Development Level

Tbio 348 | 10,625
Tdark 119 | 7,003
Tchem 51 | 1,890
Tclin 9 | 602

IMPC Term

preweaning lethality, complete... 30 | 633
decreased total body fat amoun... 11 | 186
preweaning lethality, incomple... 11 | 260
decreased body weight 10 | 174
embryonic lethality prior to t... 9 | 187
abnormal behavior 8 | 226
decreased lean body mass 8 | 195
embryonic lethality prior to o... 8 | 148
increased lean body mass 8 | 107
abnormal bone structure 7 | 131
abnormal embryo size 7 | 112
decreased caudal vertebrae num... 7 | 49
decreased circulating LDL chol... 7 | 37
decreased rib number 7 | 59
increased bone mineral content 7 | 92
increased grip strength 7 | 83
increased sacral vertebrae num... 7 | 62
decreased body length 6 | 108
decreased bone mineral content 6 | 157
decreased bone mineral density 6 | 126
decreased circulating HDL chol... 6 | 77
decreased circulating choleste... 6 | 85
hypoactivity 6 | 89
decreased grip strength 5 | 123
decreased lumbar vertebrae num... 5 | 62
increased circulating HDL chol... 5 | 63
increased circulating choleste... 5 | 53
abnormal gait 4 | 51
abnormal retina morphology 4 | 100
decreased circulating glucose ... 4 | 121
decreased circulating serum al... 4 | 79
decreased leukocyte cell numbe... 4 | 54
increased bone mineral density 4 | 52
increased circulating alkaline... 4 | 119
increased mean corpuscular vol... 4 | 91
increased or absent threshold ... 4 | 128
thrombocytopenia 4 | 46
abnormal behavioral response t... 3 | 52
abnormal bone mineralization 3 | 55
abnormal coat/hair pigmentatio... 3 | 54
abnormal rib morphology 3 | 28
decreased circulating total pr... 3 | 41
decreased hemoglobin content 3 | 53
decreased mean corpuscular vol... 3 | 50
decreased threshold for audito... 3 | 32
hydrops fetalis 3 | 22
hyperactivity 3 | 108
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 68
increased mean corpuscular hem... 3 | 93
male infertility 3 | 62
narrow eye opening 3 | 15
short tibia 3 | 82
trunk curl 3 | 15
vertebral fusion 3 | 23
abnormal coat appearance 2 | 25
abnormal coat/ hair morphology 2 | 18
abnormal embryo turning 2 | 15
abnormal eye morphology 2 | 38
abnormal lens morphology 2 | 73
abnormal neural tube closure 2 | 37
abnormal retinal pigmentation 2 | 61
abnormal sleep behavior 2 | 63
abnormal thoracic vertebrae mo... 2 | 16
abnormal vertebral arch morpho... 2 | 9
cataract 2 | 26
corneal opacity 2 | 25
decreased circulating alanine ... 2 | 53
decreased circulating aspartat... 2 | 27
decreased circulating calcium ... 2 | 33
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased erythrocyte cell num... 2 | 43
decreased heart weight 2 | 44
decreased mean corpuscular hem... 2 | 34
decreased prepulse inhibition 2 | 52
decreased total retina thickne... 2 | 20
embryonic growth retardation 2 | 28
enlarged heart 2 | 111
increased circulating chloride... 2 | 43
increased circulating creatini... 2 | 29
increased circulating fructosa... 2 | 11
increased circulating triglyce... 2 | 24
increased mean corpuscular hem... 2 | 25
increased respiratory quotient 2 | 12
increased startle reflex 2 | 38
increased thermal nociceptive ... 2 | 9
pallor 2 | 13
persistence of hyaloid vascula... 2 | 22
prolonged QRS complex duration 2 | 2
shortened RR interval 2 | 19
small heart 2 | 8
tremors 2 | 34
vertebral transformation 2 | 12
abnormal cranium morphology 1 | 32
abnormal retinal inner nuclear... 1 | 5
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
female infertility 1 | 34
thin ventricular wall 1 | 5

Disease

ovarian cancer 258 | 8,484
osteosarcoma 252 | 7,933
medulloblastoma, large-cell 187 | 6,234
psoriasis 181 | 6,685
lung cancer 156 | 4,466
glioblastoma 145 | 5,572
Breast cancer 120 | 3,094
atypical teratoid / rhabdoid tumor 119 | 4,369
malignant mesothelioma 114 | 3,162
Cancer 111 | 2,346
primitive neuroectodermal tumor 108 | 3,031
group 3 medulloblastoma 103 | 2,254
non-small cell lung cancer 93 | 2,798
lung adenocarcinoma 91 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 82 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 80 | 2,988
invasive ductal carcinoma 79 | 2,950
oligodendroglioma 67 | 2,849
pediatric high grade glioma 67 | 2,712
ependymoma 63 | 2,514
Carcinoma 57 | 2,147
sonic hedgehog group medulloblastoma 56 | 1,482
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,956
pilocytic astrocytoma 53 | 3,086
adult high grade glioma 51 | 2,148
subependymal giant cell astrocytoma 51 | 2,287
breast carcinoma 50 | 1,614
astrocytic glioma 49 | 2,241
colon cancer 49 | 1,475
pituitary cancer 49 | 1,972
Pick disease 46 | 1,893
adrenocortical carcinoma 46 | 1,427
ductal carcinoma in situ 46 | 1,745
pancreatic cancer 45 | 2,300
medulloblastoma 43 | 1,524
Multiple myeloma 41 | 1,327
diabetes mellitus 41 | 1,663
group 4 medulloblastoma 40 | 1,875
Rheumatoid Arthritis 39 | 1,160
astrocytoma 38 | 1,493
atypical teratoid/rhabdoid tumor 36 | 1,095
dermatomyositis 36 | 933
juvenile dermatomyositis 35 | 1,189
lung carcinoma 35 | 2,844
tuberculosis 35 | 1,557
cystic fibrosis 34 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,795
ulcerative colitis 33 | 2,087
spina bifida 32 | 1,064
nasopharyngeal carcinoma 31 | 1,056
acute quadriplegic myopathy 30 | 1,157
Waldenstrons macroglobulinemia 29 | 765
non primary Sjogren syndrome sicca 29 | 840
posterior fossa group A ependymoma 29 | 1,511
progressive supranuclear palsy 28 | 674
interstitial cystitis 27 | 2,299
acute myeloid leukemia 26 | 780
hepatocellular carcinoma 26 | 532
tuberculosis and treatment for 6 months 26 | 686
Intellectual disability 25 | 573
cutaneous lupus erythematosus 25 | 1,056
Mammary Neoplasms 23 | 410
posterior fossa group B ependymoma 23 | 1,530
Alzheimer's disease 21 | 644
gastric cancer 19 | 430
Endometriosis 18 | 535
Prostatic Neoplasms 18 | 471
active Crohn's disease 18 | 918
gastric carcinoma 18 | 832
primary pancreatic ductal adenocarcinoma 18 | 1,271
inflammatory breast cancer 17 | 404
non-small cell lung carcinoma 17 | 413
pancreatic carcinoma 17 | 567
Atopic dermatitis 16 | 944
Microcephaly 16 | 149
Peripheral Neuropathy 16 | 303
primary Sjogren syndrome 16 | 789
IGA Glomerulonephritis 15 | 454
Adenoid Cystic Carcinoma 14 | 99
Xeroderma pigmentosum 14 | 41
Cockayne syndrome 13 | 54
Down syndrome 13 | 548
Lynch syndrome 13 | 33
Adenoma 12 | 165
Amyotrophic Lateral Sclerosis 12 | 431
Male infertility 12 | 170
Obesity 12 | 616
aldosterone-producing adenoma 12 | 664
Acquired metabolic disease 11 | 267
Chronic Lymphocytic Leukemia 11 | 242
Leukemia 11 | 88
Prostate cancer 11 | 172
Stomach Neoplasms 11 | 282
Fanconi's anemia 10 | 50
Melanoma 10 | 261
Neurodegenerative disease 10 | 383
Parkinson's disease 10 | 364
Multiple Sclerosis 9 | 498
Polycystic Ovary Syndrome 9 | 332
esophageal adenocarcinoma 9 | 737

Tissue

Nervous System 502 | 18,561
Endocrine System 500 | 18,512
Female tissues 500 | 18,647
Urinary Tract 494 | 18,444
Digestive Tract 491 | 18,473
Male tissues 490 | 17,969
Blood and immune system 489 | 17,995
Liver and Pancreas 486 | 18,136
Skin and soft tissues 484 | 18,115
Cardiovascular System 482 | 17,958
Respiratory system 472 | 17,484

Target Family

Non-IDG 267 | 11,971
Transcription Factor 113 | 1,400
Enzyme 78 | 4,146
Epigenetic 56 | 242
TF/Epigenetic 13 | 38

PANTHER Protein Class (1)

DNA binding protein 527 | 527
kinase 502 | 502
RNA binding protein 490 | 490
zinc finger transcription fact... 403 | 403
protease 375 | 375
actin family cytoskeletal prot... 342 | 342
G-protein modulator 330 | 330
G-protein coupled receptor 325 | 325
ion channel 304 | 304
dehydrogenase 239 | 239
phosphatase 230 | 230
helix-turn-helix transcription... 221 | 221
microtubule family cytoskeleta... 211 | 211
G-protein 193 | 193
glycosyltransferase 191 | 191
ubiquitin-protein ligase 186 | 186
cytokine 175 | 175
protease inhibitor 167 | 167
immunoglobulin receptor superf... 162 | 162
peptide hormone 162 | 162
nuclease 152 | 152
kinase modulator 149 | 149
cation transporter 139 | 139
transcription cofactor 139 | 139
membrane-bound signaling molec... 125 | 125
helicase 124 | 124
growth factor 109 | 109
cadherin 107 | 107
membrane trafficking regulator... 106 | 106
acetyltransferase 91 | 91
extracellular matrix glycoprot... 85 | 85
intermediate filament 83 | 83
extracellular matrix structura... 75 | 75
antibacterial response protein 74 | 74
basic helix-loop-helix transcr... 74 | 74
oxygenase 73 | 73
acyltransferase 63 | 63
cytokine receptor 60 | 60
intracellular calcium-sensing ... 60 | 60
methyltransferase 60 | 60
mitochondrial carrier protein 58 | 58
lipase 55 | 55
esterase 54 | 54
phosphatase modulator 53 | 53
carbohydrate transporter 46 | 46
nuclear hormone receptor 46 | 46
major histocompatibility compl... 45 | 45
reductase 44 | 44
dehydratase 42 | 42
ATP-binding cassette (ABC) tra... 41 | 41
SNARE protein 40 | 40
vesicle coat protein 40 | 40
oxidase 39 | 39
amino acid transporter 37 | 37
tight junction 36 | 36
nucleotidyltransferase 33 | 33
aminoacyl-tRNA synthetase 28 | 28
phosphodiesterase 28 | 28
deaminase 27 | 27
extracellular matrix linker pr... 26 | 26
glycosidase 24 | 24
peroxidase 24 | 24
transaminase 24 | 24
HMG box transcription factor 22 | 22
cyclase 22 | 22
decarboxylase 21 | 21
gap junction 21 | 21
chaperonin 19 | 19
epimerase/racemase 19 | 19
Hsp70 family chaperone 18 | 18
apolipoprotein 16 | 16
annexin 14 | 14
immunoglobulin superfamily cel... 14 | 14
basic leucine zipper transcrip... 12 | 12
deacetylase 12 | 12
glucosidase 12 | 12
mutase 12 | 12
Hsp90 family chaperone 11 | 11
phosphorylase 11 | 11
hydroxylase 8 | 8
viral coat protein 8 | 8
amylase 6 | 6
galactosidase 6 | 6
immunoglobulin 5 | 5
pyrophosphatase 5 | 5
myelin protein 4 | 4
calsequestrin 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Sex comb on midleg-like protein 2 SCML2 Tbio Epigenetic -1.13986 13.7 93
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Interleukin enhancer-binding factor 3 ILF3 Tbio Non-IDG -2.09543 135.8 239
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64