Development Level

Tbio 311 | 11,651
Tdark 105 | 6,593
Tchem 16 | 1,388
Tclin 9 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 35 | 979
preweaning lethality, incomple... 20 | 499
hyperactivity 10 | 148
abnormal behavior 9 | 298
abnormal embryo size 9 | 220
embryonic lethality prior to t... 9 | 278
decreased total body fat amoun... 8 | 207
decreased circulating glucose ... 7 | 126
increased lean body mass 7 | 172
abnormal bone structure 6 | 187
decreased body weight 6 | 161
decreased bone mineral density 6 | 126
abnormal sleep behavior 5 | 70
embryonic lethality prior to o... 5 | 239
improved glucose tolerance 5 | 79
increased bone mineral content 5 | 108
increased circulating alkaline... 5 | 122
male infertility 5 | 123
prenatal lethality prior to he... 5 | 87
abnormal behavioral response t... 4 | 66
cataract 4 | 92
decreased body length 4 | 101
decreased bone mineral content 4 | 151
decreased circulating choleste... 4 | 93
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
decreased mean corpuscular vol... 4 | 79
decreased vertical activity 4 | 208
increased circulating chloride... 4 | 41
increased fasted circulating g... 4 | 76
increased hematocrit 4 | 46
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
abnormal bone mineralization 3 | 38
abnormal lens morphology 3 | 81
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
cardiovascular system phenotyp... 3 | 36
decreased circulating fructosa... 3 | 30
decreased circulating insulin ... 3 | 76
decreased lymphocyte cell numb... 3 | 83
embryonic growth retardation 3 | 106
enlarged lymph nodes 3 | 37
hypoactivity 3 | 132
impaired glucose tolerance 3 | 75
increased bone mineral density 3 | 72
increased circulating glucose ... 3 | 24
increased circulating phosphat... 3 | 26
increased circulating sodium l... 3 | 71
increased heart weight 3 | 62
increased startle reflex 3 | 112
long tibia 3 | 25
abnormal coat appearance 2 | 31
abnormal coat- hair morphology 2 | 19
abnormal joint morphology 2 | 23
abnormal locomotor activation 2 | 16
abnormal vertebrae morphology 2 | 18
absent pinna reflex 2 | 23
convulsive seizures 2 | 13
cyanosis 2 | 7
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased circulating alkaline... 2 | 46
decreased circulating aspartat... 2 | 34
decreased circulating iron lev... 2 | 32
decreased circulating potassiu... 2 | 20
decreased circulating sodium l... 2 | 22
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
enlarged heart 2 | 210
female infertility 2 | 60
impaired righting response 2 | 26
increased body weight 2 | 25
increased circulating creatini... 2 | 38
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
increased prepulse inhibition 2 | 32
increased red blood cell distr... 2 | 34
increased total body fat amoun... 2 | 134
pallor 2 | 34
short tibia 2 | 97
small testis 2 | 58
abnormal gait 1 | 69
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
decreased circulating calcium ... 1 | 36
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 31
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
microphthalmia 1 | 26

Disease

Carcinoma 304 | 11,493
ovarian cancer 211 | 8,520
osteosarcoma 181 | 7,950
glioblastoma 179 | 5,792
psoriasis 179 | 6,694
medulloblastoma, large-cell 171 | 6,241
ependymoma 168 | 4,679
atypical teratoid / rhabdoid tumor 155 | 5,112
lung cancer 133 | 4,740
Breast cancer 125 | 3,578
adult high grade glioma 120 | 3,801
primitive neuroectodermal tumor 113 | 3,035
group 3 medulloblastoma 111 | 4,104
Astrocytoma, Pilocytic 105 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 101 | 2,989
malignant mesothelioma 101 | 3,232
pancreatic cancer 98 | 2,398
non-small cell lung cancer 96 | 2,890
invasive ductal carcinoma 93 | 2,951
oligodendroglioma 90 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 89 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 85 | 3,291
lung carcinoma 80 | 2,843
subependymal giant cell astrocytoma 76 | 2,287
lung adenocarcinoma 75 | 2,716
Kidney cancer 72 | 2,613
astrocytic glioma 66 | 2,597
colon cancer 66 | 1,478
breast carcinoma 65 | 1,638
Pick disease 64 | 1,894
interstitial cystitis 64 | 2,312
ductal carcinoma in situ 58 | 1,745
primary pancreatic ductal adenocarcinoma 58 | 1,109
pituitary cancer 53 | 1,972
nasopharyngeal carcinoma 52 | 1,058
cystic fibrosis 44 | 1,696
spina bifida 44 | 1,074
group 4 medulloblastoma 43 | 1,855
adrenocortical carcinoma 41 | 1,428
diabetes mellitus 41 | 1,728
juvenile dermatomyositis 41 | 1,187
ulcerative colitis 41 | 1,819
acute quadriplegic myopathy 40 | 1,158
tuberculosis 38 | 2,010
astrocytoma 37 | 1,146
dermatomyositis 37 | 966
Cancer 36 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 36 | 1,962
Autosomal recessive predisposition 34 | 1,442
Atopic dermatitis 33 | 952
Duchenne muscular dystrophy 32 | 601
chronic rhinosinusitis 32 | 512
Liver cancer 31 | 604
Multiple myeloma 31 | 1,332
Rheumatoid arthritis 30 | 1,191
pediatric high grade glioma 30 | 1,064
autosomal dominant Emery-Dreifuss muscular dystrophy 26 | 510
esophageal adenocarcinoma 26 | 737
Intellectual disability 25 | 1,016
cutaneous lupus erythematosus 25 | 1,057
gastric carcinoma 24 | 807
progressive supranuclear palsy 24 | 676
Alzheimer's disease 23 | 658
Schizophrenia 23 | 1,160
Down syndrome 22 | 499
Melanoma 22 | 711
Liver Cirrhosis, Experimental 21 | 769
Amyotrophic lateral sclerosis 20 | 451
Endometriosis 20 | 540
Muscle hypotonia 20 | 571
Waldenstrons macroglobulinemia 20 | 765
Primary ciliary dyskinesia 19 | 76
active Crohn's disease 19 | 922
primary Sjogren syndrome 19 | 735
Epilepsy 18 | 792
active ulcerative colitis 18 | 764
fibroadenoma 18 | 559
gastric cancer 18 | 459
medulloblastoma 18 | 720
pancreatic carcinoma 18 | 562
Bipolar Disorder 17 | 666
Endometrial cancer 17 | 311
acute myeloid leukemia 17 | 783
aldosterone-producing adenoma 17 | 665
hereditary spastic paraplegia 17 | 318
Microcephaly 16 | 166
Neurodegenerative disease 16 | 414
Seizures 16 | 596
Short stature 16 | 531
Skin cancer 16 | 469
Small head 16 | 374
Cognitive delay 15 | 608
Dull intelligence 15 | 645
Global developmental delay 15 | 608
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental and motor retardation 15 | 608
Mental deficiency 15 | 645
Poor school performance 15 | 645
tuberculosis and treatment for 6 months 15 | 409

Tissue

Endocrine System 427 | 18,159
Female tissues 405 | 17,400
Skin and soft tissues 404 | 17,230
Digestive Tract 401 | 17,369
Male tissues 399 | 17,142
Nervous System 396 | 16,725
Liver and Pancreas 393 | 16,750
Respiratory system 393 | 16,393
Urinary Tract 392 | 16,678
Blood and immune system 391 | 16,909
Cardiovascular System 363 | 15,192

Target Family

Non-IDG 403 | 12,091
Enzyme 28 | 4,145
Kinase 6 | 634
Transcription Factor 4 | 1,400

PANTHER Protein Class (0)

cytoskeletal protein 441 | 441
transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
hydrolase 762 | 762
enzyme modulator 645 | 645
transferase 625 | 625
transporter 580 | 580
signaling molecule 554 | 554
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
cell junction protein 90 | 90
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
F-actin-capping protein subunit alpha-3 CAPZA3 Tdark Non-IDG -0.56455 3.20 78
Germ cell-specific gene 1-like protein GSG1L Tbio Non-IDG -0.69780 6.03 67
Dynein heavy chain 6, axonemal DNAH6 Tbio Non-IDG -0.53057 4.17 18
Fidgetin FIGN Tbio Enzyme -1.34015 21.2 103
Tubulin epsilon chain TUBE1 Tbio Non-IDG -2.57316 368.1 99
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
Probable tubulin polyglutamylase TTLL1 TTLL1 Tdark Enzyme -0.79170 5.84 34
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100