385
Sialic acid-binding Ig-like lectin 15 SIGLEC15 Tbio Non-IDG -0.53148 6.12 82
Cell adhesion molecule-related/down-regulated by oncogenes CDON Tbio Non-IDG -2.63973 437.0 112
C-type lectin domain family 4 member E CLEC4E Tbio Non-IDG -1.63154 46.8 109
Transmembrane protein 25 TMEM25 Tdark Non-IDG -0.14369 1.92 22