Development Level

Tbio 481 | 10,625
Tdark 154 | 7,003
Tchem 74 | 1,890
Tclin 4 | 602

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 23 | 633
decreased bone mineral content 11 | 157
preweaning lethality, incomple... 10 | 260
decreased lean body mass 9 | 195
abnormal behavior 8 | 226
decreased body weight 8 | 174
decreased total body fat amoun... 8 | 186
increased mean corpuscular vol... 8 | 91
enlarged heart 7 | 111
decreased bone mineral density 6 | 126
decreased body length 5 | 108
decreased circulating serum al... 5 | 79
hyperactivity 5 | 108
increased or absent threshold ... 5 | 128
increased total body fat amoun... 5 | 57
abnormal heart morphology 4 | 51
abnormal spleen morphology 4 | 36
decreased circulating HDL chol... 4 | 77
embryonic lethality prior to t... 4 | 187
increased circulating alkaline... 4 | 119
increased hematocrit 4 | 36
increased mean corpuscular hem... 4 | 93
increased rib number 4 | 41
abnormal bone structure 3 | 131
abnormal retina morphology 3 | 100
abnormal rib morphology 3 | 28
decreased circulating LDL chol... 3 | 37
decreased circulating choleste... 3 | 85
decreased circulating insulin ... 3 | 75
decreased circulating iron lev... 3 | 25
decreased fasted circulating g... 3 | 49
embryonic lethality prior to o... 3 | 148
hypoactivity 3 | 89
impaired glucose tolerance 3 | 52
increased blood urea nitrogen ... 3 | 44
increased circulating phosphat... 3 | 24
increased circulating potassiu... 3 | 31
increased grip strength 3 | 83
increased hemoglobin content 3 | 45
thrombocytopenia 3 | 46
abnormal cranium morphology 2 | 32
abnormal embryo size 2 | 112
abnormal epididymis morphology 2 | 31
abnormal gait 2 | 51
abnormal locomotor activation 2 | 26
abnormal retinal blood vessel ... 2 | 18
abnormal retinal pigmentation 2 | 61
cardiovascular system phenotyp... 2 | 35
decreased CD4-positive, CD25-p... 2 | 24
decreased circulating creatini... 2 | 31
decreased circulating free fat... 2 | 39
decreased circulating glucose ... 2 | 121
decreased circulating total pr... 2 | 41
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased mature B cell number 2 | 25
decreased mean corpuscular hem... 2 | 19
decreased rib number 2 | 59
decreased startle reflex 2 | 48
decreased vertical activity 2 | 22
enlarged epididymis 2 | 27
enlarged spleen 2 | 26
immune system phenotype 2 | 17
impaired righting response 2 | 19
improved glucose tolerance 2 | 56
increased bone mineral density 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating free fat... 2 | 17
increased circulating glucose ... 2 | 16
increased effector memory CD4-... 2 | 15
increased exploration in new e... 2 | 56
increased heart rate 2 | 17
increased leukocyte cell numbe... 2 | 37
increased mean platelet volume 2 | 19
increased sacral vertebrae num... 2 | 62
shortened RR interval 2 | 19
abnormal behavioral response t... 1 | 52
abnormal neural tube closure 1 | 37
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased thoracic vertebrae n... 1 | 7
increased CD5-positive Ly6C-po... 1 | 4
increased NK cell number 1 | 19
increased body length 1 | 20
increased circulating creatini... 1 | 29
limb grasping 1 | 35
long tibia 1 | 13
prenatal lethality prior to he... 1 | 64
vertebral fusion 1 | 23

Disease

ovarian cancer 358 | 8,484
osteosarcoma 341 | 7,933
medulloblastoma, large-cell 299 | 6,234
glioblastoma 280 | 5,572
psoriasis 273 | 6,685
atypical teratoid / rhabdoid tumor 226 | 4,369
lung cancer 191 | 4,466
pilocytic astrocytoma 163 | 3,086
primitive neuroectodermal tumor 161 | 3,031
lung carcinoma 153 | 2,844
Breast cancer 152 | 3,094
malignant mesothelioma 149 | 3,162
subependymal giant cell astrocytoma 148 | 2,287
invasive ductal carcinoma 147 | 2,950
oligodendroglioma 144 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 137 | 3,289
pediatric high grade glioma 137 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 134 | 2,988
non-small cell lung cancer 133 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 128 | 2,956
lung adenocarcinoma 126 | 2,713
Cancer 119 | 2,346
ependymoma 118 | 2,514
astrocytic glioma 114 | 2,241
pancreatic cancer 112 | 2,300
adult high grade glioma 110 | 2,148
ulcerative colitis 110 | 2,087
interstitial cystitis 106 | 2,299
Carcinoma 95 | 2,147
cystic fibrosis 92 | 1,665
ductal carcinoma in situ 90 | 1,745
Pick disease 89 | 1,893
medulloblastoma 89 | 1,524
group 4 medulloblastoma 88 | 1,875
pituitary cancer 85 | 1,972
posterior fossa group A ependymoma 73 | 1,511
astrocytoma 72 | 1,493
group 3 medulloblastoma 68 | 2,254
primary pancreatic ductal adenocarcinoma 67 | 1,271
breast carcinoma 66 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 65 | 1,795
juvenile dermatomyositis 64 | 1,189
sonic hedgehog group medulloblastoma 64 | 1,482
tuberculosis 64 | 1,557
colon cancer 62 | 1,475
posterior fossa group B ependymoma 62 | 1,530
cutaneous lupus erythematosus 59 | 1,056
spina bifida 59 | 1,064
Multiple myeloma 57 | 1,327
diabetes mellitus 57 | 1,663
acute quadriplegic myopathy 56 | 1,157
adrenocortical carcinoma 53 | 1,427
primary Sjogren syndrome 52 | 789
Rheumatoid Arthritis 49 | 1,160
Atopic dermatitis 47 | 944
nasopharyngeal carcinoma 47 | 1,056
active Crohn's disease 46 | 918
dermatomyositis 46 | 933
esophageal adenocarcinoma 46 | 737
atypical teratoid/rhabdoid tumor 43 | 1,095
gastric carcinoma 39 | 832
Duchenne muscular dystrophy 34 | 602
Waldenstrons macroglobulinemia 30 | 765
Intellectual disability 29 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 499
non primary Sjogren syndrome sicca 28 | 840
non-small cell lung carcinoma 28 | 413
tuberculosis and treatment for 6 months 28 | 686
Endometriosis 27 | 535
aldosterone-producing adenoma 27 | 664
Alzheimer's disease 26 | 644
gastric cancer 26 | 430
Kidney disease 25 | 396
fibroadenoma 25 | 557
pancreatic carcinoma 25 | 567
sarcoidosis 25 | 358
Amyotrophic Lateral Sclerosis 24 | 431
mucosa-associated lymphoid tissue lymphoma 24 | 480
IGA Glomerulonephritis 23 | 454
Obesity 23 | 616
Stomach Neoplasms 22 | 282
acute myeloid leukemia 22 | 780
Chronic Lymphocytic Leukemia 20 | 242
Heart disease 20 | 279
Parkinson's disease 20 | 364
Liver carcinoma 19 | 217
Mammary Neoplasms 19 | 410
active ulcerative colitis 19 | 477
tuberculosis and treatment for 3 months 19 | 327
Prostatic Neoplasms 18 | 471
Vascular disease 18 | 281
Crohn's disease 17 | 304
Hypertension 17 | 287
glioblastoma multiforme 17 | 347
hereditary spastic paraplegia 17 | 313
periodontitis 17 | 269
progressive supranuclear palsy 17 | 674
Down syndrome 16 | 548
Schizophrenia 16 | 501
urothelial carcinoma 16 | 318

Tissue

Endocrine System 700 | 18,512
Urinary Tract 699 | 18,444
Digestive Tract 697 | 18,473
Female tissues 697 | 18,647
Nervous System 697 | 18,561
Male tissues 691 | 17,969
Skin and soft tissues 689 | 18,115
Liver and Pancreas 685 | 18,136
Blood and immune system 681 | 17,995
Cardiovascular System 680 | 17,958
Respiratory system 680 | 17,484

Target Family

Non-IDG 425 | 11,971
Enzyme 280 | 4,146
Kinase 8 | 634

PANTHER Protein Class (0)

enzyme modulator 713 | 713
transcription factor 1,533 | 1,533
nucleic acid binding 1,330 | 1,330
transferase 873 | 873
signaling molecule 820 | 820
transporter 767 | 767
hydrolase 631 | 631
cytoskeletal protein 608 | 608
receptor 550 | 550
cell adhesion molecule 502 | 502
oxidoreductase 404 | 404
transfer/carrier protein 308 | 308
ligase 291 | 291
membrane traffic protein 285 | 285
extracellular matrix protein 262 | 262
defense/immunity protein 209 | 209
chaperone 163 | 163
isomerase 152 | 152
calcium-binding protein 149 | 149
cell junction protein 129 | 129
lyase 109 | 109
transmembrane receptor regulat... 68 | 68
surfactant 53 | 53
structural protein 42 | 42
storage protein 18 | 18
viral protein 13 | 13

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290
ADP-ribosylation factor-like protein 16 ARL16 Tdark Enzyme -0.13389 1.44 17
Protein phosphatase 2C-like domain-containing protein 1 PP2D1 Tdark Enzyme 0.00000 5
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.21425 1443.3 95
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
TBC1 domain family member 2B TBC1D2B Tdark Non-IDG 0.64 0.18 19
C-Jun-amino-terminal kinase-interacting protein 3 MAPK8IP3 Tbio Enzyme -1.63360 51.0 128
Protein phosphatase 1 regulatory subunit 3C PPP1R3C Tbio Enzyme -2.41843 288.0 78