Development Level

Tbio 47 | 11,651
Tdark 7 | 6,593
Tchem 6 | 1,388
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
abnormal behavior 1 | 298
abnormal digit morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
cataract 1 | 92
decreased IgM level 1 | 1
decreased body length 1 | 101
decreased body weight 1 | 161
decreased mean corpuscular vol... 1 | 79
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 42 | 11,493
ovarian cancer 36 | 8,520
osteosarcoma 25 | 7,950
psoriasis 25 | 6,694
lung cancer 23 | 4,740
medulloblastoma, large-cell 22 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Autosomal recessive predisposition 17 | 1,442
glioblastoma 17 | 5,792
invasive ductal carcinoma 17 | 2,951
atypical teratoid / rhabdoid tumor 16 | 5,112
ependymoma 13 | 4,679
group 3 medulloblastoma 13 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
lung carcinoma 13 | 2,843
Multiple myeloma 12 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
malignant mesothelioma 12 | 3,232
oligodendroglioma 12 | 2,850
Cancer 11 | 2,499
lung adenocarcinoma 11 | 2,716
Seizures 10 | 596
adult high grade glioma 10 | 3,801
colon cancer 10 | 1,478
diabetes mellitus 10 | 1,728
tuberculosis 10 | 2,010
Astrocytoma, Pilocytic 9 | 3,081
Epilepsy 9 | 792
Pick disease 9 | 1,894
interstitial cystitis 9 | 2,312
primitive neuroectodermal tumor 9 | 3,035
Muscle hypotonia 8 | 571
acute quadriplegic myopathy 8 | 1,158
astrocytic glioma 8 | 2,597
ductal carcinoma in situ 8 | 1,745
non-small cell lung cancer 8 | 2,890
ulcerative colitis 8 | 1,819
Breast cancer 7 | 3,578
Intellectual disability 7 | 1,016
aldosterone-producing adenoma 7 | 665
astrocytoma 7 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
non primary Sjogren syndrome sicca 7 | 891
pancreatic cancer 7 | 2,398
subependymal giant cell astrocytoma 7 | 2,287
Alzheimer's disease 6 | 658
Dull intelligence 6 | 645
Kidney cancer 6 | 2,613
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Obesity 6 | 678
Poor school performance 6 | 645
Schizophrenia 6 | 1,160
breast carcinoma 6 | 1,638
Anemia 5 | 365
Atopic dermatitis 5 | 952
Carcinoma, Hepatocellular 5 | 228
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Hypoglycemia 5 | 152
Liver Cirrhosis, Experimental 5 | 769
Liver carcinoma 5 | 240
Mental and motor retardation 5 | 608
Neoplasm Invasiveness 5 | 161
Small head 5 | 374
adrenocortical carcinoma 5 | 1,428
cutaneous lupus erythematosus 5 | 1,057
fibroadenoma 5 | 559
medulloblastoma 5 | 720
nephrosclerosis 5 | 333
pituitary cancer 5 | 1,972
Cerebellar Ataxia 4 | 304
Cerebral atrophy 4 | 178
Cholestasis 4 | 155
Failure to gain weight 4 | 365
Heart failure 4 | 162
Hypertension 4 | 396
Infantile onset 4 | 238
Nystagmus 4 | 317
Parkinson's disease 4 | 392
Pediatric failure to thrive 4 | 365
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
acute myeloid leukemia 4 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
posterior fossa group B ependymoma 4 | 416
Bipolar Disorder 3 | 666
Rheumatoid arthritis 3 | 1,191
chronic rhinosinusitis 3 | 512
esophageal adenocarcinoma 3 | 737
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
primary Sjogren syndrome 3 | 735
primary pancreatic ductal adenocarcinoma 3 | 1,109
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 63 | 18,159
Blood and immune system 62 | 16,909
Digestive Tract 61 | 17,369
Female tissues 61 | 17,400
Male tissues 61 | 17,142
Skin and soft tissues 61 | 17,230
Liver and Pancreas 60 | 16,750
Nervous System 60 | 16,725
Urinary Tract 60 | 16,678
Respiratory system 59 | 16,393
Cardiovascular System 58 | 15,192

Target Family

Enzyme 50 | 4,145
Kinase 7 | 634
Non-IDG 7 | 12,091

PANTHER Protein Class (0)

lyase 64 | 64
transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
hydrolase 762 | 762
enzyme modulator 645 | 645
transferase 625 | 625
transporter 580 | 580
signaling molecule 554 | 554
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial mRNA pseudouridine synthase TRUB2 TRUB2 Tdark Enzyme 0.08 0.76 124
4-hydroxy-2-oxoglutarate aldolase, mitochondrial HOGA1 Tbio Enzyme -1.37549 1.73 7
Cytochrome c-type heme lyase HCCS Tbio Enzyme -3.36456 2284.3 220
N-acetylneuraminate lyase NPL Tbio Enzyme -3.10700 1259.2 86
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 BST1 Tbio Enzyme -1.86410 73.3 284
2-hydroxyacyl-CoA lyase 1 HACL1 Tbio Enzyme -1.82472 63.8 159
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Cysteine desulfurase, mitochondrial NFS1 Tbio Enzyme -1.70267 46.3 131
Pterin-4-alpha-carbinolamine dehydratase 2 PCBD2 Tdark Enzyme -0.65206 3.67 39
Transketolase-like protein 2 TKTL2 Tdark Enzyme -0.76092 3.82 107