Development Level

Tbio 737 | 11,445
Tdark 215 | 6,588
Tchem 44 | 1,598
Tclin 10 | 613

IMPC Phenotype

preweaning lethality, complete... 102 | 979
embryonic lethality prior to o... 41 | 239
embryonic lethality prior to t... 25 | 278
preweaning lethality, incomple... 25 | 499
abnormal behavior 20 | 298
abnormal embryo size 18 | 220
abnormal bone structure 12 | 187
embryonic growth retardation 12 | 106
decreased bone mineral density 11 | 126
increased lean body mass 11 | 172
male infertility 11 | 123
decreased body weight 9 | 161
hypoactivity 9 | 132
increased total body fat amoun... 9 | 134
prenatal lethality prior to he... 9 | 87
decreased circulating glucose ... 8 | 126
decreased grip strength 8 | 116
decreased total body fat amoun... 8 | 207
increased circulating HDL chol... 8 | 80
decreased bone mineral content 7 | 151
decreased lean body mass 7 | 135
increased circulating alkaline... 7 | 122
increased circulating choleste... 7 | 66
increased fasted circulating g... 7 | 76
increased mean corpuscular vol... 7 | 92
abnormal lens morphology 6 | 81
decreased circulating choleste... 6 | 93
decreased leukocyte cell numbe... 6 | 73
decreased mean corpuscular hem... 6 | 31
increased bone mineral content 6 | 108
cataract 5 | 92
decreased circulating LDL chol... 5 | 38
decreased mean corpuscular vol... 5 | 79
decreased vertical activity 5 | 208
hyperactivity 5 | 148
increased circulating creatini... 5 | 38
increased mean corpuscular hem... 5 | 96
increased startle reflex 5 | 112
abnormal behavioral response t... 4 | 66
abnormal bone mineralization 4 | 38
abnormal embryo turning 4 | 31
abnormal retina morphology 4 | 71
decreased body length 4 | 101
decreased caudal vertebrae num... 4 | 53
decreased circulating HDL chol... 4 | 68
decreased fasted circulating g... 4 | 65
decreased hemoglobin content 4 | 68
decreased lymphocyte cell numb... 4 | 83
female infertility 4 | 60
increased circulating free fat... 4 | 20
increased grip strength 4 | 41
increased neutrophil cell numb... 4 | 46
increased or absent threshold ... 4 | 101
thrombocytopenia 4 | 56
abnormal cornea morphology 3 | 31
abnormal gait 3 | 69
abnormal heart morphology 3 | 162
abnormal neural tube closure 3 | 46
abnormal pericardium morpholog... 3 | 26
abnormal sleep behavior 3 | 70
decreased circulating alkaline... 3 | 46
decreased circulating triglyce... 3 | 79
decreased red blood cell distr... 3 | 41
enlarged heart 3 | 210
increased bone mineral density 3 | 72
increased circulating sodium l... 3 | 71
increased circulating total pr... 3 | 28
increased hemoglobin content 3 | 45
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
prenatal lethality 3 | 28
shortened RR interval 3 | 17
tremors 3 | 39
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal hair growth 2 | 10
abnormal heart left ventricle ... 2 | 16
abnormal neural tube morpholog... 2 | 12
abnormal retinal vasculature m... 2 | 27
abnormal spleen morphology 2 | 55
corneal opacity 2 | 32
decreased circulating aspartat... 2 | 34
decreased circulating chloride... 2 | 30
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating sodium l... 2 | 22
decreased eosinophil cell numb... 2 | 24
decreased hematocrit 2 | 46
decreased lactate dehydrogenas... 2 | 16
decreased neutrophil cell numb... 2 | 42
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating iron lev... 2 | 30
increased circulating serum al... 2 | 22
increased heart weight 2 | 62
increased hematocrit 2 | 46
small testis 2 | 58
thin ventricular wall 2 | 24

Disease

Carcinoma 572 | 11,493
ovarian cancer 527 | 8,520
osteosarcoma 450 | 7,950
medulloblastoma, large-cell 320 | 6,241
lung cancer 315 | 4,740
psoriasis 304 | 6,694
group 3 medulloblastoma 278 | 4,104
glioblastoma 270 | 5,792
atypical teratoid / rhabdoid tumor 228 | 5,112
Breast cancer 191 | 3,578
malignant mesothelioma 189 | 3,232
ependymoma 180 | 4,679
primitive neuroectodermal tumor 166 | 3,035
Multiple myeloma 157 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 155 | 3,291
non-small cell lung cancer 142 | 2,890
Cancer 138 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 135 | 2,989
adult high grade glioma 134 | 3,801
Kidney cancer 132 | 2,613
lung adenocarcinoma 128 | 2,716
oligodendroglioma 124 | 2,850
invasive ductal carcinoma 116 | 2,951
astrocytic glioma 110 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 107 | 2,955
acute quadriplegic myopathy 103 | 1,158
diabetes mellitus 93 | 1,728
Pick disease 89 | 1,894
subependymal giant cell astrocytoma 86 | 2,287
Waldenstrons macroglobulinemia 85 | 765
dermatomyositis 85 | 966
colon cancer 82 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 80 | 1,962
Astrocytoma, Pilocytic 78 | 3,081
pancreatic cancer 77 | 2,398
breast carcinoma 75 | 1,638
group 4 medulloblastoma 74 | 1,855
astrocytoma 73 | 1,146
Intellectual disability 69 | 1,016
juvenile dermatomyositis 69 | 1,187
acute myeloid leukemia 66 | 783
adrenocortical carcinoma 65 | 1,428
tuberculosis 64 | 2,010
Autosomal recessive predisposition 63 | 1,442
pituitary cancer 63 | 1,972
non primary Sjogren syndrome sicca 61 | 891
pediatric high grade glioma 61 | 1,064
ductal carcinoma in situ 58 | 1,745
Rheumatoid arthritis 56 | 1,191
progressive supranuclear palsy 52 | 676
lung carcinoma 48 | 2,843
cystic fibrosis 47 | 1,696
nasopharyngeal carcinoma 46 | 1,058
hepatocellular carcinoma 45 | 547
Short stature 44 | 531
spina bifida 44 | 1,074
Schizophrenia 43 | 1,160
Small head 43 | 374
Cognitive delay 39 | 608
Dull intelligence 39 | 645
Global developmental delay 39 | 608
Low intelligence 39 | 645
Mental Retardation 39 | 645
Mental and motor retardation 39 | 608
Mental deficiency 39 | 645
Poor school performance 39 | 645
ulcerative colitis 37 | 1,819
Breast Neoplasms 35 | 445
Mammary Neoplasms 35 | 425
Epilepsy 33 | 792
pancreatic carcinoma 33 | 562
primary pancreatic ductal adenocarcinoma 33 | 1,109
sonic hedgehog group medulloblastoma 33 | 467
Amyotrophic lateral sclerosis 32 | 451
aldosterone-producing adenoma 32 | 665
tuberculosis and treatment for 6 months 31 | 409
Fetal Growth Retardation 29 | 189
Infant, Small for Gestational Age 29 | 176
Intrauterine retardation 29 | 176
Cryptorchidism 28 | 296
gastric cancer 28 | 459
Cleft Palate 27 | 271
Melanoma 27 | 711
cutaneous lupus erythematosus 27 | 1,057
Adenocarcinoma of lung 26 | 142
Alzheimer's disease 26 | 658
Atopic dermatitis 26 | 952
Liver cancer 26 | 604
Male infertility 26 | 206
Anemia 25 | 365
Fatigue 25 | 182
Stomach Neoplasms 25 | 300
Attention deficit hyperactivity disorder 24 | 278
Failure to gain weight 24 | 365
Muscle hypotonia 24 | 571
Pediatric failure to thrive 24 | 365
Seizures 24 | 596
interstitial cystitis 24 | 2,312
Mandibular hypoplasia 23 | 275
Micrognathism 23 | 275

Tissue

Endocrine System 974 | 18,159
Digestive Tract 943 | 17,369
Female tissues 936 | 17,400
Skin and soft tissues 935 | 17,230
Male tissues 934 | 17,142
Nervous System 934 | 16,725
Blood and immune system 930 | 16,909
Respiratory system 929 | 16,393
Liver and Pancreas 927 | 16,750
Urinary Tract 922 | 16,678
Cardiovascular System 910 | 15,192

Target Family

Non-IDG 718 | 12,091
Enzyme 215 | 4,145
Epigenetic 36 | 242
Transcription Factor 32 | 1,400
Kinase 5 | 634

PANTHER Protein Class (0)

nucleic acid binding 1,006 | 1,006
transcription factor 1,073 | 1,073
hydrolase 762 | 762
enzyme modulator 645 | 645
transferase 625 | 625
transporter 580 | 580
signaling molecule 554 | 554
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Histone H2A type 1-A HIST1H2AA Tbio Non-IDG -0.84480 8.19 69
Putative postmeiotic segregation increased 2-like protein 1 PMS2P1 Tdark Enzyme -2.19299 339.5 0
L-amino-acid oxidase IL4I1 Tbio Enzyme -2.79074 622.3 53
Beta-citrylglutamate synthase B RIMKLB Tdark Enzyme -0.33579 2.63 48
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Protein FAM133B FAM133B Tdark Non-IDG 0.40 0.38 26
RNA-binding motif protein, Y chromosome, family 1 member B RBMY1B Tbio Non-IDG 0.00000 2
NAD-dependent protein deacylase sirtuin-5, mitochondrial SIRT5 Tchem Epigenetic -2.36015 219.3 427