Development Level

Tbio 386 | 11,445
Tchem 202 | 1,598
Tdark 146 | 6,588
Tclin 28 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 40 | 979
preweaning lethality, incomple... 22 | 499
abnormal behavior 15 | 298
decreased lean body mass 14 | 135
abnormal bone structure 12 | 187
decreased body weight 11 | 161
decreased bone mineral content 10 | 151
embryonic lethality prior to t... 10 | 278
hypoactivity 10 | 132
decreased body length 9 | 101
abnormal embryo size 8 | 220
decreased bone mineral density 8 | 126
hyperactivity 8 | 148
male infertility 8 | 123
decreased leukocyte cell numbe... 7 | 73
decreased neutrophil cell numb... 7 | 42
decreased total body fat amoun... 7 | 207
increased bone mineral content 7 | 108
increased circulating alkaline... 7 | 122
increased mean corpuscular hem... 7 | 96
increased startle reflex 7 | 112
thrombocytopenia 7 | 56
abnormal heart morphology 6 | 162
decreased circulating choleste... 6 | 93
decreased grip strength 6 | 116
decreased vertical activity 6 | 208
embryonic lethality prior to o... 6 | 239
enlarged heart 6 | 210
increased total body fat amoun... 6 | 134
abnormal gait 5 | 69
abnormal seminal vesicle morph... 5 | 114
decreased circulating triglyce... 5 | 79
decreased erythrocyte cell num... 5 | 62
decreased mean corpuscular vol... 5 | 79
embryonic growth retardation 5 | 106
increased blood urea nitrogen ... 5 | 48
increased lean body mass 5 | 172
increased lymphocyte cell numb... 5 | 32
short tibia 5 | 97
abnormal bone mineralization 4 | 38
cataract 4 | 92
decreased blood urea nitrogen ... 4 | 51
decreased circulating HDL chol... 4 | 68
decreased circulating creatini... 4 | 39
decreased lymphocyte cell numb... 4 | 83
decreased mean platelet volume 4 | 25
decreased prepulse inhibition 4 | 82
increased circulating sodium l... 4 | 71
increased leukocyte cell numbe... 4 | 47
increased mean platelet volume 4 | 45
long tibia 4 | 25
prolonged ST segment 4 | 36
tremors 4 | 39
abnormal eye morphology 3 | 68
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal locomotor behavior 3 | 24
abnormal tail morphology 3 | 25
decreased T cell number 3 | 15
decreased circulating aspartat... 3 | 34
decreased circulating calcium ... 3 | 36
decreased circulating glucose ... 3 | 126
decreased circulating phosphat... 3 | 27
decreased mean corpuscular hem... 3 | 50
decreased startle reflex 3 | 75
female infertility 3 | 60
increased body weight 3 | 25
increased circulating HDL chol... 3 | 80
increased circulating bilirubi... 3 | 16
increased circulating chloride... 3 | 41
increased circulating choleste... 3 | 66
increased circulating creatini... 3 | 38
increased circulating potassiu... 3 | 29
increased circulating serum al... 3 | 22
increased heart weight 3 | 62
increased mean corpuscular vol... 3 | 92
increased neutrophil cell numb... 3 | 46
prenatal lethality prior to he... 3 | 87
prolonged QT interval 3 | 38
thin ventricular wall 3 | 24
thrombocytosis 3 | 27
abnormal coat-hair pigmentatio... 2 | 64
abnormal limb bud morphology 2 | 17
abnormal skin coloration 2 | 25
abnormal vibrissa morphology 2 | 25
anophthalmia 2 | 33
decreased circulating bilirubi... 2 | 19
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased fasted circulating g... 2 | 65
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased cardiac muscle contr... 2 | 8
increased circulating amylase ... 2 | 25
increased circulating iron lev... 2 | 30
increased fasted circulating g... 2 | 76
increased or absent threshold ... 2 | 101
increased prepulse inhibition 2 | 32
pale yolk sac 2 | 25
pallor 2 | 34

Disease

Carcinoma 485 | 11,493
ovarian cancer 355 | 8,520
osteosarcoma 326 | 7,950
psoriasis 278 | 6,694
glioblastoma 244 | 5,792
medulloblastoma, large-cell 241 | 6,241
lung cancer 212 | 4,740
atypical teratoid / rhabdoid tumor 201 | 5,112
ependymoma 173 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 166 | 3,291
adult high grade glioma 146 | 3,801
malignant mesothelioma 143 | 3,232
group 3 medulloblastoma 142 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 140 | 2,955
Breast cancer 137 | 3,578
invasive ductal carcinoma 136 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 135 | 2,989
lung carcinoma 131 | 2,843
non-small cell lung cancer 129 | 2,890
pancreatic cancer 124 | 2,398
Cancer 123 | 2,499
lung adenocarcinoma 118 | 2,716
Astrocytoma, Pilocytic 110 | 3,081
interstitial cystitis 108 | 2,312
oligodendroglioma 108 | 2,850
primitive neuroectodermal tumor 107 | 3,035
pancreatic ductal adenocarcinoma liver metastasis 106 | 1,962
Autosomal recessive predisposition 101 | 1,442
subependymal giant cell astrocytoma 101 | 2,287
astrocytic glioma 97 | 2,597
diabetes mellitus 96 | 1,728
tuberculosis 92 | 2,010
Kidney cancer 91 | 2,613
ulcerative colitis 91 | 1,819
cystic fibrosis 90 | 1,696
group 4 medulloblastoma 82 | 1,855
ductal carcinoma in situ 77 | 1,745
colon cancer 75 | 1,478
pituitary cancer 71 | 1,972
Pick disease 70 | 1,894
Multiple myeloma 66 | 1,332
Atopic dermatitis 64 | 952
breast carcinoma 64 | 1,638
cutaneous lupus erythematosus 63 | 1,057
active Crohn's disease 59 | 922
adrenocortical carcinoma 55 | 1,428
primary pancreatic ductal adenocarcinoma 55 | 1,109
esophageal adenocarcinoma 53 | 737
juvenile dermatomyositis 52 | 1,187
Liver Cirrhosis, Experimental 49 | 769
gastric carcinoma 47 | 807
Schizophrenia 46 | 1,160
Intellectual disability 44 | 1,016
nasopharyngeal carcinoma 44 | 1,058
active ulcerative colitis 43 | 764
astrocytoma 43 | 1,146
pediatric high grade glioma 43 | 1,064
dermatomyositis 42 | 966
Epilepsy 40 | 792
Rheumatoid arthritis 39 | 1,191
Waldenstrons macroglobulinemia 39 | 765
non primary Sjogren syndrome sicca 38 | 891
Bipolar Disorder 36 | 666
Hypertension 36 | 396
acute quadriplegic myopathy 36 | 1,158
Alzheimer's disease 35 | 658
Dull intelligence 35 | 645
Low intelligence 35 | 645
Mental Retardation 35 | 645
Mental deficiency 35 | 645
Obesity 35 | 678
Poor school performance 35 | 645
spina bifida 35 | 1,074
Neurodegenerative disease 33 | 414
Seizures 33 | 596
mucosa-associated lymphoid tissue lymphoma 33 | 484
Melanoma 31 | 711
Cognitive delay 30 | 608
Global developmental delay 30 | 608
Mental and motor retardation 30 | 608
acute myeloid leukemia 30 | 783
primary Sjogren syndrome 30 | 735
Short stature 28 | 531
nephrosclerosis 28 | 333
Atherosclerosis 26 | 291
Duchenne muscular dystrophy 26 | 601
Muscle hypotonia 26 | 571
Prostatic Neoplasms 26 | 495
medulloblastoma 26 | 720
progressive supranuclear palsy 26 | 676
Kidney disease 25 | 430
Cerebrovascular disease 24 | 238
Coronary artery disease 24 | 268
Endometriosis 24 | 540
Skin cancer 24 | 469
Diarrhea 23 | 253
Hypertensive disease 23 | 292
Vascular disease 23 | 319
aldosterone-producing adenoma 23 | 665
periodontitis 23 | 293

Tissue

Endocrine System 711 | 18,159
Female tissues 705 | 17,400
Digestive Tract 698 | 17,369
Skin and soft tissues 686 | 17,230
Blood and immune system 685 | 16,909
Male tissues 678 | 17,142
Urinary Tract 674 | 16,678
Liver and Pancreas 668 | 16,750
Nervous System 653 | 16,725
Respiratory system 653 | 16,393
Cardiovascular System 586 | 15,192

Target Family

Enzyme 682 | 4,145
Non-IDG 71 | 12,091
Kinase 6 | 634
Epigenetic 2 | 242
Transporter 1 | 473

PANTHER Protein Class (0)

hydrolase 762 | 762
transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
enzyme modulator 645 | 645
transferase 625 | 625
transporter 580 | 580
signaling molecule 554 | 554
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

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