Development Level

Tchem 14 | 1,598
Tbio 12 | 11,445
Tdark 4 | 6,588

IMPC Phenotype

cataract 2 | 92
increased lean body mass 2 | 172
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal vocalization 1 | 21
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased total body fat amoun... 1 | 207
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 17 | 11,493
psoriasis 15 | 6,694
glioblastoma 12 | 5,792
osteosarcoma 12 | 7,950
lung cancer 11 | 4,740
medulloblastoma, large-cell 11 | 6,241
adult high grade glioma 10 | 3,801
ependymoma 10 | 4,679
Kidney cancer 9 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
ovarian cancer 9 | 8,520
Astrocytoma, Pilocytic 8 | 3,081
atypical teratoid / rhabdoid tumor 8 | 5,112
lung carcinoma 8 | 2,843
subependymal giant cell astrocytoma 8 | 2,287
interstitial cystitis 7 | 2,312
Bipolar Disorder 6 | 666
Cancer 6 | 2,499
Schizophrenia 6 | 1,160
colon cancer 6 | 1,478
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
Toxic encephalopathy 5 | 141
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Atherosclerosis 4 | 291
Breast cancer 4 | 3,578
Coronary artery disease 4 | 268
invasive ductal carcinoma 4 | 2,951
Arthritis 3 | 290
Autosomal recessive predisposition 3 | 1,442
Gas gangrene 3 | 17
Ileocolitis 3 | 5
adrenocortical carcinoma 3 | 1,428
cystic fibrosis 3 | 1,696
group 4 medulloblastoma 3 | 1,855
nasopharyngeal carcinoma 3 | 1,058
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
primary Sjogren syndrome 3 | 735
Acute pancreatitis 2 | 10
Amyotrophic lateral sclerosis 2 | 451
Asphyxiating thoracic dystrophy 2 | 44
Barth syndrome 2 | 23
Cerebrovascular disease 2 | 238
Epilepsy 2 | 792
Hyperreflexia 2 | 209
Liver cancer 2 | 604
MAJOR AFFECTIVE DISORDER 2 2 | 22
Melanoma 2 | 711
Membranous glomerulonephritis 2 | 13
Nephrotic Syndrome 2 | 78
Neurodegenerative disease 2 | 414
Osteoporosis 2 | 363
Paraplegia 2 | 74
Pick disease 2 | 1,894
Progressive disorder 2 | 142
Proteinuria 2 | 144
Rheumatoid arthritis 2 | 1,191
Sengers syndrome 2 | 18
Skin cancer 2 | 469
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
hereditary spastic paraplegia 2 | 318
inflammatory breast cancer 2 | 286
non diabetic and post-ischemic heart failure 2 | 200
non-small cell lung carcinoma 2 | 317
spina bifida 2 | 1,074
type II diabetes mellitus and post-ischemic heart failure 2 | 88
urothelial carcinoma 2 | 318
Adenocarcinoma 1 | 122
Adult T-Cell Lymphoma/Leukemia 1 | 30
Axial hypotonia 1 | 46
Azoospermia 1 | 110
Barrett's esophagus 1 | 182
Carcinoma of colon 1 | 32
Childhood onset 1 | 38
Deglutition Disorders 1 | 132
Esophageal Squamous Cell Carcinoma 1 | 77
Glanzmann's thrombasthenia 1 | 23
Hypsarrhythmia 1 | 25
Leukemia-Lymphoma, Adult T-Cell 1 | 30
MYELODYSPLASTIC SYNDROME 1 | 53
Myelodysplastic Syndromes 1 | 26
Panic disorder 1 | 61
Recurrent infections 1 | 48
Squamous cell carcinoma of esophagus 1 | 77
Vitiligo 1 | 73
West Syndrome 1 | 28

Tissue

Blood and immune system 29 | 16,909
Digestive Tract 29 | 17,369
Female tissues 28 | 17,400
Skin and soft tissues 28 | 17,230
Endocrine System 27 | 18,159
Male tissues 27 | 17,142
Urinary Tract 27 | 16,678
Liver and Pancreas 25 | 16,750
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Cardiovascular System 22 | 15,192

Target Family

Enzyme 26 | 4,145
Non-IDG 4 | 12,091

PANTHER Protein Class (1)

lipase 30 | 30
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

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