Development Level

Tbio 187 | 10,625
Tdark 29 | 7,003
Tchem 5 | 1,890

IMPC Term

preweaning lethality, incomple... 7 | 260
preweaning lethality, complete... 5 | 633
abnormal behavior 4 | 226
decreased grip strength 4 | 123
abnormal gait 3 | 51
decreased circulating triglyce... 3 | 83
increased or absent threshold ... 3 | 128
abnormal bone structure 2 | 131
corneal opacity 2 | 25
decreased body weight 2 | 174
decreased caudal vertebrae num... 2 | 49
enlarged heart 2 | 111
hyperactivity 2 | 108
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating alkaline... 2 | 119
increased grip strength 2 | 83
abnormal behavioral response t... 1 | 52
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal eyelid aperture 1 | 3
abnormal eyelid morphology 1 | 6
abnormal facial morphology 1 | 9
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal social/conspecific in... 1 | 3
abnormal tail morphology 1 | 17
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 7
absent vibrissae 1 | 14
anophthalmia 1 | 20
cleft palate 1 | 6
corneal vascularization 1 | 5
cyanosis 1 | 6
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased exploration in new e... 1 | 9
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
enlarged kidney 1 | 7
eyelids fail to open 1 | 2
female infertility 1 | 34
increased body length 1 | 20
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating glucose ... 1 | 16
increased circulating total pr... 1 | 20
increased coping response 1 | 3
increased exploration in new e... 1 | 56
increased heart rate 1 | 17
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased respiratory quotient 1 | 12
increased rib number 1 | 41
increased thermal nociceptive ... 1 | 9
irregularly shaped pupil 1 | 7
limb grasping 1 | 35
long tibia 1 | 13
narrow eye opening 1 | 15
oligodactyly 1 | 14
polycystic kidney 1 | 9
polydactyly 1 | 22
prenatal lethality 1 | 16
rib fusion 1 | 2
short tail 1 | 4
shortened QT interval 1 | 4
shortened ST segment 1 | 9
small superior vagus ganglion 1 | 20
small testis 1 | 37
syndactyly 1 | 4
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

psoriasis 70 | 6,685
medulloblastoma, large-cell 62 | 6,234
ovarian cancer 61 | 8,484
osteosarcoma 59 | 7,933
glioblastoma 50 | 5,572
atypical teratoid / rhabdoid tumor 41 | 4,369
malignant mesothelioma 39 | 3,162
lung cancer 36 | 4,466
Breast cancer 33 | 3,094
Cancer 32 | 2,346
interstitial cystitis 30 | 2,299
invasive ductal carcinoma 30 | 2,950
primitive neuroectodermal tumor 29 | 3,031
pilocytic astrocytoma 28 | 3,086
adult high grade glioma 27 | 2,148
non-small cell lung cancer 25 | 2,798
cystic fibrosis 24 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
group 4 medulloblastoma 21 | 1,875
Craniofacial Abnormalities 20 | 147
cutaneous lupus erythematosus 19 | 1,056
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
breast carcinoma 18 | 1,614
pituitary cancer 18 | 1,972
oligodendroglioma 17 | 2,849
pancreatic cancer 17 | 2,300
pediatric high grade glioma 17 | 2,712
sonic hedgehog group medulloblastoma 17 | 1,482
Cleft palate 16 | 125
lung adenocarcinoma 16 | 2,713
posterior fossa group A ependymoma 16 | 1,511
Microphthalmia 15 | 78
astrocytic glioma 15 | 2,241
Syndactyly 14 | 56
colon cancer 14 | 1,475
ductal carcinoma in situ 14 | 1,745
ependymoma 14 | 2,514
group 3 medulloblastoma 14 | 2,254
medulloblastoma 14 | 1,524
spina bifida 14 | 1,064
ulcerative colitis 14 | 2,087
posterior fossa group B ependymoma 13 | 1,530
Cleft Lip 12 | 91
Holoprosencephaly 12 | 52
lung carcinoma 12 | 2,844
Autistic Disorder 11 | 320
Polydactyly 10 | 93
facioscapulohumeral dystrophy 10 | 286
subependymal giant cell astrocytoma 10 | 2,287
Pituitary hypoplasia 9 | 15
Rheumatoid Arthritis 9 | 1,160
adrenocortical carcinoma 9 | 1,427
diabetes mellitus 9 | 1,663
non primary Sjogren syndrome sicca 9 | 840
Coloboma 8 | 51
Glaucoma 8 | 134
Hypospadias 8 | 65
Melanoma 8 | 261
Tooth agenesis 8 | 36
active Crohn's disease 8 | 918
active ulcerative colitis 8 | 477
gastric carcinoma 8 | 832
nasopharyngeal carcinoma 8 | 1,056
primary pancreatic ductal adenocarcinoma 8 | 1,271
Carcinoma 7 | 2,147
Clubfoot 7 | 35
Congenital heart disease 7 | 63
Female Urogenital Diseases 7 | 18
Hypopituitarism 7 | 36
Intellectual disability 7 | 573
Obesity 7 | 616
astrocytoma 7 | 1,493
primary Sjogren syndrome 7 | 789
Diabetes Mellitus, Non-Insulin-Dependent 6 | 157
Esophageal atresia 6 | 25
Hypothyroidism 6 | 89
Infertility 6 | 163
Panhypopituitarism 6 | 11
Prostate cancer 6 | 172
Renal agenesis 6 | 25
VACTERL association 6 | 23
aldosterone-producing adenoma 6 | 664
esophageal adenocarcinoma 6 | 737
head and neck cancer 6 | 270
Acquired metabolic disease 5 | 267
Cataract 5 | 104
Congenital Heart Defects 5 | 37
Kidney disease 5 | 396
Lung diseases 5 | 48
Parkinson's disease 5 | 364
Prostatic Neoplasms 5 | 471
acute quadriplegic myopathy 5 | 1,157
atypical teratoid/rhabdoid tumor 5 | 1,095
dermatomyositis 5 | 933
maturity-onset diabetes of the young 5 | 28
Duchenne muscular dystrophy 4 | 602
Endometriosis 4 | 535
Pick disease 4 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795

Tissue

Endocrine System 211 | 18,512
Female tissues 211 | 18,647
Digestive Tract 210 | 18,473
Nervous System 208 | 18,561
Skin and soft tissues 203 | 18,115
Male tissues 201 | 17,969
Urinary Tract 201 | 18,444
Liver and Pancreas 194 | 18,136
Blood and immune system 193 | 17,995
Cardiovascular System 193 | 17,958
Respiratory system 162 | 17,484

Target Family

Transcription Factor 198 | 1,400
Non-IDG 23 | 11,971

PANTHER Protein Class (1)

helix-turn-helix transcription... 221 | 221
DNA binding protein 527 | 527
kinase 502 | 502
RNA binding protein 490 | 490
zinc finger transcription fact... 403 | 403
protease 375 | 375
actin family cytoskeletal prot... 342 | 342
G-protein modulator 330 | 330
G-protein coupled receptor 325 | 325
ion channel 304 | 304
dehydrogenase 239 | 239
phosphatase 230 | 230
microtubule family cytoskeleta... 211 | 211
G-protein 193 | 193
glycosyltransferase 191 | 191
ubiquitin-protein ligase 186 | 186
cytokine 175 | 175
protease inhibitor 167 | 167
immunoglobulin receptor superf... 162 | 162
peptide hormone 162 | 162
nuclease 152 | 152
kinase modulator 149 | 149
cation transporter 139 | 139
transcription cofactor 139 | 139
membrane-bound signaling molec... 125 | 125
helicase 124 | 124
growth factor 109 | 109
cadherin 107 | 107
membrane trafficking regulator... 106 | 106
acetyltransferase 91 | 91
extracellular matrix glycoprot... 85 | 85
intermediate filament 83 | 83
extracellular matrix structura... 75 | 75
antibacterial response protein 74 | 74
basic helix-loop-helix transcr... 74 | 74
oxygenase 73 | 73
acyltransferase 63 | 63
cytokine receptor 60 | 60
intracellular calcium-sensing ... 60 | 60
methyltransferase 60 | 60
mitochondrial carrier protein 58 | 58
lipase 55 | 55
esterase 54 | 54
phosphatase modulator 53 | 53
carbohydrate transporter 46 | 46
nuclear hormone receptor 46 | 46
major histocompatibility compl... 45 | 45
reductase 44 | 44
dehydratase 42 | 42
ATP-binding cassette (ABC) tra... 41 | 41
SNARE protein 40 | 40
vesicle coat protein 40 | 40
oxidase 39 | 39
amino acid transporter 37 | 37
tight junction 36 | 36
nucleotidyltransferase 33 | 33
aminoacyl-tRNA synthetase 28 | 28
phosphodiesterase 28 | 28
deaminase 27 | 27
extracellular matrix linker pr... 26 | 26
glycosidase 24 | 24
peroxidase 24 | 24
transaminase 24 | 24
HMG box transcription factor 22 | 22
cyclase 22 | 22
decarboxylase 21 | 21
gap junction 21 | 21
chaperonin 19 | 19
epimerase/racemase 19 | 19
Hsp70 family chaperone 18 | 18
apolipoprotein 16 | 16
annexin 14 | 14
immunoglobulin superfamily cel... 14 | 14
basic leucine zipper transcrip... 12 | 12
deacetylase 12 | 12
glucosidase 12 | 12
mutase 12 | 12
Hsp90 family chaperone 11 | 11
phosphorylase 11 | 11
hydroxylase 8 | 8
viral coat protein 8 | 8
amylase 6 | 6
galactosidase 6 | 6
immunoglobulin 5 | 5
pyrophosphatase 5 | 5
myelin protein 4 | 4
calsequestrin 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
POU domain, class 3, transcription factor 4 POU3F4 Tbio Transcription Factor -2.24459 179.3 55
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.33707 243.8 508
Homeobox protein Hox-D8 HOXD8 Tbio Transcription Factor -1.03632 9.95 167
Cysteine-rich protein 2 CRIP2 Tbio Non-IDG -0.95386 10.4 115
Homeobox protein Hox-B3 HOXB3 Tbio Transcription Factor -1.60816 41.2 104
Double homeobox protein 1 DUX1 Tdark Non-IDG 0.00000 0
Double homeobox protein 4-like protein 2 DUX4L2 Tdark Transcription Factor 68.6 0
LIM/homeobox protein Lhx2 LHX2 Tbio Transcription Factor -1.89097 87.7 161
Homeobox protein Hox-B5 HOXB5 Tbio Transcription Factor -1.79865 63.7 162
Homeobox protein Nkx-2.8 NKX2-8 Tbio Transcription Factor -0.99635 11.9 122