Development Level

Tbio 253 | 10,625
Tdark 78 | 7,003
Tchem 10 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 16 | 633
decreased lean body mass 8 | 195
preweaning lethality, incomple... 8 | 260
decreased body weight 7 | 174
increased or absent threshold ... 7 | 128
abnormal behavior 6 | 226
abnormal bone structure 6 | 131
decreased circulating choleste... 6 | 85
decreased total body fat amoun... 6 | 186
embryonic lethality prior to t... 6 | 187
abnormal embryo size 5 | 112
decreased bone mineral content 5 | 157
decreased bone mineral density 5 | 126
decreased circulating HDL chol... 5 | 77
decreased circulating glucose ... 5 | 121
increased circulating alkaline... 5 | 119
abnormal behavioral response t... 4 | 52
abnormal skin coloration 4 | 18
abnormal sleep behavior 4 | 63
decreased body length 4 | 108
decreased circulating insulin ... 4 | 75
decreased circulating serum al... 4 | 79
decreased circulating total pr... 4 | 41
hyperactivity 4 | 108
increased lean body mass 4 | 107
increased mean corpuscular vol... 4 | 91
abnormal bone mineralization 3 | 55
abnormal coat/hair pigmentatio... 3 | 54
abnormal cranium morphology 3 | 32
abnormal digit morphology 3 | 13
abnormal lens morphology 3 | 73
abnormal retina morphology 3 | 100
abnormal tail morphology 3 | 17
decreased circulating free fat... 3 | 39
decreased circulating fructosa... 3 | 31
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
decreased mean corpuscular vol... 3 | 50
decreased rib number 3 | 59
hypoactivity 3 | 89
improved glucose tolerance 3 | 56
increased body weight 3 | 42
increased circulating chloride... 3 | 43
increased circulating phosphat... 3 | 24
increased circulating sodium l... 3 | 71
increased exploration in new e... 3 | 56
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
prenatal lethality prior to he... 3 | 64
short tibia 3 | 82
abnormal craniofacial morpholo... 2 | 12
abnormal eye morphology 2 | 38
abnormal locomotor activation 2 | 26
abnormal maxilla morphology 2 | 16
abnormal placenta size 2 | 10
abnormal respiratory quotient 2 | 9
abnormal retinal pigmentation 2 | 61
abnormal vertebrae morphology 2 | 14
abnormal vocalization 2 | 21
absent pinna reflex 2 | 21
cataract 2 | 26
convulsive seizures 2 | 11
decreased blood urea nitrogen ... 2 | 31
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating chloride... 2 | 32
decreased circulating creatini... 2 | 31
decreased circulating iron lev... 2 | 25
decreased heart weight 2 | 44
decreased leukocyte cell numbe... 2 | 54
decreased startle reflex 2 | 48
decreased vertical activity 2 | 22
embryonic lethality prior to o... 2 | 148
fusion of vertebral arches 2 | 7
hemorrhage 2 | 12
increased blood urea nitrogen ... 2 | 44
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased circulating iron lev... 2 | 25
increased fasted circulating g... 2 | 68
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased red blood cell distr... 2 | 21
increased rib number 2 | 41
pallor 2 | 13
persistence of hyaloid vascula... 2 | 22
shortened ST segment 2 | 9
vertebral fusion 2 | 23
abnormal embryo turning 1 | 15
abnormal motor capabilities/co... 1 | 4
abnormal neural tube closure 1 | 37
abnormal rib morphology 1 | 28
abnormal thoracic vertebrae mo... 1 | 16
corneal opacity 1 | 25
decreased cervical vertebrae n... 1 | 12
decreased mean corpuscular hem... 1 | 34
embryonic growth retardation 1 | 28
female infertility 1 | 34
increased CD4-positive, CD25-p... 1 | 18

Disease

ovarian cancer 170 | 8,484
osteosarcoma 154 | 7,933
psoriasis 153 | 6,685
glioblastoma 150 | 5,572
medulloblastoma, large-cell 136 | 6,234
atypical teratoid / rhabdoid tumor 108 | 4,369
lung cancer 100 | 4,466
pilocytic astrocytoma 98 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 97 | 2,988
primitive neuroectodermal tumor 95 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 90 | 2,956
pediatric high grade glioma 89 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 87 | 3,289
Carcinoma 86 | 2,147
invasive ductal carcinoma 86 | 2,950
pancreatic cancer 86 | 2,300
malignant mesothelioma 83 | 3,162
oligodendroglioma 83 | 2,849
Breast cancer 81 | 3,094
non-small cell lung cancer 78 | 2,798
lung carcinoma 77 | 2,844
ependymoma 74 | 2,514
lung adenocarcinoma 71 | 2,713
subependymal giant cell astrocytoma 71 | 2,287
ductal carcinoma in situ 58 | 1,745
breast carcinoma 55 | 1,614
primary pancreatic ductal adenocarcinoma 55 | 1,271
acute quadriplegic myopathy 54 | 1,157
colon cancer 54 | 1,475
astrocytic glioma 52 | 2,241
interstitial cystitis 49 | 2,299
Pick disease 47 | 1,893
pituitary cancer 46 | 1,972
cystic fibrosis 45 | 1,665
sonic hedgehog group medulloblastoma 45 | 1,482
spina bifida 42 | 1,064
group 3 medulloblastoma 41 | 2,254
adrenocortical carcinoma 40 | 1,427
adult high grade glioma 40 | 2,148
astrocytoma 40 | 1,493
Duchenne muscular dystrophy 39 | 602
tuberculosis 38 | 1,557
ulcerative colitis 38 | 2,087
medulloblastoma 37 | 1,524
group 4 medulloblastoma 36 | 1,875
juvenile dermatomyositis 36 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 35 | 1,795
diabetes mellitus 34 | 1,663
posterior fossa group A ependymoma 31 | 1,511
dermatomyositis 30 | 933
Rheumatoid Arthritis 29 | 1,160
atypical teratoid/rhabdoid tumor 29 | 1,095
gastric carcinoma 29 | 832
cutaneous lupus erythematosus 27 | 1,056
nasopharyngeal carcinoma 27 | 1,056
posterior fossa group B ependymoma 25 | 1,530
Down syndrome 24 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 24 | 499
Cancer 23 | 2,346
esophageal adenocarcinoma 23 | 737
progressive supranuclear palsy 23 | 674
pancreatic carcinoma 22 | 567
Alzheimer's disease 20 | 644
Atopic dermatitis 20 | 944
Cardiomyopathy 20 | 110
Waldenstrons macroglobulinemia 20 | 765
Multiple myeloma 19 | 1,327
fibroadenoma 19 | 557
active ulcerative colitis 17 | 477
acute myeloid leukemia 17 | 780
Becker muscular dystrophy 16 | 187
active Crohn's disease 16 | 918
chronic rhinosinusitis 16 | 512
mucosa-associated lymphoid tissue lymphoma 16 | 480
Amyotrophic Lateral Sclerosis 15 | 431
Hypertrophic Cardiomyopathy 15 | 56
aldosterone-producing adenoma 15 | 664
hereditary spastic paraplegia 15 | 313
primary Sjogren syndrome 15 | 789
Polycystic Ovary Syndrome 14 | 332
tuberculosis and treatment for 6 months 14 | 686
Dilated cardiomyopathy 13 | 50
Distal arthrogryposis 13 | 45
Nonsyndromic deafness 13 | 121
gastric cancer 13 | 430
non primary Sjogren syndrome sicca 12 | 840
Endometriosis 11 | 535
IGA Glomerulonephritis 11 | 454
Myopathy 11 | 128
Nemaline myopathy 11 | 17
Osteoporosis 11 | 257
Sensorineural hearing loss 11 | 107
interstitial lung disease 11 | 291
Intellectual disability 10 | 573
Neuropathy 10 | 210
Substance-Related Disorders 10 | 114
COPD 9 | 113
Cardiomyopathy, Hypertrophic, Familial 9 | 21
Left ventricular noncompaction 9 | 23
Prostatic Neoplasms 9 | 471

Tissue

Female tissues 336 | 18,647
Nervous System 336 | 18,561
Digestive Tract 335 | 18,473
Liver and Pancreas 335 | 18,136
Endocrine System 334 | 18,512
Male tissues 334 | 17,969
Urinary Tract 334 | 18,444
Blood and immune system 333 | 17,995
Cardiovascular System 332 | 17,958
Skin and soft tissues 328 | 18,115
Respiratory system 324 | 17,484

Target Family

Non-IDG 323 | 11,971
Enzyme 17 | 4,146
Kinase 2 | 634

PANTHER Protein Class (1)

actin family cytoskeletal prot... 342 | 342
DNA binding protein 527 | 527
kinase 502 | 502
RNA binding protein 490 | 490
zinc finger transcription fact... 403 | 403
protease 375 | 375
G-protein modulator 330 | 330
G-protein coupled receptor 325 | 325
ion channel 304 | 304
dehydrogenase 239 | 239
phosphatase 230 | 230
helix-turn-helix transcription... 221 | 221
microtubule family cytoskeleta... 211 | 211
G-protein 193 | 193
glycosyltransferase 191 | 191
ubiquitin-protein ligase 186 | 186
cytokine 175 | 175
protease inhibitor 167 | 167
immunoglobulin receptor superf... 162 | 162
peptide hormone 162 | 162
nuclease 152 | 152
kinase modulator 149 | 149
cation transporter 139 | 139
transcription cofactor 139 | 139
membrane-bound signaling molec... 125 | 125
helicase 124 | 124
growth factor 109 | 109
cadherin 107 | 107
membrane trafficking regulator... 106 | 106
acetyltransferase 91 | 91
extracellular matrix glycoprot... 85 | 85
intermediate filament 83 | 83
extracellular matrix structura... 75 | 75
antibacterial response protein 74 | 74
basic helix-loop-helix transcr... 74 | 74
oxygenase 73 | 73
acyltransferase 63 | 63
cytokine receptor 60 | 60
intracellular calcium-sensing ... 60 | 60
methyltransferase 60 | 60
mitochondrial carrier protein 58 | 58
lipase 55 | 55
esterase 54 | 54
phosphatase modulator 53 | 53
carbohydrate transporter 46 | 46
nuclear hormone receptor 46 | 46
major histocompatibility compl... 45 | 45
reductase 44 | 44
dehydratase 42 | 42
ATP-binding cassette (ABC) tra... 41 | 41
SNARE protein 40 | 40
vesicle coat protein 40 | 40
oxidase 39 | 39
amino acid transporter 37 | 37
tight junction 36 | 36
nucleotidyltransferase 33 | 33
aminoacyl-tRNA synthetase 28 | 28
phosphodiesterase 28 | 28
deaminase 27 | 27
extracellular matrix linker pr... 26 | 26
glycosidase 24 | 24
peroxidase 24 | 24
transaminase 24 | 24
HMG box transcription factor 22 | 22
cyclase 22 | 22
decarboxylase 21 | 21
gap junction 21 | 21
chaperonin 19 | 19
epimerase/racemase 19 | 19
Hsp70 family chaperone 18 | 18
apolipoprotein 16 | 16
annexin 14 | 14
immunoglobulin superfamily cel... 14 | 14
basic leucine zipper transcrip... 12 | 12
deacetylase 12 | 12
glucosidase 12 | 12
mutase 12 | 12
Hsp90 family chaperone 11 | 11
phosphorylase 11 | 11
hydroxylase 8 | 8
viral coat protein 8 | 8
amylase 6 | 6
galactosidase 6 | 6
immunoglobulin 5 | 5
pyrophosphatase 5 | 5
myelin protein 4 | 4
calsequestrin 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Wiskott-Aldrich syndrome protein family member 3 WASF3 Tbio Non-IDG -2.43045 280.1 123
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
Myosin light chain 6B MYL6B Tdark Non-IDG -0.43175 2.57 113
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
Cysteine and glycine-rich protein 3 CSRP3 Tbio Non-IDG -1.95188 93.8 215
Brefeldin A-inhibited guanine nucleotide-exchange protein 3 ARFGEF3 Tdark Non-IDG 0.27 0.56 5
PH and SEC7 domain-containing protein 3 PSD3 Tbio Non-IDG -1.18771 15.6 120
Beta-1-syntrophin SNTB1 Tbio Non-IDG -1.02258 8.71 102