Development Level

Tbio 18 | 11,445
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
abnormal clavicle morphology 1 | 6
abnormal heart morphology 1 | 162
abnormal rib morphology 1 | 10
decreased caudal vertebrae num... 1 | 53
decreased circulating creatini... 1 | 39
decreased fasted circulating g... 1 | 65
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

osteosarcoma 18 | 7,950
Carcinoma 11 | 11,493
ovarian cancer 10 | 8,520
group 3 medulloblastoma 6 | 4,104
lung cancer 6 | 4,740
medulloblastoma, large-cell 5 | 6,241
psoriasis 5 | 6,694
group 4 medulloblastoma 4 | 1,855
tuberculosis 4 | 2,010
astrocytic glioma 3 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Cerebral atrophy 2 | 178
Cognitive delay 2 | 608
Feeding difficulties 2 | 127
Global developmental delay 2 | 608
Kidney cancer 2 | 2,613
Mental and motor retardation 2 | 608
Multiple myeloma 2 | 1,332
Neurodegenerative disease 2 | 414
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 36
X-linked cerebral adrenoleukodystrophy 2 | 116
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
colon cancer 2 | 1,478
dermatomyositis 2 | 966
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
pancreatic carcinoma 2 | 562
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
Absent speech 1 | 43
Amyotrophic lateral sclerosis 1 | 451
Atrophy of cerebellum 1 | 103
Carcinoma, Hepatocellular 1 | 228
Cerebellar degeneration 1 | 103
Congenital deafness 1 | 185
Contracture 1 | 96
Contracture of joint 1 | 93
Deafness 1 | 198
Disease Progression 1 | 136
Failure to gain weight 1 | 365
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Foot Deformities 1 | 30
Gastric antral vascular ectasia 1 | 10
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hearing Loss, Partial 1 | 185
Highly variable severity 1 | 157
Hyperreflexia 1 | 209
Hypoplasia of corpus callosum 1 | 90
Infratentorial atrophy 1 | 103
Leukemia 1 | 104
Liver Cirrhosis, Experimental 1 | 769
Liver cancer 1 | 604
Liver carcinoma 1 | 240
Liver neoplasms 1 | 130
Low Vision 1 | 174
Microphthalmia with limb anomalies 1 | 40
Muscle Spasticity 1 | 195
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Nonsyndromic deafness 1 | 142
Pediatric failure to thrive 1 | 365
Polycystic ovary syndrome 1 | 360
Poor growth 1 | 114
Prenatal onset 1 | 139
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Skeletal muscle atrophy 1 | 139
Stomach Neoplasms 1 | 300
Strabismus 1 | 270
Variable expressivity 1 | 157
Very poor growth 1 | 114
Visual Impairment 1 | 174
Waldenstrons macroglobulinemia 1 | 765
adrenocortical carcinoma 1 | 1,428
atypical teratoid/rhabdoid tumor 1 | 357
glioblastoma multiforme 1 | 142
hearing impairment 1 | 199
hepatocellular carcinoma 1 | 547
muscle degeneration 1 | 139
nasopharyngeal carcinoma 1 | 1,058
nonverbal 1 | 43
posterior fossa group B ependymoma 1 | 416
progressive supranuclear palsy 1 | 676
pulmonary arterial hypertension 1 | 75

Tissue

Blood and immune system 20 | 16,909
Cardiovascular System 20 | 15,192
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678

Target Family

Enzyme 13 | 4,145
Non-IDG 8 | 12,091

PANTHER Protein Class (2)

exoribonuclease 21 | 21
protein kinase 257 | 257
serine protease 175 | 175
ribosomal protein 152 | 152
cysteine protease 142 | 142
metalloprotease 135 | 135
mRNA processing factor 122 | 122
calmodulin 113 | 113
chromatin/chromatin-binding pr... 106 | 106
serine protease inhibitor 94 | 94
non-motor actin binding protei... 90 | 90
homeodomain transcription fact... 88 | 88
small GTPase 81 | 81
guanyl-nucleotide exchange fac... 77 | 77
translation factor 76 | 76
ligand-gated ion channel 69 | 69
microtubule binding motor prot... 62 | 62
histone 61 | 61
non-motor microtubule binding ... 57 | 57
kinase activator 55 | 55
chemokine 48 | 48
DNA-directed RNA polymerase 46 | 46
ribonucleoprotein 44 | 44
heterotrimeric G-protein 43 | 43
protein phosphatase 41 | 41
nucleotide kinase 37 | 37
RNA helicase 35 | 35
phosphatase inhibitor 34 | 34
nucleotide phosphatase 33 | 33
actin and actin related protei... 31 | 31
kinase inhibitor 31 | 31
phospholipase 30 | 30
ATP synthase 28 | 28
DNA helicase 28 | 28
actin binding motor protein 27 | 27
C2H2 zinc finger transcription... 25 | 25
calcium channel 23 | 23
DNA-directed DNA polymerase 22 | 22
endoribonuclease 22 | 22
tubulin 22 | 22
aspartic protease 21 | 21
type I cytokine receptor 20 | 20
anion channel 19 | 19
carbohydrate kinase 17 | 17
endodeoxyribonuclease 15 | 15
intermediate filament binding ... 15 | 15
neuropeptide 15 | 15
potassium channel 15 | 15
DNA methyltransferase 12 | 12
type II cytokine receptor 12 | 12
RNA methyltransferase 11 | 11
damaged DNA-binding protein 11 | 11
tumor necrosis factor family m... 11 | 11
sodium channel 9 | 9
neurotrophic factor 8 | 8
replication origin binding pro... 8 | 8
winged helix/forkhead transcri... 8 | 8
carbohydrate phosphatase 6 | 6
amino acid kinase 5 | 5
guanylate cyclase 5 | 5
DNA topoisomerase 4 | 4
interleukin superfamily 4 | 4
CREB-related transcription fac... 3 | 3
C4 zinc finger nuclear recepto... 2 | 2
DNA photolyase 2 | 2
Lambda repressor-like transcri... 2 | 2
cysteine protease inhibitor 2 | 2
tumor necrosis factor receptor 2 | 2
DNA glycosylase 1 | 1
DNA polymerase processivity fa... 1 | 1
centromere DNA-binding protein 1 | 1
exodeoxyribonuclease 1 | 1
phosphatase activator 1 | 1
primase 1 | 1
reverse transcriptase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Oligoribonuclease, mitochondrial REXO2 Tbio Enzyme -2.15502 143.8 115
Putative exonuclease GOR REXO1L1P Tdark Enzyme -1.82597 59.0 0
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
Protein angel homolog 1 ANGEL1 Tbio Non-IDG -0.17609 1.15 94
5'-3' exoribonuclease 1 XRN1 Tbio Enzyme -2.13482 125.3 51
Exosome complex component MTR3 EXOSC6 Tbio Enzyme -0.78888 5.11 84
RNA exonuclease 5 REXO5 Tdark Enzyme -0.36798 0.44 31
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
RNA exonuclease 1 homolog REXO1 Tdark Enzyme 0.25 0.75 150
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.17714 13.5 92