Development Level

Tbio 210 | 10,625
Tchem 79 | 1,890
Tclin 58 | 602
Tdark 57 | 7,003

IMPC Term

preweaning lethality, complete... 19 | 633
abnormal behavior 9 | 226
embryonic lethality prior to o... 7 | 148
abnormal retina morphology 6 | 100
abnormal embryo size 5 | 112
decreased bone mineral content 5 | 157
decreased bone mineral density 5 | 126
hypoactivity 5 | 89
prenatal lethality prior to he... 5 | 64
abnormal cranium morphology 4 | 32
abnormal lens morphology 4 | 73
decreased circulating HDL chol... 4 | 77
decreased circulating choleste... 4 | 85
decreased lean body mass 4 | 195
decreased total body fat amoun... 4 | 186
embryonic lethality prior to t... 4 | 187
abnormal bone mineralization 3 | 55
abnormal bone structure 3 | 131
abnormal craniofacial morpholo... 3 | 12
decreased circulating triglyce... 3 | 83
decreased lumbar vertebrae num... 3 | 62
embryonic growth retardation 3 | 28
hyperactivity 3 | 108
increased circulating alkaline... 3 | 119
increased circulating potassiu... 3 | 31
increased circulating sodium l... 3 | 71
increased exploration in new e... 3 | 56
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased or absent threshold ... 3 | 128
increased startle reflex 3 | 38
preweaning lethality, incomple... 3 | 260
short tibia 3 | 82
abnormal QRS complex 2 | 25
abnormal behavioral response t... 2 | 52
abnormal coat/hair pigmentatio... 2 | 54
abnormal embryo turning 2 | 15
abnormal epididymis morphology 2 | 31
abnormal gait 2 | 51
abnormal limb bud morphology 2 | 15
abnormal neural tube closure 2 | 37
abnormal retinal blood vessel ... 2 | 18
abnormal retinal pigmentation 2 | 61
abnormal rib morphology 2 | 28
abnormal skin coloration 2 | 18
abnormal snout morphology 2 | 18
abnormal vocalization 2 | 21
decreased blood urea nitrogen ... 2 | 31
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating alkaline... 2 | 41
decreased circulating calcium ... 2 | 33
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased leukocyte cell numbe... 2 | 54
decreased mean platelet volume 2 | 12
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased threshold for audito... 2 | 32
enlarged heart 2 | 111
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased circulating amylase ... 2 | 13
increased erythrocyte cell num... 2 | 26
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 93
mydriasis 2 | 9
pale liver 2 | 5
pallor 2 | 13
persistence of hyaloid vascula... 2 | 22
small adrenal glands 2 | 15
small kidney 2 | 10
abnormal motor coordination/ b... 1 | 4
abnormal respiratory quotient 1 | 9
abnormal response to new envir... 1 | 8
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
craniofacial phenotype 1 | 9
decreased CD4-positive, alpha ... 1 | 19
decreased alpha-beta T cell nu... 1 | 12
decreased cervical vertebrae n... 1 | 12
decreased circulating phosphat... 1 | 15
decreased exploration in new e... 1 | 9
enlarged lymph nodes 1 | 27
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
limb grasping 1 | 35

Disease

ovarian cancer 197 | 8,484
psoriasis 166 | 6,685
osteosarcoma 165 | 7,933
lung cancer 117 | 4,466
glioblastoma 111 | 5,572
medulloblastoma, large-cell 111 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 111 | 1,795
non-small cell lung cancer 95 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 82 | 3,289
atypical teratoid / rhabdoid tumor 76 | 4,369
lung adenocarcinoma 76 | 2,713
lung carcinoma 76 | 2,844
malignant mesothelioma 76 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 74 | 2,988
invasive ductal carcinoma 73 | 2,950
interstitial cystitis 71 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 71 | 2,956
pancreatic cancer 67 | 2,300
Breast cancer 65 | 3,094
Cancer 65 | 2,346
ulcerative colitis 62 | 2,087
Multiple myeloma 59 | 1,327
primitive neuroectodermal tumor 58 | 3,031
oligodendroglioma 56 | 2,849
pilocytic astrocytoma 55 | 3,086
ductal carcinoma in situ 54 | 1,745
ependymoma 53 | 2,514
pediatric high grade glioma 53 | 2,712
adrenocortical carcinoma 52 | 1,427
tuberculosis 52 | 1,557
cystic fibrosis 51 | 1,665
astrocytic glioma 48 | 2,241
breast carcinoma 46 | 1,614
subependymal giant cell astrocytoma 46 | 2,287
group 4 medulloblastoma 42 | 1,875
diabetes mellitus 41 | 1,663
posterior fossa group A ependymoma 40 | 1,511
adult high grade glioma 39 | 2,148
colon cancer 37 | 1,475
esophageal adenocarcinoma 37 | 737
pituitary cancer 37 | 1,972
primary pancreatic ductal adenocarcinoma 36 | 1,271
active Crohn's disease 35 | 918
Pick disease 34 | 1,893
astrocytoma 33 | 1,493
Atopic dermatitis 32 | 944
Prostatic Neoplasms 32 | 471
medulloblastoma 32 | 1,524
group 3 medulloblastoma 30 | 2,254
acute quadriplegic myopathy 29 | 1,157
nasopharyngeal carcinoma 29 | 1,056
Waldenstrons macroglobulinemia 28 | 765
sonic hedgehog group medulloblastoma 28 | 1,482
Diabetes mellitus type 2 27 | 69
Treatment Refractory Type 2 Diabetes Mellitus 27 | 53
cutaneous lupus erythematosus 26 | 1,056
posterior fossa group B ependymoma 26 | 1,530
Obesity 25 | 616
acute myeloid leukemia 25 | 780
Endometriosis 23 | 535
Leigh disease 23 | 81
Rheumatoid Arthritis 23 | 1,160
aldosterone-producing adenoma 23 | 664
atypical teratoid/rhabdoid tumor 23 | 1,095
fibroadenoma 22 | 557
gastric carcinoma 21 | 832
nephrosclerosis 21 | 329
Alzheimer's disease 20 | 644
Hypertension 20 | 287
non primary Sjogren syndrome sicca 20 | 840
Mammary Neoplasms 19 | 410
Peripheral Neuropathy 19 | 303
pancreatic carcinoma 19 | 567
Polycystic Ovary Syndrome 18 | 332
primary Sjogren syndrome 18 | 789
chronic rhinosinusitis 17 | 512
Atherosclerosis 16 | 275
Neurodegenerative disease 16 | 383
Stomach Neoplasms 16 | 282
spina bifida 16 | 1,064
Diabetes Mellitus, Experimental 15 | 106
Kidney disease 15 | 396
Liver carcinoma 15 | 217
dermatomyositis 15 | 933
Down syndrome 14 | 548
Duchenne muscular dystrophy 14 | 602
MITOCHONDRIAL COMPLEX I DEFICIENCY 14 | 37
head and neck cancer and chronic obstructive pulmonary disease 14 | 237
Asthma 13 | 349
Carcinoma 13 | 2,147
Colorectal Neoplasms 13 | 217
Hypertensive disease 13 | 193
Intellectual disability 13 | 573
Liver Cirrhosis, Experimental 13 | 108
Liver disease 13 | 219
active ulcerative colitis 13 | 477
inflammatory breast cancer 13 | 404
Contact Dermatitis 12 | 80
Schizophrenia 12 | 501
progressive supranuclear palsy 12 | 674

Tissue

Digestive Tract 400 | 18,473
Endocrine System 400 | 18,512
Liver and Pancreas 400 | 18,136
Nervous System 400 | 18,561
Female tissues 399 | 18,647
Urinary Tract 399 | 18,444
Cardiovascular System 396 | 17,958
Male tissues 396 | 17,969
Blood and immune system 395 | 17,995
Skin and soft tissues 393 | 18,115
Respiratory system 390 | 17,484

Target Family

Enzyme 338 | 4,146
Non-IDG 64 | 11,971
Epigenetic 1 | 242
Ion Channel 1 | 341

PANTHER Protein Class (0)

oxidoreductase 404 | 404
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
signaling molecule 820 | 820
transporter 767 | 767
enzyme modulator 713 | 713
hydrolase 631 | 631
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
Cytochrome c oxidase subunit 6A1, mitochondrial COX6A1 Tbio Enzyme -1.00384 11.8 165
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.15826 152.2 203
Dimethylaniline monooxygenase [N-oxide-forming] 5 FMO5 Tbio Enzyme -0.93021 9.11 128
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Protein SCO2 homolog, mitochondrial SCO2 Tbio Non-IDG -2.16453 144.3 98
Nardilysin NRDC Tbio Enzyme -1.64244 49.9 83