Development Level

Tbio 460 | 11,445
Tdark 125 | 6,588
Tchem 56 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 35 | 979
preweaning lethality, incomple... 13 | 499
abnormal behavior 12 | 298
embryonic lethality prior to t... 10 | 278
decreased bone mineral content 8 | 151
embryonic lethality prior to o... 8 | 239
enlarged heart 8 | 210
short tibia 8 | 97
abnormal embryo size 7 | 220
increased startle reflex 7 | 112
abnormal heart morphology 6 | 162
decreased body weight 6 | 161
decreased total body fat amoun... 6 | 207
hyperactivity 6 | 148
abnormal bone structure 5 | 187
increased circulating alkaline... 5 | 122
abnormal seminal vesicle morph... 4 | 114
decreased circulating serum al... 4 | 82
decreased circulating triglyce... 4 | 79
impaired glucose tolerance 4 | 75
increased mean corpuscular vol... 4 | 92
increased red blood cell distr... 4 | 34
abnormal cranium morphology 3 | 36
abnormal lens morphology 3 | 81
abnormal spleen morphology 3 | 55
cataract 3 | 92
decreased body length 3 | 101
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased circulating iron lev... 3 | 32
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased prepulse inhibition 3 | 82
decreased red blood cell distr... 3 | 41
increased blood urea nitrogen ... 3 | 48
increased circulating glucose ... 3 | 24
increased lean body mass 3 | 172
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 96
thrombocytopenia 3 | 56
abnormal behavioral response t... 2 | 66
abnormal coat appearance 2 | 31
abnormal eye morphology 2 | 68
abnormal forebrain morphology 2 | 10
abnormal joint morphology 2 | 23
abnormal lung morphology 2 | 26
abnormal midbrain morphology 2 | 10
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal tooth morphology 2 | 24
cardiovascular system phenotyp... 2 | 36
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased heart rate 2 | 18
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased spleen weight 2 | 10
decreased startle reflex 2 | 75
decreased threshold for audito... 2 | 26
edema 2 | 59
enlarged spleen 2 | 41
head bobbing 2 | 5
hypoactivity 2 | 132
impaired righting response 2 | 26
increased circulating HDL chol... 2 | 80
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating free fat... 2 | 20
increased circulating phosphat... 2 | 26
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased monocyte cell number 2 | 63
increased spleen weight 2 | 10
pale yolk sac 2 | 25
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
prolonged PR interval 2 | 15
abnormal craniofacial morpholo... 1 | 33
abnormal hair growth 1 | 10
decreased IgG1 level 1 | 8
decreased fluid intake 1 | 3
decreased mean corpuscular hem... 1 | 31
increased body length 1 | 32
increased circulating triglyce... 1 | 42
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 395 | 11,493
ovarian cancer 331 | 8,520
osteosarcoma 310 | 7,950
medulloblastoma, large-cell 270 | 6,241
glioblastoma 260 | 5,792
psoriasis 250 | 6,694
atypical teratoid / rhabdoid tumor 227 | 5,112
ependymoma 204 | 4,679
lung cancer 200 | 4,740
adult high grade glioma 186 | 3,801
Breast cancer 164 | 3,578
group 3 medulloblastoma 155 | 4,104
lung carcinoma 147 | 2,843
Cancer 143 | 2,499
malignant mesothelioma 142 | 3,232
non-small cell lung cancer 140 | 2,890
Astrocytoma, Pilocytic 139 | 3,081
primitive neuroectodermal tumor 138 | 3,035
invasive ductal carcinoma 135 | 2,951
subependymal giant cell astrocytoma 133 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 129 | 3,291
lung adenocarcinoma 128 | 2,716
oligodendroglioma 127 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 124 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 123 | 2,955
astrocytic glioma 113 | 2,597
pancreatic cancer 112 | 2,398
Kidney cancer 108 | 2,613
interstitial cystitis 104 | 2,312
ulcerative colitis 95 | 1,819
cystic fibrosis 89 | 1,696
pituitary cancer 86 | 1,972
Pick disease 83 | 1,894
ductal carcinoma in situ 80 | 1,745
tuberculosis 80 | 2,010
group 4 medulloblastoma 76 | 1,855
breast carcinoma 68 | 1,638
juvenile dermatomyositis 67 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 63 | 1,962
colon cancer 62 | 1,478
adrenocortical carcinoma 58 | 1,428
astrocytoma 58 | 1,146
primary pancreatic ductal adenocarcinoma 57 | 1,109
Liver Cirrhosis, Experimental 55 | 769
cutaneous lupus erythematosus 55 | 1,057
diabetes mellitus 55 | 1,728
Rheumatoid arthritis 53 | 1,191
Multiple myeloma 51 | 1,332
Atopic dermatitis 49 | 952
active Crohn's disease 49 | 922
acute quadriplegic myopathy 49 | 1,158
primary Sjogren syndrome 49 | 735
spina bifida 47 | 1,074
Intellectual disability 44 | 1,016
dermatomyositis 43 | 966
Schizophrenia 42 | 1,160
gastric carcinoma 42 | 807
nasopharyngeal carcinoma 41 | 1,058
esophageal adenocarcinoma 40 | 737
pediatric high grade glioma 39 | 1,064
active ulcerative colitis 38 | 764
Duchenne muscular dystrophy 36 | 601
Autosomal recessive predisposition 34 | 1,442
non primary Sjogren syndrome sicca 30 | 891
Bipolar Disorder 29 | 666
Endometriosis 29 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 510
Melanoma 27 | 711
Obesity 27 | 678
Waldenstrons macroglobulinemia 27 | 765
aldosterone-producing adenoma 27 | 665
medulloblastoma 27 | 720
Alzheimer's disease 25 | 658
Amyotrophic lateral sclerosis 24 | 451
sarcoidosis 24 | 370
Vascular disease 23 | 319
mucosa-associated lymphoid tissue lymphoma 23 | 484
Breast Neoplasms 22 | 445
Heart disease 22 | 306
Stomach Neoplasms 22 | 300
fibroadenoma 22 | 559
Down syndrome 21 | 499
Dull intelligence 21 | 645
Epilepsy 21 | 792
Low intelligence 21 | 645
Mental Retardation 21 | 645
Mental deficiency 21 | 645
Poor school performance 21 | 645
gastric cancer 21 | 459
pancreatic carcinoma 21 | 562
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Kidney disease 20 | 430
Mammary Neoplasms 20 | 425
Mental and motor retardation 20 | 608
Muscle hypotonia 20 | 571
Prostatic Neoplasms 20 | 495
hepatocellular carcinoma 20 | 547
sonic hedgehog group medulloblastoma 20 | 467
Short stature 19 | 531

Tissue

Endocrine System 622 | 18,159
Digestive Tract 605 | 17,369
Female tissues 602 | 17,400
Skin and soft tissues 601 | 17,230
Male tissues 598 | 17,142
Liver and Pancreas 586 | 16,750
Blood and immune system 584 | 16,909
Urinary Tract 583 | 16,678
Respiratory system 576 | 16,393
Nervous System 574 | 16,725
Cardiovascular System 541 | 15,192

Target Family

Non-IDG 425 | 12,091
Enzyme 210 | 4,145
Kinase 8 | 634
Transporter 2 | 473

PANTHER Protein Class (0)

enzyme modulator 645 | 645
transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
hydrolase 762 | 762
transferase 625 | 625
transporter 580 | 580
signaling molecule 554 | 554
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155
Caspase-14 CASP14 Tchem Enzyme -1.81937 73.7 348
Rab-3A-interacting protein RAB3IP Tbio Non-IDG -1.03500 11.6 89
Butyrophilin-like protein 2 BTNL2 Tbio Non-IDG -2.57312 369.3 73
TBC1 domain family member 3B TBC1D3B Tbio Non-IDG 0.00000 3
Ras association domain-containing protein 3 RASSF3 Tbio Non-IDG 0.00000 130
TBC1 domain family member 3L TBC1D3L Tdark Non-IDG 0.00000 2
Rho GTPase-activating protein 9 ARHGAP9 Tbio Enzyme -1.74771 54.3 35
Zonadhesin ZAN Tdark Non-IDG 0.00000 0
G2/mitotic-specific cyclin-B3 CCNB3 Tbio Non-IDG -1.07824 12.1 272