Development Level

Tbio 136 | 11,651
Tdark 36 | 6,593
Tchem 18 | 1,388
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 20 | 979
preweaning lethality, incomple... 8 | 499
abnormal bone structure 7 | 187
decreased bone mineral content 7 | 151
decreased body weight 6 | 161
decreased bone mineral density 6 | 126
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
abnormal behavior 5 | 298
abnormal lens morphology 4 | 81
decreased circulating chloride... 4 | 30
decreased circulating total pr... 4 | 49
decreased prepulse inhibition 4 | 82
increased heart weight 4 | 62
cataract 3 | 92
corneal opacity 3 | 32
decreased body length 3 | 101
decreased circulating glucose ... 3 | 126
decreased circulating triglyce... 3 | 79
decreased grip strength 3 | 116
decreased hemoglobin content 3 | 68
decreased lean body mass 3 | 135
decreased startle reflex 3 | 75
enlarged heart 3 | 210
hypoactivity 3 | 132
increased circulating calcium ... 3 | 34
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
short tibia 3 | 97
thrombocytopenia 3 | 56
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal neural tube closure 2 | 46
abnormal vocalization 2 | 21
decreased blood urea nitrogen ... 2 | 51
decreased circulating amylase ... 2 | 28
decreased circulating fructosa... 2 | 30
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased circulating total pr... 2 | 28
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased red blood cell distr... 2 | 34
narrow eye opening 2 | 12
trunk curl 2 | 16
abnormal behavioral response t... 1 | 66
abnormal defecation 1 | 1
abnormal hair growth 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal neural tube morpholog... 1 | 12
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
abnormal vitreous body morphol... 1 | 10
cystolithiasis 1 | 3
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased exploration in new e... 1 | 11
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
decreased urine magnesium leve... 1 | 3
dilated heart left ventricle 1 | 11
edema 1 | 59
enlarged spleen 1 | 41
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality 1 | 28
thick skin 1 | 4
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 144 | 11,493
ovarian cancer 116 | 8,520
osteosarcoma 87 | 7,950
medulloblastoma, large-cell 77 | 6,241
glioblastoma 69 | 5,792
lung cancer 68 | 4,740
atypical teratoid / rhabdoid tumor 65 | 5,112
psoriasis 65 | 6,694
ependymoma 46 | 4,679
group 3 medulloblastoma 43 | 4,104
Breast cancer 38 | 3,578
non-small cell lung cancer 38 | 2,890
adult high grade glioma 37 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
oligodendroglioma 33 | 2,850
primitive neuroectodermal tumor 33 | 3,035
astrocytic glioma 31 | 2,597
malignant mesothelioma 31 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
Kidney cancer 29 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,962
subependymal giant cell astrocytoma 28 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
invasive ductal carcinoma 27 | 2,951
lung adenocarcinoma 27 | 2,716
tuberculosis 26 | 2,010
Astrocytoma, Pilocytic 25 | 3,081
Multiple myeloma 25 | 1,332
Pick disease 24 | 1,894
interstitial cystitis 24 | 2,312
Cancer 23 | 2,499
pancreatic cancer 23 | 2,398
Autosomal recessive predisposition 22 | 1,442
lung carcinoma 21 | 2,843
Rheumatoid arthritis 20 | 1,191
adrenocortical carcinoma 20 | 1,428
juvenile dermatomyositis 20 | 1,187
Epilepsy 17 | 792
group 4 medulloblastoma 17 | 1,855
ulcerative colitis 17 | 1,819
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
acute quadriplegic myopathy 16 | 1,158
pituitary cancer 16 | 1,972
spina bifida 16 | 1,074
Intellectual disability 15 | 1,016
Seizures 15 | 596
active Crohn's disease 15 | 922
astrocytoma 15 | 1,146
ductal carcinoma in situ 14 | 1,745
nasopharyngeal carcinoma 14 | 1,058
Schizophrenia 13 | 1,160
breast carcinoma 13 | 1,638
cystic fibrosis 13 | 1,696
Muscle hypotonia 12 | 571
hepatocellular carcinoma 12 | 547
pediatric high grade glioma 12 | 1,064
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
colon cancer 11 | 1,478
esophageal adenocarcinoma 11 | 737
primary pancreatic ductal adenocarcinoma 11 | 1,109
Atopic dermatitis 10 | 952
active ulcerative colitis 10 | 764
acute myeloid leukemia 10 | 783
dermatomyositis 10 | 966
medulloblastoma 10 | 720
tuberculosis and treatment for 6 months 10 | 409
Obesity 9 | 678
Waldenstrons macroglobulinemia 9 | 765
progressive supranuclear palsy 9 | 676
Duchenne muscular dystrophy 8 | 601
Multiple Sclerosis 8 | 540
chronic rhinosinusitis 8 | 512
cutaneous lupus erythematosus 8 | 1,057
gastric cancer 8 | 459
sonic hedgehog group medulloblastoma 8 | 467
Failure to gain weight 7 | 365
Hyperammonemia 7 | 30
Liver cancer 7 | 604
Neurodegenerative disease 7 | 414
Pediatric failure to thrive 7 | 365
Short stature 7 | 531
Acidosis, Lactic 6 | 97
Anemia 6 | 365
Bipolar Disorder 6 | 666
Cerebral atrophy 6 | 178
Crohn's disease 6 | 321
Degenerative brain disorder 6 | 100
Dilated ventricles (finding) 6 | 121
Down syndrome 6 | 499
Lactic acidemia 6 | 95
Melanoma 6 | 711
Neuropathy 6 | 261
inflammatory breast cancer 6 | 286
primary Sjogren syndrome 6 | 735

Tissue

Endocrine System 190 | 18,159
Female tissues 187 | 17,400
Urinary Tract 187 | 16,678
Digestive Tract 186 | 17,369
Nervous System 186 | 16,725
Skin and soft tissues 186 | 17,230
Blood and immune system 185 | 16,909
Liver and Pancreas 185 | 16,750
Male tissues 183 | 17,142
Respiratory system 183 | 16,393
Cardiovascular System 177 | 15,192

Target Family

Enzyme 129 | 4,145
Non-IDG 44 | 12,091
Transcription Factor 6 | 1,400
Transporter 6 | 473
Epigenetic 3 | 242
Kinase 3 | 634

PANTHER Protein Class (0)

ligase 191 | 191
transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
hydrolase 762 | 762
enzyme modulator 645 | 645
transferase 625 | 625
transporter 580 | 580
signaling molecule 554 | 554
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fatty-acid amide hydrolase 2 FAAH2 Tbio Enzyme -0.82593 5.68 104
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81
DALR anticodon-binding domain-containing protein 3 DALRD3 Tdark Non-IDG 0.48 0.28 46
E3 ubiquitin-protein ligase DTX1 DTX1 Tbio Enzyme -2.07595 115.2 134
E3 ubiquitin-protein ligase RNF5 RNF5 Tbio Enzyme -1.20054 15.1 166
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.52486 353.9 144
E3 ubiquitin-protein ligase MARCH5 MARCH5 Tbio Epigenetic -1.47833 33.3 156
Long-chain-fatty-acid--CoA ligase ACSBG2 ACSBG2 Tdark Enzyme -0.38371 2.13 98
ATPase inhibitor, mitochondrial ATP5IF1 Tbio Enzyme -2.19240 149.7 166