Development Level

Tbio 109 | 11,651
Tclin 26 | 612
Tchem 21 | 1,388
Tdark 17 | 6,593

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to o... 5 | 239
abnormal behavior 4 | 298
decreased total body fat amoun... 4 | 207
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased circulating alkaline... 3 | 46
decreased circulating chloride... 3 | 30
abnormal bone mineralization 2 | 38
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
abnormal skin morphology 2 | 50
abnormal stomach morphology 2 | 10
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
enlarged heart 2 | 210
hemorrhage 2 | 23
increased circulating alkaline... 2 | 122
increased circulating potassiu... 2 | 29
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal kidney morphology 1 | 65
abnormal neural tube morpholog... 1 | 12
abnormal response to tactile s... 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
absent testes 1 | 6
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
hyperactivity 1 | 148
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased vertical activity 1 | 24
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 121 | 11,493
ovarian cancer 84 | 8,520
psoriasis 70 | 6,694
osteosarcoma 66 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 62 | 1,962
medulloblastoma, large-cell 50 | 6,241
atypical teratoid / rhabdoid tumor 46 | 5,112
glioblastoma 46 | 5,792
lung cancer 46 | 4,740
ependymoma 43 | 4,679
Autosomal recessive predisposition 41 | 1,442
malignant mesothelioma 35 | 3,232
group 3 medulloblastoma 34 | 4,104
invasive ductal carcinoma 34 | 2,951
adult high grade glioma 33 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
non-small cell lung cancer 30 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
lung adenocarcinoma 28 | 2,716
lung carcinoma 28 | 2,843
Epilepsy 27 | 792
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
primitive neuroectodermal tumor 27 | 3,035
Multiple myeloma 26 | 1,332
Muscle hypotonia 26 | 571
ductal carcinoma in situ 26 | 1,745
interstitial cystitis 26 | 2,312
Breast cancer 24 | 3,578
oligodendroglioma 24 | 2,850
Astrocytoma, Pilocytic 23 | 3,081
Cancer 23 | 2,499
Intellectual disability 23 | 1,016
colon cancer 23 | 1,478
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Mental and motor retardation 22 | 608
astrocytic glioma 22 | 2,597
pancreatic cancer 22 | 2,398
ulcerative colitis 21 | 1,819
Dull intelligence 20 | 645
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
Seizures 20 | 596
subependymal giant cell astrocytoma 20 | 2,287
tuberculosis 19 | 2,010
adrenocortical carcinoma 18 | 1,428
cystic fibrosis 18 | 1,696
Liver Cirrhosis, Experimental 17 | 769
Pick disease 17 | 1,894
breast carcinoma 17 | 1,638
Hypoglycemia 16 | 152
active Crohn's disease 16 | 922
pituitary cancer 16 | 1,972
Atopic dermatitis 15 | 952
Leigh disease 15 | 100
Acidosis, Lactic 14 | 97
Cerebellar Ataxia 14 | 304
Dystonia 14 | 164
Dystonic disease 14 | 106
Kidney cancer 14 | 2,613
Prostatic Neoplasms 14 | 495
active ulcerative colitis 14 | 764
diabetes mellitus 14 | 1,728
Alcoholic Intoxication, Chronic 13 | 289
Lactic acidemia 13 | 95
Obesity 13 | 678
nasopharyngeal carcinoma 13 | 1,058
Diabetes mellitus type 2 12 | 69
Failure to gain weight 12 | 365
Infantile onset 12 | 238
Lethargy 12 | 77
Optic Atrophy 12 | 242
Pediatric failure to thrive 12 | 365
Sensorineural Hearing Loss (disorder) 12 | 284
Treatment Refractory Type 2 Diabetes Mellitus 12 | 53
Waldenstrons macroglobulinemia 12 | 765
acute quadriplegic myopathy 12 | 1,158
nephrosclerosis 12 | 333
Mitochondrial complex I deficiency 11 | 46
Nystagmus 11 | 317
Osteoarthritis 11 | 184
Schizophrenia 11 | 1,160
esophageal adenocarcinoma 11 | 737
primary pancreatic ductal adenocarcinoma 11 | 1,109
Alcohol dependence 10 | 107
Highly variable clinical phenotype 10 | 150
Highly variable phenotype and severity 10 | 150
Highly variable phenotype, even within families 10 | 150
Increased serum lactate 10 | 60
Phenotypic variability 10 | 150
Retinitis Pigmentosa 10 | 226
Stomach Neoplasms 10 | 300
acute myeloid leukemia 10 | 783
astrocytoma 10 | 1,146
fibroadenoma 10 | 559
Bipolar Disorder 9 | 666
Myopathy 9 | 185
aldosterone-producing adenoma 9 | 665

Tissue

Endocrine System 172 | 18,159
Urinary Tract 170 | 16,678
Digestive Tract 169 | 17,369
Liver and Pancreas 169 | 16,750
Female tissues 168 | 17,400
Skin and soft tissues 168 | 17,230
Blood and immune system 167 | 16,909
Male tissues 166 | 17,142
Respiratory system 163 | 16,393
Nervous System 161 | 16,725
Cardiovascular System 153 | 15,192

Target Family

Enzyme 160 | 4,145
Non-IDG 12 | 12,091
Epigenetic 1 | 242

PANTHER Protein Class (1)

dehydrogenase 173 | 173
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

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