Development Level

Tbio 768 | 11,651
Tdark 226 | 6,593
Tchem 60 | 1,388
Tclin 19 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 54 | 979
preweaning lethality, incomple... 33 | 499
abnormal embryo size 18 | 220
embryonic lethality prior to t... 14 | 278
abnormal behavior 13 | 298
decreased total body fat amoun... 13 | 207
abnormal bone structure 12 | 187
abnormal heart morphology 12 | 162
decreased vertical activity 12 | 208
decreased circulating glucose ... 11 | 126
increased bone mineral content 11 | 108
increased lean body mass 11 | 172
enlarged heart 10 | 210
increased bone mineral density 10 | 72
decreased body length 8 | 101
hyperactivity 8 | 148
increased startle reflex 8 | 112
prenatal lethality prior to he... 8 | 87
abnormal retina morphology 7 | 71
decreased body weight 7 | 161
decreased caudal vertebrae num... 7 | 53
decreased lean body mass 7 | 135
embryonic lethality prior to o... 7 | 239
increased circulating alkaline... 7 | 122
increased total body fat amoun... 7 | 134
decreased circulating serum al... 6 | 82
decreased circulating triglyce... 6 | 79
decreased grip strength 6 | 116
embryonic growth retardation 6 | 106
female infertility 6 | 60
increased mean corpuscular hem... 6 | 96
increased or absent threshold ... 6 | 101
short tibia 6 | 97
abnormal coat-hair pigmentatio... 5 | 64
abnormal craniofacial morpholo... 5 | 33
abnormal kidney morphology 5 | 65
abnormal seminal vesicle morph... 5 | 114
decreased bone mineral content 5 | 151
decreased bone mineral density 5 | 126
decreased hemoglobin content 5 | 68
impaired glucose tolerance 5 | 75
increased circulating HDL chol... 5 | 80
increased circulating sodium l... 5 | 71
increased hemoglobin content 5 | 45
increased mean corpuscular vol... 5 | 92
male infertility 5 | 123
abnormal behavioral response t... 4 | 66
abnormal eye morphology 4 | 68
abnormal gait 4 | 69
decreased blood urea nitrogen ... 4 | 51
decreased circulating choleste... 4 | 93
decreased circulating total pr... 4 | 49
decreased erythrocyte cell num... 4 | 62
decreased fasted circulating g... 4 | 65
decreased hematocrit 4 | 46
hydrometra 4 | 53
hypoactivity 4 | 132
increased body length 4 | 32
increased circulating aspartat... 4 | 15
increased erythrocyte cell num... 4 | 39
increased prepulse inhibition 4 | 32
mammalian phenotype 4 | 17
small superior vagus ganglion 4 | 74
thrombocytopenia 4 | 56
abnormal bone mineralization 3 | 38
abnormal cornea morphology 3 | 31
abnormal cranium morphology 3 | 36
abnormal facial morphology 3 | 17
abnormal neural tube closure 3 | 46
abnormal sleep behavior 3 | 70
abnormal tail morphology 3 | 25
corneal opacity 3 | 32
decreased T cell number 3 | 15
decreased circulating HDL chol... 3 | 68
decreased circulating alanine ... 3 | 47
decreased circulating alkaline... 3 | 46
decreased circulating aspartat... 3 | 34
decreased circulating bilirubi... 3 | 19
decreased circulating chloride... 3 | 30
decreased circulating insulin ... 3 | 76
decreased circulating potassiu... 3 | 20
decreased heart left ventricle... 3 | 28
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular vol... 3 | 79
edema 3 | 59
hemorrhage 3 | 23
improved glucose tolerance 3 | 79
increased anti-nuclear antigen... 3 | 19
increased circulating chloride... 3 | 41
increased circulating creatini... 3 | 38
increased circulating potassiu... 3 | 29
increased neutrophil cell numb... 3 | 46
microphthalmia 3 | 26
thin ventricular wall 3 | 24
thrombocytosis 3 | 27
vertebral transformation 3 | 12
abnormal epididymis morphology 2 | 42
abnormal retinal vasculature m... 2 | 27
increased monocyte cell number 2 | 63
small testis 2 | 58

Disease

Carcinoma 680 | 11,493
osteosarcoma 517 | 7,950
ovarian cancer 504 | 8,520
psoriasis 388 | 6,694
medulloblastoma, large-cell 377 | 6,241
glioblastoma 338 | 5,792
lung cancer 308 | 4,740
atypical teratoid / rhabdoid tumor 299 | 5,112
group 3 medulloblastoma 268 | 4,104
Cancer 263 | 2,499
Breast cancer 239 | 3,578
ependymoma 234 | 4,679
malignant mesothelioma 214 | 3,232
primitive neuroectodermal tumor 186 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 183 | 3,291
invasive ductal carcinoma 182 | 2,951
adult high grade glioma 181 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 175 | 2,989
oligodendroglioma 170 | 2,850
Kidney cancer 168 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 164 | 2,955
non-small cell lung cancer 155 | 2,890
Astrocytoma, Pilocytic 148 | 3,081
lung adenocarcinoma 145 | 2,716
astrocytic glioma 143 | 2,597
pancreatic cancer 141 | 2,398
group 4 medulloblastoma 136 | 1,855
interstitial cystitis 136 | 2,312
lung carcinoma 129 | 2,843
pituitary cancer 127 | 1,972
subependymal giant cell astrocytoma 122 | 2,287
tuberculosis 115 | 2,010
ductal carcinoma in situ 113 | 1,745
breast carcinoma 109 | 1,638
Pick disease 102 | 1,894
ulcerative colitis 99 | 1,819
cystic fibrosis 97 | 1,696
astrocytoma 93 | 1,146
adrenocortical carcinoma 89 | 1,428
juvenile dermatomyositis 89 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 86 | 1,962
Rheumatoid arthritis 85 | 1,191
diabetes mellitus 81 | 1,728
Intellectual disability 79 | 1,016
acute quadriplegic myopathy 79 | 1,158
colon cancer 78 | 1,478
pediatric high grade glioma 77 | 1,064
primary pancreatic ductal adenocarcinoma 76 | 1,109
Multiple myeloma 70 | 1,332
acute myeloid leukemia 67 | 783
spina bifida 62 | 1,074
Schizophrenia 60 | 1,160
dermatomyositis 60 | 966
cutaneous lupus erythematosus 58 | 1,057
aldosterone-producing adenoma 55 | 665
Autosomal recessive predisposition 52 | 1,442
Dull intelligence 52 | 645
Low intelligence 52 | 645
Mental Retardation 52 | 645
Mental deficiency 52 | 645
Obesity 52 | 678
Poor school performance 52 | 645
medulloblastoma 52 | 720
Short stature 51 | 531
Breast Neoplasms 49 | 445
Atopic dermatitis 48 | 952
Mammary Neoplasms 48 | 425
non primary Sjogren syndrome sicca 48 | 891
primary Sjogren syndrome 48 | 735
Cleft Palate 47 | 271
Prostatic Neoplasms 47 | 495
Bipolar Disorder 46 | 666
Cognitive delay 44 | 608
Global developmental delay 44 | 608
Mental and motor retardation 44 | 608
Waldenstrons macroglobulinemia 44 | 765
Epilepsy 43 | 792
gastric cancer 41 | 459
gastric carcinoma 41 | 807
Endometriosis 40 | 540
nasopharyngeal carcinoma 39 | 1,058
Seizures 38 | 596
active Crohn's disease 38 | 922
active ulcerative colitis 38 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 38 | 510
hepatocellular carcinoma 38 | 547
Craniofacial Abnormalities 37 | 151
Muscle hypotonia 36 | 571
sonic hedgehog group medulloblastoma 36 | 467
Acquired metabolic disease 35 | 336
Alzheimer's disease 35 | 658
Cryptorchidism 35 | 296
Small head 35 | 374
Strabismus 35 | 270
esophageal adenocarcinoma 35 | 737
progressive supranuclear palsy 34 | 676
Crohn's disease 33 | 321
fibroadenoma 33 | 559
Liver cancer 32 | 604
Multiple Sclerosis 32 | 540

Tissue

Endocrine System 1,022 | 18,159
Digestive Tract 978 | 17,369
Skin and soft tissues 972 | 17,230
Female tissues 970 | 17,400
Male tissues 963 | 17,142
Nervous System 949 | 16,725
Blood and immune system 947 | 16,909
Liver and Pancreas 930 | 16,750
Urinary Tract 925 | 16,678
Respiratory system 918 | 16,393
Cardiovascular System 860 | 15,192

Target Family

Transcription Factor 633 | 1,400
Non-IDG 283 | 12,091
Epigenetic 61 | 242
Nuclear Receptor 43 | 48
Enzyme 37 | 4,145
TF/Epigenetic 13 | 38
Kinase 2 | 634
Transporter 1 | 473

PANTHER Protein Class (0)

transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
hydrolase 762 | 762
enzyme modulator 645 | 645
transferase 625 | 625
transporter 580 | 580
signaling molecule 554 | 554
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 236 ZNF236 Tbio Transcription Factor -0.40816 2.56 30
Homeobox protein SIX6 SIX6 Tbio Transcription Factor -2.23077 163.2 112
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
ETS-related transcription factor Elf-2 ELF2 Tbio Transcription Factor -2.04794 106.4 92
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Teashirt homolog 2 TSHZ2 Tbio Non-IDG -0.01649 0.78 90
Lysine-specific demethylase 4E KDM4E Tchem Epigenetic -0.86891 5.72 23
Nuclear factor erythroid 2-related factor 1 NFE2L1 Tbio Transcription Factor -1.57346 40.9 157
Zinc finger protein 407 ZNF407 Tdark Transcription Factor -0.68124 3.81 38
CCAAT/enhancer-binding protein epsilon CEBPE Tbio Transcription Factor -1.71776 57.4 246