Development Level

Tbio 419 | 10,625
Tchem 287 | 1,890
Tdark 136 | 7,003
Tclin 31 | 602

Collection

Eligible Kinase Proteins 82 | 134

IMPC Term

preweaning lethality, complete... 40 | 633
embryonic lethality prior to t... 14 | 187
preweaning lethality, incomple... 13 | 260
embryonic lethality prior to o... 11 | 148
abnormal behavior 10 | 226
abnormal embryo size 7 | 112
decreased circulating serum al... 7 | 79
decreased lean body mass 7 | 195
abnormal lens morphology 6 | 73
abnormal retina morphology 6 | 100
decreased bone mineral content 6 | 157
decreased circulating glucose ... 6 | 121
decreased body length 5 | 108
decreased body weight 5 | 174
hypoactivity 5 | 89
increased or absent threshold ... 5 | 128
increased sacral vertebrae num... 5 | 62
abnormal behavioral response t... 4 | 52
decreased eosinophil cell numb... 4 | 41
decreased lumbar vertebrae num... 4 | 62
decreased prepulse inhibition 4 | 52
decreased total body fat amoun... 4 | 186
hyperactivity 4 | 108
increased bone mineral content 4 | 92
increased exploration in new e... 4 | 56
increased grip strength 4 | 83
increased hemoglobin content 4 | 45
increased total body fat amoun... 4 | 57
abnormal bone mineralization 3 | 55
abnormal bone structure 3 | 131
abnormal coat/hair pigmentatio... 3 | 54
abnormal eye morphology 3 | 38
abnormal kidney morphology 3 | 30
abnormal rib morphology 3 | 28
abnormal sleep behavior 3 | 63
abnormal tooth morphology 3 | 24
decreased circulating creatini... 3 | 31
decreased fasted circulating g... 3 | 49
decreased startle reflex 3 | 48
enlarged heart 3 | 111
enlarged lymph nodes 3 | 27
increased body weight 3 | 42
increased circulating alkaline... 3 | 119
increased circulating chloride... 3 | 43
increased circulating choleste... 3 | 53
increased circulating serum al... 3 | 25
increased lean body mass 3 | 107
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased neutrophil cell numb... 3 | 15
short tibia 3 | 82
small testis 3 | 37
abnormal femur morphology 2 | 14
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal lumbar vertebrae morp... 2 | 6
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal response to tactile s... 2 | 16
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
abnormal spleen morphology 2 | 36
abnormal tail movements 2 | 12
abnormal testis morphology 2 | 30
absent vibrissae 2 | 14
cataract 2 | 26
decreased NK T cell number 2 | 28
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 53
decreased circulating alkaline... 2 | 41
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating fructosa... 2 | 31
decreased circulating glycerol... 2 | 19
decreased grip strength 2 | 123
decreased neutrophil cell numb... 2 | 37
embryonic growth retardation 2 | 28
enlarged spleen 2 | 26
hydrops fetalis 2 | 22
improved glucose tolerance 2 | 56
increased circulating HDL chol... 2 | 63
increased circulating fructosa... 2 | 11
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
long tibia 2 | 13
microphthalmia 2 | 15
small seminal vesicle 2 | 6
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
decreased effector memory CD8-... 1 | 24
decreased mean corpuscular vol... 1 | 50
decreased pulmonary respirator... 1 | 4
decreased red blood cell distr... 1 | 11
female infertility 1 | 34
persistence of hyaloid vascula... 1 | 22
straub tail 1 | 26

Disease

ovarian cancer 430 | 8,484
osteosarcoma 404 | 7,933
psoriasis 322 | 6,685
medulloblastoma, large-cell 300 | 6,234
glioblastoma 275 | 5,572
atypical teratoid / rhabdoid tumor 214 | 4,369
lung cancer 209 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 175 | 3,289
malignant mesothelioma 165 | 3,162
pilocytic astrocytoma 158 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 157 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 155 | 2,956
primitive neuroectodermal tumor 139 | 3,031
Breast cancer 137 | 3,094
oligodendroglioma 134 | 2,849
invasive ductal carcinoma 131 | 2,950
lung adenocarcinoma 131 | 2,713
ependymoma 129 | 2,514
lung carcinoma 129 | 2,844
Cancer 126 | 2,346
non-small cell lung cancer 125 | 2,798
pediatric high grade glioma 123 | 2,712
astrocytic glioma 114 | 2,241
subependymal giant cell astrocytoma 113 | 2,287
interstitial cystitis 110 | 2,299
adult high grade glioma 109 | 2,148
group 3 medulloblastoma 107 | 2,254
ulcerative colitis 105 | 2,087
pancreatic cancer 104 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 100 | 1,795
Pick disease 97 | 1,893
group 4 medulloblastoma 96 | 1,875
posterior fossa group B ependymoma 86 | 1,530
medulloblastoma 85 | 1,524
pituitary cancer 85 | 1,972
tuberculosis 81 | 1,557
astrocytoma 78 | 1,493
cystic fibrosis 78 | 1,665
Carcinoma 76 | 2,147
ductal carcinoma in situ 73 | 1,745
Multiple myeloma 72 | 1,327
adrenocortical carcinoma 70 | 1,427
diabetes mellitus 67 | 1,663
posterior fossa group A ependymoma 67 | 1,511
breast carcinoma 62 | 1,614
colon cancer 62 | 1,475
primary pancreatic ductal adenocarcinoma 60 | 1,271
Rheumatoid Arthritis 59 | 1,160
juvenile dermatomyositis 54 | 1,189
atypical teratoid/rhabdoid tumor 52 | 1,095
sonic hedgehog group medulloblastoma 52 | 1,482
Waldenstrons macroglobulinemia 50 | 765
dermatomyositis 48 | 933
active Crohn's disease 47 | 918
Atopic dermatitis 45 | 944
acute quadriplegic myopathy 45 | 1,157
nasopharyngeal carcinoma 45 | 1,056
cutaneous lupus erythematosus 43 | 1,056
esophageal adenocarcinoma 42 | 737
gastric carcinoma 42 | 832
Obesity 40 | 616
acute myeloid leukemia 40 | 780
progressive supranuclear palsy 40 | 674
IGA Glomerulonephritis 39 | 454
spina bifida 39 | 1,064
primary Sjogren syndrome 38 | 789
aldosterone-producing adenoma 37 | 664
Schizophrenia 36 | 501
non primary Sjogren syndrome sicca 36 | 840
tuberculosis and treatment for 6 months 35 | 686
Alzheimer's disease 32 | 644
Renal Cell Carcinoma 30 | 199
Down syndrome 29 | 548
Intellectual disability 29 | 573
Prostatic Neoplasms 29 | 471
fibroadenoma 29 | 557
hepatocellular carcinoma 27 | 532
pancreatic carcinoma 27 | 567
Chronic Myelocytic Leukemia Accelerated Phase 24 | 59
Blastic phase chronic myeloid leukemia 23 | 58
Endometriosis 23 | 535
Neurodegenerative disease 23 | 383
Philadelphia chromosome-positive acute lymphoblastic leukemia 22 | 47
gastric cancer 22 | 430
Chronic phase chronic myeloid leukemia 21 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 21 | 45
active ulcerative colitis 21 | 477
Amyotrophic Lateral Sclerosis 20 | 431
Chronic Lymphocytic Leukemia 20 | 242
Gastrointestinal stromal tumor 20 | 61
Parkinson's disease 20 | 364
mucosa-associated lymphoid tissue lymphoma 20 | 480
chronic rhinosinusitis 19 | 512
nephrosclerosis 19 | 329
non-small cell lung carcinoma 19 | 413
Congenital disorder of glycosylation 18 | 53
Peripheral Neuropathy 18 | 303
Duchenne muscular dystrophy 17 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 499
tuberculosis and treatment for 3 months 17 | 327

Tissue

Digestive Tract 857 | 18,473
Nervous System 856 | 18,561
Urinary Tract 856 | 18,444
Endocrine System 854 | 18,512
Female tissues 854 | 18,647
Liver and Pancreas 854 | 18,136
Blood and immune system 851 | 17,995
Skin and soft tissues 847 | 18,115
Cardiovascular System 841 | 17,958
Male tissues 841 | 17,969
Respiratory system 828 | 17,484

Target Family

Enzyme 453 | 4,146
Kinase 339 | 634
Non-IDG 70 | 11,971
Epigenetic 11 | 242

PANTHER Protein Class (0)

transferase 873 | 873
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
signaling molecule 820 | 820
transporter 767 | 767
enzyme modulator 713 | 713
hydrolase 631 | 631
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

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