Development Level

Tbio 72 | 11,178
Tdark 16 | 6,569
Tchem 2 | 1,885

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

enlarged heart 3 | 210
increased or absent threshold ... 3 | 101
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased circulating amylase ... 2 | 28
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
preweaning lethality, complete... 2 | 979
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal ear morphology 1 | 9
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased heart rate variabili... 1 | 13
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged pancreas 1 | 2
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased grip strength 1 | 41
increased thermal nociceptive ... 1 | 9
increased vertical activity 1 | 24
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
shortened PR interval 1 | 6
shortened RR interval 1 | 17
stereotypic behavior 1 | 3
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 58 | 11,192
ovarian cancer 40 | 8,297
osteosarcoma 38 | 7,766
psoriasis 34 | 6,514
atypical teratoid / rhabdoid tumor 30 | 4,971
medulloblastoma, large-cell 29 | 6,086
non-small cell lung cancer 29 | 2,799
interstitial cystitis 26 | 2,237
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,902
ependymoma 24 | 4,559
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,204
lung adenocarcinoma 22 | 2,627
pancreatic cancer 21 | 2,322
subependymal giant cell astrocytoma 21 | 2,230
adult high grade glioma 20 | 3,701
glioblastoma 20 | 5,635
invasive ductal carcinoma 20 | 2,867
Breast cancer 19 | 3,469
Astrocytoma, Pilocytic 17 | 3,006
group 3 medulloblastoma 17 | 4,002
lung carcinoma 17 | 2,755
Cancer 16 | 2,388
lung cancer 16 | 4,607
malignant mesothelioma 16 | 3,135
primitive neuroectodermal tumor 16 | 2,957
Autosomal recessive predisposition 15 | 1,407
Kidney cancer 15 | 2,548
pituitary cancer 15 | 1,915
Nonsyndromic deafness 13 | 137
cystic fibrosis 13 | 1,629
ductal carcinoma in situ 13 | 1,686
ulcerative colitis 13 | 1,765
gastric carcinoma 12 | 781
spina bifida 12 | 1,053
Sensorineural hearing loss 11 | 102
astrocytic glioma 11 | 2,530
primary pancreatic ductal adenocarcinoma 11 | 1,071
breast carcinoma 10 | 1,589
oligodendroglioma 10 | 2,768
Erythrokeratodermia variabilis 8 | 10
Intellectual disability 8 | 998
Schizophrenia 8 | 1,136
active Crohn's disease 8 | 882
nasopharyngeal carcinoma 8 | 1,024
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,911
Cataract 7 | 290
Myopia 7 | 175
Oculodentodigital dysplasia 7 | 14
astrocytoma 7 | 1,113
diabetes mellitus 7 | 1,683
medulloblastoma 7 | 702
Alopecia 6 | 113
Dull intelligence 6 | 634
Epilepsy 6 | 775
Lens Opacities 6 | 227
Low intelligence 6 | 634
Mental Retardation 6 | 634
Mental deficiency 6 | 634
Poor school performance 6 | 634
Sensorineural Hearing Loss (disorder) 6 | 281
adrenocortical carcinoma 6 | 1,385
group 4 medulloblastoma 6 | 1,806
interstitial lung disease 6 | 287
pediatric high grade glioma 6 | 1,035
tuberculosis 6 | 1,963
Atopic dermatitis 5 | 915
Autistic Disorder 5 | 358
Clouston syndrome 5 | 9
Diarrhea 5 | 245
Down syndrome 5 | 480
Hypertension 5 | 372
Inflammatory bowel disease 5 | 148
Liver Cirrhosis, Experimental 5 | 733
Liver cancer 5 | 589
Palmoplantar keratosis 5 | 73
Pick disease 5 | 1,856
Prostatic Neoplasms 5 | 472
Small head 5 | 366
active ulcerative colitis 5 | 736
colon cancer 5 | 1,428
dermatomyositis 5 | 941
esophageal adenocarcinoma 5 | 696
mucosa-associated lymphoid tissue lymphoma 5 | 473
Cerebrovascular disease 4 | 223
Cognitive delay 4 | 596
Deafness 4 | 193
Global developmental delay 4 | 596
Hypertensive disease 4 | 278
Infantile onset 4 | 236
Kidney disease 4 | 411
Low Vision 4 | 167
Mental and motor retardation 4 | 596
Nephrocalcinosis 4 | 34
Seizures 4 | 584
Short stature 4 | 514
Visual Impairment 4 | 167
acute myeloid leukemia 4 | 760
acute quadriplegic myopathy 4 | 1,133
urothelial carcinoma 4 | 303

Tissue

Endocrine System 87 | 18,159
Female tissues 85 | 17,400
Digestive Tract 83 | 17,369
Urinary Tract 83 | 16,678
Skin and soft tissues 81 | 17,230
Liver and Pancreas 78 | 16,750
Blood and immune system 77 | 16,909
Male tissues 77 | 17,142
Nervous System 77 | 16,725
Respiratory system 73 | 16,393
Cardiovascular System 65 | 15,192

Target Family

Non-IDG 85 | 12,091
Enzyme 3 | 4,145
Kinase 2 | 634

PANTHER Protein Class (0)

cell junction protein 90 | 90
nucleic acid binding 995 | 995
transcription factor 989 | 989
transferase 620 | 620
enzyme modulator 585 | 585
transporter 574 | 574
signaling molecule 554 | 554
hydrolase 464 | 464
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
ligase 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gap junction gamma-2 protein GJC2 Tbio Non-IDG -1.95161 87.3 126
Tight junction protein ZO-3 TJP3 Tbio Non-IDG -1.36150 19.9 173
Putative claudin-25 CLDN25 Tdark Non-IDG 0.30 0.20 37
Gap junction delta-3 protein GJD3 Tbio Non-IDG -0.48785 4.49 23
Gap junction beta-2 protein GJB2 Tbio Non-IDG -3.17642 1514.7 242
Claudin-5 CLDN5 Tbio Non-IDG -2.58968 349.4 300
Unconventional myosin-Ih MYO1H Tdark Non-IDG -0.56690 3.82 16
Nephrin NPHS1 Tbio Non-IDG -3.16031 1396.4 555
Claudin-14 CLDN14 Tbio Non-IDG -1.58115 36.2 206
MAGUK p55 subfamily member 3 MPP3 Tbio Non-IDG -1.26124 17.3 186