Development Level

Tbio 192 | 11,445
Tclin 50 | 613
Tchem 48 | 1,598
Tdark 29 | 6,588

IMPC Phenotype

preweaning lethality, complete... 24 | 979
abnormal behavior 9 | 298
embryonic lethality prior to o... 8 | 239
abnormal embryo size 7 | 220
abnormal lens morphology 6 | 81
cataract 6 | 92
decreased total body fat amoun... 6 | 207
embryonic lethality prior to t... 6 | 278
enlarged heart 5 | 210
abnormal heart morphology 4 | 162
decreased circulating chloride... 4 | 30
decreased vertical activity 4 | 208
embryonic growth retardation 4 | 106
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased monocyte cell number 4 | 63
abnormal bone mineralization 3 | 38
abnormal bone structure 3 | 187
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating alkaline... 3 | 46
decreased fasted circulating g... 3 | 65
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
hydrometra 3 | 53
hyperactivity 3 | 148
increased circulating potassiu... 3 | 29
increased circulating sodium l... 3 | 71
pallor 3 | 34
prenatal lethality prior to he... 3 | 87
preweaning lethality, incomple... 3 | 499
abnormal cranium morphology 2 | 36
abnormal embryo turning 2 | 31
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
abnormal skin coloration 2 | 25
abnormal sleep behavior 2 | 70
abnormal stomach morphology 2 | 10
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased threshold for audito... 2 | 26
hemorrhage 2 | 23
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating amylase ... 2 | 25
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased leukocyte cell numbe... 2 | 47
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
male infertility 2 | 123
persistence of hyaloid vascula... 2 | 33
small superior vagus ganglion 2 | 74
tremors 2 | 39
abnormal craniofacial morpholo... 1 | 33
abnormal joint morphology 1 | 23
abnormal neural tube morpholog... 1 | 12
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged epididymis 1 | 31
impaired righting response 1 | 26
increased aggression 1 | 4
increased blood urea nitrogen ... 1 | 48
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
limb grasping 1 | 41
prenatal lethality 1 | 28
small kidney 1 | 16
small spleen 1 | 19

Disease

Carcinoma 186 | 11,493
ovarian cancer 155 | 8,520
psoriasis 139 | 6,694
osteosarcoma 117 | 7,950
lung cancer 95 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 90 | 1,962
glioblastoma 89 | 5,792
medulloblastoma, large-cell 88 | 6,241
atypical teratoid / rhabdoid tumor 78 | 5,112
non-small cell lung cancer 78 | 2,890
ependymoma 77 | 4,679
Autosomal recessive predisposition 72 | 1,442
intraductal papillary-mucinous neoplasm (IPMN) 66 | 3,291
lung adenocarcinoma 65 | 2,716
Breast cancer 63 | 3,578
lung carcinoma 63 | 2,843
Cancer 62 | 2,499
invasive ductal carcinoma 62 | 2,951
adult high grade glioma 61 | 3,801
malignant mesothelioma 60 | 3,232
group 3 medulloblastoma 59 | 4,104
pancreatic cancer 58 | 2,398
interstitial cystitis 57 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 57 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,955
Astrocytoma, Pilocytic 46 | 3,081
Multiple myeloma 46 | 1,332
ductal carcinoma in situ 46 | 1,745
tuberculosis 46 | 2,010
primitive neuroectodermal tumor 45 | 3,035
oligodendroglioma 44 | 2,850
cystic fibrosis 42 | 1,696
breast carcinoma 41 | 1,638
adrenocortical carcinoma 39 | 1,428
astrocytic glioma 39 | 2,597
diabetes mellitus 39 | 1,728
subependymal giant cell astrocytoma 37 | 2,287
ulcerative colitis 37 | 1,819
Epilepsy 35 | 792
pituitary cancer 34 | 1,972
Muscle hypotonia 33 | 571
Intellectual disability 32 | 1,016
colon cancer 32 | 1,478
Liver Cirrhosis, Experimental 30 | 769
Schizophrenia 30 | 1,160
Dull intelligence 29 | 645
Low intelligence 29 | 645
Mental Retardation 29 | 645
Mental deficiency 29 | 645
Poor school performance 29 | 645
Seizures 29 | 596
active Crohn's disease 29 | 922
Cognitive delay 28 | 608
Global developmental delay 28 | 608
Mental and motor retardation 28 | 608
esophageal adenocarcinoma 28 | 737
primary pancreatic ductal adenocarcinoma 28 | 1,109
Atopic dermatitis 27 | 952
Pick disease 27 | 1,894
Prostatic Neoplasms 27 | 495
Hypertension 26 | 396
astrocytoma 26 | 1,146
group 4 medulloblastoma 26 | 1,855
nasopharyngeal carcinoma 26 | 1,058
Cerebellar Ataxia 25 | 304
Obesity 25 | 678
Endometriosis 24 | 540
Failure to gain weight 23 | 365
Kidney cancer 23 | 2,613
Pediatric failure to thrive 23 | 365
acute quadriplegic myopathy 23 | 1,158
Diabetes mellitus type 2 22 | 69
Sensorineural Hearing Loss (disorder) 22 | 284
Treatment Refractory Type 2 Diabetes Mellitus 22 | 53
active ulcerative colitis 22 | 764
Acidosis, Lactic 21 | 97
Leigh disease 21 | 100
Waldenstrons macroglobulinemia 21 | 765
acute myeloid leukemia 21 | 783
cutaneous lupus erythematosus 21 | 1,057
Lactic acidemia 20 | 95
Heart failure 19 | 162
Hypertensive disease 19 | 292
fibroadenoma 19 | 559
gastric carcinoma 19 | 807
Blepharoptosis 18 | 231
Breast Neoplasms 18 | 445
Chemical and Drug Induced Liver Injury 18 | 195
Increased serum lactate 18 | 60
Mammary Neoplasms 18 | 425
Optic Atrophy 18 | 242
nephrosclerosis 18 | 333
Depressive disorder 17 | 409
Dystonia 17 | 164
Hepatomegaly 17 | 285
Kidney disease 17 | 430
Nystagmus 17 | 317
Rheumatoid arthritis 17 | 1,191
aldosterone-producing adenoma 17 | 665
pancreatic carcinoma 17 | 562

Tissue

Endocrine System 311 | 18,159
Digestive Tract 308 | 17,369
Female tissues 307 | 17,400
Male tissues 306 | 17,142
Liver and Pancreas 304 | 16,750
Skin and soft tissues 304 | 17,230
Blood and immune system 302 | 16,909
Urinary Tract 301 | 16,678
Nervous System 294 | 16,725
Respiratory system 289 | 16,393
Cardiovascular System 264 | 15,192

Target Family

Enzyme 265 | 4,145
Non-IDG 52 | 12,091
Epigenetic 1 | 242
Ion Channel 1 | 344

PANTHER Protein Class (0)

oxidoreductase 319 | 319
transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
hydrolase 762 | 762
enzyme modulator 645 | 645
transferase 625 | 625
transporter 580 | 580
signaling molecule 554 | 554
cytoskeletal protein 441 | 441
receptor 400 | 400
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alcohol dehydrogenase 6 ADH6 Tbio Enzyme -1.84121 71.7 117
Retinal dehydrogenase 2 ALDH1A2 Tbio Enzyme -2.25078 175.3 229
Peroxidasin-like protein PXDNL Tbio Non-IDG -1.10753 14.4 0
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 Tclin Enzyme -2.43529 263.5 165
Sarcosine dehydrogenase, mitochondrial SARDH Tbio Enzyme -1.78290 56.5 35
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI1 Tbio Enzyme -2.05198 103.3 194
6-phosphogluconate dehydrogenase, decarboxylating PGD Tchem Enzyme -2.56683 355.7 211
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293