Development Level

Tbio 11 | 11,445
Tchem 4 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
decreased circulating glucose ... 1 | 126
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hydrometra 1 | 53
increased bone mineral content 1 | 108
increased circulating creatini... 1 | 38
increased neutrophil cell numb... 1 | 46
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74

Disease

Carcinoma 14 | 11,493
Mucopolysaccharidosis 6 | 26
Cancer 5 | 2,499
psoriasis 5 | 6,694
Autosomal recessive predisposition 4 | 1,442
diabetes mellitus 4 | 1,728
invasive ductal carcinoma 4 | 2,951
non-small cell lung cancer 4 | 2,890
ovarian cancer 4 | 8,520
Kidney cancer 3 | 2,613
glioblastoma 3 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung adenocarcinoma 3 | 2,716
non primary Sjogren syndrome sicca 3 | 891
Big calvaria 2 | 147
Blind Vision 2 | 111
Blindness, Legal 2 | 110
Cherry red spot of the macula 2 | 7
Chronic diarrhea 2 | 29
Coarse facial features 2 | 108
Concave bridge of nose 2 | 195
Cystitis cystica 2 | 2
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Depressive disorder 2 | 409
Dermatologic disorders 2 | 93
Gangliosidosis 2 | 20
Gaucher's disease 2 | 26
Hepatosplenomegaly 2 | 22
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Infertility 2 | 188
Intellectual disability 2 | 1,016
Irritable bowel syndrome 2 | 60
Macroglossia 2 | 65
Melanoma 2 | 711
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Neurodegenerative disease 2 | 414
Obesity 2 | 678
Osteoporosis 2 | 363
Paget's disease of bone 2 | 36
Short stature 2 | 531
Skin atrophy 2 | 16
Skin cancer 2 | 469
Thickened facial skin with coarse facial features 2 | 108
Urofacial syndrome 2 | 7
cutaneous lupus erythematosus 2 | 1,057
ductal carcinoma in situ 2 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
nephrosclerosis 2 | 333
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Abnormal CNS myelination 1 | 4
Abnormal diaphysis morphology 1 | 5
Abnormal vertebral bodies 1 | 16
Abnormality of the clavicle 1 | 14
Abnormality of the elbow 1 | 6
Actual Aspiration 1 | 8
Amelogenesis imperfecta type 1G 1 | 11
Aortic valve stenosis 1 | 28
Broad face 1 | 7
Cleft uvula 1 | 27
Congenital anomaly of spine 1 | 16
Congenital hypoplasia of clavicle 1 | 18
Embryo Loss 1 | 7
Endometriosis of uterus 1 | 4
Erectile dysfunction 1 | 32
Exaggerated acoustic startle response 1 | 8
Exaggerated startle response 1 | 8
Gm2-ganglioside accumulation 1 | 2
Hyperexplexia 1 | 8
Hypotension, Orthostatic 1 | 18
Increased startle response 1 | 8
Israeli tick typhus 1 | 2
Learning Disorders 1 | 29
Memory Disorders 1 | 40
Milk allergy 1 | 3
Mucopolysaccharidosis I 1 | 4
Multiple vertebral anomalies 1 | 16
Myoma 1 | 12
Narrow pelvis 1 | 6
Ochoa syndrome 1 | 2
Poor head control 1 | 14
Pulmonary aspiration 1 | 8
Pyramidal sign 1 | 29
Retinitis pigmentosa Y-linked 1 | 9
Sandhoff disease 1 | 3
Spinal canal stenosis 1 | 12
Submucous cleft of hard palate 1 | 11
Submucous clefting 1 | 9
Tay-Sachs disease 1 | 6
Tracheal stenosis 1 | 23

Tissue

Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Blood and immune system 14 | 16,909
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Cardiovascular System 11 | 15,192

Target Family

Enzyme 16 | 4,145

PANTHER Protein Class (1)

glycosidase 16 | 16
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
aminoacyl-tRNA synthetase 24 | 24
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Poly(ADP-ribose) glycohydrolase PARG Tchem Enzyme -2.32776 229.4 126
Beta-klotho KLB Tbio Enzyme -2.02643 82.8 95
Hyaluronidase PH-20 SPAM1 Tbio Enzyme -2.18435 158.5 144
Alpha-L-iduronidase IDUA Tbio Enzyme -2.45679 291.5 129
Lactase-phlorizin hydrolase LCT Tbio Enzyme -2.65148 430.9 148
Klotho KL Tbio Enzyme -2.86543 790.6 276
Hyaluronidase-2 HYAL2 Tbio Enzyme -2.01424 105.1 212
Hyaluronidase-1 HYAL1 Tbio Enzyme -1.88328 77.3 220
Inactive heparanase-2 HPSE2 Tbio Enzyme -2.52081 326.4 137
Hyaluronidase-3 HYAL3 Tbio Enzyme -0.92743 7.88 126