Development Level

Tbio 6,593 | 11,445
Tdark 1,848 | 6,588
Tchem 954 | 1,598
Tclin 330 | 613

Collection

Kinase: IDG Consortium (Target... 67 | 125
Ion Channel: IDG Consortium (T... 39 | 99
GPCR: IDG Consortium (Targets) 30 | 126
Kinase: IDG Consortium (Comple... 17 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 748 | 979
preweaning lethality, incomple... 326 | 499
embryonic lethality prior to t... 219 | 278
abnormal behavior 207 | 298
embryonic lethality prior to o... 198 | 239
abnormal embryo size 166 | 220
enlarged heart 132 | 210
decreased vertical activity 130 | 208
decreased total body fat amoun... 128 | 207
abnormal bone structure 120 | 187
increased lean body mass 111 | 172
decreased body weight 110 | 161
abnormal heart morphology 100 | 162
decreased bone mineral content 100 | 151
hyperactivity 91 | 148
decreased lean body mass 90 | 135
increased total body fat amoun... 89 | 134
increased circulating alkaline... 87 | 122
hypoactivity 86 | 132
embryonic growth retardation 85 | 106
decreased bone mineral density 79 | 126
decreased grip strength 79 | 116
increased startle reflex 78 | 112
decreased circulating glucose ... 74 | 126
male infertility 73 | 123
increased bone mineral content 69 | 108
decreased body length 68 | 101
abnormal seminal vesicle morph... 67 | 114
increased or absent threshold ... 66 | 101
cataract 64 | 92
short tibia 64 | 97
prenatal lethality prior to he... 63 | 87
decreased circulating choleste... 62 | 93
decreased prepulse inhibition 62 | 82
increased mean corpuscular vol... 61 | 92
increased mean corpuscular hem... 58 | 96
abnormal lens morphology 57 | 81
decreased circulating triglyce... 55 | 79
decreased startle reflex 55 | 75
increased circulating HDL chol... 55 | 80
decreased circulating serum al... 54 | 82
impaired glucose tolerance 52 | 75
increased bone mineral density 52 | 72
decreased lymphocyte cell numb... 51 | 83
abnormal gait 50 | 69
decreased fasted circulating g... 50 | 65
small superior vagus ganglion 49 | 74
abnormal eye morphology 48 | 68
abnormal retina morphology 48 | 71
increased circulating choleste... 48 | 66
decreased hemoglobin content 46 | 68
decreased circulating insulin ... 45 | 76
increased circulating sodium l... 45 | 71
increased fasted circulating g... 45 | 76
thrombocytopenia 45 | 56
edema 44 | 59
abnormal coat-hair pigmentatio... 43 | 64
decreased leukocyte cell numbe... 43 | 73
decreased mean corpuscular vol... 43 | 79
decreased circulating HDL chol... 42 | 68
improved glucose tolerance 42 | 79
abnormal behavioral response t... 41 | 66
abnormal kidney morphology 40 | 65
abnormal sleep behavior 40 | 70
decreased erythrocyte cell num... 40 | 62
increased heart weight 40 | 62
increased monocyte cell number 40 | 63
small testis 39 | 58
hydrometra 38 | 53
abnormal neural tube closure 36 | 46
decreased circulating total pr... 35 | 49
decreased circulating alanine ... 34 | 47
decreased circulating alkaline... 34 | 46
abnormal skin morphology 32 | 50
decreased caudal vertebrae num... 32 | 53
decreased mean corpuscular hem... 32 | 50
tremors 32 | 39
increased hemoglobin content 31 | 45
abnormal epididymis morphology 30 | 42
abnormal spleen morphology 30 | 55
abnormal testis morphology 30 | 43
decreased hematocrit 30 | 46
increased blood urea nitrogen ... 30 | 48
decreased blood urea nitrogen ... 29 | 51
female infertility 29 | 60
increased circulating chloride... 29 | 41
increased hematocrit 29 | 46
increased circulating triglyce... 28 | 42
increased leukocyte cell numbe... 28 | 47
abnormal bone mineralization 27 | 38
abnormal cranium morphology 27 | 36
decreased circulating aspartat... 27 | 34
decreased red blood cell distr... 27 | 41
increased erythrocyte cell num... 27 | 39
increased neutrophil cell numb... 27 | 46
pallor 27 | 34
abnormal embryo turning 26 | 31
decreased neutrophil cell numb... 26 | 42
enlarged spleen 26 | 41
limb grasping 26 | 41

Disease

Carcinoma 6,013 | 11,493
ovarian cancer 5,372 | 8,520
osteosarcoma 4,594 | 7,950
medulloblastoma, large-cell 3,707 | 6,241
psoriasis 3,539 | 6,694
glioblastoma 3,500 | 5,792
atypical teratoid / rhabdoid tumor 3,082 | 5,112
lung cancer 2,804 | 4,740
ependymoma 2,786 | 4,679
group 3 medulloblastoma 2,492 | 4,104
adult high grade glioma 2,170 | 3,801
Breast cancer 2,145 | 3,578
malignant mesothelioma 1,924 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,896 | 3,291
primitive neuroectodermal tumor 1,837 | 3,035
Astrocytoma, Pilocytic 1,768 | 3,081
invasive ductal carcinoma 1,746 | 2,951
oligodendroglioma 1,720 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 1,713 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,692 | 2,955
non-small cell lung cancer 1,655 | 2,890
astrocytic glioma 1,586 | 2,597
lung adenocarcinoma 1,506 | 2,716
lung carcinoma 1,469 | 2,843
Cancer 1,433 | 2,499
Kidney cancer 1,367 | 2,613
pancreatic cancer 1,367 | 2,398
subependymal giant cell astrocytoma 1,358 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,286 | 1,962
Pick disease 1,196 | 1,894
interstitial cystitis 1,160 | 2,312
pituitary cancer 1,124 | 1,972
tuberculosis 1,100 | 2,010
group 4 medulloblastoma 1,075 | 1,855
ductal carcinoma in situ 1,037 | 1,745
Autosomal recessive predisposition 1,020 | 1,442
ulcerative colitis 1,006 | 1,819
Multiple myeloma 981 | 1,332
breast carcinoma 922 | 1,638
diabetes mellitus 917 | 1,728
cystic fibrosis 904 | 1,696
colon cancer 857 | 1,478
adrenocortical carcinoma 843 | 1,428
astrocytoma 763 | 1,146
acute quadriplegic myopathy 742 | 1,158
juvenile dermatomyositis 739 | 1,187
Intellectual disability 731 | 1,016
Schizophrenia 694 | 1,160
pediatric high grade glioma 685 | 1,064
primary pancreatic ductal adenocarcinoma 685 | 1,109
Rheumatoid arthritis 659 | 1,191
dermatomyositis 610 | 966
spina bifida 606 | 1,074
nasopharyngeal carcinoma 592 | 1,058
Epilepsy 553 | 792
Waldenstrons macroglobulinemia 549 | 765
non primary Sjogren syndrome sicca 529 | 891
active Crohn's disease 502 | 922
Atopic dermatitis 495 | 952
Dull intelligence 489 | 645
Low intelligence 489 | 645
Mental Retardation 489 | 645
Mental deficiency 489 | 645
Poor school performance 489 | 645
cutaneous lupus erythematosus 485 | 1,057
Cognitive delay 484 | 608
Global developmental delay 484 | 608
Mental and motor retardation 484 | 608
acute myeloid leukemia 483 | 783
gastric carcinoma 462 | 807
Liver Cirrhosis, Experimental 461 | 769
medulloblastoma 447 | 720
Muscle hypotonia 444 | 571
Seizures 444 | 596
aldosterone-producing adenoma 425 | 665
progressive supranuclear palsy 421 | 676
Obesity 416 | 678
active ulcerative colitis 400 | 764
Short stature 397 | 531
primary Sjogren syndrome 395 | 735
Alzheimer's disease 389 | 658
esophageal adenocarcinoma 387 | 737
Bipolar Disorder 382 | 666
Duchenne muscular dystrophy 350 | 601
pancreatic carcinoma 339 | 562
Melanoma 338 | 711
Prostatic Neoplasms 320 | 495
hepatocellular carcinoma 317 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 315 | 510
Down syndrome 303 | 499
Endometriosis 303 | 540
fibroadenoma 302 | 559
Small head 299 | 374
sonic hedgehog group medulloblastoma 295 | 467
Liver cancer 294 | 604
Breast Neoplasms 289 | 445
Amyotrophic lateral sclerosis 288 | 451
Neurodegenerative disease 288 | 414
chronic rhinosinusitis 287 | 512
tuberculosis and treatment for 6 months 279 | 409

Tissue

Endocrine System 9,621 | 18,159
Digestive Tract 9,477 | 17,369
Female tissues 9,441 | 17,400
Skin and soft tissues 9,432 | 17,230
Male tissues 9,389 | 17,142
Nervous System 9,362 | 16,725
Liver and Pancreas 9,315 | 16,750
Urinary Tract 9,313 | 16,678
Blood and immune system 9,305 | 16,909
Respiratory system 9,176 | 16,393
Cardiovascular System 8,841 | 15,192

Target Family

Non-IDG 5,478 | 12,091
Enzyme 2,509 | 4,145
Transcription Factor 580 | 1,400
Kinase 372 | 634
Transporter 265 | 473
Epigenetic 161 | 242
GPCR 159 | 408
Ion Channel 153 | 344
Nuclear Receptor 32 | 48
TF/Epigenetic 16 | 38

Ortholog Species

Zebrafish 9,725 | 9,725
Mouse 16,567 | 16,567
Cow 15,316 | 15,316
Rat 15,112 | 15,112
Dog 15,069 | 15,069
Horse 14,249 | 14,249
Chimp 14,136 | 14,136
Macaque 12,758 | 12,758
Opossum 12,223 | 12,223
Anole lizard 10,585 | 10,585
Xenopus 10,463 | 10,463
Pig 10,164 | 10,164
Chicken 7,823 | 7,823
Platypus 5,699 | 5,699
C. elegans 3,178 | 3,178
Fruitfly 3,048 | 3,048
S.cerevisiae 1,798 | 1,798

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50