Development Level

Tbio 969 | 10,625
Tdark 443 | 7,003
Tchem 104 | 1,890
Tclin 17 | 602

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 44 | 633
preweaning lethality, incomple... 26 | 260
abnormal behavior 15 | 226
decreased body weight 15 | 174
decreased lean body mass 15 | 195
abnormal bone structure 13 | 131
decreased total body fat amoun... 13 | 186
embryonic lethality prior to t... 13 | 187
decreased grip strength 12 | 123
decreased body length 11 | 108
increased circulating alkaline... 11 | 119
abnormal embryo size 10 | 112
abnormal retina morphology 10 | 100
decreased caudal vertebrae num... 10 | 49
increased bone mineral content 10 | 92
decreased circulating triglyce... 9 | 83
hypoactivity 9 | 89
increased mean corpuscular vol... 9 | 91
increased or absent threshold ... 9 | 128
decreased hemoglobin content 8 | 53
increased lean body mass 8 | 107
increased sacral vertebrae num... 8 | 62
abnormal eye morphology 7 | 38
decreased bone mineral content 7 | 157
decreased circulating serum al... 7 | 79
prenatal lethality prior to he... 7 | 64
short tibia 7 | 82
abnormal bone mineralization 6 | 55
abnormal gait 6 | 51
abnormal sleep behavior 6 | 63
decreased circulating choleste... 6 | 85
decreased circulating glucose ... 6 | 121
decreased erythrocyte cell num... 6 | 43
decreased lumbar vertebrae num... 6 | 62
embryonic lethality prior to o... 6 | 148
enlarged heart 6 | 111
hyperactivity 6 | 108
increased exploration in new e... 6 | 56
increased mean corpuscular hem... 6 | 93
abnormal cornea morphology 5 | 24
abnormal retinal pigmentation 5 | 61
decreased bone mineral density 5 | 126
decreased circulating HDL chol... 5 | 77
decreased hematocrit 5 | 25
increased circulating HDL chol... 5 | 63
increased grip strength 5 | 83
increased startle reflex 5 | 38
thrombocytopenia 5 | 46
vertebral transformation 5 | 12
abnormal coat-hair pigmentatio... 4 | 54
abnormal forebrain development 4 | 18
abnormal heart morphology 4 | 51
abnormal hindbrain development 4 | 24
abnormal locomotor activation 4 | 26
abnormal neural tube closure 4 | 37
decreased circulating alkaline... 4 | 41
decreased circulating insulin ... 4 | 75
decreased circulating total pr... 4 | 41
decreased fasted circulating g... 4 | 49
decreased rib number 4 | 59
increased circulating choleste... 4 | 53
increased circulating creatini... 4 | 29
increased circulating sodium l... 4 | 71
increased hemoglobin content 4 | 45
persistence of hyaloid vascula... 4 | 22
abnormal behavioral response t... 3 | 52
abnormal kidney morphology 3 | 30
abnormal lens morphology 3 | 73
abnormal midbrain development 3 | 22
abnormal rib morphology 3 | 28
abnormal seminal vesicle morph... 3 | 47
abnormal tail morphology 3 | 17
abnormal vertebral arch morpho... 3 | 9
corneal opacity 3 | 25
decreased B cell number 3 | 30
decreased anxiety-related resp... 3 | 12
decreased circulating LDL chol... 3 | 37
decreased circulating alanine ... 3 | 53
decreased circulating chloride... 3 | 32
decreased circulating free fat... 3 | 39
decreased heart weight 3 | 44
decreased leukocyte cell numbe... 3 | 54
decreased mean corpuscular hem... 3 | 34
decreased mean corpuscular vol... 3 | 50
decreased neutrophil cell numb... 3 | 37
decreased prepulse inhibition 3 | 52
decreased thermal nociceptive ... 3 | 4
impaired glucose tolerance 3 | 52
increased B cell number 3 | 23
increased T cell number 3 | 15
increased body length 3 | 20
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating glucose ... 3 | 16
increased circulating triglyce... 3 | 24
increased mean corpuscular hem... 3 | 25
increased thermal nociceptive ... 3 | 9
increased total body fat amoun... 3 | 57
vertebral fusion 3 | 23
abnormal head morphology 2 | 10

Disease

osteosarcoma 696 | 7,933
ovarian cancer 659 | 8,491
psoriasis 533 | 6,685
medulloblastoma, large-cell 525 | 6,234
glioblastoma 432 | 5,572
lung cancer 374 | 4,473
atypical teratoid / rhabdoid tumor 354 | 4,369
malignant mesothelioma 282 | 3,163
Cancer 281 | 2,346
primitive neuroectodermal tumor 269 | 3,031
Breast cancer 263 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 232 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 228 | 2,988
invasive ductal carcinoma 225 | 2,950
group 4 medulloblastoma 219 | 1,875
oligodendroglioma 217 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 211 | 2,956
pediatric high grade glioma 203 | 2,712
pilocytic astrocytoma 197 | 3,086
Carcinoma 191 | 2,147
non-small cell lung cancer 191 | 2,798
group 3 medulloblastoma 187 | 2,254
lung carcinoma 183 | 2,844
ependymoma 179 | 2,514
interstitial cystitis 176 | 2,299
pituitary cancer 173 | 1,972
astrocytic glioma 172 | 2,241
lung adenocarcinoma 170 | 2,714
pancreatic cancer 163 | 2,300
subependymal giant cell astrocytoma 158 | 2,287
Pick disease 151 | 1,893
adult high grade glioma 146 | 2,148
sonic hedgehog group medulloblastoma 144 | 1,482
ulcerative colitis 141 | 2,087
ductal carcinoma in situ 134 | 1,745
astrocytoma 131 | 1,493
breast carcinoma 131 | 1,614
medulloblastoma 127 | 1,524
cystic fibrosis 125 | 1,670
tuberculosis 122 | 1,563
Rheumatoid Arthritis 117 | 1,170
posterior fossa group A ependymoma 117 | 1,511
colon cancer 111 | 1,475
diabetes mellitus 109 | 1,663
juvenile dermatomyositis 106 | 1,189
adrenocortical carcinoma 102 | 1,427
primary pancreatic ductal adenocarcinoma 102 | 1,271
spina bifida 102 | 1,064
acute quadriplegic myopathy 98 | 1,157
posterior fossa group B ependymoma 97 | 1,530
pancreatic ductal adenocarcinoma liver metastasis 94 | 1,795
acute myeloid leukemia 88 | 785
Multiple myeloma 87 | 1,327
atypical teratoid/rhabdoid tumor 84 | 1,095
cutaneous lupus erythematosus 80 | 1,056
dermatomyositis 78 | 966
aldosterone-producing adenoma 68 | 664
non primary Sjogren syndrome sicca 65 | 840
primary Sjogren syndrome 65 | 788
Intellectual disability 62 | 573
Obesity 60 | 616
gastric carcinoma 59 | 832
active Crohn's disease 58 | 918
Waldenstrons macroglobulinemia 55 | 764
nasopharyngeal carcinoma 52 | 1,056
tuberculosis and treatment for 6 months 51 | 686
Mammary Neoplasms 50 | 410
hepatocellular carcinoma 50 | 550
esophageal adenocarcinoma 49 | 737
Craniofacial Abnormalities 48 | 147
Atopic dermatitis 47 | 944
Prostatic Neoplasms 46 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 45 | 499
progressive supranuclear palsy 44 | 674
Amyotrophic Lateral Sclerosis 41 | 432
pancreatic carcinoma 41 | 567
Endometriosis 40 | 535
Down syndrome 39 | 548
gastric cancer 39 | 436
Alzheimer's disease 38 | 644
Cleft palate 38 | 125
Acquired metabolic disease 36 | 267
active ulcerative colitis 36 | 477
Crohn's disease 35 | 304
fibroadenoma 35 | 557
chronic rhinosinusitis 34 | 512
inflammatory breast cancer 34 | 404
Multiple Sclerosis 33 | 498
Duchenne muscular dystrophy 32 | 602
Schizophrenia 31 | 503
glioblastoma multiforme 31 | 347
Polycystic Ovary Syndrome 30 | 334
chronic lymphocytic leukemia 29 | 244
facioscapulohumeral dystrophy 29 | 286
Kidney disease 28 | 397
Liver carcinoma 28 | 217
nephrosclerosis 28 | 329
Prostate cancer 27 | 172
chronic lymphosyte leukemia 27 | 232
urothelial carcinoma 27 | 318

Tissue

Nervous System 1,494 | 18,560
Endocrine System 1,493 | 18,511
Female tissues 1,492 | 18,646
Digestive Tract 1,488 | 18,472
Urinary Tract 1,473 | 18,443
Male tissues 1,465 | 17,968
Skin and soft tissues 1,459 | 18,114
Blood and immune system 1,456 | 17,994
Liver and Pancreas 1,455 | 18,135
Cardiovascular System 1,445 | 17,957
Respiratory system 1,387 | 17,483

Target Family

Transcription Factor 921 | 1,400
Non-IDG 408 | 11,969
Epigenetic 79 | 242
Enzyme 51 | 4,146
Nuclear Receptor 46 | 48
TF/Epigenetic 25 | 38
Kinase 2 | 634
Transporter 1 | 473

PANTHER Protein Class (0)

transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
signaling molecule 820 | 820
transporter 767 | 767
enzyme modulator 713 | 713
hydrolase 631 | 631
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 214 ZNF214 Tdark Transcription Factor -0.49369 2.48 88
Protein fosB FOSB Tbio Transcription Factor -2.64139 409.7 306
Myelin transcription factor 1-like protein MYT1L Tbio Transcription Factor -1.43180 24.8 41
Zinc finger protein 705F ZNF705F Tdark Non-IDG 0.00000 0
BTB/POZ domain-containing protein 9 BTBD9 Tbio Non-IDG -1.30579 21.1 87
Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1 Tdark Non-IDG 0.19 0.86 20
Forkhead box protein B1 FOXB1 Tbio Transcription Factor -1.13586 14.6 100
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.03044 1092.0 356
Protein quaking QKI Tbio Non-IDG -1.81649 63.7 254