Development Level

Tbio 291 | 10,625
Tchem 185 | 1,890
Tdark 116 | 7,003
Tclin 39 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 19 | 633
abnormal behavior 10 | 226
preweaning lethality, incomple... 10 | 260
decreased body weight 8 | 174
decreased body length 7 | 108
decreased lean body mass 7 | 195
abnormal bone structure 6 | 131
increased bone mineral content 6 | 92
abnormal embryo size 5 | 112
abnormal retinal pigmentation 5 | 61
decreased total body fat amoun... 5 | 186
embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 5 | 187
enlarged heart 5 | 111
increased circulating alkaline... 5 | 119
decreased bone mineral content 4 | 157
decreased bone mineral density 4 | 126
decreased prepulse inhibition 4 | 52
hyperactivity 4 | 108
hypoactivity 4 | 89
increased body weight 4 | 42
increased bone mineral density 4 | 52
increased circulating sodium l... 4 | 71
male infertility 4 | 62
short tibia 4 | 82
abnormal bone mineralization 3 | 55
abnormal lens morphology 3 | 73
abnormal retina morphology 3 | 100
decreased circulating choleste... 3 | 85
decreased circulating triglyce... 3 | 83
decreased erythrocyte cell num... 3 | 43
decreased heart weight 3 | 44
decreased neutrophil cell numb... 3 | 37
female infertility 3 | 34
increased circulating potassiu... 3 | 31
increased circulating serum al... 3 | 25
increased or absent threshold ... 3 | 128
increased rib number 3 | 41
oligodactyly 3 | 14
thrombocytopenia 3 | 46
tremors 3 | 34
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal neural tube closure 2 | 37
abnormal seminal vesicle morph... 2 | 47
abnormal tail morphology 2 | 17
abnormal testis morphology 2 | 30
abnormal vibrissa morphology 2 | 17
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 35
decreased B cell number 2 | 30
decreased NK T cell number 2 | 28
decreased cervical vertebrae n... 2 | 12
decreased circulating HDL chol... 2 | 77
decreased circulating amylase ... 2 | 24
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating phosphat... 2 | 15
decreased circulating serum al... 2 | 79
decreased effector memory CD8-... 2 | 24
decreased grip strength 2 | 123
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 34
decreased mean platelet volume 2 | 12
embryonic growth retardation 2 | 28
enlarged lymph nodes 2 | 27
hydrops fetalis 2 | 22
increased B cell number 2 | 23
increased CD4-positive, CD25-p... 2 | 18
increased heart weight 2 | 37
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased mean platelet volume 2 | 19
increased prepulse inhibition 2 | 21
increased sacral vertebrae num... 2 | 62
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
long tibia 2 | 13
prenatal lethality prior to he... 2 | 64
small adrenal glands 2 | 15
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal locomotor activation 1 | 26
abnormal motor capabilities/co... 1 | 4
decreased CD4-positive, alpha ... 1 | 19
decreased blood urea nitrogen ... 1 | 31
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased red blood cell distr... 1 | 11
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29
increased effector memory CD4-... 1 | 15
increased mean corpuscular hem... 1 | 25
limb grasping 1 | 35
premature death 1 | 5
straub tail 1 | 26

Disease

ovarian cancer 301 | 8,484
osteosarcoma 300 | 7,933
psoriasis 229 | 6,685
medulloblastoma, large-cell 223 | 6,234
glioblastoma 214 | 5,572
lung cancer 179 | 4,466
atypical teratoid / rhabdoid tumor 155 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 147 | 3,289
malignant mesothelioma 126 | 3,162
invasive ductal carcinoma 123 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 119 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 118 | 2,988
pilocytic astrocytoma 114 | 3,086
Breast cancer 113 | 3,094
lung carcinoma 112 | 2,844
primitive neuroectodermal tumor 105 | 3,031
ulcerative colitis 103 | 2,087
lung adenocarcinoma 102 | 2,713
non-small cell lung cancer 102 | 2,798
pancreatic cancer 99 | 2,300
oligodendroglioma 98 | 2,849
subependymal giant cell astrocytoma 97 | 2,287
interstitial cystitis 95 | 2,299
pediatric high grade glioma 92 | 2,712
ependymoma 90 | 2,514
adult high grade glioma 87 | 2,148
astrocytic glioma 85 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 81 | 1,795
Pick disease 79 | 1,893
diabetes mellitus 76 | 1,663
tuberculosis 75 | 1,557
Cancer 72 | 2,346
cystic fibrosis 72 | 1,665
group 3 medulloblastoma 71 | 2,254
ductal carcinoma in situ 70 | 1,745
pituitary cancer 69 | 1,972
group 4 medulloblastoma 66 | 1,875
breast carcinoma 65 | 1,614
colon cancer 63 | 1,475
Carcinoma 58 | 2,147
medulloblastoma 53 | 1,524
cutaneous lupus erythematosus 51 | 1,056
sonic hedgehog group medulloblastoma 51 | 1,482
astrocytoma 50 | 1,493
active Crohn's disease 49 | 918
posterior fossa group B ependymoma 49 | 1,530
Multiple myeloma 48 | 1,327
posterior fossa group A ependymoma 47 | 1,511
Atopic dermatitis 46 | 944
primary pancreatic ductal adenocarcinoma 46 | 1,271
adrenocortical carcinoma 40 | 1,427
gastric carcinoma 40 | 832
juvenile dermatomyositis 40 | 1,189
Rheumatoid Arthritis 39 | 1,160
atypical teratoid/rhabdoid tumor 38 | 1,095
acute quadriplegic myopathy 36 | 1,157
spina bifida 35 | 1,064
esophageal adenocarcinoma 34 | 737
Alzheimer's disease 33 | 644
Obesity 31 | 616
nasopharyngeal carcinoma 31 | 1,056
Waldenstrons macroglobulinemia 30 | 765
Duchenne muscular dystrophy 29 | 602
Neurodegenerative disease 29 | 383
non primary Sjogren syndrome sicca 29 | 840
primary Sjogren syndrome 29 | 789
progressive supranuclear palsy 29 | 674
dermatomyositis 28 | 933
aldosterone-producing adenoma 25 | 664
mucosa-associated lymphoid tissue lymphoma 25 | 480
active ulcerative colitis 24 | 477
Atrial Fibrillation 23 | 110
Schizophrenia 23 | 501
nephrosclerosis 23 | 329
Chronic heart failure 22 | 46
acute myeloid leukemia 22 | 780
Down syndrome 21 | 548
Endometriosis 20 | 535
IGA Glomerulonephritis 20 | 454
Myocardial Perfusion Imaging Adjunct 20 | 25
Platelet Aggregation Inhibition 20 | 22
Prevention of Cerebral Thrombosis 20 | 29
non-small cell lung carcinoma 20 | 413
Asthma 19 | 349
gastric cancer 19 | 430
Autistic Disorder 18 | 320
fibroadenoma 18 | 557
pancreatic carcinoma 18 | 567
Bipolar Disorder 17 | 266
Intellectual disability 17 | 573
Multiple Sclerosis 17 | 498
Prostatic Neoplasms 17 | 471
head and neck cancer and chronic obstructive pulmonary disease 17 | 237
inflammatory breast cancer 17 | 404
tuberculosis and treatment for 6 months 17 | 686
Atherosclerosis 16 | 275
Neuropathy 16 | 210
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 499
glioblastoma multiforme 16 | 347
hereditary spastic paraplegia 16 | 313

Tissue

Digestive Tract 618 | 18,473
Nervous System 617 | 18,561
Urinary Tract 617 | 18,444
Endocrine System 615 | 18,512
Female tissues 615 | 18,647
Skin and soft tissues 615 | 18,115
Liver and Pancreas 613 | 18,136
Cardiovascular System 610 | 17,958
Male tissues 609 | 17,969
Blood and immune system 608 | 17,995
Respiratory system 603 | 17,484

Target Family

Enzyme 573 | 4,146
Non-IDG 49 | 11,971
Kinase 4 | 634
Epigenetic 2 | 242
Transporter 2 | 473
Ion Channel 1 | 341

PANTHER Protein Class (0)

hydrolase 631 | 631
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
signaling molecule 820 | 820
transporter 767 | 767
enzyme modulator 713 | 713
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Transmembrane gamma-carboxyglutamic acid protein 3 PRRG3 Tdark Non-IDG -0.21639 1.71 76
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
Transmembrane gamma-carboxyglutamic acid protein 4 PRRG4 Tdark Non-IDG -0.29670 2.24 21
Sialidase-3 NEU3 Tbio Enzyme -1.97558 109.4 23
Ovochymase-2 OVCH2 Tdark Enzyme 0.00000 0
Serine protease 41 PRSS41 Tdark Enzyme 0.00000 0
Acidic mammalian chitinase CHIA Tchem Enzyme -2.59382 419.7 126
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102