Development Level

Tbio 220 | 10,625
Tchem 127 | 1,890
Tdark 111 | 7,003
Tclin 92 | 602

Collection

Eligible non-olfactory GPCR Proteins 82 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

decreased total body fat amoun... 8 | 186
preweaning lethality, complete... 8 | 633
preweaning lethality, incomple... 8 | 260
abnormal behavior 7 | 226
increased or absent threshold ... 7 | 128
decreased grip strength 6 | 123
decreased lean body mass 6 | 195
hyperactivity 5 | 108
hypoactivity 5 | 89
abnormal bone structure 4 | 131
decreased body length 4 | 108
decreased bone mineral density 4 | 126
decreased circulating creatini... 4 | 31
decreased circulating insulin ... 4 | 75
enlarged heart 4 | 111
increased bone mineral content 4 | 92
increased circulating HDL chol... 4 | 63
increased lean body mass 4 | 107
increased mean corpuscular vol... 4 | 91
abnormal embryo size 3 | 112
abnormal epididymis morphology 3 | 31
abnormal gait 3 | 51
abnormal sleep behavior 3 | 63
cardiovascular system phenotyp... 3 | 35
decreased basophil cell number 3 | 11
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
decreased heart rate 3 | 10
embryonic lethality prior to t... 3 | 187
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased circulating serum al... 3 | 25
increased fasted circulating g... 3 | 68
increased total body fat amoun... 3 | 57
small superior vagus ganglion 3 | 20
abnormal behavioral response t... 2 | 52
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
abnormal skin coloration 2 | 18
abnormal skin morphology 2 | 23
abnormal spleen morphology 2 | 36
abnormal vocalization 2 | 21
convulsive seizures 2 | 11
decreased T cell number 2 | 31
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating glucose ... 2 | 121
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased prepulse inhibition 2 | 52
decreased startle reflex 2 | 48
enlarged epididymis 2 | 27
enlarged lymph nodes 2 | 27
enlarged spleen 2 | 26
female infertility 2 | 34
improved glucose tolerance 2 | 56
increased body length 2 | 20
increased body weight 2 | 42
increased bone mineral density 2 | 52
increased circulating creatini... 2 | 29
increased circulating phosphat... 2 | 24
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased hemoglobin content 2 | 45
limb grasping 2 | 35
small adrenal glands 2 | 15
abnormal coat appearance 1 | 25
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal response to new envir... 1 | 8
abnormal retina morphology 1 | 100
abnormal sensory capabilities/... 1 | 3
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 21
decreased blood urea nitrogen ... 1 | 31
decreased cardiac muscle contr... 1 | 5
decreased circulating sodium l... 1 | 18
embryonic growth retardation 1 | 28
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
shortened ST segment 1 | 9
small kidney 1 | 10
straub tail 1 | 26
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 208 | 7,933
psoriasis 193 | 6,685
ovarian cancer 190 | 8,484
medulloblastoma, large-cell 171 | 6,234
glioblastoma 151 | 5,572
lung cancer 114 | 4,466
atypical teratoid / rhabdoid tumor 110 | 4,369
interstitial cystitis 109 | 2,299
pilocytic astrocytoma 107 | 3,086
lung carcinoma 105 | 2,844
lung adenocarcinoma 98 | 2,713
malignant mesothelioma 93 | 3,162
invasive ductal carcinoma 89 | 2,950
Cancer 85 | 2,346
primitive neuroectodermal tumor 84 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 81 | 3,289
ulcerative colitis 81 | 2,087
non-small cell lung cancer 80 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 79 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 78 | 2,988
Breast cancer 77 | 3,094
pediatric high grade glioma 77 | 2,712
pancreatic cancer 73 | 2,300
oligodendroglioma 71 | 2,849
ependymoma 63 | 2,514
pituitary cancer 62 | 1,972
Carcinoma 61 | 2,147
adult high grade glioma 61 | 2,148
diabetes mellitus 59 | 1,663
astrocytic glioma 56 | 2,241
ductal carcinoma in situ 56 | 1,745
subependymal giant cell astrocytoma 54 | 2,287
medulloblastoma 51 | 1,524
breast carcinoma 49 | 1,614
tuberculosis 49 | 1,557
group 4 medulloblastoma 47 | 1,875
cutaneous lupus erythematosus 46 | 1,056
group 3 medulloblastoma 45 | 2,254
posterior fossa group A ependymoma 45 | 1,511
Schizophrenia 44 | 501
cystic fibrosis 43 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,795
Obesity 42 | 616
adrenocortical carcinoma 41 | 1,427
astrocytoma 39 | 1,493
colon cancer 39 | 1,475
Asthma 38 | 349
Pick disease 37 | 1,893
primary Sjogren syndrome 36 | 789
gastric carcinoma 35 | 832
sonic hedgehog group medulloblastoma 35 | 1,482
juvenile dermatomyositis 34 | 1,189
posterior fossa group B ependymoma 34 | 1,530
atypical teratoid/rhabdoid tumor 33 | 1,095
Rheumatoid Arthritis 32 | 1,160
primary pancreatic ductal adenocarcinoma 31 | 1,271
acute quadriplegic myopathy 30 | 1,157
Parkinson's disease 28 | 364
mucosa-associated lymphoid tissue lymphoma 27 | 480
Multiple Sclerosis 26 | 498
Allergic rhinitis 25 | 91
Autistic Disorder 24 | 320
Atopic dermatitis 23 | 944
Duchenne muscular dystrophy 23 | 602
Attention deficit hyperactivity disorder 22 | 156
Migraine 22 | 79
pancreatic carcinoma 22 | 567
Epilepsy 21 | 346
active Crohn's disease 21 | 918
esophageal adenocarcinoma 21 | 737
nasopharyngeal carcinoma 21 | 1,056
Alzheimer's disease 20 | 644
Hypersensitivity reaction type II disease 20 | 235
Nasal congestion 20 | 24
aldosterone-producing adenoma 20 | 664
dermatomyositis 20 | 933
Common cold 19 | 63
Down syndrome 19 | 548
Nasal discharge 19 | 26
acute myeloid leukemia 19 | 780
fibroadenoma 19 | 557
spina bifida 19 | 1,064
Alcohol dependence 18 | 107
Bipolar Disorder 18 | 266
Multiple myeloma 18 | 1,327
Waldenstrons macroglobulinemia 18 | 765
non-small cell lung carcinoma 18 | 413
Cocaine-Related Disorders 17 | 88
Endometriosis 17 | 535
Hypertension 17 | 287
Major Depressive Disorder 17 | 106
Atherosclerosis 16 | 275
Crohn's disease 16 | 304
Kidney disease 16 | 396
Pain agnosia 16 | 99
active ulcerative colitis 16 | 477
head and neck cancer and chronic obstructive pulmonary disease 16 | 237
head and neck cancer 15 | 270
hepatocellular carcinoma 15 | 532
periodontitis 15 | 269

Tissue

Female tissues 528 | 18,647
Nervous System 524 | 18,561
Digestive Tract 520 | 18,473
Urinary Tract 520 | 18,444
Endocrine System 518 | 18,512
Skin and soft tissues 503 | 18,115
Liver and Pancreas 491 | 18,136
Cardiovascular System 483 | 17,958
Blood and immune system 469 | 17,995
Male tissues 469 | 17,969
Respiratory system 465 | 17,484

Target Family

GPCR 264 | 406
Non-IDG 200 | 11,971
Enzyme 32 | 4,146
oGPCR 30 | 421
Kinase 19 | 634
Transporter 3 | 473
Epigenetic 1 | 242
Ion Channel 1 | 341

PANTHER Protein Class (0)

receptor 550 | 550
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
signaling molecule 820 | 820
transporter 767 | 767
enzyme modulator 713 | 713
hydrolase 631 | 631
cytoskeletal protein 608 | 608
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Short-wave-sensitive opsin 1 OPN1SW Tbio GPCR -1.90084 81.3 15
Interleukin-1 receptor type 2 IL1R2 Tbio Non-IDG -1.85724 72.1 361
Hyaluronidase-3 HYAL3 Tbio Enzyme -0.90097 7.70 99
CD5 antigen-like CD5L Tbio Non-IDG -1.78447 64.4 287
5-hydroxytryptamine receptor 6 HTR6 Tchem GPCR -2.29395 203.8 55
Neuropeptides B/W receptor type 1 NPBWR1 Tchem GPCR -1.34565 19.5 151
Neuropeptides B/W receptor type 2 NPBWR2 Tbio GPCR -1.14202 8.84 57
Tumor necrosis factor receptor superfamily member 9 TNFRSF9 Tbio Non-IDG -2.71753 714.2 490