Development Level

Tclin 18 | 613
Tchem 13 | 1,598
Tbio 10 | 11,445

IMPC Phenotype

abnormal bone structure 3 | 187
increased bone mineral content 3 | 108
increased startle reflex 3 | 112
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
thin ventricular wall 2 | 24
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart looping 1 | 5
abnormal hindbrain development 1 | 16
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal pupil morphology 1 | 2
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal visceral yolk sac mor... 1 | 6
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased cardiac output 1 | 3
decreased circulating alkaline... 1 | 46
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating creatini... 1 | 38
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
pale yolk sac 1 | 25
prolonged QRS complex duration 1 | 8
tremors 1 | 39

Disease

Carcinoma 35 | 11,493
psoriasis 26 | 6,694
osteosarcoma 25 | 7,950
Cancer 21 | 2,499
ovarian cancer 20 | 8,520
medulloblastoma, large-cell 18 | 6,241
malignant mesothelioma 16 | 3,232
lung cancer 15 | 4,740
Endometriosis 14 | 540
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Breast cancer 13 | 3,578
Obesity 13 | 678
group 3 medulloblastoma 13 | 4,104
ductal carcinoma in situ 12 | 1,745
glioblastoma 12 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
invasive ductal carcinoma 12 | 2,951
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
diabetes mellitus 11 | 1,728
interstitial cystitis 11 | 2,312
primitive neuroectodermal tumor 11 | 3,035
ulcerative colitis 11 | 1,819
Acne vulgaris 10 | 14
Bipolar Disorder 10 | 666
Schizophrenia 10 | 1,160
adult high grade glioma 10 | 3,801
atypical teratoid / rhabdoid tumor 10 | 5,112
breast carcinoma 10 | 1,638
adrenocortical carcinoma 9 | 1,428
lung adenocarcinoma 9 | 2,716
pituitary cancer 9 | 1,972
ependymoma 8 | 4,679
group 4 medulloblastoma 8 | 1,855
pancreatic cancer 8 | 2,398
Autosomal recessive predisposition 7 | 1,442
Kaposi's Sarcoma Skin Lesions 7 | 8
Menopausal flushing 7 | 17
Prostatic Neoplasms 7 | 495
astrocytic glioma 7 | 2,597
astrocytoma 7 | 1,146
cystic fibrosis 7 | 1,696
lung carcinoma 7 | 2,843
tuberculosis 7 | 2,010
Adenocarcinoma 6 | 122
Atopic dermatitis 6 | 952
Atrophic vaginitis 6 | 14
Carcinoma, Hepatocellular 6 | 228
Depressive disorder 6 | 409
Female infertility 6 | 30
Hepatomegaly 6 | 285
Hypertension 6 | 396
Hypertensive disease 6 | 292
Kidney cancer 6 | 2,613
Liver carcinoma 6 | 240
Postmenopausal osteoporosis 6 | 19
non-small cell lung cancer 6 | 2,890
oligodendroglioma 6 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Atrophic vulva 5 | 6
Chemical and Drug Induced Liver Injury 5 | 195
Chloasma 5 | 6
Cholestasis 5 | 155
Contraception 5 | 15
Fatty Liver 5 | 70
Female hypogonadism syndrome 5 | 25
Heart disease 5 | 306
Hyperinsulinism 5 | 133
Infertility, Female 5 | 28
Insulin Resistance 5 | 72
Liver neoplasms 5 | 130
Mental Depression 5 | 333
Mood Disorders 5 | 184
Osteoporosis 5 | 363
Premenstrual dysphoric disorder 5 | 8
cutaneous lupus erythematosus 5 | 1,057
subependymal giant cell astrocytoma 5 | 2,287
Acquired metabolic disease 4 | 336
Adenoma 4 | 167
Astrocytoma, Pilocytic 4 | 3,081
Atherosclerosis 4 | 291
Coronary artery disease 4 | 268
Infertility 4 | 188
Inflammatory bowel disease 4 | 151
Kidney disease 4 | 430
Lipid metabolism disorder 4 | 114
Liver disease 4 | 237
Major Depressive Disorder 4 | 301
Pick disease 4 | 1,894
Primary cutaneous T-cell lymphoma 4 | 29
Unipolar Depression 4 | 250
atypical teratoid/rhabdoid tumor 4 | 357
chronic rhinosinusitis 4 | 512
colon cancer 4 | 1,478
esophageal adenocarcinoma 4 | 737
gastric cancer 4 | 459
nephrosclerosis 4 | 333
primary pancreatic ductal adenocarcinoma 4 | 1,109
urothelial carcinoma 4 | 318

Tissue

Endocrine System 41 | 18,159
Skin and soft tissues 41 | 17,230
Blood and immune system 40 | 16,909
Digestive Tract 40 | 17,369
Female tissues 40 | 17,400
Male tissues 40 | 17,142
Respiratory system 40 | 16,393
Urinary Tract 40 | 16,678
Liver and Pancreas 39 | 16,750
Nervous System 39 | 16,725
Cardiovascular System 36 | 15,192

Target Family

Nuclear Receptor 41 | 48

PANTHER Protein Class (1)

C4 zinc finger nuclear recepto... 41 | 41
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Photoreceptor-specific nuclear receptor NR2E3 Tbio Nuclear Receptor 0.00000 261
Steroid hormone receptor ERR2 ESRRB Tchem Nuclear Receptor -1.95523 86.9 173
Nuclear receptor subfamily 2 group C member 1 NR2C1 Tbio Nuclear Receptor -1.39182 24.4 294
Estrogen-related receptor gamma ESRRG Tchem Nuclear Receptor -2.16790 159.1 328
Retinoic acid receptor RXR-beta RXRB Tclin Nuclear Receptor -1.72557 49.3 274
Nuclear receptor subfamily 4 group A member 2 NR4A2 Tchem Nuclear Receptor -2.59490 415.4 307
Nuclear receptor subfamily 6 group A member 1 NR6A1 Tbio Nuclear Receptor -2.36193 227.5 236
COUP transcription factor 1 NR2F1 Tbio Nuclear Receptor -2.00427 106.7 184
Mineralocorticoid receptor NR3C2 Tclin Nuclear Receptor -3.08863 1005.8 203
Estrogen receptor beta ESR2 Tclin Nuclear Receptor -3.57388 3765.2 1096