Development Level

Tbio 87 | 11,445
Tdark 11 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
decreased total body fat amoun... 3 | 207
preweaning lethality, complete... 3 | 979
abnormal craniofacial morpholo... 2 | 33
abnormal embryo size 2 | 220
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
enlarged heart 2 | 210
increased body length 2 | 32
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
long tibia 2 | 25
small superior vagus ganglion 2 | 74
abnormal abdominal wall morpho... 1 | 1
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal facial morphology 1 | 17
abnormal pancreas morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
absent vibrissae 1 | 12
cleft palate 1 | 8
corneal opacity 1 | 32
corneal vascularization 1 | 6
cyanosis 1 | 7
decreased caudal vertebrae num... 1 | 53
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
eyelids fail to open 1 | 3
female infertility 1 | 60
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased hemoglobin content 1 | 45
narrow eye opening 1 | 12
rib fusion 1 | 1
shortened QT interval 1 | 4
syndactyly 1 | 23
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Carcinoma 42 | 11,493
medulloblastoma, large-cell 29 | 6,241
osteosarcoma 27 | 7,950
ovarian cancer 26 | 8,520
psoriasis 25 | 6,694
glioblastoma 23 | 5,792
lung cancer 23 | 4,740
atypical teratoid / rhabdoid tumor 21 | 5,112
malignant mesothelioma 21 | 3,232
Cancer 18 | 2,499
Breast cancer 17 | 3,578
cystic fibrosis 16 | 1,696
primitive neuroectodermal tumor 16 | 3,035
invasive ductal carcinoma 15 | 2,951
Astrocytoma, Pilocytic 14 | 3,081
adult high grade glioma 13 | 3,801
ependymoma 13 | 4,679
group 3 medulloblastoma 13 | 4,104
non-small cell lung cancer 13 | 2,890
Cleft Palate 12 | 271
astrocytic glioma 10 | 2,597
ductal carcinoma in situ 10 | 1,745
interstitial cystitis 10 | 2,312
oligodendroglioma 10 | 2,850
Cognitive delay 9 | 608
Craniofacial Abnormalities 9 | 151
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
breast carcinoma 9 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung adenocarcinoma 9 | 2,716
pituitary cancer 9 | 1,972
Autosomal recessive predisposition 8 | 1,442
cutaneous lupus erythematosus 8 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Cleft Lip 7 | 141
Muscle hypotonia 7 | 571
Uranostaphyloschisis 7 | 167
colon cancer 7 | 1,478
group 4 medulloblastoma 7 | 1,855
medulloblastoma 7 | 720
pediatric high grade glioma 7 | 1,064
Epilepsy 6 | 792
Microphthalmia 6 | 76
Seizures 6 | 596
Sensorineural Hearing Loss (disorder) 6 | 284
Tooth agenesis 6 | 44
pancreatic cancer 6 | 2,398
spina bifida 6 | 1,074
Bipolar Disorder 5 | 666
Congenital heart disease 5 | 93
Intellectual disability 5 | 1,016
Lung diseases 5 | 50
Schizophrenia 5 | 1,160
Syndactyly 5 | 88
active ulcerative colitis 5 | 764
gastric carcinoma 5 | 807
Abnormally small eyeball 4 | 97
Agenesis of corpus callosum 4 | 83
Autistic Disorder 4 | 364
Cataract 4 | 297
Coloboma 4 | 51
Congenital hypoplasia of penis 4 | 176
Cryptorchidism 4 | 296
Decreased size of eyeball 4 | 97
Dull intelligence 4 | 645
Holoprosencephaly 4 | 56
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Microphthalmos 4 | 100
Obesity 4 | 678
Poor school performance 4 | 645
Short stature 4 | 531
Split hand-foot malformation 4 | 18
Ventricular Septal Defects 4 | 119
adrenocortical carcinoma 4 | 1,428
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
lung carcinoma 4 | 2,843
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819
Byzanthine arch palate 3 | 194
Constipation 3 | 181
Frontal bossing 3 | 157
Glaucoma 3 | 239
Hernia, Inguinal 3 | 89
Hypoplastic mandible condyle 3 | 275
Lens Opacities 3 | 231
Myopia 3 | 176
Prostate cancer 3 | 175
Rheumatoid arthritis 3 | 1,191
Strabismus 3 | 270
Waldenstrons macroglobulinemia 3 | 765
aldosterone-producing adenoma 3 | 665
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
posterior fossa group A ependymoma 3 | 468
sonic hedgehog group medulloblastoma 3 | 467
tuberculosis 3 | 2,010

Tissue

Endocrine System 89 | 18,159
Digestive Tract 77 | 17,369
Skin and soft tissues 75 | 17,230
Female tissues 70 | 17,400
Blood and immune system 69 | 16,909
Male tissues 68 | 17,142
Nervous System 65 | 16,725
Liver and Pancreas 64 | 16,750
Urinary Tract 60 | 16,678
Respiratory system 57 | 16,393
Cardiovascular System 43 | 15,192

Target Family

Transcription Factor 90 | 1,400
Non-IDG 8 | 12,091

PANTHER Protein Class (1)

helix-turn-helix transcription... 98 | 98
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Homeobox protein Hox-C5 HOXC5 Tbio Transcription Factor -1.08912 11.9 114
One cut domain family member 2 ONECUT2 Tbio Transcription Factor -2.25163 169.5 107
Zinc fingers and homeoboxes protein 1 ZHX1 Tbio Transcription Factor -1.10308 15.6 134
Cone-rod homeobox protein CRX Tbio Transcription Factor -2.44826 272.0 185
Homeobox protein Nkx-2.6 NKX2-6 Tbio Transcription Factor -3.04651 1092.2 134
BarH-like 2 homeobox protein BARHL2 Tbio Transcription Factor -0.91713 9.51 53
Homeobox protein SIX4 SIX4 Tbio Transcription Factor -2.31722 197.8 141
Homeobox protein CDX-2 CDX2 Tbio Transcription Factor -2.91273 837.0 699
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.13442 140.5 524