Development Level

Tbio 58 | 10,625
Tclin 21 | 602
Tchem 20 | 1,890
Tdark 10 | 7,003

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal retina morphology 3 | 100
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
increased circulating choleste... 2 | 53
increased lean body mass 2 | 107
abnormal coping response 1 | 12
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal sleep behavior 1 | 63
decreased IgM level 1 | 1
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased prepulse inhibition 1 | 52
embryonic lethality prior to o... 1 | 148
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating glycerol... 1 | 11
increased circulating sodium l... 1 | 71
increased red blood cell distr... 1 | 21
increased vertical activity 1 | 18
male infertility 1 | 62
microphthalmia 1 | 15
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 60 | 8,492
osteosarcoma 46 | 7,933
medulloblastoma, large-cell 43 | 6,234
psoriasis 43 | 6,685
lung cancer 42 | 4,473
glioblastoma 33 | 5,572
atypical teratoid / rhabdoid tumor 30 | 4,369
invasive ductal carcinoma 26 | 2,950
lung carcinoma 26 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
malignant mesothelioma 22 | 3,163
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,795
colon cancer 21 | 1,475
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,956
lung adenocarcinoma 20 | 2,714
non-small cell lung cancer 20 | 2,798
primitive neuroectodermal tumor 20 | 3,031
ulcerative colitis 20 | 2,087
pilocytic astrocytoma 19 | 3,086
Cancer 18 | 2,346
oligodendroglioma 18 | 2,849
Breast cancer 17 | 3,099
interstitial cystitis 17 | 2,299
adult high grade glioma 16 | 2,148
medulloblastoma 16 | 1,524
pancreatic cancer 16 | 2,300
astrocytic glioma 15 | 2,241
subependymal giant cell astrocytoma 15 | 2,287
Pick disease 14 | 1,893
posterior fossa group B ependymoma 14 | 1,530
Carcinoma 13 | 2,147
Multiple myeloma 13 | 1,328
diabetes mellitus 13 | 1,663
group 3 medulloblastoma 13 | 2,254
pediatric high grade glioma 13 | 2,712
tuberculosis 13 | 1,563
astrocytoma 12 | 1,493
breast carcinoma 12 | 1,614
ductal carcinoma in situ 12 | 1,745
pituitary cancer 12 | 1,972
ependymoma 11 | 2,514
acute quadriplegic myopathy 10 | 1,157
posterior fossa group A ependymoma 10 | 1,511
sonic hedgehog group medulloblastoma 10 | 1,482
atypical teratoid/rhabdoid tumor 9 | 1,095
gastric carcinoma 9 | 832
group 4 medulloblastoma 9 | 1,875
nephrosclerosis 9 | 329
Alzheimer's disease 8 | 644
Epilepsy 8 | 346
Glaucoma 8 | 135
Obesity 8 | 616
aldosterone-producing adenoma 8 | 664
cutaneous lupus erythematosus 8 | 1,056
cystic fibrosis 8 | 1,670
non primary Sjogren syndrome sicca 8 | 840
spina bifida 8 | 1,064
Anemia 7 | 252
Atopic dermatitis 7 | 944
Cleft Lip 7 | 91
Cleft palate 7 | 125
active Crohn's disease 7 | 918
acute myeloid leukemia 7 | 785
adrenocortical carcinoma 7 | 1,427
fibroadenoma 7 | 557
Acquired metabolic disease 6 | 267
Herpangina 6 | 9
Liver carcinoma 6 | 217
Osteoporosis 6 | 259
Parkinson's disease 6 | 364
Schizophrenia 6 | 503
dermatomyositis 6 | 967
Bipolar Disorder 5 | 266
Decompensated cardiac failure 5 | 9
Down syndrome 5 | 548
Hypertension 5 | 293
Intellectual disability 5 | 573
Open-angle glaucoma 5 | 26
Pulmonary hypertension 5 | 52
Rheumatoid Arthritis 5 | 1,171
Secondary glaucoma 5 | 5
Stomach Neoplasms 5 | 282
Waldenstrons macroglobulinemia 5 | 765
active ulcerative colitis 5 | 477
angle-closure glaucoma 5 | 8
chronic rhinosinusitis 5 | 512
primary Sjogren syndrome 5 | 789
primary pancreatic ductal adenocarcinoma 5 | 1,271
Colonic Neoplasms 4 | 126
Hypertensive disease 4 | 193
IGA Glomerulonephritis 4 | 454
Prostatic Neoplasms 4 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
esophageal adenocarcinoma 4 | 737
juvenile dermatomyositis 4 | 1,189
mucosa-associated lymphoid tissue lymphoma 4 | 480
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567
tuberculosis and treatment for 3 months 4 | 327

Tissue

Blood and immune system 106 | 17,995
Digestive Tract 106 | 18,473
Endocrine System 106 | 18,512
Female tissues 106 | 18,647
Liver and Pancreas 106 | 18,136
Nervous System 106 | 18,561
Skin and soft tissues 106 | 18,115
Urinary Tract 106 | 18,444
Cardiovascular System 105 | 17,958
Male tissues 105 | 17,969
Respiratory system 105 | 17,484

Target Family

Enzyme 94 | 4,146
Non-IDG 8 | 11,969
Kinase 7 | 634

PANTHER Protein Class (0)

lyase 109 | 109
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
signaling molecule 820 | 820
transporter 767 | 767
enzyme modulator 713 | 713
hydrolase 631 | 631
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.18888 178.4 196
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tbio Enzyme -1.63886 40.3 110
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.18574 145.2 256
S-adenosylmethionine decarboxylase proenzyme AMD1 Tchem Enzyme -3.19345 1499.1 118
Deoxyribose-phosphate aldolase DERA Tbio Enzyme -2.14499 133.1 57
Methionine synthase MTR Tbio Enzyme -2.55992 290.0 77
ATP-citrate synthase ACLY Tchem Enzyme -2.81307 638.4 307
Argininosuccinate lyase ASL Tbio Enzyme -2.12423 134.6 150
N-acetylneuraminate lyase NPL Tbio Enzyme -3.09093 1195.4 65
Carbonic anhydrase 12 CA12 Tclin Enzyme -2.25292 163.5 211