Development Level

Tbio 17 | 11,445
Tchem 4 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased grip strength 3 | 116
decreased fasted circulating g... 2 | 65
embryonic lethality prior to o... 2 | 239
impaired glucose tolerance 2 | 75
increased total body fat amoun... 2 | 134
abnormal QT variability 1 | 10
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal lens morphology 1 | 81
abnormal sleep behavior 1 | 70
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating sodium l... 1 | 22
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
decreased urine magnesium leve... 1 | 3
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
preweaning lethality, incomple... 1 | 499
trunk curl 1 | 16

Disease

Carcinoma 23 | 11,493
ovarian cancer 18 | 8,520
lung cancer 11 | 4,740
Autosomal recessive predisposition 9 | 1,442
psoriasis 9 | 6,694
osteosarcoma 8 | 7,950
Multiple myeloma 7 | 1,332
medulloblastoma, large-cell 6 | 6,241
Neurodegenerative disease 5 | 414
Neuropathy 5 | 261
Breast cancer 4 | 3,578
Decreased tendon reflex 4 | 122
Distal sensory impairment 4 | 52
Leigh disease 4 | 100
Myositis 4 | 30
Nystagmus 4 | 317
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
glioblastoma 4 | 5,792
Acquired scoliosis 3 | 281
Alpers syndrome 3 | 9
Charcot-Marie-Tooth disease 3 | 62
Congenital pes cavus 3 | 88
Curvature of spine 3 | 282
Epilepsy 3 | 792
Increased serum lactate 3 | 60
Motor delay 3 | 147
No development of motor milestones 3 | 147
Perrault syndrome 3 | 19
Progressive disorder 3 | 142
Sensorineural Hearing Loss (disorder) 3 | 284
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 783
group 3 medulloblastoma 3 | 4,104
juvenile dermatomyositis 3 | 1,187
pediatric high grade glioma 3 | 1,064
Acidosis, Lactic 2 | 97
Atypical autism 2 | 26
Autistic Disorder 2 | 364
Autosomal recessive Robinow syndrome 2 | 27
Babinski Reflex 2 | 100
Blepharoptosis 2 | 231
Cancer 2 | 2,499
Cataract 2 | 297
Cerebellar Ataxia 2 | 304
Cognitive delay 2 | 608
Congenital deafness 2 | 185
Contracture 2 | 96
Contracture of joint 2 | 93
Deafness 2 | 198
Filariasis 2 | 21
Flexion contracture 2 | 93
Flexion contractures of joints 2 | 93
Gait, Drop Foot 2 | 24
Global developmental delay 2 | 608
Gonadal dysgenesis XX type deafness 2 | 5
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hammer Toe 2 | 23
Hearing Loss, Partial 2 | 185
Highly variable severity 2 | 157
Hyperreflexia 2 | 209
Impaired exercise tolerance 2 | 42
Intellectual disability 2 | 1,016
Lactic acidemia 2 | 95
Lactic acidosis 2 | 51
Lens Opacities 2 | 231
Leukoencephalopathies 2 | 29
Long philtrum 2 | 137
Mental and motor retardation 2 | 608
Muscle Spasticity 2 | 195
Muscle hypotonia 2 | 571
Muscle weakness, progressive 2 | 22
Nonsyndromic deafness 2 | 142
Pick disease 2 | 1,894
Poor growth 2 | 114
Slow progression 2 | 89
Small head 2 | 374
Spastic Ataxia 2 | 18
Subcutaneous panniculitis-like T-cell lymphoma 2 | 16
Variable expressivity 2 | 157
Very poor growth 2 | 114
acute quadriplegic myopathy 2 | 1,158
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
ependymoma 2 | 4,679
hearing impairment 2 | 199
interstitial lung disease 2 | 298
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
malignant mesothelioma 2 | 3,232
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung cancer 2 | 2,890
sonic hedgehog group medulloblastoma 2 | 467
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409
Hyperkyphosis 1 | 111
X-linked sideroblastic anemia 1 | 4

Tissue

Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678

Target Family

Enzyme 21 | 4,145
Non-IDG 3 | 12,091

PANTHER Protein Class (1)

aminoacyl-tRNA synthetase 24 | 24
protease 516 | 516
RNA binding protein 483 | 483
kinase 362 | 362
DNA binding protein 342 | 342
protease inhibitor 256 | 256
G-protein coupled receptor 221 | 221
actin family cytoskeletal prot... 221 | 221
KRAB box transcription factor 193 | 193
microtubule family cytoskeleta... 189 | 189
ion channel 186 | 186
G-protein modulator 179 | 179
dehydrogenase 173 | 173
phosphatase 163 | 163
G-protein 131 | 131
cation transporter 127 | 127
glycosyltransferase 121 | 121
nuclease 110 | 110
growth factor 104 | 104
cytokine 101 | 101
kinase modulator 99 | 99
ubiquitin-protein ligase 99 | 99
helix-turn-helix transcription... 98 | 98
transcription cofactor 96 | 96
serine protease 79 | 79
immunoglobulin 76 | 76
helicase 75 | 75
membrane trafficking regulator... 75 | 75
zinc finger transcription fact... 74 | 74
immunoglobulin receptor superf... 71 | 71
winged helix/forkhead transcri... 70 | 70
cysteine protease 69 | 69
acetyltransferase 68 | 68
oxygenase 68 | 68
basic helix-loop-helix transcr... 60 | 60
acyltransferase 59 | 59
extracellular matrix glycoprot... 53 | 53
methyltransferase 53 | 53
peptide hormone 52 | 52
phosphatase modulator 51 | 51
intracellular calcium-sensing ... 47 | 47
membrane-bound signaling molec... 47 | 47
reductase 42 | 42
C4 zinc finger nuclear recepto... 41 | 41
vesicle coat protein 40 | 40
oxidase 39 | 39
ATP-binding cassette (ABC) tra... 36 | 36
cytokine receptor 36 | 36
tight junction 35 | 35
esterase 32 | 32
extracellular matrix structura... 31 | 31
SNARE protein 30 | 30
lipase 30 | 30
amino acid transporter 28 | 28
basic leucine zipper transcrip... 27 | 27
Rel homology transcription fac... 25 | 25
peroxidase 24 | 24
dehydratase 23 | 23
deaminase 22 | 22
gap junction 21 | 21
major histocompatibility compl... 21 | 21
carbohydrate transporter 20 | 20
nucleotidyltransferase 20 | 20
transaminase 18 | 18
glycosidase 16 | 16
metalloprotease 16 | 16
homeodomain transcription fact... 15 | 15
intermediate filament 15 | 15
mitochondrial carrier protein 15 | 15
HMG box transcription factor 14 | 14
apolipoprotein 13 | 13
chaperonin 13 | 13
annexin 12 | 12
decarboxylase 12 | 12
Hsp90 family chaperone 9 | 9
phosphorylase 9 | 9
glucosidase 8 | 8
cadherin 7 | 7
cyclase 7 | 7
antibacterial response protein 6 | 6
deacetylase 6 | 6
phosphodiesterase 6 | 6
MADS box transcription factor 5 | 5
galactosidase 5 | 5
hydroxylase 5 | 5
mutase 5 | 5
immunoglobulin superfamily cel... 4 | 4
pyrophosphatase 4 | 4
P53-like transcription factor 3 | 3
Runt transcription factor 3 | 3
TATA-binding transcription fac... 3 | 3
myelin protein 3 | 3
amylase 2 | 2
epimerase/racemase 2 | 2
protein kinase receptor 2 | 2
aldolase 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.11190 1198.0 95
Glycine--tRNA ligase GARS Tbio Enzyme -2.62899 412.8 178
Aspartate--tRNA ligase, cytoplasmic DARS Tbio Enzyme -1.93573 78.1 128
Cysteine--tRNA ligase, cytoplasmic CARS Tbio Enzyme -3.00492 954.7 154
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.74520 518.6 163
Histidine--tRNA ligase, cytoplasmic HARS Tchem Enzyme -1.85612 66.8 212
Asparagine--tRNA ligase, cytoplasmic NARS Tbio Enzyme -1.97496 95.9 123
Methionine--tRNA ligase, mitochondrial MARS2 Tbio Enzyme -1.42617 25.3 73
Probable asparagine--tRNA ligase, mitochondrial NARS2 Tbio Enzyme -1.56799 38.2 93
Leucine-rich repeat-containing protein 47 LRRC47 Tdark Non-IDG 0.52 0.22 19