Development Level

Tbio 73 | 11,445
Tdark 16 | 6,588
Tchem 1 | 1,598

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

enlarged heart 3 | 210
increased or absent threshold ... 3 | 101
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased circulating amylase ... 2 | 28
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
preweaning lethality, complete... 2 | 979
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal ear morphology 1 | 9
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased heart rate variabili... 1 | 13
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged pancreas 1 | 2
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased grip strength 1 | 41
increased thermal nociceptive ... 1 | 9
increased vertical activity 1 | 24
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
shortened PR interval 1 | 6
shortened RR interval 1 | 17
stereotypic behavior 1 | 3
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 58 | 11,493
ovarian cancer 40 | 8,520
osteosarcoma 38 | 7,950
psoriasis 34 | 6,694
atypical teratoid / rhabdoid tumor 30 | 5,112
medulloblastoma, large-cell 29 | 6,241
non-small cell lung cancer 29 | 2,890
interstitial cystitis 26 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
ependymoma 24 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
lung adenocarcinoma 22 | 2,716
pancreatic cancer 21 | 2,398
subependymal giant cell astrocytoma 21 | 2,287
adult high grade glioma 20 | 3,801
glioblastoma 20 | 5,792
invasive ductal carcinoma 20 | 2,951
Breast cancer 19 | 3,578
Astrocytoma, Pilocytic 17 | 3,081
group 3 medulloblastoma 17 | 4,104
lung carcinoma 17 | 2,843
Cancer 16 | 2,499
lung cancer 16 | 4,740
malignant mesothelioma 16 | 3,232
primitive neuroectodermal tumor 16 | 3,035
Autosomal recessive predisposition 15 | 1,442
Kidney cancer 15 | 2,613
pituitary cancer 15 | 1,972
Nonsyndromic deafness 13 | 142
cystic fibrosis 13 | 1,696
ductal carcinoma in situ 13 | 1,745
ulcerative colitis 13 | 1,819
gastric carcinoma 12 | 807
spina bifida 12 | 1,074
Sensorineural hearing loss 11 | 106
astrocytic glioma 11 | 2,597
primary pancreatic ductal adenocarcinoma 11 | 1,109
breast carcinoma 10 | 1,638
oligodendroglioma 10 | 2,850
Erythrokeratodermia variabilis 8 | 10
Intellectual disability 8 | 1,016
Schizophrenia 8 | 1,160
active Crohn's disease 8 | 922
nasopharyngeal carcinoma 8 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Cataract 7 | 297
Myopia 7 | 176
Oculodentodigital dysplasia 7 | 14
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
medulloblastoma 7 | 720
Alopecia 6 | 115
Dull intelligence 6 | 645
Epilepsy 6 | 792
Lens Opacities 6 | 231
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Sensorineural Hearing Loss (disorder) 6 | 284
adrenocortical carcinoma 6 | 1,428
group 4 medulloblastoma 6 | 1,855
interstitial lung disease 6 | 298
pediatric high grade glioma 6 | 1,064
tuberculosis 6 | 2,010
Atopic dermatitis 5 | 952
Autistic Disorder 5 | 364
Clouston syndrome 5 | 9
Diarrhea 5 | 253
Down syndrome 5 | 499
Hypertension 5 | 396
Inflammatory bowel disease 5 | 151
Liver Cirrhosis, Experimental 5 | 769
Liver cancer 5 | 604
Palmoplantar keratosis 5 | 74
Pick disease 5 | 1,894
Prostatic Neoplasms 5 | 495
Small head 5 | 374
active ulcerative colitis 5 | 764
colon cancer 5 | 1,478
dermatomyositis 5 | 966
esophageal adenocarcinoma 5 | 737
mucosa-associated lymphoid tissue lymphoma 5 | 484
Cerebrovascular disease 4 | 238
Cognitive delay 4 | 608
Deafness 4 | 198
Global developmental delay 4 | 608
Hypertensive disease 4 | 292
Infantile onset 4 | 238
Kidney disease 4 | 430
Low Vision 4 | 174
Mental and motor retardation 4 | 608
Nephrocalcinosis 4 | 35
Seizures 4 | 596
Short stature 4 | 531
Visual Impairment 4 | 174
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
urothelial carcinoma 4 | 318

Tissue

Endocrine System 87 | 18,159
Female tissues 85 | 17,400
Digestive Tract 83 | 17,369
Urinary Tract 83 | 16,678
Skin and soft tissues 81 | 17,230
Liver and Pancreas 78 | 16,750
Blood and immune system 77 | 16,909
Male tissues 77 | 17,142
Nervous System 77 | 16,725
Respiratory system 73 | 16,393
Cardiovascular System 65 | 15,192

Target Family

Non-IDG 85 | 12,091
Enzyme 3 | 4,145
Kinase 2 | 634

PANTHER Protein Class (0)

cell junction protein 90 | 90
transcription factor 1,073 | 1,073
nucleic acid binding 1,006 | 1,006
hydrolase 762 | 762
enzyme modulator 645 | 645
transferase 625 | 625
transporter 580 | 580
signaling molecule 554 | 554
cytoskeletal protein 441 | 441
receptor 400 | 400
oxidoreductase 319 | 319
membrane traffic protein 217 | 217
cell adhesion molecule 191 | 191
ligase 191 | 191
defense/immunity protein 177 | 177
extracellular matrix protein 175 | 175
transfer/carrier protein 175 | 175
calcium-binding protein 105 | 105
chaperone 89 | 89
isomerase 84 | 84
lyase 64 | 64
transmembrane receptor regulat... 64 | 64
structural protein 45 | 45
storage protein 18 | 18
surfactant 8 | 8
viral protein 8 | 8

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Claudin-16 CLDN16 Tbio Non-IDG -1.98248 102.4 138
Gap junction delta-2 protein GJD2 Tbio Non-IDG -2.48933 326.9 192
Unconventional myosin-XV MYO15A Tbio Non-IDG -1.64094 42.8 15
Gap junction alpha-3 protein GJA3 Tbio Non-IDG -2.14059 135.1 171
Claudin-1 CLDN1 Tbio Non-IDG -2.07626 126.7 593
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129
MAGUK p55 subfamily member 6 MPP6 Tbio Non-IDG -0.94687 8.86 142
Lipoma-preferred partner LPP Tbio Non-IDG -2.77949 582.6 164
Gap junction alpha-8 protein GJA8 Tbio Non-IDG -2.81282 660.2 196
Nephrin NPHS1 Tbio Non-IDG -3.16031 1396.4 555