Development Level

Tbio 139 | 11,445
Tdark 30 | 6,588
Tchem 9 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal behavior 6 | 298
preweaning lethality, incomple... 4 | 499
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal forebrain morphology 2 | 10
abnormal gait 2 | 69
abnormal midbrain morphology 2 | 10
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased vertical activity 2 | 208
edema 2 | 59
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased lean body mass 2 | 172
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal gallbladder morpholog... 1 | 1
abnormal hair growth 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal iris pigmentation 1 | 4
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
absent pinna reflex 1 | 23
absent urinary bladder 1 | 1
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased granulocyte number 1 | 6
decreased heart rate 1 | 18
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
decreased threshold for audito... 1 | 26
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
hemorrhage 1 | 23
hydrometra 1 | 53
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
prolonged RR interval 1 | 8
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 136 | 11,493
osteosarcoma 100 | 7,950
ovarian cancer 98 | 8,520
medulloblastoma, large-cell 89 | 6,241
glioblastoma 87 | 5,792
atypical teratoid / rhabdoid tumor 79 | 5,112
ependymoma 72 | 4,679
psoriasis 67 | 6,694
adult high grade glioma 61 | 3,801
group 3 medulloblastoma 60 | 4,104
lung cancer 58 | 4,740
oligodendroglioma 55 | 2,850
Kidney cancer 54 | 2,613
Astrocytoma, Pilocytic 53 | 3,081
Breast cancer 51 | 3,578
invasive ductal carcinoma 50 | 2,951
primitive neuroectodermal tumor 50 | 3,035
non-small cell lung cancer 48 | 2,890
astrocytic glioma 45 | 2,597
lung carcinoma 44 | 2,843
subependymal giant cell astrocytoma 43 | 2,287
lung adenocarcinoma 40 | 2,716
malignant mesothelioma 40 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
Pick disease 37 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
interstitial cystitis 35 | 2,312
group 4 medulloblastoma 32 | 1,855
pancreatic cancer 32 | 2,398
ulcerative colitis 32 | 1,819
ductal carcinoma in situ 29 | 1,745
tuberculosis 28 | 2,010
pituitary cancer 27 | 1,972
Intellectual disability 24 | 1,016
cystic fibrosis 24 | 1,696
spina bifida 21 | 1,074
Cancer 20 | 2,499
breast carcinoma 20 | 1,638
juvenile dermatomyositis 19 | 1,187
primary Sjogren syndrome 19 | 735
Schizophrenia 18 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Rheumatoid arthritis 17 | 1,191
astrocytoma 16 | 1,146
dermatomyositis 16 | 966
pediatric high grade glioma 14 | 1,064
primary pancreatic ductal adenocarcinoma 14 | 1,109
mucosa-associated lymphoid tissue lymphoma 13 | 484
Liver cancer 12 | 604
acute quadriplegic myopathy 12 | 1,158
adrenocortical carcinoma 12 | 1,428
colon cancer 12 | 1,478
cutaneous lupus erythematosus 12 | 1,057
Autosomal recessive predisposition 11 | 1,442
Dull intelligence 11 | 645
Low intelligence 11 | 645
Melanoma 11 | 711
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Endometriosis 10 | 540
Liver Cirrhosis, Experimental 10 | 769
aldosterone-producing adenoma 10 | 665
diabetes mellitus 10 | 1,728
gastric carcinoma 10 | 807
non primary Sjogren syndrome sicca 10 | 891
Cryptorchidism 9 | 296
Multiple myeloma 9 | 1,332
Short stature 9 | 531
Waldenstrons macroglobulinemia 9 | 765
active Crohn's disease 9 | 922
nasopharyngeal carcinoma 9 | 1,058
Chronic Lymphocytic Leukemia 8 | 262
Cognitive delay 8 | 608
Down syndrome 8 | 499
Duchenne muscular dystrophy 8 | 601
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
esophageal adenocarcinoma 8 | 737
hepatocellular carcinoma 8 | 547
pancreatic carcinoma 8 | 562
progressive supranuclear palsy 8 | 676
urothelial carcinoma 8 | 318
Acquired scoliosis 7 | 281
Atopic dermatitis 7 | 952
Autistic Disorder 7 | 364
Bipolar Disorder 7 | 666
Curvature of spine 7 | 282
Endometrial cancer 7 | 311
Low-set, posteriorly rotated ears 7 | 110
Muscle hypotonia 7 | 571
Orbital separation excessive 7 | 244
gastric cancer 7 | 459
interstitial lung disease 7 | 298
sarcoidosis 7 | 370
Crohn's disease 6 | 321
Epilepsy 6 | 792
acute myeloid leukemia 6 | 783
fibroadenoma 6 | 559

Tissue

Endocrine System 176 | 18,159
Female tissues 175 | 17,400
Skin and soft tissues 175 | 17,230
Digestive Tract 174 | 17,369
Liver and Pancreas 174 | 16,750
Male tissues 173 | 17,142
Urinary Tract 172 | 16,678
Blood and immune system 171 | 16,909
Nervous System 170 | 16,725
Respiratory system 170 | 16,393
Cardiovascular System 166 | 15,192

Target Family

Non-IDG 133 | 12,091
Enzyme 46 | 4,145

PANTHER Protein Class (1)

G-protein modulator 179 | 179
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorting nexin-13 SNX13 Tbio Non-IDG -0.67169 5.24 65
Sorting nexin-14 SNX14 Tbio Non-IDG -0.86091 6.82 56
Ras association domain-containing protein 5 RASSF5 Tbio Non-IDG -1.81149 71.3 155
Signal-induced proliferation-associated 1-like protein 1 SIPA1L1 Tbio Non-IDG -0.56258 5.05 40
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
Rho GDP-dissociation inhibitor 3 ARHGDIG Tbio Non-IDG -0.82623 8.55 107
Rho GTPase-activating protein 9 ARHGAP9 Tbio Enzyme -1.74771 54.3 35
Regulating synaptic membrane exocytosis protein 3 RIMS3 Tbio Non-IDG -1.28577 18.9 75
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79