Development Level

Tbio 425 | 11,445
Tdark 72 | 6,588
Tchem 36 | 1,598
Tclin 21 | 613

Collection

RFA-RM-18-021 4 | 328
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 25 | 979
preweaning lethality, incomple... 14 | 499
decreased vertical activity 11 | 208
enlarged heart 9 | 210
abnormal gait 8 | 69
hypoactivity 8 | 132
abnormal bone structure 7 | 187
decreased bone mineral content 7 | 151
embryonic lethality prior to t... 7 | 278
increased total body fat amoun... 7 | 134
abnormal behavior 6 | 298
abnormal heart morphology 6 | 162
decreased body weight 6 | 161
decreased circulating insulin ... 6 | 76
decreased fasted circulating g... 6 | 65
increased mean corpuscular vol... 6 | 92
cataract 5 | 92
decreased bone mineral density 5 | 126
decreased lean body mass 5 | 135
hyperactivity 5 | 148
increased circulating HDL chol... 5 | 80
increased lean body mass 5 | 172
abnormal lens morphology 4 | 81
decreased circulating triglyce... 4 | 79
decreased neutrophil cell numb... 4 | 42
decreased startle reflex 4 | 75
decreased total body fat amoun... 4 | 207
hydrometra 4 | 53
impaired glucose tolerance 4 | 75
impaired pupillary reflex 4 | 26
impaired righting response 4 | 26
improved glucose tolerance 4 | 79
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
increased or absent threshold ... 4 | 101
increased startle reflex 4 | 112
abnormal bone mineralization 3 | 38
abnormal brain morphology 3 | 13
abnormal embryo size 3 | 220
abnormal locomotor behavior 3 | 24
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased leukocyte cell numbe... 3 | 73
edema 3 | 59
embryonic lethality prior to o... 3 | 239
increased circulating iron lev... 3 | 30
increased grip strength 3 | 41
increased hemoglobin content 3 | 45
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular hem... 3 | 96
limb grasping 3 | 41
prenatal lethality 3 | 28
thrombocytopenia 3 | 56
abnormal behavioral response t... 2 | 66
abnormal cornea morphology 2 | 31
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal sleep behavior 2 | 70
abnormal startle reflex 2 | 15
abnormal tail morphology 2 | 25
abnormal testis morphology 2 | 43
abnormal vocalization 2 | 21
absent startle reflex 2 | 24
corneal opacity 2 | 32
decreased body length 2 | 101
decreased circulating alkaline... 2 | 46
decreased circulating chloride... 2 | 30
decreased circulating free fat... 2 | 31
decreased circulating iron lev... 2 | 32
decreased heart weight 2 | 27
decreased lymphocyte cell numb... 2 | 83
decreased spleen weight 2 | 10
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
hemorrhage 2 | 23
hydroencephaly 2 | 14
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased circulating potassiu... 2 | 29
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 28
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased lymphocyte cell numb... 2 | 32
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
mammalian phenotype 2 | 17
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small superior vagus ganglion 2 | 74
tremors 2 | 39
trunk curl 2 | 16

Disease

Carcinoma 270 | 11,493
psoriasis 266 | 6,694
ovarian cancer 225 | 8,520
osteosarcoma 197 | 7,950
lung cancer 188 | 4,740
Cancer 180 | 2,499
glioblastoma 178 | 5,792
medulloblastoma, large-cell 163 | 6,241
ependymoma 144 | 4,679
lung carcinoma 138 | 2,843
Breast cancer 136 | 3,578
malignant mesothelioma 136 | 3,232
interstitial cystitis 130 | 2,312
atypical teratoid / rhabdoid tumor 128 | 5,112
invasive ductal carcinoma 128 | 2,951
adult high grade glioma 127 | 3,801
lung adenocarcinoma 118 | 2,716
Astrocytoma, Pilocytic 116 | 3,081
non-small cell lung cancer 110 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 105 | 2,955
group 3 medulloblastoma 102 | 4,104
cystic fibrosis 99 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 98 | 2,989
tuberculosis 95 | 2,010
ulcerative colitis 95 | 1,819
intraductal papillary-mucinous neoplasm (IPMN) 93 | 3,291
pancreatic cancer 91 | 2,398
diabetes mellitus 89 | 1,728
breast carcinoma 80 | 1,638
pituitary cancer 80 | 1,972
ductal carcinoma in situ 79 | 1,745
oligodendroglioma 77 | 2,850
colon cancer 74 | 1,478
astrocytic glioma 70 | 2,597
subependymal giant cell astrocytoma 68 | 2,287
cutaneous lupus erythematosus 66 | 1,057
primitive neuroectodermal tumor 65 | 3,035
Schizophrenia 59 | 1,160
Kidney cancer 57 | 2,613
group 4 medulloblastoma 56 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,962
Rheumatoid arthritis 53 | 1,191
Atopic dermatitis 51 | 952
Autosomal recessive predisposition 47 | 1,442
Pick disease 45 | 1,894
Liver Cirrhosis, Experimental 44 | 769
Asthma 43 | 385
nasopharyngeal carcinoma 43 | 1,058
gastric carcinoma 42 | 807
adrenocortical carcinoma 40 | 1,428
Bipolar Disorder 39 | 666
fibroadenoma 39 | 559
pediatric high grade glioma 39 | 1,064
Multiple Sclerosis 37 | 540
Obesity 37 | 678
juvenile dermatomyositis 37 | 1,187
spina bifida 37 | 1,074
Breast Neoplasms 34 | 445
Depressive disorder 34 | 409
Mammary Neoplasms 34 | 425
esophageal adenocarcinoma 34 | 737
Hypertension 33 | 396
Kidney disease 33 | 430
active Crohn's disease 33 | 922
mucosa-associated lymphoid tissue lymphoma 33 | 484
primary pancreatic ductal adenocarcinoma 33 | 1,109
active ulcerative colitis 32 | 764
Atherosclerosis 31 | 291
Vascular disease 31 | 319
primary Sjogren syndrome 31 | 735
Alzheimer's disease 30 | 658
Arthritis 30 | 290
Mental Depression 30 | 333
aldosterone-producing adenoma 30 | 665
Down syndrome 29 | 499
Endometriosis 28 | 540
Osteoporosis 28 | 363
acute quadriplegic myopathy 28 | 1,158
medulloblastoma 28 | 720
Major Depressive Disorder 27 | 301
Lung disease 26 | 142
Prostatic Neoplasms 26 | 495
posterior fossa group A ependymoma 26 | 468
Duchenne muscular dystrophy 25 | 601
Melanoma 25 | 711
non primary Sjogren syndrome sicca 25 | 891
Coronary artery disease 24 | 268
Pulmonary Fibrosis 24 | 106
Unipolar Depression 24 | 250
Cleft Palate 23 | 271
Hypersensitivity 23 | 63
Pneumonia 23 | 174
astrocytoma 23 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 510
head and neck cancer 23 | 271
non-small cell lung carcinoma 23 | 317
sarcoidosis 23 | 370
Arthritis, Rheumatoid 22 | 174
acute myeloid leukemia 22 | 783
chronic rhinosinusitis 22 | 512

Tissue

Endocrine System 502 | 18,159
Digestive Tract 496 | 17,369
Female tissues 491 | 17,400
Blood and immune system 483 | 16,909
Skin and soft tissues 482 | 17,230
Liver and Pancreas 478 | 16,750
Urinary Tract 471 | 16,678
Male tissues 468 | 17,142
Respiratory system 462 | 16,393
Nervous System 452 | 16,725
Cardiovascular System 397 | 15,192

Target Family

Non-IDG 480 | 12,091
Enzyme 51 | 4,145
GPCR 11 | 408
Ion Channel 6 | 344
Epigenetic 3 | 242
Kinase 3 | 634

PANTHER Protein Class (0)

signaling molecule 554 | 554
transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
hydrolase 762 | 762
enzyme modulator 645 | 645
transferase 625 | 625
transporter 580 | 580
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
Endothelin-3 EDN3 Tbio Non-IDG -2.96371 794.0 219
Ephrin-A3 EFNA3 Tbio Non-IDG -1.53049 26.8 219
Ephrin-A4 EFNA4 Tbio Non-IDG -1.23647 17.4 213
cTAGE family member 8 CTAGE8 Tdark Non-IDG 0.00000 3
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
CD40 ligand CD40LG Tbio Non-IDG -4.58203 37578.3 1461
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305