Development Level

Tbio 7,075 | 11,445
Tdark 2,018 | 6,588
Tchem 1,012 | 1,598
Tclin 363 | 613

Collection

RFA-RM-18-021 155 | 328
Kinase: IDG Consortium (Target... 69 | 125
Ion Channel: IDG Consortium (T... 46 | 99
GPCR: IDG Consortium (Targets) 43 | 126
Kinase: IDG Consortium (Comple... 19 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 810 | 979
preweaning lethality, incomple... 349 | 499
embryonic lethality prior to t... 230 | 278
abnormal behavior 216 | 298
embryonic lethality prior to o... 201 | 239
abnormal embryo size 184 | 220
enlarged heart 149 | 210
decreased total body fat amoun... 141 | 207
abnormal bone structure 132 | 187
decreased vertical activity 129 | 208
increased lean body mass 123 | 172
abnormal heart morphology 115 | 162
decreased body weight 115 | 161
decreased bone mineral content 114 | 151
hyperactivity 101 | 148
increased total body fat amoun... 98 | 134
decreased lean body mass 94 | 135
embryonic growth retardation 90 | 106
increased circulating alkaline... 90 | 122
decreased bone mineral density 89 | 126
decreased circulating glucose ... 88 | 126
hypoactivity 82 | 132
increased startle reflex 81 | 112
increased bone mineral content 80 | 108
increased or absent threshold ... 77 | 101
decreased grip strength 76 | 116
prenatal lethality prior to he... 73 | 87
male infertility 72 | 123
abnormal seminal vesicle morph... 71 | 114
increased mean corpuscular hem... 68 | 96
decreased body length 67 | 101
short tibia 66 | 97
increased mean corpuscular vol... 65 | 92
cataract 61 | 92
decreased circulating choleste... 61 | 93
decreased prepulse inhibition 61 | 82
abnormal lens morphology 58 | 81
decreased lymphocyte cell numb... 57 | 83
increased circulating HDL chol... 57 | 80
decreased circulating serum al... 55 | 82
abnormal retina morphology 54 | 71
decreased circulating triglyce... 54 | 79
increased fasted circulating g... 54 | 76
decreased leukocyte cell numbe... 52 | 73
decreased startle reflex 52 | 75
decreased mean corpuscular vol... 51 | 79
increased bone mineral density 51 | 72
decreased circulating insulin ... 50 | 76
abnormal gait 49 | 69
increased circulating choleste... 49 | 66
abnormal sleep behavior 48 | 70
small superior vagus ganglion 48 | 74
edema 47 | 59
abnormal coat-hair pigmentatio... 46 | 64
abnormal eye morphology 45 | 68
decreased fasted circulating g... 45 | 65
increased monocyte cell number 45 | 63
impaired glucose tolerance 44 | 75
increased circulating sodium l... 44 | 71
decreased circulating HDL chol... 43 | 68
decreased erythrocyte cell num... 42 | 62
decreased hemoglobin content 42 | 68
improved glucose tolerance 42 | 79
thrombocytopenia 42 | 56
abnormal behavioral response t... 40 | 66
abnormal kidney morphology 40 | 65
increased heart weight 40 | 62
decreased caudal vertebrae num... 38 | 53
abnormal neural tube closure 37 | 46
decreased blood urea nitrogen ... 36 | 51
decreased circulating alkaline... 36 | 46
decreased circulating total pr... 35 | 49
increased blood urea nitrogen ... 35 | 48
small testis 35 | 58
abnormal skin morphology 34 | 50
hydrometra 34 | 53
increased leukocyte cell numbe... 34 | 47
decreased circulating alanine ... 33 | 47
decreased mean corpuscular hem... 33 | 50
decreased neutrophil cell numb... 33 | 42
abnormal epididymis morphology 32 | 42
decreased hematocrit 32 | 46
increased mean platelet volume 32 | 45
abnormal spleen morphology 31 | 55
increased hematocrit 31 | 46
increased hemoglobin content 31 | 45
pallor 31 | 34
tremors 31 | 39
abnormal bone mineralization 30 | 38
female infertility 30 | 60
anophthalmia 29 | 33
increased grip strength 29 | 41
increased neutrophil cell numb... 29 | 46
prolonged QT interval 29 | 38
increased erythrocyte cell num... 28 | 39
increased lymphocyte cell numb... 28 | 32
decreased red blood cell distr... 27 | 41
enlarged spleen 27 | 41
increased circulating chloride... 27 | 41
increased circulating triglyce... 27 | 42

Disease

Carcinoma 6,647 | 11,493
ovarian cancer 5,741 | 8,520
osteosarcoma 4,968 | 7,950
medulloblastoma, large-cell 4,034 | 6,241
psoriasis 3,847 | 6,694
glioblastoma 3,799 | 5,792
atypical teratoid / rhabdoid tumor 3,349 | 5,112
lung cancer 3,055 | 4,740
ependymoma 3,023 | 4,679
group 3 medulloblastoma 2,670 | 4,104
adult high grade glioma 2,343 | 3,801
Breast cancer 2,321 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,132 | 3,291
malignant mesothelioma 2,121 | 3,232
primitive neuroectodermal tumor 1,986 | 3,035
invasive ductal carcinoma 1,923 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 1,922 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,891 | 2,955
oligodendroglioma 1,883 | 2,850
Astrocytoma, Pilocytic 1,860 | 3,081
non-small cell lung cancer 1,816 | 2,890
astrocytic glioma 1,715 | 2,597
lung adenocarcinoma 1,687 | 2,716
lung carcinoma 1,639 | 2,843
Cancer 1,572 | 2,499
pancreatic cancer 1,529 | 2,398
Kidney cancer 1,459 | 2,613
subependymal giant cell astrocytoma 1,427 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,345 | 1,962
interstitial cystitis 1,317 | 2,312
Pick disease 1,284 | 1,894
pituitary cancer 1,229 | 1,972
group 4 medulloblastoma 1,216 | 1,855
tuberculosis 1,185 | 2,010
ductal carcinoma in situ 1,120 | 1,745
ulcerative colitis 1,117 | 1,819
breast carcinoma 1,047 | 1,638
Autosomal recessive predisposition 1,040 | 1,442
Multiple myeloma 1,036 | 1,332
cystic fibrosis 1,015 | 1,696
diabetes mellitus 961 | 1,728
adrenocortical carcinoma 944 | 1,428
colon cancer 933 | 1,478
acute quadriplegic myopathy 833 | 1,158
juvenile dermatomyositis 805 | 1,187
astrocytoma 781 | 1,146
primary pancreatic ductal adenocarcinoma 771 | 1,109
Rheumatoid arthritis 750 | 1,191
Intellectual disability 744 | 1,016
pediatric high grade glioma 733 | 1,064
Schizophrenia 725 | 1,160
spina bifida 703 | 1,074
dermatomyositis 676 | 966
nasopharyngeal carcinoma 650 | 1,058
Waldenstrons macroglobulinemia 588 | 765
non primary Sjogren syndrome sicca 575 | 891
Epilepsy 562 | 792
Atopic dermatitis 543 | 952
active Crohn's disease 543 | 922
cutaneous lupus erythematosus 531 | 1,057
acute myeloid leukemia 522 | 783
gastric carcinoma 521 | 807
Liver Cirrhosis, Experimental 513 | 769
Dull intelligence 492 | 645
Low intelligence 492 | 645
Mental Retardation 492 | 645
Mental deficiency 492 | 645
Poor school performance 492 | 645
Cognitive delay 477 | 608
Global developmental delay 477 | 608
Mental and motor retardation 477 | 608
medulloblastoma 470 | 720
aldosterone-producing adenoma 460 | 665
progressive supranuclear palsy 447 | 676
Seizures 446 | 596
Obesity 441 | 678
active ulcerative colitis 439 | 764
esophageal adenocarcinoma 436 | 737
Muscle hypotonia 433 | 571
Alzheimer's disease 424 | 658
Bipolar Disorder 423 | 666
primary Sjogren syndrome 421 | 735
Short stature 395 | 531
Duchenne muscular dystrophy 393 | 601
pancreatic carcinoma 362 | 562
Melanoma 361 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 357 | 510
fibroadenoma 352 | 559
Endometriosis 351 | 540
hepatocellular carcinoma 350 | 547
Down syndrome 338 | 499
Prostatic Neoplasms 333 | 495
chronic rhinosinusitis 319 | 512
Liver cancer 317 | 604
Breast Neoplasms 316 | 445
Amyotrophic lateral sclerosis 313 | 451
Small head 302 | 374
Neurodegenerative disease 301 | 414
tuberculosis and treatment for 6 months 300 | 409
Mammary Neoplasms 299 | 425

Tissue

Endocrine System 10,347 | 18,159
Digestive Tract 10,189 | 17,369
Female tissues 10,157 | 17,400
Skin and soft tissues 10,130 | 17,230
Male tissues 10,093 | 17,142
Nervous System 10,054 | 16,725
Urinary Tract 10,004 | 16,678
Blood and immune system 9,998 | 16,909
Liver and Pancreas 9,997 | 16,750
Respiratory system 9,847 | 16,393
Cardiovascular System 9,447 | 15,192

Target Family

Non-IDG 5,889 | 12,091
Enzyme 2,630 | 4,145
Transcription Factor 685 | 1,400
Kinase 405 | 634
Transporter 269 | 473
GPCR 187 | 408
Ion Channel 166 | 344
Epigenetic 163 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 28 | 38
oGPCR 8 | 421

Ortholog Species

Xenopus 10,468 | 10,468
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141