Development Level

Tbio 564 | 10,625
Tchem 114 | 1,890
Tdark 111 | 7,003
Tclin 31 | 602

Collection

Eligible Ion Channel Proteins 3 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 28 | 633
preweaning lethality, incomple... 12 | 260
enlarged heart 11 | 111
decreased bone mineral content 10 | 157
decreased body weight 9 | 174
decreased bone mineral density 9 | 126
decreased lean body mass 9 | 195
abnormal behavior 8 | 226
abnormal bone structure 8 | 131
increased circulating HDL chol... 7 | 63
increased mean corpuscular hem... 7 | 93
increased mean corpuscular vol... 7 | 91
abnormal QRS complex 6 | 25
decreased circulating alanine ... 6 | 53
decreased circulating insulin ... 6 | 75
decreased circulating triglyce... 6 | 83
decreased total body fat amoun... 6 | 186
abnormal bone mineralization 5 | 55
abnormal embryo size 5 | 112
decreased T cell number 5 | 31
decreased circulating choleste... 5 | 85
embryonic lethality prior to t... 5 | 187
hypoactivity 5 | 89
improved glucose tolerance 5 | 56
increased circulating alkaline... 5 | 119
increased lean body mass 5 | 107
increased or absent threshold ... 5 | 128
abnormal gait 4 | 51
abnormal retina morphology 4 | 100
decreased circulating HDL chol... 4 | 77
decreased circulating free fat... 4 | 39
decreased circulating glucose ... 4 | 121
decreased fasted circulating g... 4 | 49
decreased grip strength 4 | 123
decreased leukocyte cell numbe... 4 | 54
decreased lumbar vertebrae num... 4 | 62
decreased startle reflex 4 | 48
enlarged spleen 4 | 26
hydrops fetalis 4 | 22
impaired glucose tolerance 4 | 52
increased blood urea nitrogen ... 4 | 44
increased circulating choleste... 4 | 53
increased leukocyte cell numbe... 4 | 37
increased sacral vertebrae num... 4 | 62
increased total body fat amoun... 4 | 57
short tibia 4 | 82
thrombocytopenia 4 | 46
abnormal coping response 3 | 12
abnormal heart morphology 3 | 51
abnormal response to tactile s... 3 | 16
corneal opacity 3 | 25
decreased B cell number 3 | 30
decreased caudal vertebrae num... 3 | 49
decreased circulating serum al... 3 | 79
decreased hemoglobin content 3 | 53
decreased monocyte cell number 3 | 28
decreased spleen weight 3 | 13
enlarged kidney 3 | 7
hydrometra 3 | 13
impaired pupillary reflex 3 | 14
impaired righting response 3 | 19
increased body length 3 | 20
increased circulating total pr... 3 | 20
increased grip strength 3 | 83
increased hematocrit 3 | 36
limb grasping 3 | 35
prenatal lethality prior to he... 3 | 64
abnormal behavioral response t... 2 | 52
abnormal eye size 2 | 11
abnormal kidney morphology 2 | 30
abnormal startle reflex 2 | 14
abnormal vocalization 2 | 21
absent startle reflex 2 | 15
decreased blood urea nitrogen ... 2 | 31
decreased circulating chloride... 2 | 32
decreased circulating fructosa... 2 | 31
decreased circulating iron lev... 2 | 25
decreased circulating total pr... 2 | 41
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased threshold for audito... 2 | 32
enlarged lymph nodes 2 | 27
female infertility 2 | 34
hyperactivity 2 | 108
increased bone mineral density 2 | 52
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating fructosa... 2 | 11
increased circulating glucose ... 2 | 16
increased circulating iron lev... 2 | 25
increased circulating serum al... 2 | 25
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased hemoglobin content 2 | 45
increased startle reflex 2 | 38
male infertility 2 | 62
small testis 2 | 37
straub tail 2 | 26
tremors 2 | 34

Disease

psoriasis 382 | 6,685
ovarian cancer 322 | 8,484
osteosarcoma 297 | 7,933
lung cancer 253 | 4,466
glioblastoma 247 | 5,572
Cancer 242 | 2,346
medulloblastoma, large-cell 235 | 6,234
lung carcinoma 185 | 2,844
invasive ductal carcinoma 174 | 2,950
interstitial cystitis 173 | 2,299
pilocytic astrocytoma 168 | 3,086
atypical teratoid / rhabdoid tumor 166 | 4,369
malignant mesothelioma 164 | 3,162
lung adenocarcinoma 163 | 2,713
Breast cancer 152 | 3,094
non-small cell lung cancer 148 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 143 | 2,956
ulcerative colitis 142 | 2,087
intraductal papillary-mucinous neoplasm (IPMN) 141 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 137 | 2,988
cystic fibrosis 136 | 1,665
pancreatic cancer 130 | 2,300
diabetes mellitus 123 | 1,663
pediatric high grade glioma 122 | 2,712
adult high grade glioma 120 | 2,148
oligodendroglioma 113 | 2,849
pituitary cancer 106 | 1,972
tuberculosis 106 | 1,557
breast carcinoma 105 | 1,614
colon cancer 105 | 1,475
posterior fossa group A ependymoma 104 | 1,511
ductal carcinoma in situ 101 | 1,745
subependymal giant cell astrocytoma 96 | 2,287
ependymoma 94 | 2,514
cutaneous lupus erythematosus 92 | 1,056
primitive neuroectodermal tumor 91 | 3,031
Carcinoma 88 | 2,147
group 3 medulloblastoma 86 | 2,254
group 4 medulloblastoma 85 | 1,875
astrocytic glioma 83 | 2,241
Rheumatoid Arthritis 74 | 1,160
Atopic dermatitis 73 | 944
Pick disease 69 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 66 | 1,795
Obesity 65 | 616
Asthma 63 | 349
posterior fossa group B ependymoma 63 | 1,530
gastric carcinoma 61 | 832
adrenocortical carcinoma 60 | 1,427
medulloblastoma 60 | 1,524
nasopharyngeal carcinoma 57 | 1,056
primary pancreatic ductal adenocarcinoma 57 | 1,271
Kidney disease 55 | 396
Multiple Sclerosis 55 | 498
astrocytoma 55 | 1,493
esophageal adenocarcinoma 53 | 737
juvenile dermatomyositis 53 | 1,189
sonic hedgehog group medulloblastoma 52 | 1,482
spina bifida 52 | 1,064
Alzheimer's disease 50 | 644
Hypertension 50 | 287
primary Sjogren syndrome 50 | 789
Atherosclerosis 49 | 275
Mammary Neoplasms 49 | 410
Arthritis 47 | 248
active Crohn's disease 47 | 918
fibroadenoma 47 | 557
Heart disease 44 | 279
Endometriosis 43 | 535
aldosterone-producing adenoma 43 | 664
Prostatic Neoplasms 42 | 471
mucosa-associated lymphoid tissue lymphoma 42 | 480
Hypersensitivity reaction type II disease 41 | 235
Cerebrovascular disease 40 | 231
non-small cell lung carcinoma 40 | 413
Coronary artery disease 39 | 240
Lung disease 39 | 132
Schizophrenia 39 | 501
Inflammatory bowel disease 38 | 142
acute quadriplegic myopathy 38 | 1,157
Down syndrome 37 | 548
atypical teratoid/rhabdoid tumor 37 | 1,095
sarcoidosis 37 | 358
Diarrhea 36 | 155
Hypertensive disease 36 | 193
Osteoporosis 35 | 257
Vascular disease 35 | 281
Inflammation 33 | 109
Pneumonia 33 | 133
dermatomyositis 32 | 933
periodontitis 32 | 269
Autistic Disorder 31 | 320
Dermatitis 31 | 107
Duchenne muscular dystrophy 31 | 602
Influenza 30 | 142
Polycystic Ovary Syndrome 30 | 332
non primary Sjogren syndrome sicca 30 | 840
Adenoma 29 | 165
Hypersensitivity 29 | 63
chronic rhinosinusitis 29 | 512

Tissue

Nervous System 783 | 18,561
Digestive Tract 782 | 18,473
Female tissues 776 | 18,647
Endocrine System 770 | 18,512
Urinary Tract 761 | 18,444
Blood and immune system 759 | 17,995
Liver and Pancreas 759 | 18,136
Skin and soft tissues 759 | 18,115
Cardiovascular System 740 | 17,958
Male tissues 729 | 17,969
Respiratory system 725 | 17,484

Target Family

Non-IDG 678 | 11,971
Enzyme 117 | 4,146
GPCR 11 | 406
Ion Channel 7 | 341
Epigenetic 3 | 242
Kinase 3 | 634
Transcription Factor 1 | 1,400

PANTHER Protein Class (0)

signaling molecule 820 | 820
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
transporter 767 | 767
enzyme modulator 713 | 713
hydrolase 631 | 631
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Coagulation factor XI F11 Tchem Enzyme -2.65863 487.3 216
Plasma kallikrein KLKB1 Tclin Enzyme -2.88472 708.0 231
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Interleukin-15 IL15 Tbio Non-IDG -3.01964 1248.2 612