Development Level

Tbio 195 | 10,625
Tdark 61 | 7,003
Tchem 34 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 16 | 633
decreased lean body mass 11 | 195
decreased bone mineral content 9 | 157
decreased body weight 8 | 174
abnormal behavior 7 | 226
decreased grip strength 7 | 123
decreased heart weight 7 | 44
embryonic lethality prior to t... 7 | 187
preweaning lethality, incomple... 7 | 260
abnormal bone structure 6 | 131
decreased bone mineral density 6 | 126
increased or absent threshold ... 6 | 128
decreased body length 5 | 108
decreased total body fat amoun... 5 | 186
abnormal retina morphology 4 | 100
decreased circulating HDL chol... 4 | 77
embryonic lethality prior to o... 4 | 148
abnormal embryo size 3 | 112
abnormal spleen morphology 3 | 36
decreased circulating glucose ... 3 | 121
decreased circulating triglyce... 3 | 83
decreased hemoglobin content 3 | 53
decreased prepulse inhibition 3 | 52
enlarged heart 3 | 111
hyperactivity 3 | 108
hypoactivity 3 | 89
increased circulating alkaline... 3 | 119
increased fasted circulating g... 3 | 68
increased heart weight 3 | 37
short tibia 3 | 82
thrombocytopenia 3 | 46
trunk curl 3 | 15
abnormal bone mineralization 2 | 55
abnormal forebrain development 2 | 18
abnormal heart left ventricle ... 2 | 20
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal retinal pigmentation 2 | 61
abnormal skin morphology 2 | 23
abnormal spinal cord morpholog... 2 | 8
abnormal tail movements 2 | 12
abnormal vocalization 2 | 21
corneal opacity 2 | 25
decreased B cell number 2 | 30
decreased blood urea nitrogen ... 2 | 31
decreased circulating alkaline... 2 | 41
decreased circulating choleste... 2 | 85
decreased circulating fructosa... 2 | 31
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
decreased startle reflex 2 | 48
increased circulating calcium ... 2 | 32
increased circulating total pr... 2 | 20
increased exploration in new e... 2 | 56
narrow eye opening 2 | 15
small spleen 2 | 11
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal defecation 1 | 1
abnormal eye morphology 1 | 38
abnormal eyelid morphology 1 | 6
abnormal gait 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 11
decreased circulating chloride... 1 | 32
decreased circulating serum al... 1 | 79
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased heart rate 1 | 10
decreased hematocrit 1 | 25
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
dilated heart left ventricle 1 | 10
female infertility 1 | 34
hydrops fetalis 1 | 22
increased KLRG1+ CD4 alpha bet... 1 | 5
increased effector memory CD4-... 1 | 15
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
prolonged RR interval 1 | 2
shortened ST segment 1 | 9
small thymus 1 | 11
straub tail 1 | 26

Disease

ovarian cancer 167 | 8,484
osteosarcoma 139 | 7,933
medulloblastoma, large-cell 112 | 6,234
glioblastoma 99 | 5,572
psoriasis 95 | 6,685
lung cancer 94 | 4,466
atypical teratoid / rhabdoid tumor 76 | 4,369
Breast cancer 53 | 3,094
oligodendroglioma 49 | 2,849
ependymoma 47 | 2,514
malignant mesothelioma 46 | 3,162
pilocytic astrocytoma 46 | 3,086
adult high grade glioma 44 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
non-small cell lung cancer 44 | 2,798
primitive neuroectodermal tumor 43 | 3,031
subependymal giant cell astrocytoma 40 | 2,287
Multiple myeloma 39 | 1,327
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
ulcerative colitis 39 | 2,087
invasive ductal carcinoma 38 | 2,950
juvenile dermatomyositis 38 | 1,189
astrocytic glioma 37 | 2,241
lung adenocarcinoma 37 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
pediatric high grade glioma 36 | 2,712
group 4 medulloblastoma 35 | 1,875
group 3 medulloblastoma 33 | 2,254
interstitial cystitis 33 | 2,299
Pick disease 32 | 1,893
astrocytoma 32 | 1,493
Cancer 30 | 2,346
lung carcinoma 28 | 2,844
tuberculosis 28 | 1,557
Carcinoma 26 | 2,147
Rheumatoid Arthritis 26 | 1,160
acute quadriplegic myopathy 26 | 1,157
pancreatic cancer 26 | 2,300
medulloblastoma 25 | 1,524
adrenocortical carcinoma 24 | 1,427
dermatomyositis 24 | 933
pituitary cancer 24 | 1,972
sonic hedgehog group medulloblastoma 24 | 1,482
atypical teratoid/rhabdoid tumor 23 | 1,095
ductal carcinoma in situ 23 | 1,745
active Crohn's disease 22 | 918
colon cancer 20 | 1,475
breast carcinoma 19 | 1,614
primary Sjogren syndrome 19 | 789
spina bifida 19 | 1,064
tuberculosis and treatment for 6 months 19 | 686
cystic fibrosis 18 | 1,665
posterior fossa group B ependymoma 18 | 1,530
primary pancreatic ductal adenocarcinoma 18 | 1,271
nasopharyngeal carcinoma 17 | 1,056
Intellectual disability 16 | 573
cutaneous lupus erythematosus 15 | 1,056
diabetes mellitus 14 | 1,663
esophageal adenocarcinoma 14 | 737
hepatocellular carcinoma 14 | 532
acute myeloid leukemia 12 | 780
posterior fossa group A ependymoma 12 | 1,511
progressive supranuclear palsy 12 | 674
Atopic dermatitis 11 | 944
Obesity 11 | 616
Waldenstrons macroglobulinemia 11 | 765
Down syndrome 10 | 548
Multiple Sclerosis 10 | 498
Neurodegenerative disease 10 | 383
IGA Glomerulonephritis 9 | 454
Amyotrophic Lateral Sclerosis 8 | 431
Duchenne muscular dystrophy 8 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
gastric cancer 8 | 430
gastric carcinoma 8 | 832
sarcoidosis 8 | 358
Epilepsy 7 | 346
Gout 7 | 93
Neuropathy 7 | 210
glioblastoma multiforme 7 | 347
inflammatory breast cancer 7 | 404
non primary Sjogren syndrome sicca 7 | 840
Endometriosis 6 | 535
Parkinson's disease 6 | 364
aldosterone-producing adenoma 6 | 664
chronic rhinosinusitis 6 | 512
hereditary spastic paraplegia 6 | 313
nephrosclerosis 6 | 329
pancreatic carcinoma 6 | 567
tuberculosis and treatment for 3 months 6 | 327
Charcot-Marie-Tooth disease 5 | 74
Crohn's disease 5 | 304
Gaucher disease type 1 5 | 171
Malaria 5 | 140
Methylmalonic acidemia 5 | 39
Polycystic Ovary Syndrome 5 | 332
Toxic encephalopathy 5 | 131
mucosa-associated lymphoid tissue lymphoma 5 | 480
systemic lupus erythematosus 5 | 156

Tissue

Nervous System 289 | 18,561
Blood and immune system 288 | 17,995
Digestive Tract 288 | 18,473
Female tissues 288 | 18,647
Cardiovascular System 287 | 17,958
Endocrine System 286 | 18,512
Liver and Pancreas 286 | 18,136
Urinary Tract 286 | 18,444
Male tissues 285 | 17,969
Respiratory system 284 | 17,484
Skin and soft tissues 284 | 18,115

Target Family

Enzyme 189 | 4,146
Non-IDG 81 | 11,971
Transcription Factor 7 | 1,400
Transporter 6 | 473
Epigenetic 5 | 242
Kinase 3 | 634

PANTHER Protein Class (0)

ligase 291 | 291
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
signaling molecule 820 | 820
transporter 767 | 767
enzyme modulator 713 | 713
hydrolase 631 | 631
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
E3 ubiquitin-protein ligase ZSWIM2 ZSWIM2 Tbio Enzyme -2.21919 171.7 87
Ubiquitin-conjugating enzyme E2 variant 3 UEVLD Tdark Non-IDG 0.18 0.85 86
Phosphoribosylformylglycinamidine synthase PFAS Tbio Enzyme -2.68616 520.0 75
Cullin-5 CUL5 Tbio Non-IDG -1.93258 89.1 172
E3 ubiquitin-protein ligase TRIM62 TRIM62 Tbio Enzyme -0.57145 6.96 129
39S ribosomal protein L39, mitochondrial MRPL39 Tdark Non-IDG -0.45143 2.82 129
Tripartite motif-containing protein 67 TRIM67 Tdark Non-IDG -1.92838 86.9 22
NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 Tbio Enzyme -1.57709 42.8 121
Glutathione synthetase GSS Tbio Enzyme -2.75264 568.9 200