Development Level

Tbio 379 | 10,625
Tclin 142 | 602
Tchem 125 | 1,890
Tdark 121 | 7,003

Collection

Eligible Ion Channel Proteins 83 | 117
Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 26 | 633
abnormal behavior 12 | 226
embryonic lethality prior to t... 11 | 187
preweaning lethality, incomple... 11 | 260
embryonic lethality prior to o... 9 | 148
increased mean corpuscular hem... 9 | 93
decreased body weight 8 | 174
decreased total body fat amoun... 8 | 186
increased mean corpuscular vol... 7 | 91
decreased bone mineral density 6 | 126
decreased lean body mass 6 | 195
decreased rib number 6 | 59
hyperactivity 6 | 108
increased circulating alkaline... 6 | 119
abnormal bone structure 5 | 131
abnormal embryo size 5 | 112
abnormal retina morphology 5 | 100
decreased circulating alkaline... 5 | 41
decreased circulating glucose ... 5 | 121
decreased circulating serum al... 5 | 79
decreased prepulse inhibition 5 | 52
increased bone mineral density 5 | 52
increased circulating sodium l... 5 | 71
abnormal epididymis morphology 4 | 31
abnormal eye morphology 4 | 38
abnormal gait 4 | 51
abnormal retinal pigmentation 4 | 61
decreased bone mineral content 4 | 157
decreased circulating triglyce... 4 | 83
decreased erythrocyte cell num... 4 | 43
decreased grip strength 4 | 123
decreased mean corpuscular vol... 4 | 50
enlarged heart 4 | 111
increased circulating HDL chol... 4 | 63
increased circulating choleste... 4 | 53
increased grip strength 4 | 83
increased sacral vertebrae num... 4 | 62
increased startle reflex 4 | 38
abnormal rib morphology 3 | 28
abnormal thoracic vertebrae mo... 3 | 16
absent vibrissae 3 | 14
cardiovascular system phenotyp... 3 | 35
decreased caudal vertebrae num... 3 | 49
decreased circulating amylase ... 3 | 24
decreased circulating sodium l... 3 | 18
decreased circulating total pr... 3 | 41
decreased hemoglobin content 3 | 53
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
enlarged epididymis 3 | 27
hypoactivity 3 | 89
impaired glucose tolerance 3 | 52
improved glucose tolerance 3 | 56
increased blood urea nitrogen ... 3 | 44
increased body weight 3 | 42
increased bone mineral content 3 | 92
increased caudal vertebrae num... 3 | 8
increased circulating chloride... 3 | 43
increased circulating potassiu... 3 | 31
increased circulating serum al... 3 | 25
increased exploration in new e... 3 | 56
increased fasted circulating g... 3 | 68
increased or absent threshold ... 3 | 128
increased prepulse inhibition 3 | 21
increased rib number 3 | 41
limb grasping 3 | 35
short tibia 3 | 82
straub tail 3 | 26
abnormal coat appearance 2 | 25
abnormal coping response 2 | 12
abnormal cornea morphology 2 | 24
abnormal eye size 2 | 11
abnormal heart morphology 2 | 51
abnormal lens morphology 2 | 73
abnormal lung morphology 2 | 15
abnormal neural tube closure 2 | 37
abnormal response to new envir... 2 | 8
corneal opacity 2 | 25
decreased CD4-positive, alpha ... 2 | 19
decreased blood urea nitrogen ... 2 | 31
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating calcium ... 2 | 33
decreased circulating choleste... 2 | 85
decreased circulating glycerol... 2 | 19
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased total retina thickne... 2 | 20
impaired righting response 2 | 19
increased circulating alanine ... 2 | 11
increased circulating aspartat... 2 | 17
increased circulating iron lev... 2 | 25
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 25
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
small adrenal glands 2 | 15
vertebral fusion 2 | 23

Disease

ovarian cancer 314 | 8,484
osteosarcoma 308 | 7,933
medulloblastoma, large-cell 288 | 6,234
psoriasis 279 | 6,685
glioblastoma 263 | 5,572
atypical teratoid / rhabdoid tumor 202 | 4,369
lung cancer 190 | 4,466
Carcinoma 183 | 2,147
lung carcinoma 167 | 2,844
pilocytic astrocytoma 163 | 3,086
oligodendroglioma 158 | 2,849
primitive neuroectodermal tumor 157 | 3,031
pediatric high grade glioma 155 | 2,712
ependymoma 132 | 2,514
malignant mesothelioma 126 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 122 | 2,956
lung adenocarcinoma 119 | 2,713
astrocytic glioma 117 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 117 | 3,289
subependymal giant cell astrocytoma 111 | 2,287
Breast cancer 110 | 3,094
non-small cell lung cancer 110 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 107 | 2,988
Pick disease 102 | 1,893
pituitary cancer 102 | 1,972
invasive ductal carcinoma 99 | 2,950
Epilepsy 97 | 346
interstitial cystitis 92 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 91 | 1,795
adult high grade glioma 90 | 2,148
pancreatic cancer 90 | 2,300
cystic fibrosis 85 | 1,665
ulcerative colitis 84 | 2,087
group 3 medulloblastoma 78 | 2,254
group 4 medulloblastoma 76 | 1,875
colon cancer 75 | 1,475
posterior fossa group A ependymoma 74 | 1,511
medulloblastoma 73 | 1,524
sonic hedgehog group medulloblastoma 72 | 1,482
astrocytoma 66 | 1,493
atypical teratoid/rhabdoid tumor 64 | 1,095
ductal carcinoma in situ 64 | 1,745
posterior fossa group B ependymoma 62 | 1,530
active Crohn's disease 60 | 918
adrenocortical carcinoma 54 | 1,427
tuberculosis 54 | 1,557
Cancer 53 | 2,346
Schizophrenia 51 | 501
Multiple Sclerosis 49 | 498
breast carcinoma 48 | 1,614
diabetes mellitus 46 | 1,663
Multiple myeloma 44 | 1,327
primary pancreatic ductal adenocarcinoma 43 | 1,271
non primary Sjogren syndrome sicca 42 | 840
Alzheimer's disease 41 | 644
Parkinson's disease 41 | 364
nasopharyngeal carcinoma 41 | 1,056
Eaton-Lambert syndrome 40 | 40
Rheumatoid Arthritis 40 | 1,160
General anesthesia 39 | 53
progressive supranuclear palsy 39 | 674
active ulcerative colitis 38 | 477
acute quadriplegic myopathy 38 | 1,157
cutaneous lupus erythematosus 38 | 1,056
Intellectual disability 36 | 573
Tonic-clonic epilepsy 35 | 47
Colorectal Neoplasms 33 | 217
juvenile dermatomyositis 33 | 1,189
Autistic Disorder 32 | 320
gastric carcinoma 32 | 832
Atopic dermatitis 31 | 944
Atrial Fibrillation 31 | 110
Bipolar Disorder 31 | 266
Local anesthesia 31 | 40
spina bifida 31 | 1,064
primary Sjogren syndrome 30 | 789
Neurodegenerative disease 28 | 383
aldosterone-producing adenoma 28 | 664
dermatomyositis 27 | 933
Endometriosis 26 | 535
Lennox-Gastaut syndrome 25 | 34
Waldenstrons macroglobulinemia 24 | 765
esophageal adenocarcinoma 24 | 737
Epilepsy characterized by intractable complex partial seizures 23 | 28
Obesity 23 | 616
Simple partial seizure 23 | 26
fibroadenoma 23 | 557
nephrosclerosis 23 | 329
Alcohol dependence 22 | 107
Amyotrophic Lateral Sclerosis 22 | 431
Duchenne muscular dystrophy 22 | 602
Hypertension 22 | 287
Status Epilepticus 22 | 85
Nicotine dependence 21 | 53
acute myeloid leukemia 21 | 780
non-small cell lung carcinoma 21 | 413
Long QT syndrome 20 | 52
pancreatic carcinoma 20 | 567
Down syndrome 19 | 548
tuberculosis and treatment for 6 months 19 | 686

Tissue

Endocrine System 761 | 18,512
Nervous System 761 | 18,561
Female tissues 760 | 18,647
Urinary Tract 759 | 18,444
Digestive Tract 757 | 18,473
Liver and Pancreas 753 | 18,136
Skin and soft tissues 750 | 18,115
Cardiovascular System 748 | 17,958
Blood and immune system 745 | 17,995
Male tissues 741 | 17,969
Respiratory system 728 | 17,484

Target Family

Transporter 313 | 473
Ion Channel 258 | 341
Non-IDG 135 | 11,971
Enzyme 50 | 4,146
GPCR 8 | 406
Kinase 3 | 634

PANTHER Protein Class (0)

transporter 767 | 767
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
signaling molecule 820 | 820
enzyme modulator 713 | 713
hydrolase 631 | 631
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Taste receptor type 1 member 3 TAS1R3 Tbio GPCR -2.19758 165.4 232
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165
Monocarboxylate transporter 14 SLC16A14 Tdark Transporter -0.69265 4.88 34
Monocarboxylate transporter 13 SLC16A13 Tdark Transporter -0.40437 1.87 71
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18
Equilibrative nucleoside transporter 4 SLC29A4 Tbio Transporter -1.79381 73.1 189
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20