Development Level

Tbio 134 | 10,625
Tchem 37 | 1,890
Tdark 37 | 7,003
Tclin 31 | 602

IMPC Term

preweaning lethality, complete... 13 | 633
abnormal behavior 4 | 226
abnormal lens morphology 4 | 73
embryonic lethality prior to o... 4 | 148
abnormal retina morphology 3 | 100
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased lean body mass 3 | 195
abnormal QRS complex 2 | 25
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal embryo size 2 | 112
abnormal heart morphology 2 | 51
abnormal retinal pigmentation 2 | 61
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
decreased circulating alkaline... 2 | 41
decreased circulating choleste... 2 | 85
decreased circulating sodium l... 2 | 18
decreased lumbar vertebrae num... 2 | 62
decreased prepulse inhibition 2 | 52
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
increased circulating potassiu... 2 | 31
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 93
prenatal lethality prior to he... 2 | 64
abnormal bone structure 1 | 131
abnormal craniofacial morpholo... 1 | 12
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal heart left ventricle ... 1 | 20
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal lumbar vertebrae morp... 1 | 6
abnormal motor coordination/ b... 1 | 4
abnormal pericardium morpholog... 1 | 11
abnormal response to tactile s... 1 | 16
abnormal sacral vertebrae morp... 1 | 5
abnormal startle reflex 1 | 14
abnormal stomach morphology 1 | 4
abnormal visceral yolk sac mor... 1 | 2
abnormal vocalization 1 | 21
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive CD4-p... 1 | 1
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating chloride... 1 | 32
decreased circulating glucose ... 1 | 121
decreased circulating thyroxin... 1 | 5
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased hemoglobin content 1 | 53
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
edema 1 | 11
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
hemorrhage 1 | 12
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired righting response 1 | 19
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased effector memory CD8-... 1 | 14
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
pale liver 1 | 5
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 119 | 8,484
osteosarcoma 96 | 7,933
psoriasis 89 | 6,685
pancreatic ductal adenocarcinoma liver metastasis 85 | 1,795
medulloblastoma, large-cell 67 | 6,234
lung cancer 66 | 4,466
glioblastoma 59 | 5,572
malignant mesothelioma 48 | 3,162
atypical teratoid / rhabdoid tumor 45 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,289
invasive ductal carcinoma 43 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,956
non-small cell lung cancer 42 | 2,798
ulcerative colitis 40 | 2,087
interstitial cystitis 39 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
lung adenocarcinoma 37 | 2,713
lung carcinoma 37 | 2,844
primitive neuroectodermal tumor 37 | 3,031
Multiple myeloma 34 | 1,327
ductal carcinoma in situ 34 | 1,745
ependymoma 34 | 2,514
pilocytic astrocytoma 33 | 3,086
adult high grade glioma 31 | 2,148
adrenocortical carcinoma 29 | 1,427
oligodendroglioma 29 | 2,849
Breast cancer 28 | 3,094
Cancer 28 | 2,346
pancreatic cancer 28 | 2,300
astrocytic glioma 27 | 2,241
colon cancer 27 | 1,475
cystic fibrosis 26 | 1,665
tuberculosis 26 | 1,557
subependymal giant cell astrocytoma 24 | 2,287
Pick disease 23 | 1,893
pediatric high grade glioma 23 | 2,712
breast carcinoma 21 | 1,614
posterior fossa group B ependymoma 21 | 1,530
active Crohn's disease 20 | 918
esophageal adenocarcinoma 20 | 737
group 4 medulloblastoma 20 | 1,875
pituitary cancer 20 | 1,972
Atopic dermatitis 19 | 944
Prostatic Neoplasms 19 | 471
sonic hedgehog group medulloblastoma 19 | 1,482
Leigh disease 18 | 81
Waldenstrons macroglobulinemia 18 | 765
astrocytoma 18 | 1,493
atypical teratoid/rhabdoid tumor 18 | 1,095
group 3 medulloblastoma 18 | 2,254
nasopharyngeal carcinoma 18 | 1,056
acute quadriplegic myopathy 17 | 1,157
Diabetes mellitus type 2 16 | 69
Treatment Refractory Type 2 Diabetes Mellitus 16 | 53
acute myeloid leukemia 16 | 780
diabetes mellitus 16 | 1,663
medulloblastoma 16 | 1,524
posterior fossa group A ependymoma 16 | 1,511
Obesity 15 | 616
aldosterone-producing adenoma 15 | 664
primary pancreatic ductal adenocarcinoma 14 | 1,271
MITOCHONDRIAL COMPLEX I DEFICIENCY 13 | 37
fibroadenoma 13 | 557
nephrosclerosis 13 | 329
gastric carcinoma 12 | 832
Rheumatoid Arthritis 11 | 1,160
Alcohol dependence 10 | 107
Degenerative polyarthritis 10 | 93
Intellectual disability 10 | 573
Stomach Neoplasms 10 | 282
spina bifida 10 | 1,064
Liver Cirrhosis, Experimental 9 | 108
Maple syrup urine disease 9 | 25
Methylmalonic acidemia 9 | 39
Polycystic Ovary Syndrome 9 | 332
Succinic semialdehyde dehydrogenase deficiency 9 | 16
Alzheimer's disease 8 | 644
Hypoglycemia 8 | 81
Liver carcinoma 8 | 217
Liver disease 8 | 219
Multiple acyl-CoA dehydrogenase deficiency 8 | 26
chronic rhinosinusitis 8 | 512
non primary Sjogren syndrome sicca 8 | 840
progressive supranuclear palsy 8 | 674
Carcinoma 7 | 2,147
Down syndrome 7 | 548
Epilepsy 7 | 346
Lactic acidosis 7 | 42
NADH:Q(1) Oxidoreductase deficiency 7 | 20
Neurodegenerative disease 7 | 383
active ulcerative colitis 7 | 477
beta-ketothiolase deficiency 7 | 13
cutaneous lupus erythematosus 7 | 1,056
dermatomyositis 7 | 933
head and neck cancer 7 | 270
inflammatory breast cancer 7 | 404
pancreatic carcinoma 7 | 567
primary Sjogren syndrome 7 | 789
Disease Progression 6 | 125
Endometriosis 6 | 535

Tissue

Liver and Pancreas 239 | 18,136
Cardiovascular System 238 | 17,958
Digestive Tract 238 | 18,473
Endocrine System 238 | 18,512
Female tissues 238 | 18,647
Male tissues 238 | 17,969
Nervous System 238 | 18,561
Urinary Tract 238 | 18,444
Blood and immune system 237 | 17,995
Respiratory system 235 | 17,484
Skin and soft tissues 234 | 18,115

Target Family

Enzyme 216 | 4,146
Non-IDG 22 | 11,971
Epigenetic 1 | 242

PANTHER Protein Class (1)

dehydrogenase 239 | 239
DNA binding protein 527 | 527
kinase 502 | 502
RNA binding protein 490 | 490
zinc finger transcription fact... 403 | 403
protease 375 | 375
actin family cytoskeletal prot... 342 | 342
G-protein modulator 330 | 330
G-protein coupled receptor 325 | 325
ion channel 304 | 304
phosphatase 230 | 230
helix-turn-helix transcription... 221 | 221
microtubule family cytoskeleta... 211 | 211
G-protein 193 | 193
glycosyltransferase 191 | 191
ubiquitin-protein ligase 186 | 186
cytokine 175 | 175
protease inhibitor 167 | 167
immunoglobulin receptor superf... 162 | 162
peptide hormone 162 | 162
nuclease 152 | 152
kinase modulator 149 | 149
cation transporter 139 | 139
transcription cofactor 139 | 139
membrane-bound signaling molec... 125 | 125
helicase 124 | 124
growth factor 109 | 109
cadherin 107 | 107
membrane trafficking regulator... 106 | 106
acetyltransferase 91 | 91
extracellular matrix glycoprot... 85 | 85
intermediate filament 83 | 83
extracellular matrix structura... 75 | 75
antibacterial response protein 74 | 74
basic helix-loop-helix transcr... 74 | 74
oxygenase 73 | 73
acyltransferase 63 | 63
cytokine receptor 60 | 60
intracellular calcium-sensing ... 60 | 60
methyltransferase 60 | 60
mitochondrial carrier protein 58 | 58
lipase 55 | 55
esterase 54 | 54
phosphatase modulator 53 | 53
carbohydrate transporter 46 | 46
nuclear hormone receptor 46 | 46
major histocompatibility compl... 45 | 45
reductase 44 | 44
dehydratase 42 | 42
ATP-binding cassette (ABC) tra... 41 | 41
SNARE protein 40 | 40
vesicle coat protein 40 | 40
oxidase 39 | 39
amino acid transporter 37 | 37
tight junction 36 | 36
nucleotidyltransferase 33 | 33
aminoacyl-tRNA synthetase 28 | 28
phosphodiesterase 28 | 28
deaminase 27 | 27
extracellular matrix linker pr... 26 | 26
glycosidase 24 | 24
peroxidase 24 | 24
transaminase 24 | 24
HMG box transcription factor 22 | 22
cyclase 22 | 22
decarboxylase 21 | 21
gap junction 21 | 21
chaperonin 19 | 19
epimerase/racemase 19 | 19
Hsp70 family chaperone 18 | 18
apolipoprotein 16 | 16
annexin 14 | 14
immunoglobulin superfamily cel... 14 | 14
basic leucine zipper transcrip... 12 | 12
deacetylase 12 | 12
glucosidase 12 | 12
mutase 12 | 12
Hsp90 family chaperone 11 | 11
phosphorylase 11 | 11
hydroxylase 8 | 8
viral coat protein 8 | 8
amylase 6 | 6
galactosidase 6 | 6
immunoglobulin 5 | 5
pyrophosphatase 5 | 5
myelin protein 4 | 4
calsequestrin 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.15826 152.2 203
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Glutamate dehydrogenase 2, mitochondrial GLUD2 Tbio Enzyme -1.13407 13.6 143
Dehydrogenase/reductase SDR family member 7B DHRS7B Tdark Enzyme 0.48 0.25 86