Development Level

Tbio 6,593 | 11,445
Tdark 1,848 | 6,588
Tchem 955 | 1,598
Tclin 330 | 613

Collection

RFA-RM-18-021 135 | 328
Kinase: IDG Consortium (Target... 67 | 125
Ion Channel: IDG Consortium (T... 39 | 99
GPCR: IDG Consortium (Targets) 30 | 126
Kinase: IDG Consortium (Comple... 17 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 747 | 979
preweaning lethality, incomple... 326 | 499
embryonic lethality prior to t... 219 | 278
abnormal behavior 207 | 298
embryonic lethality prior to o... 198 | 239
abnormal embryo size 166 | 220
enlarged heart 132 | 210
decreased vertical activity 130 | 208
decreased total body fat amoun... 128 | 207
abnormal bone structure 120 | 187
increased lean body mass 111 | 172
decreased body weight 110 | 161
abnormal heart morphology 100 | 162
decreased bone mineral content 100 | 151
hyperactivity 91 | 148
decreased lean body mass 90 | 135
increased total body fat amoun... 89 | 134
increased circulating alkaline... 87 | 122
hypoactivity 86 | 132
embryonic growth retardation 85 | 106
decreased grip strength 80 | 116
decreased bone mineral density 79 | 126
increased startle reflex 78 | 112
decreased circulating glucose ... 74 | 126
male infertility 73 | 123
increased bone mineral content 69 | 108
decreased body length 68 | 101
abnormal seminal vesicle morph... 67 | 114
increased or absent threshold ... 66 | 101
cataract 64 | 92
short tibia 64 | 97
prenatal lethality prior to he... 63 | 87
decreased circulating choleste... 62 | 93
decreased prepulse inhibition 62 | 82
increased mean corpuscular vol... 61 | 92
increased mean corpuscular hem... 58 | 96
abnormal lens morphology 57 | 81
decreased circulating triglyce... 55 | 79
decreased startle reflex 55 | 75
increased circulating HDL chol... 55 | 80
decreased circulating serum al... 54 | 82
impaired glucose tolerance 52 | 75
increased bone mineral density 52 | 72
decreased lymphocyte cell numb... 51 | 83
abnormal gait 50 | 69
decreased fasted circulating g... 50 | 65
small superior vagus ganglion 49 | 74
abnormal eye morphology 48 | 68
abnormal retina morphology 48 | 71
increased circulating choleste... 48 | 66
decreased hemoglobin content 46 | 68
decreased circulating insulin ... 45 | 76
increased circulating sodium l... 45 | 71
increased fasted circulating g... 45 | 76
thrombocytopenia 45 | 56
edema 44 | 59
abnormal coat-hair pigmentatio... 43 | 64
decreased leukocyte cell numbe... 43 | 73
decreased mean corpuscular vol... 43 | 79
decreased circulating HDL chol... 42 | 68
improved glucose tolerance 42 | 79
abnormal behavioral response t... 41 | 66
abnormal kidney morphology 40 | 65
abnormal sleep behavior 40 | 70
decreased erythrocyte cell num... 40 | 62
increased heart weight 40 | 62
increased monocyte cell number 40 | 63
small testis 39 | 58
hydrometra 38 | 53
abnormal neural tube closure 36 | 46
decreased circulating total pr... 35 | 49
decreased circulating alanine ... 34 | 47
decreased circulating alkaline... 34 | 46
abnormal skin morphology 32 | 50
decreased caudal vertebrae num... 32 | 53
decreased mean corpuscular hem... 32 | 50
tremors 32 | 39
increased hemoglobin content 31 | 45
abnormal epididymis morphology 30 | 42
abnormal spleen morphology 30 | 55
abnormal testis morphology 30 | 43
decreased hematocrit 30 | 46
increased blood urea nitrogen ... 30 | 48
decreased blood urea nitrogen ... 29 | 51
female infertility 29 | 60
increased circulating chloride... 29 | 41
increased circulating triglyce... 28 | 42
increased hematocrit 28 | 46
increased leukocyte cell numbe... 28 | 47
abnormal bone mineralization 27 | 38
abnormal cranium morphology 27 | 36
decreased circulating aspartat... 27 | 34
decreased red blood cell distr... 27 | 41
increased erythrocyte cell num... 27 | 39
increased neutrophil cell numb... 27 | 46
pallor 27 | 34
abnormal embryo turning 26 | 31
decreased neutrophil cell numb... 26 | 42
enlarged spleen 26 | 41
limb grasping 26 | 41

Disease

Carcinoma 6,013 | 11,493
ovarian cancer 5,373 | 8,520
osteosarcoma 4,593 | 7,950
medulloblastoma, large-cell 3,706 | 6,241
psoriasis 3,541 | 6,694
glioblastoma 3,501 | 5,792
atypical teratoid / rhabdoid tumor 3,081 | 5,112
lung cancer 2,806 | 4,740
ependymoma 2,787 | 4,679
group 3 medulloblastoma 2,492 | 4,104
adult high grade glioma 2,171 | 3,801
Breast cancer 2,147 | 3,578
malignant mesothelioma 1,925 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,898 | 3,291
primitive neuroectodermal tumor 1,838 | 3,035
Astrocytoma, Pilocytic 1,769 | 3,081
invasive ductal carcinoma 1,747 | 2,951
oligodendroglioma 1,719 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 1,715 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,693 | 2,955
non-small cell lung cancer 1,655 | 2,890
astrocytic glioma 1,585 | 2,597
lung adenocarcinoma 1,506 | 2,716
lung carcinoma 1,470 | 2,843
Cancer 1,434 | 2,499
pancreatic cancer 1,369 | 2,398
Kidney cancer 1,366 | 2,613
subependymal giant cell astrocytoma 1,357 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,287 | 1,962
Pick disease 1,195 | 1,894
interstitial cystitis 1,161 | 2,312
pituitary cancer 1,123 | 1,972
tuberculosis 1,100 | 2,010
group 4 medulloblastoma 1,076 | 1,855
ductal carcinoma in situ 1,038 | 1,745
Autosomal recessive predisposition 1,019 | 1,442
ulcerative colitis 1,007 | 1,819
Multiple myeloma 981 | 1,332
breast carcinoma 922 | 1,638
diabetes mellitus 917 | 1,728
cystic fibrosis 906 | 1,696
colon cancer 857 | 1,478
adrenocortical carcinoma 843 | 1,428
astrocytoma 764 | 1,146
acute quadriplegic myopathy 743 | 1,158
juvenile dermatomyositis 738 | 1,187
Intellectual disability 730 | 1,016
Schizophrenia 695 | 1,160
pediatric high grade glioma 685 | 1,064
primary pancreatic ductal adenocarcinoma 685 | 1,109
Rheumatoid arthritis 659 | 1,191
dermatomyositis 610 | 966
spina bifida 606 | 1,074
nasopharyngeal carcinoma 593 | 1,058
Epilepsy 553 | 792
Waldenstrons macroglobulinemia 549 | 765
non primary Sjogren syndrome sicca 528 | 891
active Crohn's disease 502 | 922
Atopic dermatitis 496 | 952
Dull intelligence 488 | 645
Low intelligence 488 | 645
Mental Retardation 488 | 645
Mental deficiency 488 | 645
Poor school performance 488 | 645
cutaneous lupus erythematosus 485 | 1,057
Cognitive delay 484 | 608
Global developmental delay 484 | 608
Mental and motor retardation 484 | 608
acute myeloid leukemia 483 | 783
gastric carcinoma 462 | 807
Liver Cirrhosis, Experimental 461 | 769
medulloblastoma 446 | 720
Muscle hypotonia 444 | 571
Seizures 444 | 596
aldosterone-producing adenoma 426 | 665
progressive supranuclear palsy 421 | 676
Obesity 416 | 678
active ulcerative colitis 401 | 764
Short stature 397 | 531
primary Sjogren syndrome 395 | 735
Alzheimer's disease 389 | 658
esophageal adenocarcinoma 387 | 737
Bipolar Disorder 383 | 666
Duchenne muscular dystrophy 350 | 601
pancreatic carcinoma 339 | 562
Melanoma 338 | 711
Prostatic Neoplasms 320 | 495
hepatocellular carcinoma 317 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 316 | 510
Down syndrome 303 | 499
Endometriosis 303 | 540
fibroadenoma 302 | 559
Small head 299 | 374
sonic hedgehog group medulloblastoma 295 | 467
Liver cancer 294 | 604
Amyotrophic lateral sclerosis 289 | 451
Breast Neoplasms 289 | 445
Neurodegenerative disease 288 | 414
chronic rhinosinusitis 287 | 512
tuberculosis and treatment for 6 months 278 | 409

Tissue

Endocrine System 9,622 | 18,159
Digestive Tract 9,478 | 17,369
Female tissues 9,442 | 17,400
Skin and soft tissues 9,433 | 17,230
Male tissues 9,390 | 17,142
Nervous System 9,363 | 16,725
Liver and Pancreas 9,316 | 16,750
Urinary Tract 9,314 | 16,678
Blood and immune system 9,306 | 16,909
Respiratory system 9,177 | 16,393
Cardiovascular System 8,842 | 15,192

Target Family

Non-IDG 5,479 | 12,091
Enzyme 2,508 | 4,145
Transcription Factor 580 | 1,400
Kinase 372 | 634
Transporter 265 | 473
Epigenetic 161 | 242
GPCR 159 | 408
Ion Channel 154 | 344
Nuclear Receptor 32 | 48
TF/Epigenetic 16 | 38

Ortholog Species

Zebrafish 9,726 | 9,726
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59