Development Level

Tbio 91 | 10,625
Tdark 31 | 7,003
Tchem 26 | 1,890
Tclin 4 | 602

Collection

Eligible Ion Channel Proteins 4 | 117

IMPC Term

abnormal coat/hair pigmentatio... 2 | 54
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
preweaning lethality, complete... 2 | 633
preweaning lethality, incomple... 2 | 260
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
absent pinna reflex 1 | 21
absent vibrissae 1 | 14
decreased CD4-positive NK T ce... 1 | 4
decreased CD4-positive, CD25-p... 1 | 24
decreased CD4-positive, alpha ... 1 | 19
decreased CD5-positive gamma-d... 1 | 3
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased basophil cell number 1 | 11
decreased body weight 1 | 174
decreased cervical vertebrae n... 1 | 12
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating glucose ... 1 | 121
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased dendritic cell numbe... 1 | 3
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased hemoglobin content 1 | 53
decreased macrophage cell numb... 1 | 4
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
female infertility 1 | 34
increased B cell number 1 | 23
increased CD4-negative NK T ce... 1 | 4
increased CD4-positive, alpha ... 1 | 15
increased CD5-positive Ly6C-po... 1 | 4
increased CD8-positive, alpha-... 1 | 11
increased KLRG1+ CD4 alpha bet... 1 | 5
increased Ly6C high monocyte n... 1 | 12
increased NK T cell number 1 | 11
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating free fat... 1 | 17
increased circulating iron lev... 1 | 25
increased gamma-delta T cell n... 1 | 16
increased granulocyte number 1 | 8
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased neutrophil cell numb... 1 | 15
increased prepulse inhibition 1 | 21
increased respiratory quotient 1 | 12
increased rib number 1 | 41
male infertility 1 | 62
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

ovarian cancer 73 | 8,484
osteosarcoma 47 | 7,933
psoriasis 47 | 6,685
lung cancer 41 | 4,466
medulloblastoma, large-cell 39 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,795
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,289
glioblastoma 30 | 5,572
Breast cancer 29 | 3,094
atypical teratoid / rhabdoid tumor 27 | 4,369
malignant mesothelioma 27 | 3,162
pilocytic astrocytoma 27 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,956
non-small cell lung cancer 26 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
invasive ductal carcinoma 24 | 2,950
lung adenocarcinoma 24 | 2,713
astrocytic glioma 23 | 2,241
pancreatic cancer 23 | 2,300
ductal carcinoma in situ 22 | 1,745
group 3 medulloblastoma 22 | 2,254
ulcerative colitis 22 | 2,087
interstitial cystitis 20 | 2,299
oligodendroglioma 20 | 2,849
Cancer 19 | 2,346
lung carcinoma 19 | 2,844
ependymoma 18 | 2,514
subependymal giant cell astrocytoma 18 | 2,287
Pick disease 17 | 1,893
Rheumatoid Arthritis 17 | 1,160
adult high grade glioma 17 | 2,148
pediatric high grade glioma 16 | 2,712
pituitary cancer 16 | 1,972
posterior fossa group A ependymoma 15 | 1,511
primitive neuroectodermal tumor 15 | 3,031
Multiple myeloma 14 | 1,327
cystic fibrosis 13 | 1,665
group 4 medulloblastoma 13 | 1,875
medulloblastoma 13 | 1,524
adrenocortical carcinoma 12 | 1,427
astrocytoma 12 | 1,493
breast carcinoma 12 | 1,614
colon cancer 12 | 1,475
tuberculosis 12 | 1,557
Prostatic Neoplasms 11 | 471
active Crohn's disease 10 | 918
diabetes mellitus 10 | 1,663
nasopharyngeal carcinoma 10 | 1,056
Atopic dermatitis 9 | 944
acute myeloid leukemia 9 | 780
acute quadriplegic myopathy 9 | 1,157
posterior fossa group B ependymoma 9 | 1,530
primary pancreatic ductal adenocarcinoma 9 | 1,271
sonic hedgehog group medulloblastoma 9 | 1,482
spina bifida 9 | 1,064
tuberculosis and treatment for 6 months 9 | 686
Waldenstrons macroglobulinemia 8 | 765
aldosterone-producing adenoma 8 | 664
atypical teratoid/rhabdoid tumor 8 | 1,095
gastric carcinoma 8 | 832
pancreatic carcinoma 8 | 567
progressive supranuclear palsy 8 | 674
Prevention of Cardiac Transplant Rejection 7 | 14
Prevention of Kidney Transplant Rejection 7 | 16
Prevention of Liver Transplant Rejection 7 | 14
juvenile dermatomyositis 7 | 1,189
Mammary Neoplasms 6 | 410
Obesity 6 | 616
Schizophrenia 6 | 501
esophageal adenocarcinoma 6 | 737
gastric cancer 6 | 430
hepatocellular carcinoma 6 | 532
non primary Sjogren syndrome sicca 6 | 840
Carcinoma 5 | 2,147
Congenital disorder of glycosylation 5 | 53
Duchenne muscular dystrophy 5 | 602
Keratoconjunctivitis sicca 5 | 19
Kidney disease 5 | 396
Polycystic Ovary Syndrome 5 | 332
Renal Cell Carcinoma 5 | 199
Severe Recalcitrant Psoriasis 5 | 11
Squamous cell carcinoma of esophagus 5 | 82
Tear film insufficiency 5 | 14
dermatomyositis 5 | 933
Becker muscular dystrophy 4 | 187
Degenerative polyarthritis 4 | 93
Down syndrome 4 | 548
Endometriosis 4 | 535
Intellectual disability 4 | 573
Neurodegenerative disease 4 | 383
Stomach Neoplasms 4 | 282
Vascular disease 4 | 281
active ulcerative colitis 4 | 477
chronic rhinosinusitis 4 | 512
cutaneous lupus erythematosus 4 | 1,056
glioblastoma multiforme 4 | 347
inflammatory breast cancer 4 | 404
nephrosclerosis 4 | 329
primary Sjogren syndrome 4 | 789
urothelial carcinoma 4 | 318

Tissue

Endocrine System 149 | 18,512
Female tissues 149 | 18,647
Blood and immune system 148 | 17,995
Digestive Tract 148 | 18,473
Male tissues 148 | 17,969
Liver and Pancreas 147 | 18,136
Nervous System 147 | 18,561
Cardiovascular System 146 | 17,958
Respiratory system 146 | 17,484
Urinary Tract 146 | 18,444
Skin and soft tissues 145 | 18,115

Target Family

Enzyme 113 | 4,146
Non-IDG 29 | 11,971
Ion Channel 6 | 341
Epigenetic 4 | 242

PANTHER Protein Class (0)

isomerase 152 | 152
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
signaling molecule 820 | 820
transporter 767 | 767
enzyme modulator 713 | 713
hydrolase 631 | 631
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
N-acylglucosamine 2-epimerase RENBP Tbio Enzyme -1.52686 33.5 80
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Peptidyl-prolyl cis-trans isomerase FKBP11 FKBP11 Tbio Enzyme -0.78905 6.36 123
DNA topoisomerase 2-alpha TOP2A Tclin Enzyme -2.81595 662.3 551
Inactive L-threonine 3-dehydrogenase, mitochondrial TDH Tdark Enzyme 0.00000 0
Peptidyl-prolyl cis-trans isomerase A PPIA Tclin Enzyme -2.94458 833.5 354
Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Tclin Enzyme -2.75744 370.6 255
Methylmalonyl-CoA mutase, mitochondrial MUT Tbio Enzyme -2.48654 293.0 56
Chloride intracellular channel protein 2 CLIC2 Tbio Ion Channel -1.42344 26.3 95
Threonine synthase-like 1 THNSL1 Tdark Enzyme 0.00000 76